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Entry version 131 (18 Sep 2019)
Sequence version 2 (13 Nov 2007)
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Protein

cAMP-regulated phosphoprotein 21

Gene

ARPP21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-regulated phosphoprotein 21
Short name:
ARPP-21
Alternative name(s):
Thymocyte cAMP-regulated phosphoprotein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARPP21
Synonyms:TARPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16968 ARPP21

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605488 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBL0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10777

Open Targets

More...
OpenTargetsi
ENSG00000172995

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARPP21

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160332340

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646822 – 812cAMP-regulated phosphoprotein 21Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei33PhosphoserineCombined sources1
Modified residuei56PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei363PhosphoserineBy similarity1
Modified residuei383PhosphoserineCombined sources1
Modified residuei562PhosphoserineCombined sources1
Modified residuei655Omega-N-methylated arginine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-56 favors interaction with CALM1.By similarity
Isoform 1 is methylated by CARM1 in immature thymocytes.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UBL0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UBL0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UBL0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBL0

PeptideAtlas

More...
PeptideAtlasi
Q9UBL0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBL0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83988 [Q9UBL0-1]
83989 [Q9UBL0-2]
83990 [Q9UBL0-3]
83991 [Q9UBL0-4]
83992 [Q9UBL0-5]
83993 [Q9UBL0-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBL0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBL0

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9UBL0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172995 Expressed in 136 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UBL0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBL0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017303

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CALM1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115995, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UBL0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000412326

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBL0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini164 – 227R3HPROSITE-ProRule annotationAdd BLAST64
Domaini228 – 300SUZPROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili32 – 58Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi338 – 423Ser-richAdd BLAST86
Compositional biasi506 – 754Gln-richAdd BLAST249

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2953 Eukaryota
ENOG4111U9N LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160796

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBL0

Identification of Orthologs from Complete Genome Data

More...
OMAi
QEDDKSR

Database of Orthologous Groups

More...
OrthoDBi
137913at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBL0

TreeFam database of animal gene trees

More...
TreeFami
TF315915

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR024771 SUZ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01424 R3H, 1 hit
PF12752 SUZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00393 R3H, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82708 SSF82708, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51061 R3H, 1 hit
PS51673 SUZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBL0-1) [UniParc]FASTAAdd to basket
Also known as: TARPP

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEQGDLNQA IAEEGGTEQE TATPENGIVK SESLDEEEKL ELQRRLEAQN
60 70 80 90 100
QERRKSKSGA GKGKLTRSLA VCEESSARPG GESLQDQESI HLQLSSFSSL
110 120 130 140 150
QEEDKSRKDD SEREKEKDKN KDKTSEKPKI RMLSKDCSQE YTDSTGIDLH
160 170 180 190 200
EFLINTLKNN SRDRMILLKM EQEIIDFIAD NNNHYKKFPQ MSSYQRMLVH
210 220 230 240 250
RVAAYFGLDH NVDQTGKSVI INKTSSTRIP EQRFCEHLKD EKGEESQKRF
260 270 280 290 300
ILKRDNSSID KEDNQQNRMH PFRDDRRSKS IEEREEEYQR VRERIFAHDS
310 320 330 340 350
VCSQESLFVE NSRLLEDSNI CNETYKKRQL FRGNRDGSGR TSGSRQSSSE
360 370 380 390 400
NELKWSDHQR AWSSTDSDSS NRNLKPAMTK TASFGGITVL TRGDSTSSTR
410 420 430 440 450
STGKLSKAGS ESSSSAGSSG SLSRTHPPLQ STPLVSGVAA GSPGCVPYPE
460 470 480 490 500
NGIGGQVAPS STSYILLPLE AATGIPPGSI LLNPHTGQPF VNPDGTPAIY
510 520 530 540 550
NPPTSQQPLR SAMVGQSQQQ PPQQQPSPQP QQQVQPPQPQ MAGPLVTQRD
560 570 580 590 600
DVATQFGQMT LSRQSSGETP EPPSGPVYPS SLMPQPAQQP SYVIASTGQQ
610 620 630 640 650
LPTGGFSGSG PPISQQVLQP PPSPQGFVQQ PPPAQMPVYY YPSGQYPTST
660 670 680 690 700
TQQYRPMAPV QYNAQRSQQM PQAAQQAGYQ PVLSGQQGFQ GLIGVQQPPQ
710 720 730 740 750
SQNVINNQQG TPVQSVMVSY PTMSSYQVPM TQGSQGLPQQ SYQQPIMLPN
760 770 780 790 800
QAGQGSLPAT GMPVYCNVTP PTPQNNLRLI GPHCPSSTVP VMSASCRTNC
810
ASMSNAGWQV KF
Length:812
Mass (Da):89,196
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73981A8341BB3359
GO
Isoform 2 (identifier: Q9UBL0-2) [UniParc]FASTAAdd to basket
Also known as: ARPP-21

