UniProtKB - Q9UBL0 (ARP21_HUMAN)
Protein
cAMP-regulated phosphoprotein 21
Gene
ARPP21
Organism
Homo sapiens (Human)
Status
Functioni
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.By similarity
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
GO - Biological processi
- cellular response to heat Source: Ensembl
Keywordsi
Molecular function | Calmodulin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UBL0 |
Names & Taxonomyi
Protein namesi | Recommended name: cAMP-regulated phosphoprotein 21Short name: ARPP-21 Alternative name(s): Thymocyte cAMP-regulated phosphoprotein |
Gene namesi | Name:ARPP21 Synonyms:TARPP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16968, ARPP21 |
MIMi | 605488, gene |
neXtProti | NX_Q9UBL0 |
VEuPathDBi | HostDB:ENSG00000172995.16 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 10777 |
OpenTargetsi | ENSG00000172995 |
Miscellaneous databases
Pharosi | Q9UBL0, Tbio |
Genetic variation databases
BioMutai | ARPP21 |
DMDMi | 160332340 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000064682 | 2 – 812 | cAMP-regulated phosphoprotein 21Add BLAST | 811 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 33 | PhosphoserineCombined sources | 1 | |
Modified residuei | 56 | PhosphoserineBy similarity | 1 | |
Modified residuei | 134 | PhosphoserineBy similarity | 1 | |
Modified residuei | 300 | PhosphoserineBy similarity | 1 | |
Modified residuei | 363 | PhosphoserineBy similarity | 1 | |
Modified residuei | 383 | PhosphoserineCombined sources | 1 | |
Modified residuei | 562 | PhosphoserineCombined sources | 1 | |
Modified residuei | 655 | Asymmetric dimethylarginine1 Publication | 1 |
Post-translational modificationi
Phosphorylation at Ser-56 favors interaction with CALM1.By similarity
Isoform 1 is methylated by CARM1 at Arg-655 in immature thymocytes.1 Publication
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
jPOSTi | Q9UBL0 |
MassIVEi | Q9UBL0 |
MaxQBi | Q9UBL0 |
PaxDbi | Q9UBL0 |
PeptideAtlasi | Q9UBL0 |
PRIDEi | Q9UBL0 |
ProteomicsDBi | 83988 [Q9UBL0-1] 83989 [Q9UBL0-2] 83990 [Q9UBL0-3] 83991 [Q9UBL0-4] 83992 [Q9UBL0-5] 83993 [Q9UBL0-6] |
PTM databases
iPTMneti | Q9UBL0 |
PhosphoSitePlusi | Q9UBL0 |
Expressioni
Tissue specificityi
Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).2 Publications
Gene expression databases
Bgeei | ENSG00000172995, Expressed in caudate nucleus and 153 other tissues |
ExpressionAtlasi | Q9UBL0, baseline and differential |
Genevisiblei | Q9UBL0, HS |
Organism-specific databases
HPAi | ENSG00000172995, Group enriched (brain, lymphoid tissue, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with CALM1.
By similarityBinary interactionsi
Isoform 2 [Q9UBL0-2]
With | #Exp. | IntAct |
---|---|---|
SPRED1 [Q7Z699] | 3 | EBI-25931672,EBI-5235340 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 115995, 3 interactors |
IntActi | Q9UBL0, 3 interactors |
STRINGi | 9606.ENSP00000412326 |
Miscellaneous databases
RNActi | Q9UBL0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 164 – 227 | R3HPROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 228 – 300 | SUZPROSITE-ProRule annotationAdd BLAST | 73 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 32 – 58 | Sequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 338 – 423 | Ser-richAdd BLAST | 86 | |
Compositional biasi | 506 – 754 | Gln-richAdd BLAST | 249 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2953, Eukaryota |
GeneTreei | ENSGT00940000160796 |
HOGENOMi | CLU_2256194_0_0_1 |
InParanoidi | Q9UBL0 |
OMAi | ANCRTNC |
OrthoDBi | 137913at2759 |
PhylomeDBi | Q9UBL0 |
TreeFami | TF315915 |
Family and domain databases
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR024771, SUZ |
Pfami | View protein in Pfam PF01424, R3H, 1 hit PF12752, SUZ, 1 hit |
SMARTi | View protein in SMART SM00393, R3H, 1 hit |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit PS51673, SUZ, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UBL0-1) [UniParc]FASTAAdd to basket
Also known as: TARPP
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEQGDLNQA IAEEGGTEQE TATPENGIVK SESLDEEEKL ELQRRLEAQN
60 70 80 90 100
QERRKSKSGA GKGKLTRSLA VCEESSARPG GESLQDQESI HLQLSSFSSL
110 120 130 140 150
QEEDKSRKDD SEREKEKDKN KDKTSEKPKI RMLSKDCSQE YTDSTGIDLH
160 170 180 190 200
EFLINTLKNN SRDRMILLKM EQEIIDFIAD NNNHYKKFPQ MSSYQRMLVH
210 220 230 240 250
RVAAYFGLDH NVDQTGKSVI INKTSSTRIP EQRFCEHLKD EKGEESQKRF
260 270 280 290 300
ILKRDNSSID KEDNQQNRMH PFRDDRRSKS IEEREEEYQR VRERIFAHDS
310 320 330 340 350
VCSQESLFVE NSRLLEDSNI CNETYKKRQL FRGNRDGSGR TSGSRQSSSE
360 370 380 390 400
NELKWSDHQR AWSSTDSDSS NRNLKPAMTK TASFGGITVL TRGDSTSSTR
410 420 430 440 450
STGKLSKAGS ESSSSAGSSG SLSRTHPPLQ STPLVSGVAA GSPGCVPYPE
460 470 480 490 500
NGIGGQVAPS STSYILLPLE AATGIPPGSI LLNPHTGQPF VNPDGTPAIY
510 520 530 540 550
NPPTSQQPLR SAMVGQSQQQ PPQQQPSPQP QQQVQPPQPQ MAGPLVTQRD
560 570 580 590 600
DVATQFGQMT LSRQSSGETP EPPSGPVYPS SLMPQPAQQP SYVIASTGQQ
610 620 630 640 650
LPTGGFSGSG PPISQQVLQP PPSPQGFVQQ PPPAQMPVYY YPSGQYPTST
660 670 680 690 700
TQQYRPMAPV QYNAQRSQQM PQAAQQAGYQ PVLSGQQGFQ GLIGVQQPPQ
710 720 730 740 750
SQNVINNQQG TPVQSVMVSY PTMSSYQVPM TQGSQGLPQQ SYQQPIMLPN
760 770 780 790 800
QAGQGSLPAT GMPVYCNVTP PTPQNNLRLI GPHCPSSTVP VMSASCRTNC
810
ASMSNAGWQV KF
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C2X8 | H7C2X8_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 261 | Annotation score: | ||
C9JD93 | C9JD93_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 96 | Annotation score: | ||
C9JQQ6 | C9JQQ6_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 54 | Annotation score: | ||
C9J091 | C9J091_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 101 | Annotation score: | ||
C9J5R1 | C9J5R1_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 104 | Annotation score: | ||
C9JI74 | C9JI74_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 98 | Annotation score: | ||
C9JTF2 | C9JTF2_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 94 | Annotation score: | ||
C9JTX6 | C9JTX6_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 43 | Annotation score: | ||
F8WDL2 | F8WDL2_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 98 | Annotation score: | ||
H7C3J7 | H7C3J7_HUMAN | cAMP-regulated phosphoprotein 21 | ARPP21 | 241 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 312 | Missing in CAB61414 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029469 | 1 – 512 | Missing in isoform 5. 1 PublicationAdd BLAST | 512 | |
Alternative sequenceiVSP_029470 | 88 – 108 | ESIHL…DKSRK → VYPLAIIINCMNGIHLCVHD S in isoform 6. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_029471 | 88 – 89 | ES → TL in isoform 2. 3 Publications | 2 | |
Alternative sequenceiVSP_029472 | 90 – 812 | Missing in isoform 2. 3 PublicationsAdd BLAST | 723 | |
Alternative sequenceiVSP_029473 | 109 – 812 | Missing in isoform 6. 1 PublicationAdd BLAST | 704 | |
Alternative sequenceiVSP_029474 | 266 – 299 | Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 34 | |
Alternative sequenceiVSP_029475 | 312 – 331 | Missing in isoform 4. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_029476 | 548 | Q → QSVQGLQASSQSVQYPAVSF PPQHLLPVSPTQHFPM in isoform 3, isoform 4 and isoform 5. 3 Publications | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q9UBL0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115995, 3 interactors |
IntActi | Q9UBL0, 3 interactors |
STRINGi | 9606.ENSP00000412326 |
PTM databases
iPTMneti | Q9UBL0 |
PhosphoSitePlusi | Q9UBL0 |
Genetic variation databases
BioMutai | ARPP21 |
DMDMi | 160332340 |
Proteomic databases
jPOSTi | Q9UBL0 |
MassIVEi | Q9UBL0 |
MaxQBi | Q9UBL0 |
PaxDbi | Q9UBL0 |
PeptideAtlasi | Q9UBL0 |
PRIDEi | Q9UBL0 |
ProteomicsDBi | 83988 [Q9UBL0-1] 83989 [Q9UBL0-2] 83990 [Q9UBL0-3] 83991 [Q9UBL0-4] 83992 [Q9UBL0-5] 83993 [Q9UBL0-6] |
Protocols and materials databases
Antibodypediai | 2806, 158 antibodies |
DNASUi | 10777 |
Genome annotation databases
Organism-specific databases
CTDi | 10777 |
DisGeNETi | 10777 |
GeneCardsi | ARPP21 |
HGNCi | HGNC:16968, ARPP21 |
HPAi | ENSG00000172995, Group enriched (brain, lymphoid tissue, skeletal muscle) |
MIMi | 605488, gene |
neXtProti | NX_Q9UBL0 |
OpenTargetsi | ENSG00000172995 |
VEuPathDBi | HostDB:ENSG00000172995.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2953, Eukaryota |
GeneTreei | ENSGT00940000160796 |
HOGENOMi | CLU_2256194_0_0_1 |
InParanoidi | Q9UBL0 |
OMAi | ANCRTNC |
OrthoDBi | 137913at2759 |
PhylomeDBi | Q9UBL0 |
TreeFami | TF315915 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBL0 |
Miscellaneous databases
BioGRID-ORCSi | 10777, 5 hits in 977 CRISPR screens |
ChiTaRSi | ARPP21, human |
GeneWikii | ARPP-21 |
GenomeRNAii | 10777 |
Pharosi | Q9UBL0, Tbio |
PROi | PR:Q9UBL0 |
RNActi | Q9UBL0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172995, Expressed in caudate nucleus and 153 other tissues |
ExpressionAtlasi | Q9UBL0, baseline and differential |
Genevisiblei | Q9UBL0, HS |
Family and domain databases
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR024771, SUZ |
Pfami | View protein in Pfam PF01424, R3H, 1 hit PF12752, SUZ, 1 hit |
SMARTi | View protein in SMART SM00393, R3H, 1 hit |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit PS51673, SUZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARP21_HUMAN | |
Accessioni | Q9UBL0Primary (citable) accession number: Q9UBL0 Secondary accession number(s): B4DG96 Q9UF93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | November 13, 2007 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot