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Protein

Histone deacetylase 6

Gene

HDAC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.By similarity3 Publications
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. EC:3.5.1.98

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 3 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei21611
Active sitei61121
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1113Zinc 11
Metal bindingi1115Zinc 11
Metal bindingi1133Zinc 31
Metal bindingi1136Zinc 31
Metal bindingi1145Zinc 21
Metal bindingi1148Zinc 21
Metal bindingi1153Zinc 31
Metal bindingi1160Zinc 31
Metal bindingi1164Zinc 21
Metal bindingi1170Zinc 21
Metal bindingi1183Zinc 11
Metal bindingi1186Zinc 11

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1131 – 1192UBP-typePROSITE-ProRule annotationAdd BLAST62

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Chromatin regulator, Hydrolase, Repressor
Biological processAutophagy, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.1.98 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3371511 HSF1 activation
R-HSA-5617833 Cilium Assembly
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8940973 RUNX2 regulates osteoblast differentiation

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
Q9UBN7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9UBN7

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UBN7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone deacetylase 6 (EC:3.5.1.98)
Short name:
HD6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDAC6
Synonyms:KIAA0901
ORF Names:JM21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000094631.18

Human Gene Nomenclature Database

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HGNCi
HGNC:14064 HDAC6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300272 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBN7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation.
See also OMIM:300863

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi216H → A: Reduces histone deacetylase activity. 1 Publication1
Mutagenesisi611H → A: Reduces histone deacetylase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10013

MalaCards human disease database

More...
MalaCardsi
HDAC6
MIMi300863 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000094631

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
163966 X-linked dominant chondrodysplasia, Chassaing-Lacombe type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29231

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1865

Drug and drug target database

More...
DrugBanki
DB05015 Belinostat
DB06603 Panobinostat
DB06176 Romidepsin
DB05223 SB939
DB02546 Vorinostat

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2618

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HDAC6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205371758

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001147031 – 1215Histone deacetylase 6Add BLAST1215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei33Omega-N-methylarginineBy similarity1
Modified residuei1016PhosphothreonineCombined sources1
Modified residuei1021PhosphothreonineCombined sources1
Modified residuei1027PhosphothreonineCombined sources1
Modified residuei1031PhosphothreonineCombined sources1
Modified residuei1034PhosphothreonineCombined sources1
Modified residuei1035PhosphoserineCombined sources1
Modified residuei1040PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AURKA.1 Publication
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.1 Publication
Sumoylated in vitro.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBN7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBN7

PeptideAtlas

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PeptideAtlasi
Q9UBN7

PRoteomics IDEntifications database

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PRIDEi
Q9UBN7

ProteomicsDB human proteome resource

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ProteomicsDBi
84019

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UBN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UBN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000094631 Expressed in 223 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

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CleanExi
HS_HDAC6

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBN7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBN7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004236
HPA003714
HPA026321

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZMYND15 (By similarity). Interacts with SIRT2 (via both phosphorylated, unphosphorylated, active or inactive forms); the interaction is necessary for the complex to interact with alpha-tubulin. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with BBIP10, CBFA2T3, CYLD, DDIT3/CHOP, F-actin and HDAC11. Interacts with RIPOR2; this interaction occurs during early myogenic differentiation and prevents HDAC6 to deacetylate tubulin (PubMed:24687993). Interacts with DYSF; this interaction occurs during early myogenic differentiation (PubMed:24687993).By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115330, 317 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UBN7

Database of interacting proteins

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DIPi
DIP-27544N

Protein interaction database and analysis system

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IntActi
Q9UBN7, 119 interactors

Molecular INTeraction database

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MINTi
Q9UBN7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000334061

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UBN7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UBN7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBN7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UBN7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 404Histone deacetylase 1Add BLAST318
Regioni482 – 800Histone deacetylase 2Add BLAST319
Regioni1154 – 1156Ubiquitin binding3
Regioni1182 – 1189Ubiquitin binding8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1131 – 1192UBP-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1343 Eukaryota
COG0123 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159563

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000004769

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051894

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBN7

KEGG Orthology (KO)

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KOi
K11407

Identification of Orthologs from Complete Genome Data

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OMAi
QPHGFCI

Database of Orthologous Groups

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OrthoDBi
EOG091G0210

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBN7

TreeFam database of animal gene trees

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TreeFami
TF106173

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit
3.40.800.20, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP

The PANTHER Classification System

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PANTHERi
PTHR10625 PTHR10625, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00850 Hist_deacetyl, 2 hits
PF02148 zf-UBP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01270 HDASUPER

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00290 ZnF_UBP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52768 SSF52768, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50271 ZF_UBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBN7-1) [UniParc]FASTAAdd to basket
Also known as: HDAC6p131

