UniProtKB - Q9UBQ5 (EIF3K_HUMAN)
Eukaryotic translation initiation factor 3 subunit K
EIF3K
Functioni
GO - Molecular functioni
- ribosome binding Source: InterPro
- translation initiation factor activity Source: UniProtKB-UniRule
GO - Biological processi
- formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
- regulation of translational initiation Source: InterPro
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
PathwayCommonsi | Q9UBQ5 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 3 subunit KUniRule annotationShort name: eIF3kUniRule annotation Alternative name(s): Eukaryotic translation initiation factor 3 subunit 12UniRule annotation Muscle-specific gene M9 protein PLAC-24 eIF-3 p25UniRule annotation eIF-3 p28 |
Gene namesi | ORF Names:ARG134, HSPC029, MSTP001, PTD001 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24656, EIF3K |
MIMi | 609596, gene |
neXtProti | NX_Q9UBQ5 |
VEuPathDBi | HostDB:ENSG00000178982.9 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- eukaryotic 43S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic 48S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic translation initiation factor 3 complex Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 27335 |
OpenTargetsi | ENSG00000178982 |
PharmGKBi | PA162384923 |
Miscellaneous databases
Pharosi | Q9UBQ5, Tbio |
Genetic variation databases
BioMutai | EIF3K |
DMDMi | 23396628 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedUniRule annotationCombined sources2 Publications | |||
ChainiPRO_0000123546 | 2 – 218 | Eukaryotic translation initiation factor 3 subunit KAdd BLAST | 217 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineUniRule annotationCombined sources2 Publications | 1 | |
Modified residuei | 28 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 217 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9UBQ5 |
jPOSTi | Q9UBQ5 |
MassIVEi | Q9UBQ5 |
PaxDbi | Q9UBQ5 |
PeptideAtlasi | Q9UBQ5 |
PRIDEi | Q9UBQ5 |
ProteomicsDBi | 7071 84032 [Q9UBQ5-1] |
TopDownProteomicsi | Q9UBQ5-1 [Q9UBQ5-1] |
PTM databases
iPTMneti | Q9UBQ5 |
PhosphoSitePlusi | Q9UBQ5 |
SwissPalmi | Q9UBQ5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000178982, Expressed in heart left ventricle and 251 other tissues |
ExpressionAtlasi | Q9UBQ5, baseline and differential |
Genevisiblei | Q9UBQ5, HS |
Organism-specific databases
HPAi | ENSG00000178982, Low tissue specificity |
Interactioni
Subunit structurei
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
Interacts with CCND3, but not with CCND1 and CCND2.
UniRule annotation6 PublicationsBinary interactionsi
Hide detailsQ9UBQ5
Protein-protein interaction databases
BioGRIDi | 118148, 89 interactors |
ComplexPortali | CPX-6036, Eukaryotic translation initiation factor 3 complex |
CORUMi | Q9UBQ5 |
DIPi | DIP-32880N |
IntActi | Q9UBQ5, 43 interactors |
MINTi | Q9UBQ5 |
STRINGi | 9606.ENSP00000248342 |
Miscellaneous databases
RNActi | Q9UBQ5, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UBQ5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UBQ5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 204 | PCIPROSITE-ProRule annotationAdd BLAST | 163 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3252, Eukaryota |
GeneTreei | ENSGT00390000009409 |
HOGENOMi | CLU_076723_1_0_1 |
InParanoidi | Q9UBQ5 |
OMAi | YVQDQAK |
OrthoDBi | 1576799at2759 |
PhylomeDBi | Q9UBQ5 |
