UniProtKB - Q9UBP9 (GULP1_HUMAN)
PTB domain-containing engulfment adapter protein 1
GULP1
Functioni
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
4 PublicationsGO - Biological processi
- apoptotic process Source: ProtInc
- lipid transport Source: UniProtKB-KW
- phagocytosis, engulfment Source: MGI
Keywordsi
Biological process | Apoptosis, Lipid transport, Phagocytosis, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9UBP9 |
SignaLinki | Q9UBP9 |
Names & Taxonomyi
Protein namesi | Recommended name: PTB domain-containing engulfment adapter protein 1Alternative name(s): Cell death protein 6 homolog PTB domain adapter protein CED-6 Protein GULP |
Gene namesi | Name:GULP1 Synonyms:CED6, GULP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18649, GULP1 |
MIMi | 608165, gene |
neXtProti | NX_Q9UBP9 |
VEuPathDBi | HostDB:ENSG00000144366 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 176 | L → P: Loss of dimerization; when associated with P-183. 1 Publication | 1 | |
Mutagenesisi | 183 | L → P: Loss of dimerization; when associated with P-176. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51454 |
OpenTargetsi | ENSG00000144366 |
PharmGKBi | PA134993283 |
Miscellaneous databases
Pharosi | Q9UBP9, Tbio |
Genetic variation databases
BioMutai | GULP1 |
DMDMi | 74720076 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000296679 | 1 – 304 | PTB domain-containing engulfment adapter protein 1Add BLAST | 304 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 223 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UBP9 |
jPOSTi | Q9UBP9 |
MassIVEi | Q9UBP9 |
MaxQBi | Q9UBP9 |
PaxDbi | Q9UBP9 |
PeptideAtlasi | Q9UBP9 |
PRIDEi | Q9UBP9 |
ProteomicsDBi | 19167 7320 84028 [Q9UBP9-1] 84029 [Q9UBP9-2] |
PTM databases
iPTMneti | Q9UBP9 |
PhosphoSitePlusi | Q9UBP9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000144366, Expressed in chorionic villus and 240 other tissues |
ExpressionAtlasi | Q9UBP9, baseline and differential |
Genevisiblei | Q9UBP9, HS |
Organism-specific databases
HPAi | ENSG00000144366, Tissue enhanced (epididymis) |
Interactioni
Subunit structurei
Homodimer.
Interacts with clathrin.
Interacts with GDP-bound ARF6, but not with GTP-bound ARF6.
Part of a complex composed of GULP1, ACAP1 and ARF6.
Interacts with ACAP1, LRP1, MEGF10 and STAB2.
5 PublicationsProtein-protein interaction databases
BioGRIDi | 119550, 35 interactors |
ELMi | Q9UBP9 |
IntActi | Q9UBP9, 10 interactors |
MINTi | Q9UBP9 |
STRINGi | 9606.ENSP00000386289 |
Miscellaneous databases
RNActi | Q9UBP9, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UBP9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 176 | PIDPROSITE-ProRule annotationAdd BLAST | 156 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 223 – 246 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 158 – 202 | Sequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 223 – 244 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3536, Eukaryota |
GeneTreei | ENSGT00940000156186 |
HOGENOMi | CLU_024530_0_0_1 |
InParanoidi | Q9UBP9 |
OMAi | CLDPVDS |
PhylomeDBi | Q9UBP9 |
TreeFami | TF314159 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
Pfami | View protein in Pfam PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNRAFSRKKD KTWMHTPEAL SKHFIPYNAK FLGSTEVEQP KGTEVVRDAV
60 70 80 90 100
RKLKFARHIK KSEGQKIPKV ELQISIYGVK ILEPKTKEVQ HNCQLHRISF
110 120 130 140 150
CADDKTDKRI FTFICKDSES NKHLCYVFDS EKCAEEITLT IGQAFDLAYR
160 170 180 190 200
KFLESGGKDV ETRKQIAGLQ KRIQDLETEN MELKNKVQDL ENQLRITQVS
210 220 230 240 250
APPAGSMTPK SPSTDIFDMI PFSPISHQSS MPTRNGTQPP PVPSRSTEIK
260 270 280 290 300
RDLFGAEPFD PFNCGAADFP PDIQSKLDEM QEGFKMGLTL EGTVFCLDPL
DSRC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y6R1 | H0Y6R1_HUMAN | PTB domain-containing engulfment ad... | GULP1 | 147 | Annotation score: | ||
H7BZV7 | H7BZV7_HUMAN | PTB domain-containing engulfment ad... | GULP1 | 189 | Annotation score: | ||
B8ZZL1 | B8ZZL1_HUMAN | PTB domain-containing engulfment ad... | GULP1 | 68 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 292 | G → S in BAG60802 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044703 | 31 – 133 | Missing in isoform 3. 1 PublicationAdd BLAST | 103 | |
Alternative sequenceiVSP_027250 | 134 – 167 | AEEIT…RKQIA → VSIPDVVGWFVLFYKPGIVL LLALAKYLKMNNFL in isoform 2. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_027251 | 168 – 304 | Missing in isoform 2. 1 PublicationAdd BLAST | 137 | |
