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Protein

Rab-like protein 2A

Gene

RABL2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 2A
Gene namesi
Name:RABL2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144134.18
HGNCiHGNC:9799 RABL2A
MIMi605412 gene
neXtProtiNX_Q9UBK7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi11159
OpenTargetsiENSG00000144134
PharmGKBiPA34159

Polymorphism and mutation databases

BioMutaiRABL2A
DMDMi12643870

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212631 – 228Rab-like protein 2AAdd BLAST228

Proteomic databases

EPDiQ9UBK7
MaxQBiQ9UBK7
PaxDbiQ9UBK7
PeptideAtlasiQ9UBK7
PRIDEiQ9UBK7
ProteomicsDBi83981
83982 [Q9UBK7-2]
83983 [Q9UBK7-3]

PTM databases

iPTMnetiQ9UBK7
PhosphoSitePlusiQ9UBK7

Expressioni

Tissue specificityi

Expressed in the testis.1 Publication

Gene expression databases

BgeeiENSG00000144134 Expressed in 91 organ(s), highest expression level in right uterine tube
CleanExiHS_RABL2A
ExpressionAtlasiQ9UBK7 baseline and differential
GenevisibleiQ9UBK7 HS

Organism-specific databases

HPAiHPA042642
HPA042700
HPA044007

Interactioni

Subunit structurei

Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC, MAPRE1 and HSPA2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP19Q96LK05EBI-4402837,EBI-741885

Protein-protein interaction databases

BioGridi116330, 21 interactors
IntActiQ9UBK7, 1 interactor
STRINGi9606.ENSP00000376871

Structurei

3D structure databases

ProteinModelPortaliQ9UBK7
SMRiQ9UBK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00840000129836
HOGENOMiHOG000233971
HOVERGENiHBG106536
InParanoidiQ9UBK7
KOiK07931
OMAiKIDDISM
OrthoDBiEOG091G0Q2L
PhylomeDBiQ9UBK7
TreeFamiTF329398

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBK7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ
60 70 80 90 100
LSTYALTLYK HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV
110 120 130 140 150
FDIQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDDINV TQKSFNFAKK
160 170 180 190 200
FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY KQNSQDFMDE IFQELENFSL
210 220
EQEEEDVPDQ EQSSSIETPS EEVASPHS
Length:228
Mass (Da):26,115
Last modified:May 1, 2000 - v1
Checksum:i96947DD254886B3C
GO
Isoform 2 (identifier: Q9UBK7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: D → DA

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):26,186
Checksum:i20148DE39EC474A5
GO
Isoform 3 (identifier: Q9UBK7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-168: K → KVWLTAEVASK

Show »
Length:238
Mass (Da):27,201
Checksum:i974E9EE00BCE3854
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBD4B7ZBD4_HUMAN
Rab-like protein 2A
RABL2A
114Annotation score:
F2Z2E5F2Z2E5_HUMAN
Rab-like protein 2A
RABL2A
54Annotation score:
E7EWW3E7EWW3_HUMAN
Rab-like protein 2A
RABL2A
101Annotation score:
B7ZBD5B7ZBD5_HUMAN
Rab-like protein 2A
RABL2A
165Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005531136D → DA in isoform 2. Curated1
Alternative sequenceiVSP_041060168K → KVWLTAEVASK in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095350 mRNA Translation: AAD51377.1
AF095351 mRNA Translation: AAD51378.1
AL078621 Genomic DNA No translation available.
CCDSiCCDS2118.1 [Q9UBK7-1]
CCDS77454.1 [Q9UBK7-2]
CCDS77455.1 [Q9UBK7-3]
RefSeqiNP_001293089.1, NM_001306160.1 [Q9UBK7-3]
NP_009013.1, NM_007082.4 [Q9UBK7-1]
NP_038198.1, NM_013412.3 [Q9UBK7-1]
XP_016858697.1, XM_017003208.1
XP_016858698.1, XM_017003209.1
XP_016858709.1, XM_017003220.1 [Q9UBK7-1]
XP_016858710.1, XM_017003221.1
XP_016858711.1, XM_017003222.1 [Q9UBK7-1]
UniGeneiHs.446425

Genome annotation databases

EnsembliENST00000393165; ENSP00000376870; ENSG00000144134 [Q9UBK7-2]
ENST00000393166; ENSP00000376871; ENSG00000144134 [Q9UBK7-1]
ENST00000393167; ENSP00000376872; ENSG00000144134 [Q9UBK7-1]
ENST00000409875; ENSP00000387229; ENSG00000144134 [Q9UBK7-3]
GeneIDi11159
KEGGihsa:11159
UCSCiuc002tkn.5 human [Q9UBK7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095350 mRNA Translation: AAD51377.1
AF095351 mRNA Translation: AAD51378.1
AL078621 Genomic DNA No translation available.
CCDSiCCDS2118.1 [Q9UBK7-1]
CCDS77454.1 [Q9UBK7-2]
CCDS77455.1 [Q9UBK7-3]
RefSeqiNP_001293089.1, NM_001306160.1 [Q9UBK7-3]
NP_009013.1, NM_007082.4 [Q9UBK7-1]
NP_038198.1, NM_013412.3 [Q9UBK7-1]
XP_016858697.1, XM_017003208.1
XP_016858698.1, XM_017003209.1
XP_016858709.1, XM_017003220.1 [Q9UBK7-1]
XP_016858710.1, XM_017003221.1
XP_016858711.1, XM_017003222.1 [Q9UBK7-1]
UniGeneiHs.446425

3D structure databases

ProteinModelPortaliQ9UBK7
SMRiQ9UBK7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116330, 21 interactors
IntActiQ9UBK7, 1 interactor
STRINGi9606.ENSP00000376871

PTM databases

iPTMnetiQ9UBK7
PhosphoSitePlusiQ9UBK7

Polymorphism and mutation databases

BioMutaiRABL2A
DMDMi12643870

Proteomic databases

EPDiQ9UBK7
MaxQBiQ9UBK7
PaxDbiQ9UBK7
PeptideAtlasiQ9UBK7
PRIDEiQ9UBK7
ProteomicsDBi83981
83982 [Q9UBK7-2]
83983 [Q9UBK7-3]

Protocols and materials databases

DNASUi11159
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393165; ENSP00000376870; ENSG00000144134 [Q9UBK7-2]
ENST00000393166; ENSP00000376871; ENSG00000144134 [Q9UBK7-1]
ENST00000393167; ENSP00000376872; ENSG00000144134 [Q9UBK7-1]
ENST00000409875; ENSP00000387229; ENSG00000144134 [Q9UBK7-3]
GeneIDi11159
KEGGihsa:11159
UCSCiuc002tkn.5 human [Q9UBK7-1]

Organism-specific databases

CTDi11159
DisGeNETi11159
EuPathDBiHostDB:ENSG00000144134.18
GeneCardsiRABL2A
HGNCiHGNC:9799 RABL2A
HPAiHPA042642
HPA042700
HPA044007
MIMi605412 gene
neXtProtiNX_Q9UBK7
OpenTargetsiENSG00000144134
PharmGKBiPA34159
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00840000129836
HOGENOMiHOG000233971
HOVERGENiHBG106536
InParanoidiQ9UBK7
KOiK07931
OMAiKIDDISM
OrthoDBiEOG091G0Q2L
PhylomeDBiQ9UBK7
TreeFamiTF329398

Miscellaneous databases

GenomeRNAii11159
PROiPR:Q9UBK7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144134 Expressed in 91 organ(s), highest expression level in right uterine tube
CleanExiHS_RABL2A
ExpressionAtlasiQ9UBK7 baseline and differential
GenevisibleiQ9UBK7 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBL2A_HUMAN
AccessioniPrimary (citable) accession number: Q9UBK7
Secondary accession number(s): B7ZBD6, Q9NU37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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