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV
60 70 80 90 100
KKKGKMKKLG QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL
110 120 130 140 150
WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI
160 170 180 190 200
DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG
210 220 230 240 250
AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV
260 270 280 290 300
DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG
310 320 330 340 350
QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG
360 370 380 390 400
DPKGEMAATP AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH
410 420 430 440 450
TLLGDPCPML ESPGAPCRSA QASVSCALEA LEPFWEVLVR STETVERDNM
460 470 480 490 500
EEDNVEESEE EGPWEPPVLP ILTWPVLQSR TGLVYDQNMM NHCNLWDSHH
510 520 530 540 550
PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH SAEYVGHLRA
560 570 580 590 600
TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN
610 620 630 640 650
GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQTISGHA LRILIVDWDV
660 670 680 690 700
HHGNGTQHMF EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT
710 720 730 740 750
VNVAWNGPRM GDADYLAAWH RLVLPIAYEF NPELVLVSAG FDAARGDPLG
760 770 780 790 800
GCQVSPEGYA HLTHLLMGLA SGRIILILEG GYNLTSISES MAACTRSLLG
810 820 830 840 850
DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE DREGPSSSKL
860 870 880 890 900
VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KVTSASFGEE STPGQTNSET
910 920 930 940 950
AVVALTQDQP SEAATGGATL AQTISEAAIG GAMLGQTTSE EAVGGATPDQ
960 970 980 990 1000
TTSEETVGGA ILDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME
1010 1020 1030 1040 1050
GATLDQTTSE EAPGGTELIQ TPLASSTDHQ TPPTSPVQGT TPQISPSTLI
1060 1070 1080 1090 1100
GSLRTLELGS ESQGASESQA PGEENLLGEA AGGQDMADSM LMQGSRGLTD
1110 1120 1130 1140 1150
QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ ENWVCLSCYQ
1160 1170 1180 1190 1200
VYCGRYINGH MLQHHGNSGH PLVLSYIDLS AWCYYCQAYV HHQALLDVKN
1210
IAHQNKFGED MPHPH
Length:1,215
Mass (Da):131,419
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F17731268A33114
GO
Isoform 2 (identifier: Q9UBN7-2) [UniParc]FASTAAdd to basket
Also known as: HDAC6p114

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Note: Required for TGF-beta1-activated gene expression associated with epithelial-mesenchymal transition (EMT) in A549 cells.
Show »
Length:1,063
Mass (Da):114,361
Checksum:iE77E732ACF187AB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YDE6A0A2R8YDE6_HUMAN
Histone deacetylase
HDAC6
1,160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGC5A0A2R8YGC5_HUMAN
Histone deacetylase 6
HDAC6
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9BRX7Q9BRX7_HUMAN
HDAC6 protein
HDAC6
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5Z4A0A2R8Y5Z4_HUMAN
Histone deacetylase 6
HDAC6
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NDI8A6NDI8_HUMAN
Histone deacetylase 6
HDAC6
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPS2E7EPS2_HUMAN
Histone deacetylase 6
HDAC6
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J172C9J172_HUMAN
Histone deacetylase 6
HDAC6
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ER52E7ER52_HUMAN
Histone deacetylase 6
HDAC6
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EP63E7EP63_HUMAN
Histone deacetylase 6
HDAC6
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEF4C9JEF4_HUMAN
Histone deacetylase 6
HDAC6
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74924 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046300994T → I2 PublicationsCorresponds to variant dbSNP:rs1127346Ensembl.1
Natural variantiVAR_0689621200N → D1 PublicationCorresponds to variant dbSNP:rs151130423Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0445761 – 152Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF132609 mRNA Translation: AAD29048.1
AB020708 mRNA Translation: BAA74924.2 Different initiation.
AJ011972 mRNA Translation: CAA09893.1
AF196971 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50748.1
BC013737 mRNA Translation: AAH13737.1
BC069243 mRNA Translation: AAH69243.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14306.1 [Q9UBN7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001308155.1, NM_001321226.1 [Q9UBN7-1]
NP_001308156.1, NM_001321227.1 [Q9UBN7-1]
NP_001308157.1, NM_001321228.1 [Q9UBN7-1]
NP_001308158.1, NM_001321229.1 [Q9UBN7-1]
NP_006035.2, NM_006044.3 [Q9UBN7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.6764

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334136; ENSP00000334061; ENSG00000094631 [Q9UBN7-1]
ENST00000376619; ENSP00000365804; ENSG00000094631 [Q9UBN7-1]
ENST00000426196; ENSP00000402189; ENSG00000094631 [Q9UBN7-1]
ENST00000643374; ENSP00000496046; ENSG00000094631 [Q9UBN7-1]
ENST00000644068; ENSP00000496013; ENSG00000094631 [Q9UBN7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10013

UCSC genome browser

More...
UCSCi
uc004dks.2 human [Q9UBN7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132609 mRNA Translation: AAD29048.1
AB020708 mRNA Translation: BAA74924.2 Different initiation.
AJ011972 mRNA Translation: CAA09893.1
AF196971 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50748.1
BC013737 mRNA Translation: AAH13737.1
BC069243 mRNA Translation: AAH69243.1
CCDSiCCDS14306.1 [Q9UBN7-1]
RefSeqiNP_001308155.1, NM_001321226.1 [Q9UBN7-1]
NP_001308156.1, NM_001321227.1 [Q9UBN7-1]
NP_001308157.1, NM_001321228.1 [Q9UBN7-1]
NP_001308158.1, NM_001321229.1 [Q9UBN7-1]
NP_006035.2, NM_006044.3 [Q9UBN7-1]
UniGeneiHs.6764

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C5KX-ray1.55A1109-1215[»]
3GV4X-ray1.72A1109-1215[»]
3PHDX-ray3.00A/B/C/D1109-1215[»]
5B8DX-ray1.05A1109-1213[»]
5EDUX-ray2.79A/B479-835[»]
5KH3X-ray1.60A1109-1213[»]
5KH7X-ray1.70A1109-1213[»]
5KH9X-ray1.07A1109-1213[»]
5WBNX-ray1.64A1108-1213[»]
5WPBX-ray1.55A1109-1208[»]
6CE6X-ray1.60A1109-1213[»]
6CE8X-ray1.55A1109-1213[»]
6CEAX-ray1.60A1109-1213[»]
6CECX-ray1.55A1109-1213[»]
6CEDX-ray1.70A1109-1213[»]
6CEEX-ray1.55A1109-1213[»]
6CEFX-ray1.80A1109-1213[»]
ProteinModelPortaliQ9UBN7
SMRiQ9UBN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115330, 317 interactors
CORUMiQ9UBN7
DIPiDIP-27544N
IntActiQ9UBN7, 119 interactors
MINTiQ9UBN7
STRINGi9606.ENSP00000334061

Chemistry databases

BindingDBiQ9UBN7
ChEMBLiCHEMBL1865
DrugBankiDB05015 Belinostat
DB06603 Panobinostat
DB06176 Romidepsin
DB05223 SB939
DB02546 Vorinostat
GuidetoPHARMACOLOGYi2618

PTM databases

iPTMnetiQ9UBN7
PhosphoSitePlusiQ9UBN7

Polymorphism and mutation databases

BioMutaiHDAC6
DMDMi205371758

Proteomic databases

EPDiQ9UBN7
PaxDbiQ9UBN7
PeptideAtlasiQ9UBN7
PRIDEiQ9UBN7
ProteomicsDBi84019

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10013
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334136; ENSP00000334061; ENSG00000094631 [Q9UBN7-1]
ENST00000376619; ENSP00000365804; ENSG00000094631 [Q9UBN7-1]
ENST00000426196; ENSP00000402189; ENSG00000094631 [Q9UBN7-1]
ENST00000643374; ENSP00000496046; ENSG00000094631 [Q9UBN7-1]
ENST00000644068; ENSP00000496013; ENSG00000094631 [Q9UBN7-1]
GeneIDi10013
KEGGihsa:10013
UCSCiuc004dks.2 human [Q9UBN7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10013
DisGeNETi10013
EuPathDBiHostDB:ENSG00000094631.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HDAC6

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016783
HGNCiHGNC:14064 HDAC6
HPAiCAB004236
HPA003714
HPA026321
MalaCardsiHDAC6
MIMi300272 gene
300863 phenotype
neXtProtiNX_Q9UBN7
OpenTargetsiENSG00000094631
Orphaneti163966 X-linked dominant chondrodysplasia, Chassaing-Lacombe type
PharmGKBiPA29231

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00940000159563
HOGENOMiHOG000004769
HOVERGENiHBG051894
InParanoidiQ9UBN7
KOiK11407
OMAiQPHGFCI
OrthoDBiEOG091G0210
PhylomeDBiQ9UBN7
TreeFamiTF106173

Enzyme and pathway databases

BRENDAi3.5.1.98 2681
ReactomeiR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3371511 HSF1 activation
R-HSA-5617833 Cilium Assembly
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SABIO-RKiQ9UBN7
SignaLinkiQ9UBN7
SIGNORiQ9UBN7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HDAC6 human
EvolutionaryTraceiQ9UBN7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HDAC6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10013

Protein Ontology

More...
PROi
PR:Q9UBN7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000094631 Expressed in 223 organ(s), highest expression level in adenohypophysis
CleanExiHS_HDAC6
ExpressionAtlasiQ9UBN7 baseline and differential
GenevisibleiQ9UBN7 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.40.800.20, 2 hits
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PANTHERiPTHR10625 PTHR10625, 5 hits
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 2 hits
PF02148 zf-UBP, 1 hit
PRINTSiPR01270 HDASUPER
SMARTiView protein in SMART
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF52768 SSF52768, 2 hits
PROSITEiView protein in PROSITE
PS50271 ZF_UBP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDAC6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBN7
Secondary accession number(s): O94975
, Q6NT75, Q7L3E5, Q96CY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 2, 2008
Last modified: December 5, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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