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Entry version 172 (13 Feb 2019)
Sequence version 1 (01 May 2000)
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Protein

Glyoxylate reductase/hydroxypyruvate reductase

Gene

GRHPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei217NADP1 Publication1
Binding sitei243NADP; via carbonyl oxygen1 Publication1
Binding sitei245Substrate1 Publication1
Binding sitei269Substrate1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei274Raises pKa of active site His1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei293Proton donor1 Publication1
Binding sitei295NADP; via amide nitrogen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi162 – 164NADP1 Publication3
Nucleotide bindingi185 – 188NADP1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06275-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-389661 Glyoxylate metabolism and glycine degradation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9UBQ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glyoxylate reductase/hydroxypyruvate reductase (EC:1.1.1.79, EC:1.1.1.81)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRHPR
Synonyms:GLXR
ORF Names:MSTP035
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137106.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4570 GRHPR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604296 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperoxaluria primary 2 (HP2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by elevated urinary excretion of oxalate and L-glycerate, progressive tissue accumulation of insoluble calcium oxalate, nephrolithiasis, nephrocalcinosis, and end-stage renal disease.
See also OMIM:260000

Organism-specific databases

DisGeNET

More...
DisGeNETi
9380

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
GRHPR

MalaCards human disease database

More...
MalaCardsi
GRHPR
MIMi260000 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137106

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93599 Primary hyperoxaluria type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28965

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRHPR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47116943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759441 – 328Glyoxylate reductase/hydroxypyruvate reductaseAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Modified residuei298PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBQ7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UBQ7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBQ7

PeptideAtlas

More...
PeptideAtlasi
Q9UBQ7

PRoteomics IDEntifications database

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PRIDEi
Q9UBQ7

ProteomicsDB human proteome resource

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ProteomicsDBi
84034

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00037448

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
Q9UBQ7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UBQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UBQ7

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9UBQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Most abundantly expressed in the liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137106 Expressed in 237 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBQ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBQ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022971

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114781, 37 interactors

Protein interaction database and analysis system

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IntActi
Q9UBQ7, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000313432

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GCGX-ray2.20A/B/C/D1-328[»]
2H1SX-ray2.45A/B/C/D2-328[»]
2Q50X-ray2.45A/B/C/D2-328[»]
2WWRX-ray2.82A/B/C/D1-328[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UBQ7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBQ7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UBQ7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni83 – 84Substrate binding1 Publication2
Regioni293 – 296Substrate binding1 Publication4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0069 Eukaryota
COG1052 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158578

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000136702

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051838

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBQ7

KEGG Orthology (KO)

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KOi
K00049

Identification of Orthologs from Complete Genome Data

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OMAi
KWIAHNG

Database of Orthologous Groups

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OrthoDBi
1378766at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBQ7

TreeFam database of animal gene trees

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TreeFami
TF324791

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA
60 70 80 90 100
GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV
110 120 130 140 150
GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG
160 170 180 190 200
LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV
210 220 230 240 250
STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN
260 270 280 290 300
QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR
310 320
TRNTMSLLAA NNLLAGLRGE PMPSELKL
Length:328
Mass (Da):35,668
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68A0E311AA4E5650
GO
Isoform 2 (identifier: Q9UBQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MRPVRLMKVFVTRRIPAEGRV → MLGGVPTLCGTGNETWTLLAL
     22-164: Missing.
     246-328: GDVVNQDDLY...GEPMPSELKL → YPRATLPSKP...GGQTLKLTWS

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):27,843
Checksum:i75454F0946FC8BE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ56U3KQ56_HUMAN
Glyoxylate reductase/hydroxypyruvat...
GRHPR
358Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD54066 differs from that shown. Reason: Frameshift at positions 109 and 137.Curated
The sequence AAG39286 differs from that shown. Reason: Frameshift at position 237.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032762170R → Q. Corresponds to variant dbSNP:rs12002324Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0570161 – 21MRPVR…AEGRV → MLGGVPTLCGTGNETWTLLA L in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_05701722 – 164Missing in isoform 2. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_057018246 – 328GDVVN…SELKL → YPRATLPSKPGEEPSPLLPS GDFLPRGLLVRPQAELAGFH KPNNQLRNSWEYTRPPYREE EPSEWAWPVCFSAVAPTRRG LAHSSVASGSVPREPLQAHY PPPQRAGLEDLKGPLEAASH TAEPGFVWLWFSDTLNLMLL GGQTLKLTWS in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF134895 mRNA Translation: AAF00111.1
AF146018 mRNA Translation: AAD45886.1
AF146689 Genomic DNA Translation: AAD46517.1
AF113215 mRNA Translation: AAG39286.1 Frameshift.
AK026287 mRNA Translation: BAB15430.1
AK315690 mRNA Translation: BAG38053.1
AL158155 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58284.1
CH471071 Genomic DNA Translation: EAW58285.1
BC000605 mRNA Translation: AAH00605.1
AF113251 mRNA Translation: AAD54066.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6609.1 [Q9UBQ7-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC7190