Alternative sequenceiVSP_045540 | 282 – 304 | EGFKM…LDSRC → RQRWRGSKWD in isoform 4. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF200715 mRNA Translation: AAF08006.1 AF191771 mRNA Translation: AAF18975.1 AK055718 mRNA No translation available. AK298626 mRNA Translation: BAG60802.1 AK314498 mRNA Translation: BAG37098.1 AC092598 Genomic DNA Translation: AAX93242.1 AC125490 Genomic DNA Translation: AAY24122.1 AC104131 Genomic DNA No translation available. AC108493 Genomic DNA No translation available. AC133606 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX10913.1 CH471058 Genomic DNA Translation: EAX10914.1 CH471058 Genomic DNA Translation: EAX10915.1 CH471058 Genomic DNA Translation: EAX10917.1 BC001103 mRNA Translation: AAH01103.1 |
CCDSi | CCDS2295.1 [Q9UBP9-1] CCDS58742.1 [Q9UBP9-4] CCDS58743.1 [Q9UBP9-3] |
RefSeqi | NP_001239597.1, NM_001252668.1 [Q9UBP9-4] NP_001239598.1, NM_001252669.1 [Q9UBP9-3] NP_057399.1, NM_016315.3 [Q9UBP9-1] XP_016859795.1, XM_017004306.1 [Q9UBP9-1] |
Genome annotation databases
Ensembli | ENST00000359135; ENSP00000352047; ENSG00000144366 ENST00000409580; ENSP00000386289; ENSG00000144366 ENST00000409609; ENSP00000386867; ENSG00000144366 ENST00000409637; ENSP00000386402; ENSG00000144366 [Q9UBP9-2] ENST00000409805; ENSP00000387171; ENSG00000144366 [Q9UBP9-3] ENST00000409830; ENSP00000386732; ENSG00000144366 ENST00000409843; ENSP00000387144; ENSG00000144366 [Q9UBP9-4] ENST00000410051; ENSP00000387013; ENSG00000144366 [Q9UBP9-2] |
GeneIDi | 51454 |
KEGGi | hsa:51454 |
MANE-Selecti | ENST00000409830.6; ENSP00000386732.1; NM_016315.4; NP_057399.1 |
UCSCi | uc002uqc.5, human [Q9UBP9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF200715 mRNA Translation: AAF08006.1 AF191771 mRNA Translation: AAF18975.1 AK055718 mRNA No translation available. AK298626 mRNA Translation: BAG60802.1 AK314498 mRNA Translation: BAG37098.1 AC092598 Genomic DNA Translation: AAX93242.1 AC125490 Genomic DNA Translation: AAY24122.1 AC104131 Genomic DNA No translation available. AC108493 Genomic DNA No translation available. AC133606 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX10913.1 CH471058 Genomic DNA Translation: EAX10914.1 CH471058 Genomic DNA Translation: EAX10915.1 CH471058 Genomic DNA Translation: EAX10917.1 BC001103 mRNA Translation: AAH01103.1 |
CCDSi | CCDS2295.1 [Q9UBP9-1] CCDS58742.1 [Q9UBP9-4] CCDS58743.1 [Q9UBP9-3] |
RefSeqi | NP_001239597.1, NM_001252668.1 [Q9UBP9-4] NP_001239598.1, NM_001252669.1 [Q9UBP9-3] NP_057399.1, NM_016315.3 [Q9UBP9-1] XP_016859795.1, XM_017004306.1 [Q9UBP9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6ITU | X-ray | 2.17 | A | 1-168 | [»] | |
SMRi | Q9UBP9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119550, 35 interactors |
ELMi | Q9UBP9 |
IntActi | Q9UBP9, 10 interactors |
MINTi | Q9UBP9 |
STRINGi | 9606.ENSP00000386289 |
PTM databases
iPTMneti | Q9UBP9 |
PhosphoSitePlusi | Q9UBP9 |
Genetic variation databases
BioMutai | GULP1 |
DMDMi | 74720076 |
Proteomic databases
EPDi | Q9UBP9 |
jPOSTi | Q9UBP9 |
MassIVEi | Q9UBP9 |
MaxQBi | Q9UBP9 |
PaxDbi | Q9UBP9 |
PeptideAtlasi | Q9UBP9 |
PRIDEi | Q9UBP9 |
ProteomicsDBi | 19167 7320 84028 [Q9UBP9-1] 84029 [Q9UBP9-2] |
Protocols and materials databases
Antibodypediai | 19788, 197 antibodies from 32 providers |
DNASUi | 51454 |
Genome annotation databases
Organism-specific databases
CTDi | 51454 |
DisGeNETi | 51454 |
GeneCardsi | GULP1 |
HGNCi | HGNC:18649, GULP1 |
HPAi | ENSG00000144366, Tissue enhanced (epididymis) |
MIMi | 608165, gene |
neXtProti | NX_Q9UBP9 |
OpenTargetsi | ENSG00000144366 |
PharmGKBi | PA134993283 |
VEuPathDBi | HostDB:ENSG00000144366 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3536, Eukaryota |
GeneTreei | ENSGT00940000156186 |
HOGENOMi | CLU_024530_0_0_1 |
InParanoidi | Q9UBP9 |
OMAi | CLDPVDS |
PhylomeDBi | Q9UBP9 |
TreeFami | TF314159 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBP9 |
SignaLinki | Q9UBP9 |
Miscellaneous databases
BioGRID-ORCSi | 51454, 8 hits in 1047 CRISPR screens |
ChiTaRSi | GULP1, human |
GenomeRNAii | 51454 |
Pharosi | Q9UBP9, Tbio |
PROi | PR:Q9UBP9 |
RNActi | Q9UBP9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144366, Expressed in chorionic villus and 240 other tissues |
ExpressionAtlasi | Q9UBP9, baseline and differential |
Genevisiblei | Q9UBP9, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
Pfami | View protein in Pfam PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GULP1_HUMAN | |
Accessioni | Q9UBP9Primary (citable) accession number: Q9UBP9 Secondary accession number(s): B2RB51 Q9BVL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families