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Protein

Voltage-dependent calcium channel gamma-4 subunit

Gene

CACNG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5576893 Phase 2 - plateau phase
R-HSA-5682910 LGI-ADAM interactions

Protein family/group databases

TCDBi8.A.16.2.3 the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-4 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-4 subunit
Transmembrane AMPAR regulatory protein gamma-4
Short name:
TARP gamma-4
Gene namesi
Name:CACNG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000075461.5
HGNCiHGNC:1408 CACNG4
MIMi606404 gene
neXtProtiNX_Q9UBN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 107ExtracellularSequence analysisAdd BLAST77
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 136CytoplasmicSequence analysis8
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 186ExtracellularSequence analysisAdd BLAST29
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 327CytoplasmicSequence analysisAdd BLAST120

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27092
OpenTargetsiENSG00000075461
PharmGKBiPA26018

Chemistry databases

ChEMBLiCHEMBL2363032

Polymorphism and mutation databases

BioMutaiCACNG4
DMDMi10719940

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646781 – 327Voltage-dependent calcium channel gamma-4 subunitAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei259PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UBN1
PeptideAtlasiQ9UBN1
PRIDEiQ9UBN1
ProteomicsDBi84011

PTM databases

iPTMnetiQ9UBN1
PhosphoSitePlusiQ9UBN1

Expressioni

Tissue specificityi

Detected in heart left ventricle.1 Publication

Gene expression databases

BgeeiENSG00000075461 Expressed in 129 organ(s), highest expression level in spinal cord
CleanExiHS_CACNG4
ExpressionAtlasiQ9UBN1 baseline and differential
GenevisibleiQ9UBN1 HS

Organism-specific databases

HPAiHPA005803
HPA065370

Interactioni

Subunit structurei

Interacts with CACNA1C. Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (PubMed:21127204). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs) (PubMed:21172611). Interacts with GRIA1 (PubMed:21172611).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117994, 18 interactors
STRINGi9606.ENSP00000262138

Structurei

3D structure databases

ProteinModelPortaliQ9UBN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJYN Eukaryota
ENOG4111W1R LUCA
GeneTreeiENSGT00550000074547
HOGENOMiHOG000233440
HOVERGENiHBG003682
InParanoidiQ9UBN1
KOiK04869
OMAiICNGTNL
OrthoDBiEOG091G0D2Z
PhylomeDBiQ9UBN1
TreeFamiTF327980

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR005423 VDCC_g4su
IPR008368 VDCC_gsu
PANTHERiPTHR12107:SF7 PTHR12107:SF7, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01603 VDCCGAMMA4

Sequencei

Sequence statusi: Complete.

Q9UBN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD
60 70 80 90 100
GPPPRRARGD LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL
110 120 130 140 150
LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL
160 170 180 190 200
SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV
210 220 230 240 250
LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR RRSRSSSRST
260 270 280 290 300
EASPSRDVSP MGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQEASF
310 320
LQVHDFFQQD LKEGFHVSML NRRTTPV
Length:327
Mass (Da):36,579
Last modified:May 1, 2000 - v1
Checksum:i79630ACC03B1DAE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142625
, AF142622, AF142623, AF142624 Genomic DNA Translation: AAF03090.1
AF162692 mRNA Translation: AAF14538.1
AK315149 mRNA Translation: BAG37597.1
CH471099 Genomic DNA Translation: EAW89020.1
BC034532 mRNA Translation: AAH34532.1
CCDSiCCDS11667.1
RefSeqiNP_055220.1, NM_014405.3
UniGeneiHs.514423

Genome annotation databases

EnsembliENST00000262138; ENSP00000262138; ENSG00000075461
GeneIDi27092
KEGGihsa:27092
UCSCiuc002jft.3 human

Similar proteinsi

Entry informationi

Entry nameiCCG4_HUMAN
AccessioniPrimary (citable) accession number: Q9UBN1
Secondary accession number(s): B2RCK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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