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Entry version 168 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

P2X purinoceptor 2

Gene

P2RX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K+ recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processHearing, Ion transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UBL9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-139853, Elevation of cytosolic Ca2+ levels
R-HSA-418346, Platelet homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2X purinoceptor 2
Short name:
P2X2
Alternative name(s):
ATP receptor
Purinergic receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2RX2
Synonyms:P2X2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187848.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15459, P2RX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600844, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBL9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 42CytoplasmicSequence analysisAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 337ExtracellularSequence analysisAdd BLAST274
Transmembranei338 – 358Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini359 – 471CytoplasmicSequence analysisAdd BLAST113

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal dominant, 41 (DFNA41)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic deafness characterized by onset of progressive sensorineural hearing loss usually in the second decade. The hearing loss is severe and ultimately affects all frequencies. Exposure to noise exacerbates the hearing loss, particularly at high frequencies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07068760V → L in DFNA41; found in heterozygous status in patients; abolished ATP-stimulated permeability. 1 PublicationCorresponds to variant dbSNP:rs587777692EnsemblClinVar.1
Natural variantiVAR_070688353G → R in DFNA41. 1 PublicationCorresponds to variant dbSNP:rs202138002EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
22953

MalaCards human disease database

More...
MalaCardsi
P2RX2
MIMi608224, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000187848

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32862

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBL9, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2531

Drug and drug target database

More...
DrugBanki
DB01069, Promethazine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
479

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
P2RX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643353

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001615491 – 471P2X purinoceptor 2Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi21 ↔ 439By similarity
Disulfide bondi125 ↔ 176By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 159By similarity
Disulfide bondi142 ↔ 170By similarity
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi226 ↔ 236By similarity
Disulfide bondi270 ↔ 279By similarity
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UBL9

PeptideAtlas

More...
PeptideAtlasi
Q9UBL9

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBL9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83999 [Q9UBL9-1]
84000 [Q9UBL9-2]
84001 [Q9UBL9-3]
84002 [Q9UBL9-4]
84003 [Q9UBL9-5]
84004 [Q9UBL9-6]
84005 [Q9UBL9-7]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9UBL9, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBL9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187848, Expressed in esophagus and 97 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UBL9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBL9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187848, Tissue enhanced (epididymis, prostate, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer and heterotrimer; functional P2XRs are organized as homomeric and heteromeric trimers.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116607, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UBL9, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343339

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UBL9

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UBL9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBL9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni320 – 333Pore-forming motifSequence analysisAdd BLAST14

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVP9, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214492

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034469_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBL9

KEGG Orthology (KO)

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KOi
K05216

Identification of Orthologs from Complete Genome Data

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OMAi
ICTIICD

Database of Orthologous Groups

More...
OrthoDBi
1128763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBL9

TreeFam database of animal gene trees

More...
TreeFami
TF328633

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003045, P2X2_purnocptor
IPR027309, P2X_extracellular_dom_sf
IPR001429, P2X_purnocptor

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005713, P2X_purinoceptor, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01309, P2X2RECEPTOR
PR01307, P2XRECEPTOR

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00863, P2X, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01212, P2X_RECEPTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: Q9UBL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL
60 70 80 90 100
LILLYFVWYV FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK
110 120 130 140 150
PPEGGSVFSI ITRVEATHSQ TQGTCPESIR VHNATCLSDA DCVAGELDML
160 170 180 190 200
GNGLRTGRCV PYYQGPSKTC EVFGWCPVED GASVSQFLGT MAPNFTILIK
210 220 230 240 250
NSIHYPKFHF SKGNIADRTD GYLKRCTFHE ASDLYCPIFK LGFIVEKAGE
260 270 280 290 300
SFTELAHKGG VIGVIINWDC DLDLPASECN PKYSFRRLDP KHVPASSGYN
310 320 330 340 350
FRFAKYYKIN GTTTRTLIKA YGIRIDVIVH GQAGKFSLIP TIINLATALT
360 370 380 390 400
SVGVGSFLCD WILLTFMNKN KVYSHKKFDK VCTPSHPSGS WPVTLARVLG
410 420 430 440 450
QAPPEPGHRS EDQHPSPPSG QEGQQGAECG PAFPPLRPCP ISAPSEQMVD
460 470
TPASEPAQAS TPTDPKGLAQ L
Length:471
Mass (Da):51,754
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84CD61DA136EF420
GO
Isoform B (identifier: Q9UBL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-447: Missing.

Show »
Length:404
Mass (Da):44,842
Checksum:i695AC6C1655DB952
GO
Isoform C (identifier: Q9UBL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-127: Missing.

Show »
Length:447
Mass (Da):49,266
Checksum:iBAF5513A27314D1D
GO
Isoform D (identifier: Q9UBL9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: V → VVRNPLWGPSGCGGSTRPLHTGLCWPQ

Show »
Length:497
Mass (Da):54,513
Checksum:iFC4007F5BDD46E0E
GO
Isoform H (identifier: Q9UBL9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-127: Missing.