NCBI Reference Sequences

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RefSeqi
NP_036335.1, NM_012203.1 [Q9UBQ7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.155742

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318158; ENSP00000313432; ENSG00000137106 [Q9UBQ7-1]
ENST00000494290; ENSP00000432021; ENSG00000137106 [Q9UBQ7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9380

UCSC genome browser

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UCSCi
uc003zzu.2 human [Q9UBQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134895 mRNA Translation: AAF00111.1
AF146018 mRNA Translation: AAD45886.1
AF146689 Genomic DNA Translation: AAD46517.1
AF113215 mRNA Translation: AAG39286.1 Frameshift.
AK026287 mRNA Translation: BAB15430.1
AK315690 mRNA Translation: BAG38053.1
AL158155 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58284.1
CH471071 Genomic DNA Translation: EAW58285.1
BC000605 mRNA Translation: AAH00605.1
AF113251 mRNA Translation: AAD54066.1 Frameshift.
CCDSiCCDS6609.1 [Q9UBQ7-1]
PIRiJC7190
RefSeqiNP_036335.1, NM_012203.1 [Q9UBQ7-1]
UniGeneiHs.155742

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GCGX-ray2.20A/B/C/D1-328[»]
2H1SX-ray2.45A/B/C/D2-328[»]
2Q50X-ray2.45A/B/C/D2-328[»]
2WWRX-ray2.82A/B/C/D1-328[»]
ProteinModelPortaliQ9UBQ7
SMRiQ9UBQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114781, 37 interactors
IntActiQ9UBQ7, 5 interactors
STRINGi9606.ENSP00000313432

PTM databases

iPTMnetiQ9UBQ7
PhosphoSitePlusiQ9UBQ7
SwissPalmiQ9UBQ7

Polymorphism and mutation databases

BioMutaiGRHPR
DMDMi47116943

2D gel databases

REPRODUCTION-2DPAGEiIPI00037448
UCD-2DPAGEiQ9UBQ7

Proteomic databases

EPDiQ9UBQ7
jPOSTiQ9UBQ7
PaxDbiQ9UBQ7
PeptideAtlasiQ9UBQ7
PRIDEiQ9UBQ7
ProteomicsDBi84034

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9380
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318158; ENSP00000313432; ENSG00000137106 [Q9UBQ7-1]
ENST00000494290; ENSP00000432021; ENSG00000137106 [Q9UBQ7-2]
GeneIDi9380
KEGGihsa:9380
UCSCiuc003zzu.2 human [Q9UBQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9380
DisGeNETi9380
EuPathDBiHostDB:ENSG00000137106.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRHPR
GeneReviewsiGRHPR
HGNCiHGNC:4570 GRHPR
HPAiHPA022971
MalaCardsiGRHPR
MIMi260000 phenotype
604296 gene
neXtProtiNX_Q9UBQ7
OpenTargetsiENSG00000137106
Orphaneti93599 Primary hyperoxaluria type 2
PharmGKBiPA28965

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0069 Eukaryota
COG1052 LUCA
GeneTreeiENSGT00940000158578
HOGENOMiHOG000136702
HOVERGENiHBG051838
InParanoidiQ9UBQ7
KOiK00049
OMAiKWIAHNG
OrthoDBi1378766at2759
PhylomeDBiQ9UBQ7
TreeFamiTF324791

Enzyme and pathway databases

BioCyciMetaCyc:HS06275-MONOMER
ReactomeiR-HSA-389661 Glyoxylate metabolism and glycine degradation
SABIO-RKiQ9UBQ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRHPR human
EvolutionaryTraceiQ9UBQ7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GRHPR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9380

Protein Ontology

More...
PROi
PR:Q9UBQ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137106 Expressed in 237 organ(s), highest expression level in liver
ExpressionAtlasiQ9UBQ7 baseline and differential
GenevisibleiQ9UBQ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRHPR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBQ7
Secondary accession number(s): Q5T945
, Q9H3E9, Q9H636, Q9UKX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: February 13, 2019
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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