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Protein

Cathepsin Z

Gene

CTSZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.

Catalytic activityi

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei921
Active sitei2411
Active sitei2611

GO - Molecular functioni

  • carboxypeptidase activity Source: CAFA
  • cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.18.1 2681
ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-5694530 Cargo concentration in the ER
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiC01.013

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin Z (EC:3.4.18.1)
Alternative name(s):
Cathepsin P
Cathepsin X
Gene namesi
Name:CTSZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101160.13
HGNCiHGNC:2547 CTSZ
MIMi603169 gene
neXtProtiNX_Q9UBR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1522
OpenTargetsiENSG00000101160
PharmGKBiPA27043

Chemistry databases

ChEMBLiCHEMBL4160
GuidetoPHARMACOLOGYi2354

Polymorphism and mutation databases

BioMutaiCTSZ
DMDMi12643324

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000002628524 – 61Activation peptideAdd BLAST38
ChainiPRO_000002628662 – 303Cathepsin ZAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 132
Disulfide bondi126 ↔ 164
Disulfide bondi154 ↔ 170
Disulfide bondi173 ↔ 179
Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi214 ↔ 296
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiQ9UBR2
MaxQBiQ9UBR2
PaxDbiQ9UBR2
PeptideAtlasiQ9UBR2
PRIDEiQ9UBR2
ProteomicsDBi84036

PTM databases

iPTMnetiQ9UBR2
PhosphoSitePlusiQ9UBR2
SwissPalmiQ9UBR2

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000101160
CleanExiHS_CTSZ
GenevisibleiQ9UBR2 HS

Organism-specific databases

HPAiCAB025114
HPA049876
HPA053504

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107902, 15 interactors
IntActiQ9UBR2, 24 interactors
MINTiQ9UBR2
STRINGi9606.ENSP00000217131

Chemistry databases

BindingDBiQ9UBR2

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 42Combined sources3
Helixi59 – 61Combined sources3
Beta strandi85 – 87Combined sources3
Helixi92 – 108Combined sources17
Turni109 – 111Combined sources3
Helixi120 – 126Combined sources7
Beta strandi127 – 131Combined sources5
Beta strandi133 – 135Combined sources3
Helixi137 – 146Combined sources10
Beta strandi149 – 151Combined sources3
Helixi152 – 154Combined sources3
Helixi166 – 169Combined sources4
Beta strandi170 – 175Combined sources6
Beta strandi178 – 181Combined sources4
Beta strandi190 – 196Combined sources7
Helixi199 – 209Combined sources11
Beta strandi212 – 216Combined sources5
Helixi220 – 223Combined sources4
Beta strandi227 – 230Combined sources4
Beta strandi241 – 251Combined sources11
Beta strandi254 – 260Combined sources7
Beta strandi272 – 276Combined sources5
Helixi280 – 283Combined sources4
Helixi285 – 287Combined sources3
Turni290 – 293Combined sources4
Beta strandi296 – 301Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEUX-ray1.70A/B27-303[»]
1EF7X-ray2.67A/B62-303[»]
ProteinModelPortaliQ9UBR2
SMRiQ9UBR2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UBR2

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140859
HOGENOMiHOG000264454
HOVERGENiHBG004456
InParanoidiQ9UBR2
KOiK08568
OMAiQCGTCTE
OrthoDBiEOG091G0BNT
PhylomeDBiQ9UBR2
TreeFamiTF313225

Family and domain databases

InterProiView protein in InterPro
IPR033157 Cathepsin_X
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
PANTHERiPTHR12411 PTHR12411, 1 hit
PTHR12411:SF14 PTHR12411:SF14, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRGPGWRP LLLLVLLAGA AQGGLYFRRG QTCYRPLRGD GLAPLGRSTY
60 70 80 90 100
PRPHEYLSPA DLPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA
110 120 130 140 150
MADRINIKRK GAWPSTLLSV QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP
160 170 180 190 200
DETCNNYQAK DQECDKFNQC GTCNEFKECH AIRNYTLWRV GDYGSLSGRE
210 220 230 240 250
KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN HVVSVAGWGI
260 270 280 290 300
SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD

PIV
Length:303
Mass (Da):33,868
Last modified:May 1, 2000 - v1
Checksum:i6274FD1974D0EBDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48S → T in AAC39839 (PubMed:9642240).Curated1
Sequence conflicti150P → S in AAC61477 (PubMed:9738465).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01025436P → S1 PublicationCorresponds to variant dbSNP:rs778998634Ensembl.1
Natural variantiVAR_010255129A → R Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_033719286A → T. Corresponds to variant dbSNP:rs34069356Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073890 mRNA Translation: AAC61477.1
AF032906 mRNA Translation: AAC39839.1
AF136273 mRNA Translation: AAF13145.1
AF136276, AF136274, AF136275 Genomic DNA Translation: AAF13148.1
AK314931 mRNA Translation: BAG37437.1
AL109840 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75448.1
BC042168 mRNA Translation: AAH42168.1
AF009923 mRNA Translation: AAC63141.1
CCDSiCCDS13474.1
RefSeqiNP_001327.2, NM_001336.3
UniGeneiHs.252549

Genome annotation databases

EnsembliENST00000217131; ENSP00000217131; ENSG00000101160
GeneIDi1522
KEGGihsa:1522
UCSCiuc002yai.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCATZ_HUMAN
AccessioniPrimary (citable) accession number: Q9UBR2
Secondary accession number(s): B2RC40
, O75331, Q9UQV5, Q9UQV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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