UniProtKB - Q9UBS0 (KS6B2_HUMAN)
Ribosomal protein S6 kinase beta-2
RPS6KB2
Functioni
Phosphorylates specifically ribosomal protein S6 (PubMed:29750193).
Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
1 PublicationCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 99 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 194 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 73 – 81 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- peptide binding Source: Ensembl
- protein kinase activity Source: ProtInc
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- ribosomal protein S6 kinase activity Source: GO_Central
GO - Biological processi
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of translational initiation Source: UniProtKB
- protein kinase B signaling Source: Ensembl
- signal transduction Source: ProtInc
- TOR signaling Source: UniProtKB
- translation Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9UBS0 |
Reactomei | R-HSA-198693, AKT phosphorylates targets in the nucleus R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer |
SignaLinki | Q9UBS0 |
SIGNORi | Q9UBS0 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein S6 kinase beta-2 (EC:2.7.11.1)Short name: S6K-beta-2 Short name: S6K2 Alternative name(s): 70 kDa ribosomal protein S6 kinase 2 Short name: P70S6K2 Short name: p70-S6K 2 S6 kinase-related kinase Short name: SRK Serine/threonine-protein kinase 14B p70 ribosomal S6 kinase beta Short name: S6K-beta Short name: p70 S6 kinase beta Short name: p70 S6K-beta Short name: p70 S6KB Short name: p70-beta |
Gene namesi | Name:RPS6KB2 Synonyms:STK14B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10437, RPS6KB2 |
MIMi | 608939, gene |
neXtProti | NX_Q9UBS0 |
VEuPathDBi | HostDB:ENSG00000175634 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6199 |
OpenTargetsi | ENSG00000175634 |
PharmGKBi | PA34852 |
Miscellaneous databases
Pharosi | Q9UBS0, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3111 |
Genetic variation databases
BioMutai | RPS6KB2 |
DMDMi | 296434560 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086214 | 1 – 482 | Ribosomal protein S6 kinase beta-2Add BLAST | 482 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 417 | PhosphoserineCombined sources | 1 | |
Modified residuei | 423 | PhosphoserineCombined sources | 1 | |
Modified residuei | 473 | Phosphoserine; by PKC1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UBS0 |
jPOSTi | Q9UBS0 |
MassIVEi | Q9UBS0 |
MaxQBi | Q9UBS0 |
PaxDbi | Q9UBS0 |
PeptideAtlasi | Q9UBS0 |
PRIDEi | Q9UBS0 |
ProteomicsDBi | 4623 84044 [Q9UBS0-1] |
PTM databases
iPTMneti | Q9UBS0 |
PhosphoSitePlusi | Q9UBS0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175634, Expressed in skin of leg and 190 other tissues |
ExpressionAtlasi | Q9UBS0, baseline and differential |
Genevisiblei | Q9UBS0, HS |
Organism-specific databases
HPAi | ENSG00000175634, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112113, 230 interactors |
ELMi | Q9UBS0 |
IntActi | Q9UBS0, 21 interactors |
MINTi | Q9UBS0 |
STRINGi | 9606.ENSP00000308413 |
Chemistry databases
BindingDBi | Q9UBS0 |
Miscellaneous databases
RNActi | Q9UBS0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 67 – 328 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 329 – 399 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 407 – 482 | DisorderedSequence analysisAdd BLAST | 76 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 471 – 477 | Nuclear localization signal1 Publication | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 435 – 463 | Pro residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0598, Eukaryota |
GeneTreei | ENSGT00940000155062 |
HOGENOMi | CLU_000288_63_5_1 |
InParanoidi | Q9UBS0 |
OMAi | CVIYDMM |
OrthoDBi | 1132245at2759 |
PhylomeDBi | Q9UBS0 |
TreeFami | TF313438 |
Family and domain databases
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016238, Ribosomal_S6_kinase IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000605, Ribsml_S6_kin_1, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAVFDLDLE TEEGSEGEGE PELSPADACP LAELRAAGLE PVGHYEEVEL
60 70 80 90 100
TETSVNVGPE RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV
110 120 130 140 150
LRKAKIVRNA KDTAHTRAER NILESVKHPF IVELAYAFQT GGKLYLILEC
160 170 180 190 200
LSGGELFTHL EREGIFLEDT ACFYLAEITL ALGHLHSQGI IYRDLKPENI
210 220 230 240 250
MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI LVRSGHNRAV
260 270 280 290 300
DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIRGKLALPP YLTPDARDLV
310 320 330 340 350
KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH MNWDDLLAWR VDPPFRPCLQ
360 370 380 390 400
SEEDVSQFDT RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE
410 420 430 440 450
GFSFQPKLRS PRRLNSSPRA PVSPLKFSPF EGFRPSPSLP EPTELPLPPL
460 470 480
LPPPPPSTTA PLPIRPPSGT KKSKRGRGRP GR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PQF6 | E9PQF6_HUMAN | Ribosomal protein S6 kinase beta-2 | RPS6KB2 | 138 | Annotation score: | ||
G3V2F1 | G3V2F1_HUMAN | Ribosomal protein S6 kinase beta-2 | RPS6KB2 | 153 | Annotation score: | ||