The sequence of this isoform differs from the canonical sequence as follows:
     88-89: ES → TL
     90-812: Missing.

Show »
Length:89
Mass (Da):9,674
Checksum:i94654817C61B4C94
GO
Isoform 3 (identifier: Q9UBL0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-299: Missing.
     548-548: Q → QSVQGLQASSQSVQYPAVSFPPQHLLPVSPTQHFPM

Show »
Length:813
Mass (Da):88,570
Checksum:i1F6E07737C11CC45
GO
Isoform 4 (identifier: Q9UBL0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-299: Missing.
     312-331: Missing.
     548-548: Q → QSVQGLQASSQSVQYPAVSFPPQHLLPVSPTQHFPM

Show »
Length:793
Mass (Da):86,131
Checksum:iF523AEF3E39114BE
GO
Isoform 5 (identifier: Q9UBL0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-512: Missing.
     548-548: Q → QSVQGLQASSQSVQYPAVSFPPQHLLPVSPTQHFPM

Note: No experimental confirmation available.
Show »
Length:335
Mass (Da):35,931
Checksum:i3AF26F827EDD5066
GO
Isoform 6 (identifier: Q9UBL0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-108: ESIHLQLSSFSSLQEEDKSRK → VYPLAIIINCMNGIHLCVHDS
     109-812: Missing.

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):11,768
Checksum:i2AABF43866F7CCE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2X8H7C2X8_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5R1C9J5R1_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J091C9J091_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQQ6C9JQQ6_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDL2F8WDL2_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JI74C9JI74_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTF2C9JTF2_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTX6C9JTX6_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JD93C9JD93_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3J7H7C3J7_HUMAN
cAMP-regulated phosphoprotein 21
ARPP21
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti312Missing in CAB61414 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0294691 – 512Missing in isoform 5. 1 PublicationAdd BLAST512
Alternative sequenceiVSP_02947088 – 108ESIHL…DKSRK → VYPLAIIINCMNGIHLCVHD S in isoform 6. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_02947188 – 89ES → TL in isoform 2. 3 Publications2
Alternative sequenceiVSP_02947290 – 812Missing in isoform 2. 3 PublicationsAdd BLAST723
Alternative sequenceiVSP_029473109 – 812Missing in isoform 6. 1 PublicationAdd BLAST704
Alternative sequenceiVSP_029474266 – 299Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST34
Alternative sequenceiVSP_029475312 – 331Missing in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_029476548Q → QSVQGLQASSQSVQYPAVSF PPQHLLPVSPTQHFPM in isoform 3, isoform 4 and isoform 5. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF112220 mRNA Translation: AAF17207.1
AK294484 mRNA Translation: BAG57707.1
CH471055 Genomic DNA Translation: EAW64471.1
BC017805 mRNA Translation: AAH17805.1
BC031106 mRNA Translation: AAH31106.1
BC036399 mRNA Translation: AAH36399.1
BC041385 mRNA Translation: AAH41385.1
BC051828 mRNA Translation: AAH51828.1
BC066651 mRNA Translation: AAH66651.1
AL133109 mRNA Translation: CAB61414.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2661.1 [Q9UBL0-1]
CCDS43063.1 [Q9UBL0-2]
CCDS58823.1 [Q9UBL0-3]
CCDS58824.1 [Q9UBL0-4]

Protein sequence database of the Protein Information Resource

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PIRi
T42644

NCBI Reference Sequences

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RefSeqi
NP_001020239.1, NM_001025068.1 [Q9UBL0-2]
NP_001020240.1, NM_001025069.1 [Q9UBL0-2]
NP_001254545.1, NM_001267616.1 [Q9UBL0-2]
NP_001254546.1, NM_001267617.1 [Q9UBL0-4]
NP_001254547.1, NM_001267618.1 [Q9UBL0-2]
NP_001254548.1, NM_001267619.1 [Q9UBL0-3]
NP_057384.2, NM_016300.4 [Q9UBL0-1]
NP_938409.1, NM_198399.1 [Q9UBL0-2]
XP_006713006.1, XM_006712943.2 [Q9UBL0-3]
XP_006713007.1, XM_006712944.2 [Q9UBL0-4]
XP_016861081.1, XM_017005592.1 [Q9UBL0-3]
XP_016861082.1, XM_017005593.1 [Q9UBL0-3]
XP_016861083.1, XM_017005594.1 [Q9UBL0-3]
XP_016861084.1, XM_017005595.1 [Q9UBL0-3]
XP_016861091.1, XM_017005602.1 [Q9UBL0-4]
XP_016861092.1, XM_017005603.1 [Q9UBL0-4]
XP_016861093.1, XM_017005604.1 [Q9UBL0-4]
XP_016861094.1, XM_017005605.1 [Q9UBL0-4]
XP_016861095.1, XM_017005606.1 [Q9UBL0-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000187397; ENSP00000187397; ENSG00000172995 [Q9UBL0-1]
ENST00000396481; ENSP00000379741; ENSG00000172995 [Q9UBL0-2]
ENST00000396482; ENSP00000379742; ENSG00000172995 [Q9UBL0-2]
ENST00000412048; ENSP00000390151; ENSG00000172995 [Q9UBL0-2]
ENST00000417925; ENSP00000412326; ENSG00000172995 [Q9UBL0-3]
ENST00000427542; ENSP00000401602; ENSG00000172995 [Q9UBL0-2]
ENST00000428373; ENSP00000412411; ENSG00000172995 [Q9UBL0-2]
ENST00000432682; ENSP00000389754; ENSG00000172995 [Q9UBL0-2]
ENST00000436702; ENSP00000397720; ENSG00000172995 [Q9UBL0-2]
ENST00000438071; ENSP00000410171; ENSG00000172995 [Q9UBL0-2]
ENST00000441454; ENSP00000406964; ENSG00000172995 [Q9UBL0-2]
ENST00000444190; ENSP00000405276; ENSG00000172995 [Q9UBL0-4]
ENST00000474696; ENSP00000417838; ENSG00000172995 [Q9UBL0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10777

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10777

UCSC genome browser

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UCSCi
uc003cfz.5 human [Q9UBL0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112220 mRNA Translation: AAF17207.1
AK294484 mRNA Translation: BAG57707.1
CH471055 Genomic DNA Translation: EAW64471.1
BC017805 mRNA Translation: AAH17805.1
BC031106 mRNA Translation: AAH31106.1
BC036399 mRNA Translation: AAH36399.1
BC041385 mRNA Translation: AAH41385.1
BC051828 mRNA Translation: AAH51828.1
BC066651 mRNA Translation: AAH66651.1
AL133109 mRNA Translation: CAB61414.1
CCDSiCCDS2661.1 [Q9UBL0-1]
CCDS43063.1 [Q9UBL0-2]
CCDS58823.1 [Q9UBL0-3]
CCDS58824.1 [Q9UBL0-4]
PIRiT42644
RefSeqiNP_001020239.1, NM_001025068.1 [Q9UBL0-2]
NP_001020240.1, NM_001025069.1 [Q9UBL0-2]
NP_001254545.1, NM_001267616.1 [Q9UBL0-2]
NP_001254546.1, NM_001267617.1 [Q9UBL0-4]
NP_001254547.1, NM_001267618.1 [Q9UBL0-2]
NP_001254548.1, NM_001267619.1 [Q9UBL0-3]
NP_057384.2, NM_016300.4 [Q9UBL0-1]
NP_938409.1, NM_198399.1 [Q9UBL0-2]
XP_006713006.1, XM_006712943.2 [Q9UBL0-3]
XP_006713007.1, XM_006712944.2 [Q9UBL0-4]
XP_016861081.1, XM_017005592.1 [Q9UBL0-3]
XP_016861082.1, XM_017005593.1 [Q9UBL0-3]
XP_016861083.1, XM_017005594.1 [Q9UBL0-3]
XP_016861084.1, XM_017005595.1 [Q9UBL0-3]
XP_016861091.1, XM_017005602.1 [Q9UBL0-4]
XP_016861092.1, XM_017005603.1 [Q9UBL0-4]
XP_016861093.1, XM_017005604.1 [Q9UBL0-4]
XP_016861094.1, XM_017005605.1 [Q9UBL0-4]
XP_016861095.1, XM_017005606.1 [Q9UBL0-4]

3D structure databases

SMRiQ9UBL0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115995, 3 interactors
IntActiQ9UBL0, 2 interactors
STRINGi9606.ENSP00000412326

PTM databases

iPTMnetiQ9UBL0
PhosphoSitePlusiQ9UBL0

Polymorphism and mutation databases

BioMutaiARPP21
DMDMi160332340

Proteomic databases

jPOSTiQ9UBL0
MassIVEiQ9UBL0
MaxQBiQ9UBL0
PaxDbiQ9UBL0
PeptideAtlasiQ9UBL0
PRIDEiQ9UBL0
ProteomicsDBi83988 [Q9UBL0-1]
83989 [Q9UBL0-2]
83990 [Q9UBL0-3]
83991 [Q9UBL0-4]
83992 [Q9UBL0-5]
83993 [Q9UBL0-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10777
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000187397; ENSP00000187397; ENSG00000172995 [Q9UBL0-1]
ENST00000396481; ENSP00000379741; ENSG00000172995 [Q9UBL0-2]
ENST00000396482; ENSP00000379742; ENSG00000172995 [Q9UBL0-2]
ENST00000412048; ENSP00000390151; ENSG00000172995 [Q9UBL0-2]
ENST00000417925; ENSP00000412326; ENSG00000172995 [Q9UBL0-3]
ENST00000427542; ENSP00000401602; ENSG00000172995 [Q9UBL0-2]
ENST00000428373; ENSP00000412411; ENSG00000172995 [Q9UBL0-2]
ENST00000432682; ENSP00000389754; ENSG00000172995 [Q9UBL0-2]
ENST00000436702; ENSP00000397720; ENSG00000172995 [Q9UBL0-2]
ENST00000438071; ENSP00000410171; ENSG00000172995 [Q9UBL0-2]
ENST00000441454; ENSP00000406964; ENSG00000172995 [Q9UBL0-2]
ENST00000444190; ENSP00000405276; ENSG00000172995 [Q9UBL0-4]
ENST00000474696; ENSP00000417838; ENSG00000172995 [Q9UBL0-2]
GeneIDi10777
KEGGihsa:10777
UCSCiuc003cfz.5 human [Q9UBL0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10777
DisGeNETi10777

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARPP21
HGNCiHGNC:16968 ARPP21
HPAiHPA017303
MIMi605488 gene
neXtProtiNX_Q9UBL0
OpenTargetsiENSG00000172995

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2953 Eukaryota
ENOG4111U9N LUCA
GeneTreeiENSGT00940000160796
InParanoidiQ9UBL0
OMAiQEDDKSR
OrthoDBi137913at2759
PhylomeDBiQ9UBL0
TreeFamiTF315915

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARPP21 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARPP-21

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10777

Pharos

More...
Pharosi
Q9UBL0
PMAP-CutDBiQ9UBL0

Protein Ontology

More...
PROi
PR:Q9UBL0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172995 Expressed in 136 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ9UBL0 baseline and differential
GenevisibleiQ9UBL0 HS

Family and domain databases

Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR024771 SUZ
PfamiView protein in Pfam
PF01424 R3H, 1 hit
PF12752 SUZ, 1 hit
SMARTiView protein in SMART
SM00393 R3H, 1 hit
SUPFAMiSSF82708 SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061 R3H, 1 hit
PS51673 SUZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARP21_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBL0
Secondary accession number(s): B4DG96
, Q49AK3, Q49AS6, Q4G0V4, Q6NYC3, Q86V31, Q9UF93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 13, 2007
Last modified: September 18, 2019
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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