Show »
Length:379
Mass (Da):41,254
Checksum:i8D1AA9A069D7F008
GO
Isoform I (identifier: Q9UBL9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-152: NRRLGVLYRA...VAGELDMLGN → IHRAEKLPGE...GRGGVREAPR

Show »
Length:399
Mass (Da):43,726
Checksum:i8B55562C9BAEAE5E
GO
Isoform K (identifier: Q9UBL9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-127: Missing.
     154-258: LRTGRCVPYY...GESFTELAHK → ALQDLRGVRL...ELHRARTQGR
     381-447: Missing.

Show »
Length:370
Mass (Da):41,370
Checksum:i36FC1F15D45624DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q32MC3Q32MC3_HUMAN
ATP receptor
P2RX2
349Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 14MAAAQ…AGATA → MV in AAD42947 (Ref. 3) CuratedAdd BLAST14
Sequence conflicti1 – 14MAAAQ…AGATA → MV in AAD42948 (Ref. 3) CuratedAdd BLAST14
Sequence conflicti48V → A in AAQ54329 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07068760V → L in DFNA41; found in heterozygous status in patients; abolished ATP-stimulated permeability. 1 PublicationCorresponds to variant dbSNP:rs587777692EnsemblClinVar.1
Natural variantiVAR_070688353G → R in DFNA41. 1 PublicationCorresponds to variant dbSNP:rs202138002EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00449536 – 127Missing in isoform H. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_00449638 – 152NRRLG…DMLGN → IHRAEKLPGERDGPRELHHH QGQGDHHVRAQSVGRGGVRE APR in isoform I. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_004497104 – 127Missing in isoform C and isoform K. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_014135154 – 258LRTGR…ELAHK → ALQDLRGVRLVPGGRWGLCQ PISGYDGPKFHHPHQEQHPL PQIPLLQGQHRRPHRRVPEA LHVPRGLRPLLPHLQAGLYR GEGWGELHRARTQGR in isoform K. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_004498354V → VVRNPLWGPSGCGGSTRPLH TGLCWPQ in isoform D. 1 Publication1
Alternative sequenceiVSP_004499381 – 447Missing in isoform B and isoform K. 3 PublicationsAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF190822 mRNA Translation: AAF19170.1
AF190823 mRNA Translation: AAF19171.1
AF190824 mRNA Translation: AAF19172.1
AF190825 mRNA Translation: AAF19173.1
AF190826 Genomic DNA Translation: AAF19174.1
AF109387 mRNA Translation: AAD42947.1
AF109388 mRNA Translation: AAD42948.1
AF260426 mRNA Translation: AAF74201.1
AF260427 mRNA Translation: AAF74202.1
AF260428 mRNA Translation: AAF74203.1
AF260429 mRNA Translation: AAF74204.1
AY346374 mRNA Translation: AAQ54329.1
AC131212 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS31930.1 [Q9UBL9-4]
CCDS31931.1 [Q9UBL9-1]
CCDS31932.1 [Q9UBL9-2]
CCDS31933.1 [Q9UBL9-3]
CCDS31934.1 [Q9UBL9-6]
CCDS31935.1 [Q9UBL9-5]
CCDS61286.1 [Q9UBL9-7]

NCBI Reference Sequences

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RefSeqi
NP_001269093.1, NM_001282164.1 [Q9UBL9-7]
NP_001269094.1, NM_001282165.1
NP_036358.2, NM_012226.4 [Q9UBL9-6]
NP_057402.1, NM_016318.3 [Q9UBL9-3]
NP_733782.1, NM_170682.3 [Q9UBL9-1]
NP_733783.1, NM_170683.3 [Q9UBL9-4]
NP_777361.1, NM_174872.2 [Q9UBL9-5]
NP_777362.1, NM_174873.2 [Q9UBL9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343948; ENSP00000343339; ENSG00000187848 [Q9UBL9-4]
ENST00000348800; ENSP00000345095; ENSG00000187848 [Q9UBL9-2]
ENST00000350048; ENSP00000343904; ENSG00000187848 [Q9UBL9-3]
ENST00000351222; ENSP00000344502; ENSG00000187848 [Q9UBL9-5]
ENST00000352418; ENSP00000341419; ENSG00000187848 [Q9UBL9-6]
ENST00000449132; ENSP00000405531; ENSG00000187848 [Q9UBL9-7]
ENST00000643471; ENSP00000494644; ENSG00000187848 [Q9UBL9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22953

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22953

UCSC genome browser

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UCSCi
uc001uki.3, human [Q9UBL9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190822 mRNA Translation: AAF19170.1
AF190823 mRNA Translation: AAF19171.1
AF190824 mRNA Translation: AAF19172.1
AF190825 mRNA Translation: AAF19173.1
AF190826 Genomic DNA Translation: AAF19174.1
AF109387 mRNA Translation: AAD42947.1
AF109388 mRNA Translation: AAD42948.1
AF260426 mRNA Translation: AAF74201.1
AF260427 mRNA Translation: AAF74202.1
AF260428 mRNA Translation: AAF74203.1
AF260429 mRNA Translation: AAF74204.1
AY346374 mRNA Translation: AAQ54329.1
AC131212 Genomic DNA No translation available.
CCDSiCCDS31930.1 [Q9UBL9-4]
CCDS31931.1 [Q9UBL9-1]
CCDS31932.1 [Q9UBL9-2]
CCDS31933.1 [Q9UBL9-3]
CCDS31934.1 [Q9UBL9-6]
CCDS31935.1 [Q9UBL9-5]
CCDS61286.1 [Q9UBL9-7]
RefSeqiNP_001269093.1, NM_001282164.1 [Q9UBL9-7]
NP_001269094.1, NM_001282165.1
NP_036358.2, NM_012226.4 [Q9UBL9-6]
NP_057402.1, NM_016318.3 [Q9UBL9-3]
NP_733782.1, NM_170682.3 [Q9UBL9-1]
NP_733783.1, NM_170683.3 [Q9UBL9-4]
NP_777361.1, NM_174872.2 [Q9UBL9-5]
NP_777362.1, NM_174873.2 [Q9UBL9-2]

3D structure databases

SMRiQ9UBL9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116607, 23 interactors
IntActiQ9UBL9, 21 interactors
STRINGi9606.ENSP00000343339

Chemistry databases

BindingDBiQ9UBL9
ChEMBLiCHEMBL2531
DrugBankiDB01069, Promethazine
GuidetoPHARMACOLOGYi479

PTM databases

GlyGeniQ9UBL9, 3 sites
iPTMnetiQ9UBL9
PhosphoSitePlusiQ9UBL9

Polymorphism and mutation databases

BioMutaiP2RX2
DMDMi12643353

Proteomic databases

MassIVEiQ9UBL9
PeptideAtlasiQ9UBL9
PRIDEiQ9UBL9
ProteomicsDBi83999 [Q9UBL9-1]
84000 [Q9UBL9-2]
84001 [Q9UBL9-3]
84002 [Q9UBL9-4]
84003 [Q9UBL9-5]
84004 [Q9UBL9-6]
84005 [Q9UBL9-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2714, 322 antibodies

Genome annotation databases

EnsembliENST00000343948; ENSP00000343339; ENSG00000187848 [Q9UBL9-4]
ENST00000348800; ENSP00000345095; ENSG00000187848 [Q9UBL9-2]
ENST00000350048; ENSP00000343904; ENSG00000187848 [Q9UBL9-3]
ENST00000351222; ENSP00000344502; ENSG00000187848 [Q9UBL9-5]
ENST00000352418; ENSP00000341419; ENSG00000187848 [Q9UBL9-6]
ENST00000449132; ENSP00000405531; ENSG00000187848 [Q9UBL9-7]
ENST00000643471; ENSP00000494644; ENSG00000187848 [Q9UBL9-1]
GeneIDi22953
KEGGihsa:22953
UCSCiuc001uki.3, human [Q9UBL9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22953
DisGeNETi22953
EuPathDBiHostDB:ENSG00000187848.12

GeneCards: human genes, protein and diseases

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GeneCardsi
P2RX2
HGNCiHGNC:15459, P2RX2
HPAiENSG00000187848, Tissue enhanced (epididymis, prostate, seminal vesicle)
MalaCardsiP2RX2
MIMi600844, gene
608224, phenotype
neXtProtiNX_Q9UBL9
OpenTargetsiENSG00000187848
Orphaneti90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA32862

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QVP9, Eukaryota
GeneTreeiENSGT01000000214492
HOGENOMiCLU_034469_4_0_1
InParanoidiQ9UBL9
KOiK05216
OMAiICTIICD
OrthoDBi1128763at2759
PhylomeDBiQ9UBL9
TreeFamiTF328633

Enzyme and pathway databases

PathwayCommonsiQ9UBL9
ReactomeiR-HSA-139853, Elevation of cytosolic Ca2+ levels
R-HSA-418346, Platelet homeostasis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
22953, 8 hits in 869 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
P2RX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22953
PharosiQ9UBL9, Tchem

Protein Ontology

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PROi
PR:Q9UBL9
RNActiQ9UBL9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187848, Expressed in esophagus and 97 other tissues
ExpressionAtlasiQ9UBL9, baseline and differential
GenevisibleiQ9UBL9, HS

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003045, P2X2_purnocptor
IPR027309, P2X_extracellular_dom_sf
IPR001429, P2X_purnocptor
PIRSFiPIRSF005713, P2X_purinoceptor, 1 hit
PRINTSiPR01309, P2X2RECEPTOR
PR01307, P2XRECEPTOR
TIGRFAMsiTIGR00863, P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212, P2X_RECEPTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RX2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBL9
Secondary accession number(s): A6NGB4
, A6NH93, A6NHC2, A6NHU3, A6NIG9, Q6V9R6, Q9NR37, Q9NR38, Q9UHD5, Q9UHD6, Q9UHD7, Q9Y637, Q9Y638
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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