TreeFami | TF314893 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.25.40.250, 1 hit |
HAMAPi | MF_03010, eIF3k, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR033464, CSN8_PSD8_EIF3K IPR009374, eIF3k IPR000717, PCI_dom IPR016020, Transl_init_fac_sub12_N_euk IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR13022, PTHR13022, 1 hit |
Pfami | View protein in Pfam PF10075, CSN8_PSD8_EIF3K, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAMFEQMRAN VGKLLKGIDR YNPENLATLE RYVETQAKEN AYDLEANLAV
60 70 80 90 100
LKLYQFNPAF FQTTVTAQIL LKALTNLPHT DFTLCKCMID QAHQEERPIR
110 120 130 140 150
QILYLGDLLE TCHFQAFWQA LDENMDLLEG ITGFEDSVRK FICHVVGITY
160 170 180 190 200
QHIDRWLLAE MLGDLSDSQL KVWMSKYGWS ADESGQIFIC SQEESIKPKN
210
IVEKIDFDSV SSIMASSQ
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WVB9 | A0A087WVB9_HUMAN | Eukaryotic translation initiation f... | EIF3K EIF3S12, hCG_2040051 | 185 | Annotation score: | ||
K7ERF1 | K7ERF1_HUMAN | Eukaryotic translation initiation f... | EIF3K EIF3S12, hCG_2040051 | 192 | Annotation score: | ||
K7EK53 | K7EK53_HUMAN | Eukaryotic translation initiation f... | EIF3K | 131 | Annotation score: | ||
B4DQ48 | B4DQ48_HUMAN | Eukaryotic translation initiation f... | EIF3K | 124 | Annotation score: | ||
K7ES31 | K7ES31_HUMAN | Eukaryotic translation initiation f... | EIF3K | 137 | Annotation score: | ||
K7EQM4 | K7EQM4_HUMAN | Eukaryotic translation initiation f... | EIF3K | 170 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 119 | Q → K in AAD40193 (PubMed:11042152).Curated | 1 |
Mass spectrometryi
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055475 | 210 – 218 | VSSIMASSQ → EW in isoform 2. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY245432 mRNA Translation: AAP22070.1 AB019392 mRNA Translation: BAA76626.1 AF077051 mRNA Translation: AAD27784.1 AF109355 mRNA Translation: AAQ13503.1 AF315506 mRNA Translation: AAK01365.1 AF085358 mRNA Translation: AAD40193.1 AK289554 mRNA Translation: BAF82243.1 AK316344 mRNA Translation: BAH14715.1 AC008649 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW56807.1 BC001031 mRNA Translation: AAH01031.1 BC007335 mRNA Translation: AAH07335.2 BC007559 mRNA Translation: AAH07559.1 |
CCDSi | CCDS12517.1 [Q9UBQ5-1] |
RefSeqi | NP_037366.1, NM_013234.3 [Q9UBQ5-1] |
Genome annotation databases
Ensembli | ENST00000248342; ENSP00000248342; ENSG00000178982 [Q9UBQ5-1] ENST00000545173; ENSP00000438145; ENSG00000178982 [Q9UBQ5-2] ENST00000635417; ENSP00000489379; ENSG00000282986 [Q9UBQ5-2] ENST00000635567; ENSP00000489438; ENSG00000282986 [Q9UBQ5-1] |
GeneIDi | 27335 |
KEGGi | hsa:27335 |
UCSCi | uc002oiz.2, human [Q9UBQ5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY245432 mRNA Translation: AAP22070.1 AB019392 mRNA Translation: BAA76626.1 AF077051 mRNA Translation: AAD27784.1 AF109355 mRNA Translation: AAQ13503.1 AF315506 mRNA Translation: AAK01365.1 AF085358 mRNA Translation: AAD40193.1 AK289554 mRNA Translation: BAF82243.1 AK316344 mRNA Translation: BAH14715.1 AC008649 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW56807.1 BC001031 mRNA Translation: AAH01031.1 BC007335 mRNA Translation: AAH07335.2 BC007559 mRNA Translation: AAH07559.1 |
CCDSi | CCDS12517.1 [Q9UBQ5-1] |
RefSeqi | NP_037366.1, NM_013234.3 [Q9UBQ5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RZ4 | X-ray | 2.10 | A | 1-218 | [»] | |
3J8B | electron microscopy | - | K | 1-190 | [»] | |
3J8C | electron microscopy | - | K | 1-190 | [»] | |
6FEC | electron microscopy | 6.30 | 6 | 1-218 | [»] | |
6YBD | electron microscopy | 3.30 | 3 | 1-218 | [»] | |
6ZMW | electron microscopy | 3.70 | 3 | 1-218 | [»] | |
6ZON | electron microscopy | 3.00 | K | 1-218 | [»] | |
6ZP4 | electron microscopy | 2.90 | K | 1-218 | [»] | |
6ZVJ | electron microscopy | 3.80 | K | 2-218 | [»] | |
7A09 | electron microscopy | 3.50 | K | 1-218 | [»] | |
SMRi | Q9UBQ5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118148, 89 interactors |
ComplexPortali | CPX-6036, Eukaryotic translation initiation factor 3 complex |
CORUMi | Q9UBQ5 |
DIPi | DIP-32880N |
IntActi | Q9UBQ5, 43 interactors |
MINTi | Q9UBQ5 |
STRINGi | 9606.ENSP00000248342 |
PTM databases
iPTMneti | Q9UBQ5 |
PhosphoSitePlusi | Q9UBQ5 |
SwissPalmi | Q9UBQ5 |
Genetic variation databases
BioMutai | EIF3K |
DMDMi | 23396628 |
Proteomic databases
EPDi | Q9UBQ5 |
jPOSTi | Q9UBQ5 |
MassIVEi | Q9UBQ5 |
PaxDbi | Q9UBQ5 |
PeptideAtlasi | Q9UBQ5 |
PRIDEi | Q9UBQ5 |
ProteomicsDBi | 7071 84032 [Q9UBQ5-1] |
TopDownProteomicsi | Q9UBQ5-1 [Q9UBQ5-1] |
Protocols and materials databases
Antibodypediai | 30132, 230 antibodies |
DNASUi | 27335 |
Genome annotation databases
Ensembli | ENST00000248342; ENSP00000248342; ENSG00000178982 [Q9UBQ5-1] ENST00000545173; ENSP00000438145; ENSG00000178982 [Q9UBQ5-2] ENST00000635417; ENSP00000489379; ENSG00000282986 [Q9UBQ5-2] ENST00000635567; ENSP00000489438; ENSG00000282986 [Q9UBQ5-1] |
GeneIDi | 27335 |
KEGGi | hsa:27335 |
UCSCi | uc002oiz.2, human [Q9UBQ5-1] |
Organism-specific databases
CTDi | 27335 |
DisGeNETi | 27335 |
GeneCardsi | EIF3K |
HGNCi | HGNC:24656, EIF3K |
HPAi | ENSG00000178982, Low tissue specificity |
MIMi | 609596, gene |
neXtProti | NX_Q9UBQ5 |
OpenTargetsi | ENSG00000178982 |
PharmGKBi | PA162384923 |
VEuPathDBi | HostDB:ENSG00000178982.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3252, Eukaryota |
GeneTreei | ENSGT00390000009409 |
HOGENOMi | CLU_076723_1_0_1 |
InParanoidi | Q9UBQ5 |
OMAi | YVQDQAK |
OrthoDBi | 1576799at2759 |
PhylomeDBi | Q9UBQ5 |
TreeFami | TF314893 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBQ5 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit |
Miscellaneous databases
BioGRID-ORCSi | 27335, 113 hits in 888 CRISPR screens |
ChiTaRSi | EIF3K, human |
EvolutionaryTracei | Q9UBQ5 |
GeneWikii | EIF3K |
GenomeRNAii | 27335 |
Pharosi | Q9UBQ5, Tbio |
PROi | PR:Q9UBQ5 |
RNActi | Q9UBQ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178982, Expressed in heart left ventricle and 251 other tissues |
ExpressionAtlasi | Q9UBQ5, baseline and differential |
Genevisiblei | Q9UBQ5, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.25.40.250, 1 hit |
HAMAPi | MF_03010, eIF3k, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR033464, CSN8_PSD8_EIF3K IPR009374, eIF3k IPR000717, PCI_dom IPR016020, Transl_init_fac_sub12_N_euk IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR13022, PTHR13022, 1 hit |
Pfami | View protein in Pfam PF10075, CSN8_PSD8_EIF3K, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EIF3K_HUMAN | |
Accessioni | Q9UBQ5Primary (citable) accession number: Q9UBQ5 Secondary accession number(s): A8K0I9 Q9Y6D1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 192 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Translation initiation factors
List of translation initiation factor entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families