Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 170 (13 Feb 2019)
Sequence version 1 (01 May 2000)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Tumor necrosis factor receptor superfamily member 10D

Gene

TNFRSF10D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-75158 TRAIL signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UBN6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UBN6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10D
Alternative name(s):
Decoy receptor 2
Short name:
DcR2
TNF-related apoptosis-inducing ligand receptor 4
Short name:
TRAIL receptor 4
Short name:
TRAIL-R4
TRAIL receptor with a truncated death domain
CD_antigen: CD264
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF10D
Synonyms:DCR2, TRAILR4, TRUNDD
ORF Names:UNQ251/PRO288
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173530.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11907 TNFRSF10D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603614 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBN6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini56 – 211ExtracellularSequence analysisAdd BLAST156
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 386CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8793

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36600

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFRSF10D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18203495

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 552 PublicationsAdd BLAST55
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003458456 – 386Tumor necrosis factor receptor superfamily member 10DAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi83 ↔ 96PROSITE-ProRule annotation
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi118 ↔ 131PROSITE-ProRule annotation
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 155PROSITE-ProRule annotation
Disulfide bondi158 ↔ 172PROSITE-ProRule annotation
Disulfide bondi162 ↔ 180PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UBN6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UBN6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBN6

PeptideAtlas

More...
PeptideAtlasi
Q9UBN6

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBN6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84018

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBN6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UBN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173530 Expressed in 159 organ(s), highest expression level in cartilage tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBN6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA070971

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114321, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-6231N

Protein interaction database and analysis system

More...
IntActi
Q9UBN6, 26 interactors

Molecular INTeraction database

More...
MINTi
Q9UBN6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310263

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UBN6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBN6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati58 – 97TNFR-Cys 1Add BLAST40
Repeati98 – 139TNFR-Cys 2Add BLAST42
Repeati140 – 180TNFR-Cys 3Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini340 – 366Death; truncatedAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi225 – 228Poly-Val4
Compositional biasi246 – 250Poly-Gly5

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZX0 Eukaryota
ENOG4111ZZM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000142423

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG061626

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBN6

KEGG Orthology (KO)

More...
KOi
K22702

Database of Orthologous Groups

More...
OrthoDBi
1448442at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBN6

TreeFam database of animal gene trees

More...
TreeFami
TF333916

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10580 TNFRSF10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00020 TNFR_c6, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01956 TNFACTORR10

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00208 TNFR, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP
60 70 80 90 100
VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT
110 120 130 140 150
EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN
160 170 180 190 200
SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT
210 220 230 240 250
TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG
260 270 280 290 300
PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL
310 320 330 340 350
AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS
360 370 380
ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL
Length:386
Mass (Da):41,823
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77A93577CAAF2632
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01141735P → S in TRAIL-R4-B. 1 PublicationCorresponds to variant dbSNP:rs11135703Ensembl.1
Natural variantiVAR_061854276R → H. Corresponds to variant dbSNP:rs55636833Ensembl.1
Natural variantiVAR_011418310S → L in TRAIL-R4-B. 1 PublicationCorresponds to variant dbSNP:rs1133782Ensembl.1
Natural variantiVAR_057288345T → P. Corresponds to variant dbSNP:rs34622674Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF029761 mRNA Translation: AAD03477.1
AF021232 mRNA Translation: AAC32765.1
AF021233 mRNA Translation: AAC32766.1
AF023849 mRNA Translation: AAC52053.1
AY358285 mRNA Translation: AAQ88652.1
AK313528 mRNA Translation: BAG36307.1
BC052270 mRNA Translation: AAH52270.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6038.1

NCBI Reference Sequences

More...
RefSeqi
NP_003831.2, NM_003840.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.213467

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312584; ENSP00000310263; ENSG00000173530

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8793

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8793

UCSC genome browser

More...
UCSCi
uc003xcz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029761 mRNA Translation: AAD03477.1
AF021232 mRNA Translation: AAC32765.1
AF021233 mRNA Translation: AAC32766.1
AF023849 mRNA Translation: AAC52053.1
AY358285 mRNA Translation: AAQ88652.1
AK313528 mRNA Translation: BAG36307.1
BC052270 mRNA Translation: AAH52270.1
CCDSiCCDS6038.1
RefSeqiNP_003831.2, NM_003840.4
UniGeneiHs.213467

3D structure databases

ProteinModelPortaliQ9UBN6
SMRiQ9UBN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114321, 6 interactors
DIPiDIP-6231N
IntActiQ9UBN6, 26 interactors
MINTiQ9UBN6
STRINGi9606.ENSP00000310263

PTM databases

iPTMnetiQ9UBN6
PhosphoSitePlusiQ9UBN6
SwissPalmiQ9UBN6

Polymorphism and mutation databases

BioMutaiTNFRSF10D
DMDMi18203495

Proteomic databases

EPDiQ9UBN6
MaxQBiQ9UBN6
PaxDbiQ9UBN6
PeptideAtlasiQ9UBN6
PRIDEiQ9UBN6
ProteomicsDBi84018

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8793
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312584; ENSP00000310263; ENSG00000173530
GeneIDi8793
KEGGihsa:8793
UCSCiuc003xcz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8793
DisGeNETi8793
EuPathDBiHostDB:ENSG00000173530.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFRSF10D

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0025539
HGNCiHGNC:11907 TNFRSF10D
HPAiHPA070971
MIMi603614 gene
neXtProtiNX_Q9UBN6
PharmGKBiPA36600

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZX0 Eukaryota
ENOG4111ZZM LUCA
HOGENOMiHOG000142423
HOVERGENiHBG061626
InParanoidiQ9UBN6
KOiK22702
OrthoDBi1448442at2759
PhylomeDBiQ9UBN6
TreeFamiTF333916

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-75158 TRAIL signaling
SignaLinkiQ9UBN6
SIGNORiQ9UBN6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNFRSF10D human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TNFRSF10D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8793

Protein Ontology

More...
PROi
PR:Q9UBN6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173530 Expressed in 159 organ(s), highest expression level in cartilage tissue
GenevisibleiQ9UBN6 HS

Family and domain databases

CDDicd10580 TNFRSF10, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01956 TNFACTORR10
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTR10D_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBN6
Secondary accession number(s): B2R8W0, Q9Y6Q4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: February 13, 2019
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again