RABL2A

Functionⁱ

Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	28 – 35	GTPBy similarity	8
Nucleotide bindingⁱ	76 – 80	GTPBy similarity	5
Nucleotide bindingⁱ	133 – 136	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Rab-like protein 2A
Gene namesⁱ	Name:RABL2A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144134.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9799 RABL2A
MIMⁱ	605412 gene
neXtProtⁱ	NX_Q9UBK7

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11159
Open Targets More...OpenTargetsⁱ	ENSG00000144134
PharmGKBⁱ	PA34159

Polymorphism and mutation databases

BioMutaⁱ	RABL2A
DMDMⁱ	12643870

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121263	1 – 228	Rab-like protein 2AAdd BLAST		228

Proteomic databases

EPDⁱ	Q9UBK7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UBK7
PaxDbⁱ	Q9UBK7
PeptideAtlas More...PeptideAtlasⁱ	Q9UBK7
PRIDEⁱ	Q9UBK7
ProteomicsDBⁱ	83981 83982 [Q9UBK7-2] 83983 [Q9UBK7-3]

PTM databases

iPTMnetⁱ	Q9UBK7
PhosphoSitePlusⁱ	Q9UBK7

Expressionⁱ

Tissue specificityⁱ

Expressed in the testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000144134 Expressed in 91 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_RABL2A
ExpressionAtlasⁱ	Q9UBK7 baseline and differential
Genevisibleⁱ	Q9UBK7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042642 HPA042700 HPA044007

HPAⁱ

HPA042642
HPA042700
HPA044007

Interactionⁱ

Subunit structureⁱ

Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC, MAPRE1 and HSPA2.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CEP19	Q96LK0	5	EBI-4402837,EBI-741885

With

Entry

#Exp.

IntAct

Notes

CEP19

Q96LK0

5

EBI-4402837,EBI-741885

Protein-protein interaction databases

BioGridⁱ	116330, 21 interactors
IntActⁱ	Q9UBK7, 1 interactor
STRINGⁱ	9606.ENSP00000376871

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UBK7
SMRⁱ	Q9UBK7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0087 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129836
HOGENOMⁱ	HOG000233971
HOVERGENⁱ	HBG106536
InParanoidⁱ	Q9UBK7
KEGG Orthology (KO) More...KOⁱ	K07931
OMAⁱ	KIDDISM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q2L
PhylomeDBⁱ	Q9UBK7
TreeFamⁱ	TF329398

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UBK7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ 
        60         70         80         90        100
LSTYALTLYK HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV 
       110        120        130        140        150
FDIQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDDINV TQKSFNFAKK 
       160        170        180        190        200
FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY KQNSQDFMDE IFQELENFSL 
       210        220 
EQEEEDVPDQ EQSSSIETPS EEVASPHS

Length:228

Mass (Da):26,115

Last modified:May 1, 2000 - v1

Checksum:ⁱ96947DD254886B3C

GO

Isoform 2 (identifier: Q9UBK7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
136-136: D → DA

« Hide

        10         20         30         40         50
MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ 
        60         70         80         90        100
LSTYALTLYK HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV 
       110        120        130        140        150
FDIQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDADIN VTQKSFNFAK 
       160        170        180        190        200
KFSLPLYFVS AADGTNVVKL FNDAIRLAVS YKQNSQDFMD EIFQELENFS 
       210        220 
LEQEEEDVPD QEQSSSIETP SEEVASPHS

Note: No experimental confirmation available.

Show »

Length:229

Mass (Da):26,186

Checksum:ⁱ20148DE39EC474A5

GO

Isoform 3 (identifier: Q9UBK7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
168-168: K → KVWLTAEVASK

« Hide

        10         20         30         40         50
MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ 
        60         70         80         90        100
LSTYALTLYK HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV 
       110        120        130        140        150
FDIQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDDINV TQKSFNFAKK 
       160        170        180        190        200
FSLPLYFVSA ADGTNVVKVW LTAEVASKLF NDAIRLAVSY KQNSQDFMDE 
       210        220        230 
IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEVASPHS

Show »

Length:238

Mass (Da):27,201

Checksum:ⁱ974E9EE00BCE3854

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B7ZBD4	B7ZBD4_HUMAN	Rab-like protein 2A Rab-like protein 2A	RABL2A	114	Annotation score:
F2Z2E5	F2Z2E5_HUMAN	Rab-like protein 2A Rab-like protein 2A	RABL2A	54	Annotation score:
E7EWW3	E7EWW3_HUMAN	Rab-like protein 2A Rab-like protein 2A	RABL2A	101	Annotation score:
B7ZBD5	B7ZBD5_HUMAN	Rab-like protein 2A Rab-like protein 2A	RABL2A	165	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005531	136	D → DA in isoform 2. Curated		1
Alternative sequenceⁱVSP_041060	168	K → KVWLTAEVASK in isoform 3. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF095350 mRNA Translation: AAD51377.1 AF095351 mRNA Translation: AAD51378.1 AL078621 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2118.1 [Q9UBK7-1] CCDS77454.1 [Q9UBK7-2] CCDS77455.1 [Q9UBK7-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001293089.1, NM_001306160.1 [Q9UBK7-3] NP_009013.1, NM_007082.4 [Q9UBK7-1] NP_038198.1, NM_013412.3 [Q9UBK7-1] XP_016858697.1, XM_017003208.1 XP_016858698.1, XM_017003209.1 XP_016858709.1, XM_017003220.1 [Q9UBK7-1] XP_016858710.1, XM_017003221.1 XP_016858711.1, XM_017003222.1 [Q9UBK7-1]
UniGeneⁱ	Hs.446425

Genome annotation databases

Ensemblⁱ	ENST00000393165; ENSP00000376870; ENSG00000144134 [Q9UBK7-2] ENST00000393166; ENSP00000376871; ENSG00000144134 [Q9UBK7-1] ENST00000393167; ENSP00000376872; ENSG00000144134 [Q9UBK7-1] ENST00000409875; ENSP00000387229; ENSG00000144134 [Q9UBK7-3]
GeneIDⁱ	11159
KEGGⁱ	hsa:11159
UCSC genome browser More...UCSCⁱ	uc002tkn.5 human [Q9UBK7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9UBK7	Rab-like protein 2B		HUMAN		228	UniRef90_Q9UNT1
Rab-like protein 2A		PONAB		229
Uncharacterized protein		PAPAN		238
Uncharacterized protein		MACMU		235
Uncharacterized protein		CHLSB		231
+76
Q9UBK7-3	Isoform 3 of Rab-like protein 2B		HUMAN		238	UniRef90_Q9UNT1-3
Uncharacterized protein		CALJA		250
Uncharacterized protein		MACFA		238
Uncharacterized protein		MACMU		238
Uncharacterized protein		MACNE		99
+27

Protein	Similar proteins		Species	Score	Length	Source
Q9UBK7	Rab-like protein 2B		HUMAN		228	UniRef50_Q9UNT1
Rab-like protein 2A		PONAB		229
Uncharacterized protein		PAPAN		238
Uncharacterized protein		MACMU		235
Uncharacterized protein		CHLSB		231
+169
Q9UBK7-3	Isoform 3 of Rab-like protein 2B		HUMAN		238	UniRef50_Q9UNT1-3
Uncharacterized protein		CALJA		250
Uncharacterized protein		MACMU		238
Uncharacterized protein		MACFA		99
Uncharacterized protein		MACNE		99
+37

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF095350 mRNA Translation: AAD51377.1 AF095351 mRNA Translation: AAD51378.1 AL078621 Genomic DNA No translation available.
CCDSⁱ	CCDS2118.1 [Q9UBK7-1] CCDS77454.1 [Q9UBK7-2] CCDS77455.1 [Q9UBK7-3]
RefSeqⁱ	NP_001293089.1, NM_001306160.1 [Q9UBK7-3] NP_009013.1, NM_007082.4 [Q9UBK7-1] NP_038198.1, NM_013412.3 [Q9UBK7-1] XP_016858697.1, XM_017003208.1 XP_016858698.1, XM_017003209.1 XP_016858709.1, XM_017003220.1 [Q9UBK7-1] XP_016858710.1, XM_017003221.1 XP_016858711.1, XM_017003222.1 [Q9UBK7-1]
UniGeneⁱ	Hs.446425

3D structure databases

ProteinModelPortalⁱ	Q9UBK7
SMRⁱ	Q9UBK7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116330, 21 interactors
IntActⁱ	Q9UBK7, 1 interactor
STRINGⁱ	9606.ENSP00000376871

PTM databases

iPTMnetⁱ	Q9UBK7
PhosphoSitePlusⁱ	Q9UBK7

Polymorphism and mutation databases

BioMutaⁱ	RABL2A
DMDMⁱ	12643870

Proteomic databases

EPDⁱ	Q9UBK7
MaxQBⁱ	Q9UBK7
PaxDbⁱ	Q9UBK7
PeptideAtlasⁱ	Q9UBK7
PRIDEⁱ	Q9UBK7
ProteomicsDBⁱ	83981 83982 [Q9UBK7-2] 83983 [Q9UBK7-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11159
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000393165; ENSP00000376870; ENSG00000144134 [Q9UBK7-2] ENST00000393166; ENSP00000376871; ENSG00000144134 [Q9UBK7-1] ENST00000393167; ENSP00000376872; ENSG00000144134 [Q9UBK7-1] ENST00000409875; ENSP00000387229; ENSG00000144134 [Q9UBK7-3]
GeneIDⁱ	11159
KEGGⁱ	hsa:11159
UCSCⁱ	uc002tkn.5 human [Q9UBK7-1]

Organism-specific databases

CTDⁱ	11159
DisGeNETⁱ	11159
EuPathDBⁱ	HostDB:ENSG00000144134.18
GeneCardsⁱ	RABL2A
HGNCⁱ	HGNC:9799 RABL2A
HPAⁱ	HPA042642 HPA042700 HPA044007
MIMⁱ	605412 gene
neXtProtⁱ	NX_Q9UBK7
OpenTargetsⁱ	ENSG00000144134
PharmGKBⁱ	PA34159
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0087 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00840000129836
HOGENOMⁱ	HOG000233971
HOVERGENⁱ	HBG106536
InParanoidⁱ	Q9UBK7
KOⁱ	K07931
OMAⁱ	KIDDISM
OrthoDBⁱ	EOG091G0Q2L
PhylomeDBⁱ	Q9UBK7
TreeFamⁱ	TF329398

Miscellaneous databases

GenomeRNAiⁱ	11159
Protein Ontology More...PROⁱ	PR:Q9UBK7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144134 Expressed in 91 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_RABL2A
ExpressionAtlasⁱ	Q9UBK7 baseline and differential
Genevisibleⁱ	Q9UBK7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RBL2A_HUMAN
Accessionⁱ	Q9UBK7Primary (citable) accession number: Q9UBK7 Secondary accession number(s): B7ZBD6, Q9NU37
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - Q9UBK7 (RBL2A_HUMAN)

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Rab-like protein 2A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