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Protein

Tumor necrosis factor receptor superfamily member 10D

Gene

TNFRSF10D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-75158 TRAIL signaling
SignaLinkiQ9UBN6
SIGNORiQ9UBN6

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10D
Alternative name(s):
Decoy receptor 2
Short name:
DcR2
TNF-related apoptosis-inducing ligand receptor 4
Short name:
TRAIL receptor 4
Short name:
TRAIL-R4
TRAIL receptor with a truncated death domain
CD_antigen: CD264
Gene namesi
Name:TNFRSF10D
Synonyms:DCR2, TRAILR4, TRUNDD
ORF Names:UNQ251/PRO288
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000173530.5
HGNCiHGNC:11907 TNFRSF10D
MIMi603614 gene
neXtProtiNX_Q9UBN6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini56 – 211ExtracellularSequence analysisAdd BLAST156
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 386CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8793
PharmGKBiPA36600

Polymorphism and mutation databases

BioMutaiTNFRSF10D
DMDMi18203495

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 552 PublicationsAdd BLAST55
ChainiPRO_000003458456 – 386Tumor necrosis factor receptor superfamily member 10DAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 96PROSITE-ProRule annotation
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi118 ↔ 131PROSITE-ProRule annotation
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 155PROSITE-ProRule annotation
Disulfide bondi158 ↔ 172PROSITE-ProRule annotation
Disulfide bondi162 ↔ 180PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UBN6
MaxQBiQ9UBN6
PaxDbiQ9UBN6
PeptideAtlasiQ9UBN6
PRIDEiQ9UBN6
ProteomicsDBi84018

PTM databases

iPTMnetiQ9UBN6
PhosphoSitePlusiQ9UBN6
SwissPalmiQ9UBN6

Expressioni

Tissue specificityi

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Gene expression databases

BgeeiENSG00000173530 Expressed in 159 organ(s), highest expression level in cartilage tissue
CleanExiHS_TNFRSF10D
GenevisibleiQ9UBN6 HS

Organism-specific databases

HPAiHPA070971

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114321, 6 interactors
DIPiDIP-6231N
IntActiQ9UBN6, 26 interactors
MINTiQ9UBN6
STRINGi9606.ENSP00000310263

Structurei

3D structure databases

ProteinModelPortaliQ9UBN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 97TNFR-Cys 1Add BLAST40
Repeati98 – 139TNFR-Cys 2Add BLAST42
Repeati140 – 180TNFR-Cys 3Add BLAST41
Domaini340 – 366Death; truncatedAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi225 – 228Poly-Val4
Compositional biasi246 – 250Poly-Gly5

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZX0 Eukaryota
ENOG4111ZZM LUCA
HOGENOMiHOG000142423
HOVERGENiHBG061626
InParanoidiQ9UBN6
KOiK22702
OrthoDBiEOG091G0MOV
PhylomeDBiQ9UBN6
TreeFamiTF333916

Family and domain databases

CDDicd10580 TNFRSF10, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01956 TNFACTORR10
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP
60 70 80 90 100
VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT
110 120 130 140 150
EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN
160 170 180 190 200
SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT
210 220 230 240 250
TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG
260 270 280 290 300
PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL
310 320 330 340 350
AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS
360 370 380
ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL
Length:386
Mass (Da):41,823
Last modified:May 1, 2000 - v1
Checksum:i77A93577CAAF2632
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01141735P → S in TRAIL-R4-B. 1 PublicationCorresponds to variant dbSNP:rs11135703Ensembl.1
Natural variantiVAR_061854276R → H. Corresponds to variant dbSNP:rs55636833Ensembl.1
Natural variantiVAR_011418310S → L in TRAIL-R4-B. 1 PublicationCorresponds to variant dbSNP:rs1133782Ensembl.1
Natural variantiVAR_057288345T → P. Corresponds to variant dbSNP:rs34622674Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029761 mRNA Translation: AAD03477.1
AF021232 mRNA Translation: AAC32765.1
AF021233 mRNA Translation: AAC32766.1
AF023849 mRNA Translation: AAC52053.1
AY358285 mRNA Translation: AAQ88652.1
AK313528 mRNA Translation: BAG36307.1
BC052270 mRNA Translation: AAH52270.1
CCDSiCCDS6038.1
RefSeqiNP_003831.2, NM_003840.4
UniGeneiHs.213467

Genome annotation databases

EnsembliENST00000312584; ENSP00000310263; ENSG00000173530
GeneIDi8793
KEGGihsa:8793
UCSCiuc003xcz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029761 mRNA Translation: AAD03477.1
AF021232 mRNA Translation: AAC32765.1
AF021233 mRNA Translation: AAC32766.1
AF023849 mRNA Translation: AAC52053.1
AY358285 mRNA Translation: AAQ88652.1
AK313528 mRNA Translation: BAG36307.1
BC052270 mRNA Translation: AAH52270.1
CCDSiCCDS6038.1
RefSeqiNP_003831.2, NM_003840.4
UniGeneiHs.213467

3D structure databases

ProteinModelPortaliQ9UBN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114321, 6 interactors
DIPiDIP-6231N
IntActiQ9UBN6, 26 interactors
MINTiQ9UBN6
STRINGi9606.ENSP00000310263

PTM databases

iPTMnetiQ9UBN6
PhosphoSitePlusiQ9UBN6
SwissPalmiQ9UBN6

Polymorphism and mutation databases

BioMutaiTNFRSF10D
DMDMi18203495

Proteomic databases

EPDiQ9UBN6
MaxQBiQ9UBN6
PaxDbiQ9UBN6
PeptideAtlasiQ9UBN6
PRIDEiQ9UBN6
ProteomicsDBi84018

Protocols and materials databases

DNASUi8793
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312584; ENSP00000310263; ENSG00000173530
GeneIDi8793
KEGGihsa:8793
UCSCiuc003xcz.4 human

Organism-specific databases

CTDi8793
DisGeNETi8793
EuPathDBiHostDB:ENSG00000173530.5
GeneCardsiTNFRSF10D
H-InvDBiHIX0025539
HGNCiHGNC:11907 TNFRSF10D
HPAiHPA070971
MIMi603614 gene
neXtProtiNX_Q9UBN6
PharmGKBiPA36600
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZX0 Eukaryota
ENOG4111ZZM LUCA
HOGENOMiHOG000142423
HOVERGENiHBG061626
InParanoidiQ9UBN6
KOiK22702
OrthoDBiEOG091G0MOV
PhylomeDBiQ9UBN6
TreeFamiTF333916

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-75158 TRAIL signaling
SignaLinkiQ9UBN6
SIGNORiQ9UBN6

Miscellaneous databases

ChiTaRSiTNFRSF10D human
GeneWikiiTNFRSF10D
GenomeRNAii8793
PROiPR:Q9UBN6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173530 Expressed in 159 organ(s), highest expression level in cartilage tissue
CleanExiHS_TNFRSF10D
GenevisibleiQ9UBN6 HS

Family and domain databases

CDDicd10580 TNFRSF10, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01956 TNFACTORR10
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTR10D_HUMAN
AccessioniPrimary (citable) accession number: Q9UBN6
Secondary accession number(s): B2R8W0, Q9Y6Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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