UniProtKB - Q9UBK7 (RBL2A_HUMAN)
Protein
Rab-like protein 2A
Gene
RABL2A
Organism
Homo sapiens (Human)
Status
Functioni
Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 28 – 35 | GTPBy similarity | 8 | |
Nucleotide bindingi | 76 – 80 | GTPBy similarity | 5 | |
Nucleotide bindingi | 133 – 136 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- intracellular protein transport Source: GO_Central
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UBK7 |
Names & Taxonomyi
Protein namesi | Recommended name: Rab-like protein 2A |
Gene namesi | Name:RABL2A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9799, RABL2A |
MIMi | 605412, gene |
neXtProti | NX_Q9UBK7 |
VEuPathDBi | HostDB:ENSG00000144134.18 |
Subcellular locationi
Other locations
- endomembrane system Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 11159 |
OpenTargetsi | ENSG00000144134 |
PharmGKBi | PA34159 |
Miscellaneous databases
Pharosi | Q9UBK7, Tdark |
Genetic variation databases
BioMutai | RABL2A |
DMDMi | 12643870 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121263 | 1 – 228 | Rab-like protein 2AAdd BLAST | 228 |
Proteomic databases
EPDi | Q9UBK7 |
jPOSTi | Q9UBK7 |
MassIVEi | Q9UBK7 |
MaxQBi | Q9UBK7 |
PaxDbi | Q9UBK7 |
PeptideAtlasi | Q9UBK7 |
PRIDEi | Q9UBK7 |
ProteomicsDBi | 83981 [Q9UBK7-1] 83982 [Q9UBK7-2] 83983 [Q9UBK7-3] |
PTM databases
iPTMneti | Q9UBK7 |
PhosphoSitePlusi | Q9UBK7 |
Expressioni
Tissue specificityi
Expressed in the testis.1 Publication
Gene expression databases
Bgeei | ENSG00000144134, Expressed in right uterine tube and 116 other tissues |
ExpressionAtlasi | Q9UBK7, baseline and differential |
Genevisiblei | Q9UBK7, HS |
Organism-specific databases
HPAi | ENSG00000144134, Tissue enhanced (fallopian) |
Interactioni
Subunit structurei
Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC, MAPRE1 and HSPA2.
By similarityBinary interactionsi
Isoform 2 [Q9UBK7-2]
With | #Exp. | IntAct |
---|---|---|
CEP19 [Q96LK0] | 6 | EBI-4402837,EBI-741885 |
Protein-protein interaction databases
BioGRIDi | 116330, 22 interactors |
IntActi | Q9UBK7, 1 interactor |
STRINGi | 9606.ENSP00000376872 |
Miscellaneous databases
RNActi | Q9UBK7, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0087, Eukaryota |
GeneTreei | ENSGT00940000156551 |
HOGENOMi | CLU_041217_13_1_1 |
InParanoidi | Q9UBK7 |
OMAi | KIDDISM |
OrthoDBi | 1340129at2759 |
PhylomeDBi | Q9UBK7 |
TreeFami | TF329398 |
Family and domain databases
CDDi | cd04124, RabL2, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041835, RabL2 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UBK7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ
60 70 80 90 100
LSTYALTLYK HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV
110 120 130 140 150
FDIQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDDINV TQKSFNFAKK
160 170 180 190 200
FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY KQNSQDFMDE IFQELENFSL
210 220
EQEEEDVPDQ EQSSSIETPS EEVASPHS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZBD5 | B7ZBD5_HUMAN | Rab-like protein 2A | RABL2A | 165 | Annotation score: | ||
E7EWW3 | E7EWW3_HUMAN | Rab-like protein 2A | RABL2A | 101 | Annotation score: | ||
B7ZBD4 | B7ZBD4_HUMAN | Rab-like protein 2A | RABL2A | 114 | Annotation score: | ||
F2Z2E5 | F2Z2E5_HUMAN | Rab-like protein 2A | RABL2A | 54 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005531 | 136 | D → DA in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_041060 | 168 | K → KVWLTAEVASK in isoform 3. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095350 mRNA Translation: AAD51377.1 AF095351 mRNA Translation: AAD51378.1 AL078621 Genomic DNA No translation available. |
