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Protein

Vacuolar protein sorting-associated protein 29

Gene

VPS29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (Probable). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (PubMed:24856514).3 PublicationsBy similarity2 Publications
(Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus.1 Publication

Caution

Was originally believed to be a metal-dependent phosphatase but shown to lack catalytic activity; can bind metals with very low affinity suggesting that metal binding is not required for its function.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi8Zinc 1By similarity1
Metal bindingi10Zinc 1By similarity1
Metal bindingi39Zinc 1By similarity1
Metal bindingi39Zinc 2By similarity1
Metal bindingi62Zinc 2By similarity1
Metal bindingi86Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi117Zinc 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • retrograde transport, endosome to Golgi Source: GO_Central
  • retrograde transport, endosome to plasma membrane Source: UniProtKB
  • viral process Source: UniProtKB-KW
  • Wnt signaling pathway Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3238698 WNT ligand biogenesis and trafficking

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.3.1.1 the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family
9.A.3.1.2 the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 29
Short name:
hVPS29
Alternative name(s):
PEP11 homolog
Vesicle protein sorting 29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS29
ORF Names:DC15, DC7, MDS007
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000111237.18

Human Gene Nomenclature Database

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HGNCi
HGNC:14340 VPS29

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606932 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8D → A: Loss of in vitro protein phosphatase activity. 1 Publication1
Mutagenesisi39N → A: Loss of in vitro protein phosphatase activity. 1 Publication1
Mutagenesisi39N → D: No effect on in vitro protein phosphatase activity. 1 Publication1
Mutagenesisi62D → A or N: Loss of in vitro protein phosphatase activity. 1 Publication1
Mutagenesisi86H → A: Loss of in vitro protein phosphatase activity. 1 Publication1
Mutagenesisi90V → D: Decreases interaction with VPS35. 1
Mutagenesisi91I → D: Disrupts interaction with VPS35. 1
Mutagenesisi117H → A: Loss of in vitro protein phosphatase activity. 1 Publication1
Mutagenesisi152L → E: Disrupts interaction with TBC1D5. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
51699

Open Targets

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OpenTargetsi
ENSG00000111237

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37875

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
VPS29

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25453325

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000658941 – 182Vacuolar protein sorting-associated protein 29Add BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBQ0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UBQ0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBQ0

PeptideAtlas

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PeptideAtlasi
Q9UBQ0

PRoteomics IDEntifications database

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PRIDEi
Q9UBQ0

ProteomicsDB human proteome resource

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ProteomicsDBi
84030
84031 [Q9UBQ0-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q9UBQ0-1 [Q9UBQ0-1]
Q9UBQ0-2 [Q9UBQ0-2]

PTM databases

DEPOD human dephosphorylation database

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DEPODi
Q9UBQ0

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UBQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UBQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000111237 Expressed in 197 organ(s), highest expression level in small intestine Peyer's patch

CleanEx database of gene expression profiles

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CleanExi
HS_VPS29

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBQ0 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA039748

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:11102511, PubMed:16737443, PubMed:17891154). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (Probable). Interacts with VPS26A, VPS35, SNX1, SNX2, SNX27, WASHC5, TBC1D5 (PubMed:11102511, PubMed:20923837, PubMed:23331060, PubMed:23563491). Interacts with VPS26B and ANKRD27 (By similarity).2 PublicationsBy similarity6 Publications
(Microbial infection) Interacts with human papillomavirus 16 minor capsid protein L2 (via C-terminus); this interaction mediates the transport of the capsid from the early endosome to the Golgi apparatus.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119683, 91 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UBQ0

Database of interacting proteins

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DIPi
DIP-29077N

Protein interaction database and analysis system

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IntActi
Q9UBQ0, 22 interactors

Molecular INTeraction database

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MINTi
Q9UBQ0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000380795

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W24X-ray2.10A1-182[»]
2R17X-ray2.80A/B1-182[»]
5GTUX-ray1.50A2-182[»]
5OSHX-ray4.30A/D/G/J1-182[»]
5OSIX-ray2.52A/D/G/J1-182[»]
5WYHX-ray2.46A/C2-182[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UBQ0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBQ0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9UBQ0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS29 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3325 Eukaryota
COG0622 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012669

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG056165

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBQ0

KEGG Orthology (KO)

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KOi
K18467

Database of Orthologous Groups

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OrthoDBi
1233814at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBQ0

TreeFam database of animal gene trees

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TreeFami
TF300880

Family and domain databases

Conserved Domains Database

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CDDi
cd07394 MPP_Vps29, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.60.21.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024654 Calcineurin-like_PHP_lpxH
IPR029052 Metallo-depent_PP-like
IPR000979 Phosphodiesterase_MJ0936/Vps29
IPR028661 Vps29

The PANTHER Classification System

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PANTHERi
PTHR11124 PTHR11124, 1 hit
PTHR11124:SF12 PTHR11124:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12850 Metallophos_2, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00040 yfcE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLVLVLGDLH IPHRCNSLPA KFKKLLVPGK IQHILCTGNL CTKESYDYLK
60 70 80 90 100
TLAGDVHIVR GDFDENLNYP EQKVVTVGQF KIGLIHGHQV IPWGDMASLA
110 120 130 140 150
LLQRQFDVDI LISGHTHKFE AFEHENKFYI NPGSATGAYN ALETNIIPSF
160 170 180
VLMDIQASTV VTYVYQLIGD DVKVERIEYK KP
Length:182
Mass (Da):20,506
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E0CDE6B720C9BF8
GO
Isoform 2 (identifier: Q9UBQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGHR

Show »
Length:186
Mass (Da):20,927
Checksum:i7875116A30665D6F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VXU5F8VXU5_HUMAN
Vacuolar protein sorting-associated...
VPS29
214Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q05DG7Q05DG7_HUMAN
VPS29 protein
VPS29
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 2ML → MKIVLYPV in AAF86872 (Ref. 4) Curated2
Sequence conflicti119F → S in CAB66549 (PubMed:11230166).Curated1
Sequence conflicti119F → S in CAG38499 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0040731M → MAGHR in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF193795 mRNA Translation: AAF04596.1
AF175264 mRNA Translation: AAF89952.1
AF168716 mRNA Translation: AAF87318.1
AF201936 mRNA Translation: AAF86872.1
AF201946 mRNA Translation: AAF17238.1
AL136614 mRNA Translation: CAB66549.1
CR457182 mRNA Translation: CAG33463.1
CR533468 mRNA Translation: CAG38499.1
BC000880 mRNA Translation: AAH00880.1
BC095446 mRNA Translation: AAH95446.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41832.1 [Q9UBQ0-1]
CCDS53832.1 [Q9UBQ0-2]

Protein sequence database of the Protein Information Resource

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PIRi
JC7515

NCBI Reference Sequences

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RefSeqi
NP_057310.1, NM_016226.4 [Q9UBQ0-1]
NP_476528.1, NM_057180.2 [Q9UBQ0-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.600114

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000360579; ENSP00000353786; ENSG00000111237 [Q9UBQ0-2]
ENST00000549578; ENSP00000447058; ENSG00000111237 [Q9UBQ0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51699

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51699

UCSC genome browser

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UCSCi
uc001tqx.5 human [Q9UBQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193795 mRNA Translation: AAF04596.1
AF175264 mRNA Translation: AAF89952.1
AF168716 mRNA Translation: AAF87318.1
AF201936 mRNA Translation: AAF86872.1
AF201946 mRNA Translation: AAF17238.1
AL136614 mRNA Translation: CAB66549.1
CR457182 mRNA Translation: CAG33463.1
CR533468 mRNA Translation: CAG38499.1
BC000880 mRNA Translation: AAH00880.1
BC095446 mRNA Translation: AAH95446.1
CCDSiCCDS41832.1 [Q9UBQ0-1]
CCDS53832.1 [Q9UBQ0-2]
PIRiJC7515
RefSeqiNP_057310.1, NM_016226.4 [Q9UBQ0-1]
NP_476528.1, NM_057180.2 [Q9UBQ0-2]
UniGeneiHs.600114

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W24X-ray2.10A1-182[»]
2R17X-ray2.80A/B1-182[»]
5GTUX-ray1.50A2-182[»]
5OSHX-ray4.30A/D/G/J1-182[»]
5OSIX-ray2.52A/D/G/J1-182[»]
5WYHX-ray2.46A/C2-182[»]
ProteinModelPortaliQ9UBQ0
SMRiQ9UBQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119683, 91 interactors
CORUMiQ9UBQ0
DIPiDIP-29077N
IntActiQ9UBQ0, 22 interactors
MINTiQ9UBQ0
STRINGi9606.ENSP00000380795

Protein family/group databases

TCDBi9.A.3.1.1 the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family
9.A.3.1.2 the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family

PTM databases

DEPODiQ9UBQ0
iPTMnetiQ9UBQ0
PhosphoSitePlusiQ9UBQ0

Polymorphism and mutation databases

BioMutaiVPS29
DMDMi25453325

Proteomic databases

EPDiQ9UBQ0
jPOSTiQ9UBQ0
PaxDbiQ9UBQ0
PeptideAtlasiQ9UBQ0
PRIDEiQ9UBQ0
ProteomicsDBi84030
84031 [Q9UBQ0-2]
TopDownProteomicsiQ9UBQ0-1 [Q9UBQ0-1]
Q9UBQ0-2 [Q9UBQ0-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51699
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360579; ENSP00000353786; ENSG00000111237 [Q9UBQ0-2]
ENST00000549578; ENSP00000447058; ENSG00000111237 [Q9UBQ0-1]
GeneIDi51699
KEGGihsa:51699
UCSCiuc001tqx.5 human [Q9UBQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51699
DisGeNETi51699
EuPathDBiHostDB:ENSG00000111237.18

GeneCards: human genes, protein and diseases

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GeneCardsi
VPS29
HGNCiHGNC:14340 VPS29
HPAiHPA039748
MIMi606932 gene
neXtProtiNX_Q9UBQ0
OpenTargetsiENSG00000111237
PharmGKBiPA37875

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3325 Eukaryota
COG0622 LUCA
GeneTreeiENSGT00390000012669
HOVERGENiHBG056165
InParanoidiQ9UBQ0
KOiK18467
OrthoDBi1233814at2759
PhylomeDBiQ9UBQ0
TreeFamiTF300880

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VPS29 human
EvolutionaryTraceiQ9UBQ0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
VPS29

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51699

Protein Ontology

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PROi
PR:Q9UBQ0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111237 Expressed in 197 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_VPS29
ExpressionAtlasiQ9UBQ0 baseline and differential
GenevisibleiQ9UBQ0 HS

Family and domain databases

CDDicd07394 MPP_Vps29, 1 hit
Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR024654 Calcineurin-like_PHP_lpxH
IPR029052 Metallo-depent_PP-like
IPR000979 Phosphodiesterase_MJ0936/Vps29
IPR028661 Vps29
PANTHERiPTHR11124 PTHR11124, 1 hit
PTHR11124:SF12 PTHR11124:SF12, 1 hit
PfamiView protein in Pfam
PF12850 Metallophos_2, 1 hit
TIGRFAMsiTIGR00040 yfcE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS29_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBQ0
Secondary accession number(s): Q502Y5
, Q6FIF8, Q6IAH3, Q9H0W0, Q9NRP1, Q9NRU7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: January 16, 2019
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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