R4GN47 | R4GN47_HUMAN | Ribosomal protein S6 kinase beta-2 | RPS6KB2 | 107 | Annotation score: | ||
E9PIP7 | E9PIP7_HUMAN | Ribosomal protein S6 kinase beta-2 | RPS6KB2 | 20 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | Missing in BAA37145 (PubMed:9878560).Curated | 1 | |
Sequence conflicti | 409 | R → C in BAA37145 (PubMed:9878560).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040643 | 267 | P → L1 PublicationCorresponds to variant dbSNP:rs55987642Ensembl. | 1 | |
Natural variantiVAR_040644 | 368 | V → M1 PublicationCorresponds to variant dbSNP:rs55642995Ensembl. | 1 | |
Natural variantiVAR_040645 | 420 | A → VCombined sources5 PublicationsCorresponds to variant dbSNP:rs13859Ensembl. | 1 | |
Natural variantiVAR_040646 | 443 | T → M in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs374535834Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056441 | 153 – 154 | GG → VD in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_056442 | 155 – 482 | Missing in isoform 2. 1 PublicationAdd BLAST | 328 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB016869 mRNA Translation: BAA34402.1 Different initiation. AB019245 mRNA Translation: BAA37145.1 AF076931 mRNA Translation: AAD46063.1 AF099739 mRNA Translation: AAD20990.1 AK297527 mRNA Translation: BAG59930.1 AP003419 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74621.1 BC000094 mRNA Translation: AAH00094.3 BC136564 mRNA Translation: AAI36565.1 |
CCDSi | CCDS41677.1 [Q9UBS0-1] |
PIRi | JE0377 |
RefSeqi | NP_003943.2, NM_003952.2 [Q9UBS0-1] |
Genome annotation databases
Ensembli | ENST00000312629.10; ENSP00000308413.5; ENSG00000175634.15 ENST00000528964.5; ENSP00000432847.1; ENSG00000175634.15 [Q9UBS0-2] |
GeneIDi | 6199 |
KEGGi | hsa:6199 |
MANE-Selecti | ENST00000312629.10; ENSP00000308413.5; NM_003952.3; NP_003943.2 |
UCSCi | uc001old.4, human [Q9UBS0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB016869 mRNA Translation: BAA34402.1 Different initiation. AB019245 mRNA Translation: BAA37145.1 AF076931 mRNA Translation: AAD46063.1 AF099739 mRNA Translation: AAD20990.1 AK297527 mRNA Translation: BAG59930.1 AP003419 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74621.1 BC000094 mRNA Translation: AAH00094.3 BC136564 mRNA Translation: AAI36565.1 |
CCDSi | CCDS41677.1 [Q9UBS0-1] |
PIRi | JE0377 |
RefSeqi | NP_003943.2, NM_003952.2 [Q9UBS0-1] |
3D structure databases
AlphaFoldDBi | Q9UBS0 |
SMRi | Q9UBS0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112113, 230 interactors |
ELMi | Q9UBS0 |
IntActi | Q9UBS0, 21 interactors |
MINTi | Q9UBS0 |
STRINGi | 9606.ENSP00000308413 |
Chemistry databases
BindingDBi | Q9UBS0 |
ChEMBLi | CHEMBL3111 |
PTM databases
iPTMneti | Q9UBS0 |
PhosphoSitePlusi | Q9UBS0 |
Genetic variation databases
BioMutai | RPS6KB2 |
DMDMi | 296434560 |
Proteomic databases
EPDi | Q9UBS0 |
jPOSTi | Q9UBS0 |
MassIVEi | Q9UBS0 |
MaxQBi | Q9UBS0 |
PaxDbi | Q9UBS0 |
PeptideAtlasi | Q9UBS0 |
PRIDEi | Q9UBS0 |
ProteomicsDBi | 4623 84044 [Q9UBS0-1] |
Protocols and materials databases
Antibodypediai | 1546, 791 antibodies from 39 providers |
DNASUi | 6199 |
Genome annotation databases
Ensembli | ENST00000312629.10; ENSP00000308413.5; ENSG00000175634.15 ENST00000528964.5; ENSP00000432847.1; ENSG00000175634.15 [Q9UBS0-2] |
GeneIDi | 6199 |
KEGGi | hsa:6199 |
MANE-Selecti | ENST00000312629.10; ENSP00000308413.5; NM_003952.3; NP_003943.2 |
UCSCi | uc001old.4, human [Q9UBS0-1] |
Organism-specific databases
CTDi | 6199 |
DisGeNETi | 6199 |
GeneCardsi | RPS6KB2 |
HGNCi | HGNC:10437, RPS6KB2 |
HPAi | ENSG00000175634, Low tissue specificity |
MIMi | 608939, gene |
neXtProti | NX_Q9UBS0 |
OpenTargetsi | ENSG00000175634 |
PharmGKBi | PA34852 |
VEuPathDBi | HostDB:ENSG00000175634 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0598, Eukaryota |
GeneTreei | ENSGT00940000155062 |
HOGENOMi | CLU_000288_63_5_1 |
InParanoidi | Q9UBS0 |
OMAi | CVIYDMM |
OrthoDBi | 1132245at2759 |
PhylomeDBi | Q9UBS0 |
TreeFami | TF313438 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9UBS0 |
Reactomei | R-HSA-198693, AKT phosphorylates targets in the nucleus R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer |
SignaLinki | Q9UBS0 |
SIGNORi | Q9UBS0 |
Miscellaneous databases
BioGRID-ORCSi | 6199, 14 hits in 1107 CRISPR screens |
ChiTaRSi | RPS6KB2, human |
GeneWikii | RPS6KB2 |
GenomeRNAii | 6199 |
Pharosi | Q9UBS0, Tchem |
PROi | PR:Q9UBS0 |
RNActi | Q9UBS0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175634, Expressed in skin of leg and 190 other tissues |
ExpressionAtlasi | Q9UBS0, baseline and differential |
Genevisiblei | Q9UBS0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016238, Ribosomal_S6_kinase IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000605, Ribsml_S6_kin_1, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KS6B2_HUMAN | |
Accessioni | Q9UBS0Primary (citable) accession number: Q9UBS0 Secondary accession number(s): B2RMZ9 Q9UEC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 207 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families