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UniProtKB - Q9UBS4 (DJB11_HUMAN)

Entry version 194 (23 Feb 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

DnaJ homolog subfamily B member 11

Gene

DNAJB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351).

Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676).

May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079).

It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351).

3 Publications

Caution

PubMed:11584023 reported a cytosolic, as well as nuclear subcellular location. This result was obtained using an N-terminally GFP-tagged construct which most probably affected signal peptide-driven targeting to the ER. As a consequence, the in vivo revelance of the observed interaction with APOBEC1, a nuclear protein, is dubious. This holds true for the interaction with PWP1.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UBS4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381038, XBP1(S) activates chaperone genes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UBS4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DnaJ homolog subfamily B member 11
Alternative name(s):
APOBEC1-binding protein 2
Short name:
ABBP-2
DnaJ protein homolog 9
ER-associated DNAJ
ER-associated Hsp40 co-chaperone
Endoplasmic reticulum DNA J domain-containing protein 3
Short name:
ER-resident protein ERdj3
Short name:
ERdj3
Short name:
ERj3p
HEDJ
Human DnaJ protein 9
Short name:
hDj-9
PWP1-interacting protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAJB11
Synonyms:EDJ, ERJ3, HDJ9
ORF Names:PSEC0121, UNQ537/PRO1080
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14889, DNAJB11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611341, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UBS4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000090520

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Polycystic kidney disease 6 with or without polycystic liver disease (PKD6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of polycystic kidney disease, a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occur in other organs, particularly the liver. PKD6 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08100254P → R in PKD6. 1 PublicationCorresponds to variant dbSNP:rs1553849919EnsemblClinVar.1
Natural variantiVAR_08100377L → P in PKD6. 1 PublicationCorresponds to variant dbSNP:rs1553850185EnsemblClinVar.1
Natural variantiVAR_081004206 – 358Missing in PKD6. 1 PublicationAdd BLAST153

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi53H → Q: Loss of HSPA5-binding, but no effect on interaction with denatured substrates. 1 Publication1
Mutagenesisi169C → S: Drastic loss of interaction with denatured substrates. 1 Publication1
Mutagenesisi171C → S: Drastic loss of interaction with denatured substrates. 1 Publication1
Mutagenesisi193C → S: Drastic loss of interaction with denatured substrates. 1 Publication1
Mutagenesisi196C → S: Drastic loss of interaction with denatured substrates. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		51726

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		DNAJB11

MalaCards human disease database

More...MalaCardsi		DNAJB11
MIMi618061, phenotype

Open Targets

More...OpenTargetsi		ENSG00000090520

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		730, Autosomal dominant polycystic kidney disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27413

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UBS4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNAJB11

Domain mapping of disease mutations (DMDM)

More...DMDMi		18203497

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000726023 – 358DnaJ homolog subfamily B member 11Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei188PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi261N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains high-mannose Endo H-sensitive carbohydrates.
Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known.
Thr-188 was reported to be phosphorylated upon DNA damage by ATM or ATR; however as this position has been shown to be in the ER lumen, the in vivo relevance is not proven.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UBS4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UBS4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UBS4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UBS4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UBS4

PeptideAtlas

More...PeptideAtlasi		Q9UBS4

PRoteomics IDEntifications database

More...PRIDEi		Q9UBS4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84046

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9UBS4

2D gel databases

USC-OGP 2-DE database

More...OGPi		Q9UBS4

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00008454

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1185, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UBS4, 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UBS4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UBS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By endoplasmic reticulum stress-inducing agents such as thapsigargin and tunicamycin.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000090520, Expressed in tendon of biceps brachii and 216 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UBS4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000090520, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Binds to denatured substrates in an ATP-independent manner.

Interacts via the J domain with HSPA5 in an ATP-dependent manner.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119699, 240 interactors

Database of interacting proteins

More...DIPi		DIP-29678N

Protein interaction database and analysis system

More...IntActi		Q9UBS4, 95 interactors

Molecular INTeraction database

More...MINTi		Q9UBS4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000414398

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UBS4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UBS4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 90JPROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0713, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155792

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017633_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UBS4

Identification of Orthologs from Complete Genome Data

More...OMAi		THLDGHI

Database of Orthologous Groups

More...OrthoDBi		687505at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UBS4

TreeFam database of animal gene trees

More...TreeFami		TF105144

Family and domain databases

Conserved Domains Database

More...CDDi		cd06257, DnaJ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002939, DnaJ_C
IPR001623, DnaJ_domain
IPR018253, DnaJ_domain_CS
IPR008971, HSP40/DnaJ_pept-bd
IPR036869, J_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00226, DnaJ, 1 hit
PF01556, DnaJ_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00625, JDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00271, DnaJ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46565, SSF46565, 1 hit
SSF49493, SSF49493, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00636, DNAJ_1, 1 hit
PS50076, DNAJ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UBS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPQNLSTFC LLLLYLIGAV IAGRDFYKIL GVPRSASIKD IKKAYRKLAL 
        60         70         80         90        100
QLHPDRNPDD PQAQEKFQDL GAAYEVLSDS EKRKQYDTYG EEGLKDGHQS 
       110        120        130        140        150
SHGDIFSHFF GDFGFMFGGT PRQQDRNIPR GSDIIVDLEV TLEEVYAGNF 
       160        170        180        190        200
VEVVRNKPVA RQAPGKRKCN CRQEMRTTQL GPGRFQMTQE VVCDECPNVK 
       210        220        230        240        250
LVNEERTLEV EIEPGVRDGM EYPFIGEGEP HVDGEPGDLR FRIKVVKHPI 
       260        270        280        290        300
FERRGDDLYT NVTISLVESL VGFEMDITHL DGHKVHISRD KITRPGAKLW 
       310        320        330        340        350
KKGEGLPNFD NNNIKGSLII TFDVDFPKEQ LTEEAREGIK QLLKQGSVQK 

VYNGLQGY
Length:358
Mass (Da):40,514
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i580CC4D66A06B734
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7P0T9E8A0A7P0T9E8_HUMAN
DnaJ homolog subfamily B member 11
DNAJB11
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti247K → R in CAG33377 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08100254P → R in PKD6. 1 PublicationCorresponds to variant dbSNP:rs1553849919EnsemblClinVar.1
Natural variantiVAR_08100377L → P in PKD6. 1 PublicationCorresponds to variant dbSNP:rs1553850185EnsemblClinVar.1
Natural variantiVAR_081004206 – 358Missing in PKD6. 1 PublicationAdd BLAST153
Natural variantiVAR_016092264I → V2 PublicationsCorresponds to variant dbSNP:rs8147Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB028859 mRNA Translation: BAA88307.1
AF228505 mRNA Translation: AAF61711.1
AJ250137 mRNA Translation: CAB65118.1
AF277317 mRNA Translation: AAK69110.1
AY359043 mRNA Translation: AAQ89402.1
AK075300 mRNA Translation: BAC11533.1
AK075430 mRNA Translation: BAC11617.1
BT007063 mRNA Translation: AAP35712.1
CR457096 mRNA Translation: CAG33377.1
CH471052 Genomic DNA Translation: EAW78190.1
BC001144 mRNA Translation: AAH01144.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3277.1

Protein sequence database of the Protein Information Resource

More...PIRi		T52073

NCBI Reference Sequences

More...RefSeqi		NP_057390.1, NM_016306.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265028; ENSP00000265028; ENSG00000090520
ENST00000439351; ENSP00000414398; ENSG00000090520

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51726

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000265028.8; ENSP00000265028.3; NM_016306.6; NP_057390.1

UCSC genome browser

More...UCSCi		uc003fqi.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028859 mRNA Translation: BAA88307.1
AF228505 mRNA Translation: AAF61711.1
AJ250137 mRNA Translation: CAB65118.1
AF277317 mRNA Translation: AAK69110.1
AY359043 mRNA Translation: AAQ89402.1
AK075300 mRNA Translation: BAC11533.1
AK075430 mRNA Translation: BAC11617.1
BT007063 mRNA Translation: AAP35712.1
CR457096 mRNA Translation: CAG33377.1
CH471052 Genomic DNA Translation: EAW78190.1
BC001144 mRNA Translation: AAH01144.1
CCDSiCCDS3277.1
PIRiT52073
RefSeqiNP_057390.1, NM_016306.5

3D structure databases

SMRiQ9UBS4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119699, 240 interactors
DIPiDIP-29678N
IntActiQ9UBS4, 95 interactors
MINTiQ9UBS4
STRINGi9606.ENSP00000414398

PTM databases

GlyConnecti1185, 1 N-Linked glycan (1 site)
GlyGeniQ9UBS4, 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
iPTMnetiQ9UBS4
PhosphoSitePlusiQ9UBS4

Genetic variation databases

BioMutaiDNAJB11
DMDMi18203497

2D gel databases

OGPiQ9UBS4
REPRODUCTION-2DPAGEiIPI00008454

Proteomic databases

EPDiQ9UBS4
jPOSTiQ9UBS4
MassIVEiQ9UBS4
MaxQBiQ9UBS4
PaxDbiQ9UBS4
PeptideAtlasiQ9UBS4
PRIDEiQ9UBS4
ProteomicsDBi84046
TopDownProteomicsiQ9UBS4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2272, 247 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		51726

Genome annotation databases

EnsembliENST00000265028; ENSP00000265028; ENSG00000090520
ENST00000439351; ENSP00000414398; ENSG00000090520
GeneIDi51726
KEGGihsa:51726
MANE-SelectiENST00000265028.8; ENSP00000265028.3; NM_016306.6; NP_057390.1
UCSCiuc003fqi.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51726
DisGeNETi51726

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNAJB11
GeneReviewsiDNAJB11
HGNCiHGNC:14889, DNAJB11
HPAiENSG00000090520, Low tissue specificity
MalaCardsiDNAJB11
MIMi611341, gene
618061, phenotype
neXtProtiNX_Q9UBS4
OpenTargetsiENSG00000090520
Orphaneti730, Autosomal dominant polycystic kidney disease
PharmGKBiPA27413
VEuPathDBiHostDB:ENSG00000090520

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0713, Eukaryota
GeneTreeiENSGT00940000155792
HOGENOMiCLU_017633_0_0_1
InParanoidiQ9UBS4
OMAiTHLDGHI
OrthoDBi687505at2759
PhylomeDBiQ9UBS4
TreeFamiTF105144

Enzyme and pathway databases

PathwayCommonsiQ9UBS4
ReactomeiR-HSA-381038, XBP1(S) activates chaperone genes
SignaLinkiQ9UBS4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51726, 48 hits in 1059 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNAJB11, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DNAJB11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51726
PharosiQ9UBS4, Tbio

Protein Ontology

More...PROi		PR:Q9UBS4
RNActiQ9UBS4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000090520, Expressed in tendon of biceps brachii and 216 other tissues
GenevisibleiQ9UBS4, HS

Family and domain databases

CDDicd06257, DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR002939, DnaJ_C
IPR001623, DnaJ_domain
IPR018253, DnaJ_domain_CS
IPR008971, HSP40/DnaJ_pept-bd
IPR036869, J_dom_sf
PfamiView protein in Pfam
PF00226, DnaJ, 1 hit
PF01556, DnaJ_C, 1 hit
PRINTSiPR00625, JDOMAIN
SMARTiView protein in SMART
SM00271, DnaJ, 1 hit
SUPFAMiSSF46565, SSF46565, 1 hit
SSF49493, SSF49493, 2 hits
PROSITEiView protein in PROSITE
PS00636, DNAJ_1, 1 hit
PS50076, DNAJ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDJB11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBS4
Secondary accession number(s): Q542Y5
, Q542Y9, Q6IAQ8, Q96JC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: February 23, 2022
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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