CCDSi | CCDS2118.1 [Q9UBK7-1] CCDS77454.1 [Q9UBK7-2] CCDS77455.1 [Q9UBK7-3] |
RefSeqi | NP_001293089.1, NM_001306160.1 [Q9UBK7-3] NP_009013.1, NM_007082.4 [Q9UBK7-1] NP_038198.1, NM_013412.3 [Q9UBK7-1] XP_016858697.1, XM_017003208.1 XP_016858698.1, XM_017003209.1 XP_016858709.1, XM_017003220.1 [Q9UBK7-1] XP_016858710.1, XM_017003221.1 XP_016858711.1, XM_017003222.1 [Q9UBK7-1] |
Genome annotation databases
Ensembli | ENST00000393165; ENSP00000376870; ENSG00000144134 [Q9UBK7-2] ENST00000393166; ENSP00000376871; ENSG00000144134 [Q9UBK7-1] ENST00000393167; ENSP00000376872; ENSG00000144134 [Q9UBK7-1] ENST00000409875; ENSP00000387229; ENSG00000144134 [Q9UBK7-3] |
GeneIDi | 11159 |
KEGGi | hsa:11159 |
UCSCi | uc002tkn.5, human [Q9UBK7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095350 mRNA Translation: AAD51377.1 AF095351 mRNA Translation: AAD51378.1 AL078621 Genomic DNA No translation available. |
CCDSi | CCDS2118.1 [Q9UBK7-1] CCDS77454.1 [Q9UBK7-2] CCDS77455.1 [Q9UBK7-3] |
RefSeqi | NP_001293089.1, NM_001306160.1 [Q9UBK7-3] NP_009013.1, NM_007082.4 [Q9UBK7-1] NP_038198.1, NM_013412.3 [Q9UBK7-1] XP_016858697.1, XM_017003208.1 XP_016858698.1, XM_017003209.1 XP_016858709.1, XM_017003220.1 [Q9UBK7-1] XP_016858710.1, XM_017003221.1 XP_016858711.1, XM_017003222.1 [Q9UBK7-1] |
3D structure databases
SMRi | Q9UBK7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116330, 22 interactors |
IntActi | Q9UBK7, 1 interactor |
STRINGi | 9606.ENSP00000376872 |
PTM databases
iPTMneti | Q9UBK7 |
PhosphoSitePlusi | Q9UBK7 |
Genetic variation databases
BioMutai | RABL2A |
DMDMi | 12643870 |
Proteomic databases
EPDi | Q9UBK7 |
jPOSTi | Q9UBK7 |
MassIVEi | Q9UBK7 |
MaxQBi | Q9UBK7 |
PaxDbi | Q9UBK7 |
PeptideAtlasi | Q9UBK7 |
PRIDEi | Q9UBK7 |
ProteomicsDBi | 83981 [Q9UBK7-1] 83982 [Q9UBK7-2] 83983 [Q9UBK7-3] |
Protocols and materials databases
Antibodypediai | 47553, 199 antibodies |
DNASUi | 11159 |
Genome annotation databases
Ensembli | ENST00000393165; ENSP00000376870; ENSG00000144134 [Q9UBK7-2] ENST00000393166; ENSP00000376871; ENSG00000144134 [Q9UBK7-1] ENST00000393167; ENSP00000376872; ENSG00000144134 [Q9UBK7-1] ENST00000409875; ENSP00000387229; ENSG00000144134 [Q9UBK7-3] |
GeneIDi | 11159 |
KEGGi | hsa:11159 |
UCSCi | uc002tkn.5, human [Q9UBK7-1] |
Organism-specific databases
CTDi | 11159 |
DisGeNETi | 11159 |
GeneCardsi | RABL2A |
HGNCi | HGNC:9799, RABL2A |
HPAi | ENSG00000144134, Tissue enhanced (fallopian) |
MIMi | 605412, gene |
neXtProti | NX_Q9UBK7 |
OpenTargetsi | ENSG00000144134 |
PharmGKBi | PA34159 |
VEuPathDBi | HostDB:ENSG00000144134.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0087, Eukaryota |
GeneTreei | ENSGT00940000156551 |
HOGENOMi | CLU_041217_13_1_1 |
InParanoidi | Q9UBK7 |
OMAi | KIDDISM |
OrthoDBi | 1340129at2759 |
PhylomeDBi | Q9UBK7 |
TreeFami | TF329398 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBK7 |
Miscellaneous databases
BioGRID-ORCSi | 11159, 209 hits in 843 CRISPR screens |
ChiTaRSi | RABL2A, human |
GenomeRNAii | 11159 |
Pharosi | Q9UBK7, Tdark |
PROi | PR:Q9UBK7 |
RNActi | Q9UBK7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144134, Expressed in right uterine tube and 116 other tissues |
ExpressionAtlasi | Q9UBK7, baseline and differential |
Genevisiblei | Q9UBK7, HS |
Family and domain databases
CDDi | cd04124, RabL2, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041835, RabL2 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBL2A_HUMAN | |
Accessioni | Q9UBK7Primary (citable) accession number: Q9UBK7 Secondary accession number(s): B7ZBD6, Q9NU37 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM