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Entry version 185 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Gene

PPARGC1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400253 Circadian Clock
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UBK2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Short name:
PGC-1-alpha
Short name:
PPAR-gamma coactivator 1-alpha
Short name:
PPARGC-1-alpha
Alternative name(s):
Ligand effect modulator 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPARGC1A
Synonyms:LEM6, PGC1, PGC1A, PPARGC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9237 PPARGC1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604517 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBK2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10891

MalaCards human disease database

More...
MalaCardsi
PPARGC1A

Open Targets

More...
OpenTargetsi
ENSG00000109819

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
803 Amyotrophic lateral sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33558

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBK2

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6116

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPARGC1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117335

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817321 – 798Peroxisome proliferator-activated receptor gamma coactivator 1-alphaAdd BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79N6-acetyllysineBy similarity1
Modified residuei146N6-acetyllysineBy similarity1
Modified residuei178Phosphothreonine; by AMPKBy similarity1
Modified residuei184N6-acetyllysineBy similarity1
Modified residuei254N6-acetyllysineBy similarity1
Modified residuei271N6-acetyllysineBy similarity1
Modified residuei278N6-acetyllysineBy similarity1
Modified residuei321N6-acetyllysineBy similarity1
Modified residuei347N6-acetyllysineBy similarity1
Modified residuei413N6-acetyllysineBy similarity1
Modified residuei442N6-acetyllysineBy similarity1
Modified residuei451N6-acetyllysineBy similarity1
Modified residuei539Phosphoserine; by AMPKBy similarity1
Modified residuei758N6-acetyllysineBy similarity1
Modified residuei779N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.By similarity
Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UBK2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UBK2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBK2

PeptideAtlas

More...
PeptideAtlasi
Q9UBK2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBK2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
61778
6560
83978 [Q9UBK2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBK2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBK2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcription is repressed by ZNF746 which binds to 'insulin response sequences' its promoter.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109819 Expressed in 205 organ(s), highest expression level in right atrium auricular region

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBK2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBK2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA063136

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer.

Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (By similarity).

Interacts with PRDM16, LPIN1 and PML (By similarity).

Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity).

Interacts with LRPPRC.

Interacts with RNF34 (via RING-type zinc finger).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116097, 68 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UBK2

Database of interacting proteins

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DIPi
DIP-38449N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9UBK2

Protein interaction database and analysis system

More...
IntActi
Q9UBK2, 19 interactors

Molecular INTeraction database

More...
MINTi
Q9UBK2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264867

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1798
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBK2

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UBK2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini677 – 753RRMPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni293 – 339Interaction with PPARGAdd BLAST47
Regioni350 – 798Mediates interaction with RNF341 PublicationAdd BLAST449

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi144 – 148LXXLL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi566 – 599Arg/Ser-richAdd BLAST34
Compositional biasi621 – 633Arg/Ser-richAdd BLAST13

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIVU Eukaryota
ENOG410YQI0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183137

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000082404

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBK2

KEGG Orthology (KO)

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KOi
K07202

Identification of Orthologs from Complete Genome Data

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OMAi
CQSVNSK

Database of Orthologous Groups

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OrthoDBi
94418at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBK2

TreeFam database of animal gene trees

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TreeFami
TF343068

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12623 RRM_PPARGC1A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034625 PGC-1alpha
IPR034833 PPARGC1A_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

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PANTHERi
PTHR15528 PTHR15528, 1 hit
PTHR15528:SF10 PTHR15528:SF10, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWDMCNQDS ESVWSDIECA ALVGEDQPLC PDLPELDLSE LDVNDLDTDS
60 70 80 90 100
FLGGLKWCSD QSEIISNQYN NEPSNIFEKI DEENEANLLA VLTETLDSLP
110 120 130 140 150
VDEDGLPSFD ALTDGDVTTD NEASPSSMPD GTPPPQEAEE PSLLKKLLLA
160 170 180 190 200
PANTQLSYNE CSGLSTQNHA NHNHRIRTNP AIVKTENSWS NKAKSICQQQ
210 220 230 240 250
KPQRRPCSEL LKYLTTNDDP PHTKPTENRN SSRDKCTSKK KSHTQSQSQH
260 270 280 290 300
LQAKPTTLSL PLTPESPNDP KGSPFENKTI ERTLSVELSG TAGLTPPTTP
310 320 330 340 350
PHKANQDNPF RASPKLKSSC KTVVPPPSKK PRYSESSGTQ GNNSTKKGPE
360 370 380 390 400
QSELYAQLSK SSVLTGGHEE RKTKRPSLRL FGDHDYCQSI NSKTEILINI
410 420 430 440 450
SQELQDSRQL ENKDVSSDWQ GQICSSTDSD QCYLRETLEA SKQVSPCSTR
460 470 480 490 500
KQLQDQEIRA ELNKHFGHPS QAVFDDEADK TGELRDSDFS NEQFSKLPMF
510 520 530 540 550
INSGLAMDGL FDDSEDESDK LSYPWDGTQS YSLFNVSPSC SSFNSPCRDS
560 570 580 590 600
VSPPKSLFSQ RPQRMRSRSR SFSRHRSCSR SPYSRSRSRS PGSRSSSRSC
610 620 630 640 650
YYYESSHYRH RTHRNSPLYV RSRSRSPYSR RPRYDSYEEY QHERLKREEY
660 670 680 690 700
RREYEKRESE RAKQRERQRQ KAIEERRVIY VGKIRPDTTR TELRDRFEVF
710 720 730 740 750
GEIEECTVNL RDDGDSYGFI TYRYTCDAFA ALENGYTLRR SNETDFELYF
760 770 780 790
CGRKQFFKSN YADLDSNSDD FDPASTKSKY DSLDFDSLLK EAQRSLRR
Length:798
Mass (Da):91,027
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97DDD3643051A5F1
GO
Isoform NT-7a (identifier: Q9UBK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-271: DPK → LFL
     272-798: Missing.

Show »
Length:271
Mass (Da):30,031
Checksum:i0F7BB8B4136DE6E3
GO
Isoform B5 (identifier: Q9UBK2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDETSPRLEEDWKKVLQREAGWQ

Note: Produced by alternative promoter usage.
Show »
Length:803
Mass (Da):91,713
Checksum:i5AD73310B38C36D8
GO
Isoform B4 (identifier: Q9UBK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDEGYF

Note: Produced by alternative promoter usage.
Show »
Length:786
Mass (Da):89,641
Checksum:i61A006A08CD2862C
GO
Isoform B4-8a (identifier: Q9UBK2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDEGYF
     294-301: LTPPTTPP → VKTNLISK
     302-798: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:289
Mass (Da):31,772
Checksum:i7551B9318C4F7BA9
GO
Isoform B5-NT (identifier: Q9UBK2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDETSPRLEEDWKKVLQREAGWQ
     269-271: DPK → LFL
     272-798: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:276
Mass (Da):30,717
Checksum:i6818E49B958E2F21
GO
Isoform B4-3ext (identifier: Q9UBK2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDEGYF
     144-150: LKKLLLA → VRTLPTV
     151-798: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:138
Mass (Da):14,964
Checksum:i913391C42BA4D8B2
GO
Isoform 8a (identifier: Q9UBK2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-301: LTPPTTPP → VKTNLISK
     302-798: Missing.

Show »
Length:301
Mass (Da):33,157
Checksum:i31AACF20FC3B29F9
GO
Isoform 9 (identifier: Q9UBK2-9) [UniParc]FASTAAdd to basket
Also known as: L-PGG-1alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: Produced by alternative promoter usage. May be involved in gluconeogenesis, liver-specific.
Show »
Length:671
Mass (Da):77,139
Checksum:iD84936587B7C36CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTJ3A0A087WTJ3_HUMAN
Peroxisome proliferator-activated r...
PPARGC1A
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVW3A0A087WVW3_HUMAN
Peroxisome proliferator-activated r...
PPARGC1A
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBF3D6RBF3_HUMAN
Peroxisome proliferator-activated r...
PPARGC1A
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018450482G → S1 PublicationCorresponds to variant dbSNP:rs8192678Ensembl.1
Natural variantiVAR_018451612T → M. Corresponds to variant dbSNP:rs3736265Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0537701 – 127Missing in isoform 9. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_0537251 – 18MAWDM…WSDIE → MDEGYF in isoform B4, isoform B4-8a and isoform B4-3ext. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0537241 – 18MAWDM…WSDIE → MDETSPRLEEDWKKVLQREA GWQ in isoform B5 and isoform B5-NT. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_053726144 – 150LKKLLLA → VRTLPTV in isoform B4-3ext. 1 Publication7
Alternative sequenceiVSP_053727151 – 798Missing in isoform B4-3ext. 1 PublicationAdd BLAST648
Alternative sequenceiVSP_047684269 – 271DPK → LFL in isoform NT-7a and isoform B5-NT. 2 Publications3
Alternative sequenceiVSP_047685272 – 798Missing in isoform NT-7a and isoform B5-NT. 2 PublicationsAdd BLAST527
Alternative sequenceiVSP_053728294 – 301LTPPTTPP → VKTNLISK in isoform B4-8a and isoform 8a. 2 Publications8
Alternative sequenceiVSP_053729302 – 798Missing in isoform B4-8a and isoform 8a. 2 PublicationsAdd BLAST497

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF108205
, AF108193, AF108194, AF108195, AF108196, AF108197, AF108198, AF108199, AF108200, AF108201, AF108202, AF108203, AF108204 Genomic DNA Translation: AAF19083.1
AF106698 mRNA Translation: AAF18573.1
AF159714 mRNA Translation: AAD51615.1
AF186379 mRNA Translation: AAD56250.1
HQ695733 mRNA Translation: ADW77180.1
JQ772116 mRNA Translation: AFK29753.1
JQ772117 mRNA Translation: AFK29754.1
JQ772118 mRNA Translation: AFK29755.1
JQ772119 mRNA Translation: AFK29756.1
JQ772120 mRNA Translation: AFK29757.1
AB061325 mRNA Translation: BAE46508.1
EU280319 Genomic DNA Translation: ABX44665.1
AK296591 mRNA Translation: BAH12392.1
AC092834 Genomic DNA Translation: AAY41058.1
AC097508 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92811.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3429.1 [Q9UBK2-1]
CCDS87211.1 [Q9UBK2-9]

NCBI Reference Sequences

More...
RefSeqi
NP_001317680.1, NM_001330751.1 [Q9UBK2-3]
NP_001317681.1, NM_001330752.1 [Q9UBK2-4]
NP_001317682.1, NM_001330753.1 [Q9UBK2-9]
NP_037393.1, NM_013261.4 [Q9UBK2-1]
XP_011512073.1, XM_011513771.1 [Q9UBK2-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264867; ENSP00000264867; ENSG00000109819 [Q9UBK2-1]
ENST00000506055; ENSP00000423075; ENSG00000109819 [Q9UBK2-2]
ENST00000513205; ENSP00000421632; ENSG00000109819 [Q9UBK2-8]
ENST00000613098; ENSP00000481498; ENSG00000109819 [Q9UBK2-9]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10891

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10891

UCSC genome browser

More...
UCSCi
uc003gqs.3 human [Q9UBK2-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108205
, AF108193, AF108194, AF108195, AF108196, AF108197, AF108198, AF108199, AF108200, AF108201, AF108202, AF108203, AF108204 Genomic DNA Translation: AAF19083.1
AF106698 mRNA Translation: AAF18573.1
AF159714 mRNA Translation: AAD51615.1
AF186379 mRNA Translation: AAD56250.1
HQ695733 mRNA Translation: ADW77180.1
JQ772116 mRNA Translation: AFK29753.1
JQ772117 mRNA Translation: AFK29754.1
JQ772118 mRNA Translation: AFK29755.1
JQ772119 mRNA Translation: AFK29756.1
JQ772120 mRNA Translation: AFK29757.1
AB061325 mRNA Translation: BAE46508.1
EU280319 Genomic DNA Translation: ABX44665.1
AK296591 mRNA Translation: BAH12392.1
AC092834 Genomic DNA Translation: AAY41058.1
AC097508 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92811.1
CCDSiCCDS3429.1 [Q9UBK2-1]
CCDS87211.1 [Q9UBK2-9]
RefSeqiNP_001317680.1, NM_001330751.1 [Q9UBK2-3]
NP_001317681.1, NM_001330752.1 [Q9UBK2-4]
NP_001317682.1, NM_001330753.1 [Q9UBK2-9]
NP_037393.1, NM_013261.4 [Q9UBK2-1]
XP_011512073.1, XM_011513771.1 [Q9UBK2-9]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB7X-ray2.50P205-216[»]
3B1MX-ray1.60B136-154[»]
3CS8X-ray2.30B141-152[»]
3D24X-ray2.11B/D198-219[»]
3U9QX-ray1.52B142-150[»]
3V9TX-ray1.65C136-154[»]
3V9VX-ray1.60C136-154[»]
4QJRX-ray2.40B139-152[»]
4QK4X-ray2.81B139-152[»]
5Q0IX-ray1.70B141-152[»]
5TWOX-ray1.93B138-152[»]
5UNJX-ray1.96C139-152[»]
5Z5SX-ray1.80C136-154[»]
5Z6SX-ray1.80C136-154[»]
6AD9X-ray2.20B141-152[»]
6FZFX-ray1.95C/D139-152[»]
6FZPX-ray2.30C139-152[»]
6IZMX-ray1.80C136-154[»]
6IZNX-ray1.75C136-154[»]
SMRiQ9UBK2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116097, 68 interactors
CORUMiQ9UBK2
DIPiDIP-38449N
ELMiQ9UBK2
IntActiQ9UBK2, 19 interactors
MINTiQ9UBK2
STRINGi9606.ENSP00000264867

Chemistry databases

ChEMBLiCHEMBL6116

PTM databases

iPTMnetiQ9UBK2
PhosphoSitePlusiQ9UBK2

Polymorphism and mutation databases

BioMutaiPPARGC1A
DMDMi47117335

Proteomic databases

MassIVEiQ9UBK2
MaxQBiQ9UBK2
PaxDbiQ9UBK2
PeptideAtlasiQ9UBK2
PRIDEiQ9UBK2
ProteomicsDBi61778
6560
83978 [Q9UBK2-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10891

Genome annotation databases

EnsembliENST00000264867; ENSP00000264867; ENSG00000109819 [Q9UBK2-1]
ENST00000506055; ENSP00000423075; ENSG00000109819 [Q9UBK2-2]
ENST00000513205; ENSP00000421632; ENSG00000109819 [Q9UBK2-8]
ENST00000613098; ENSP00000481498; ENSG00000109819 [Q9UBK2-9]
GeneIDi10891
KEGGihsa:10891
UCSCiuc003gqs.3 human [Q9UBK2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10891
DisGeNETi10891

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPARGC1A
HGNCiHGNC:9237 PPARGC1A
HPAiHPA063136
MalaCardsiPPARGC1A
MIMi604517 gene
neXtProtiNX_Q9UBK2
OpenTargetsiENSG00000109819
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33558

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIVU Eukaryota
ENOG410YQI0 LUCA
GeneTreeiENSGT00950000183137
HOGENOMiHOG000082404
InParanoidiQ9UBK2
KOiK07202
OMAiCQSVNSK
OrthoDBi94418at2759
PhylomeDBiQ9UBK2
TreeFamiTF343068

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400253 Circadian Clock
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
SIGNORiQ9UBK2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPARGC1A human
EvolutionaryTraceiQ9UBK2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPARGC1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10891
PharosiQ9UBK2

Protein Ontology

More...
PROi
PR:Q9UBK2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109819 Expressed in 205 organ(s), highest expression level in right atrium auricular region
ExpressionAtlasiQ9UBK2 baseline and differential
GenevisibleiQ9UBK2 HS

Family and domain databases

CDDicd12623 RRM_PPARGC1A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034625 PGC-1alpha
IPR034833 PPARGC1A_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF10 PTHR15528:SF10, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRGC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBK2
Secondary accession number(s): B7Z406
, G8DM16, I3RTT5, I3RTT6, I3RTT7, I3RTT8, I3RTT9, Q3LIG1, Q4W5M7, Q9UN32
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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