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Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Gene

PPARGC1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, RNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400253 Circadian Clock
R-HSA-8939902 Regulation of RUNX2 expression and activity
SIGNORiQ9UBK2

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Short name:
PGC-1-alpha
Short name:
PPAR-gamma coactivator 1-alpha
Short name:
PPARGC-1-alpha
Alternative name(s):
Ligand effect modulator 6
Gene namesi
Name:PPARGC1A
Synonyms:LEM6, PGC1, PGC1A, PPARGC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109819.8
HGNCiHGNC:9237 PPARGC1A
MIMi604517 gene
neXtProtiNX_Q9UBK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10891
MalaCardsiPPARGC1A
OpenTargetsiENSG00000109819
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33558

Chemistry databases

ChEMBLiCHEMBL6116

Polymorphism and mutation databases

BioMutaiPPARGC1A
DMDMi47117335

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817321 – 798Peroxisome proliferator-activated receptor gamma coactivator 1-alphaAdd BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79N6-acetyllysineBy similarity1
Modified residuei146N6-acetyllysineBy similarity1
Modified residuei178Phosphothreonine; by AMPKBy similarity1
Modified residuei184N6-acetyllysineBy similarity1
Modified residuei254N6-acetyllysineBy similarity1
Modified residuei271N6-acetyllysineBy similarity1
Modified residuei278N6-acetyllysineBy similarity1
Modified residuei321N6-acetyllysineBy similarity1
Modified residuei347N6-acetyllysineBy similarity1
Modified residuei413N6-acetyllysineBy similarity1
Modified residuei442N6-acetyllysineBy similarity1
Modified residuei451N6-acetyllysineBy similarity1
Modified residuei539Phosphoserine; by AMPKBy similarity1
Modified residuei758N6-acetyllysineBy similarity1
Modified residuei779N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.By similarity
Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9UBK2
PaxDbiQ9UBK2
PeptideAtlasiQ9UBK2
PRIDEiQ9UBK2
ProteomicsDBi83978

PTM databases

iPTMnetiQ9UBK2
PhosphoSitePlusiQ9UBK2

Expressioni

Tissue specificityi

Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.3 Publications

Inductioni

Transcription is repressed by ZNF746 which binds to 'insulin response sequences' its promoter.1 Publication

Gene expression databases

BgeeiENSG00000109819 Expressed in 205 organ(s), highest expression level in right atrium auricular region
CleanExiHS_PPARGC1A
ExpressionAtlasiQ9UBK2 baseline and differential
GenevisibleiQ9UBK2 HS

Organism-specific databases

HPAiHPA063136

Interactioni

Subunit structurei

Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (By similarity). Interacts with PRDM16, LPIN1 and PML (By similarity). Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity). Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116097, 66 interactors
CORUMiQ9UBK2
DIPiDIP-38449N
ELMiQ9UBK2
IntActiQ9UBK2, 18 interactors
MINTiQ9UBK2
STRINGi9606.ENSP00000264867

Structurei

Secondary structure

1798
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UBK2
SMRiQ9UBK2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UBK2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini677 – 753RRMPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni293 – 339Interaction with PPARGAdd BLAST47
Regioni350 – 798Mediates interaction with RNF341 PublicationAdd BLAST449

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi144 – 148LXXLL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi566 – 599Arg/Ser-richAdd BLAST34
Compositional biasi621 – 633Arg/Ser-richAdd BLAST13

Phylogenomic databases

eggNOGiENOG410IIVU Eukaryota
ENOG410YQI0 LUCA
GeneTreeiENSGT00530000063196
HOGENOMiHOG000082404
HOVERGENiHBG053678
InParanoidiQ9UBK2
KOiK07202
OMAiENGYTLR
OrthoDBiEOG091G029M
PhylomeDBiQ9UBK2
TreeFamiTF343068

Family and domain databases

CDDicd12623 RRM_PPARGC1A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034625 PGC-1alpha
IPR034833 PPARGC1A_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF10 PTHR15528:SF10, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (9+)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWDMCNQDS ESVWSDIECA ALVGEDQPLC PDLPELDLSE LDVNDLDTDS
60 70 80 90 100
FLGGLKWCSD QSEIISNQYN NEPSNIFEKI DEENEANLLA VLTETLDSLP
110 120 130 140 150
VDEDGLPSFD ALTDGDVTTD NEASPSSMPD GTPPPQEAEE PSLLKKLLLA
160 170 180 190 200
PANTQLSYNE CSGLSTQNHA NHNHRIRTNP AIVKTENSWS NKAKSICQQQ
210 220 230 240 250
KPQRRPCSEL LKYLTTNDDP PHTKPTENRN SSRDKCTSKK KSHTQSQSQH
260 270 280 290 300
LQAKPTTLSL PLTPESPNDP KGSPFENKTI ERTLSVELSG TAGLTPPTTP
310 320 330 340 350
PHKANQDNPF RASPKLKSSC KTVVPPPSKK PRYSESSGTQ GNNSTKKGPE
360 370 380 390 400
QSELYAQLSK SSVLTGGHEE RKTKRPSLRL FGDHDYCQSI NSKTEILINI
410 420 430 440 450
SQELQDSRQL ENKDVSSDWQ GQICSSTDSD QCYLRETLEA SKQVSPCSTR
460 470 480 490 500
KQLQDQEIRA ELNKHFGHPS QAVFDDEADK TGELRDSDFS NEQFSKLPMF
510 520 530 540 550
INSGLAMDGL FDDSEDESDK LSYPWDGTQS YSLFNVSPSC SSFNSPCRDS
560 570 580 590 600
VSPPKSLFSQ RPQRMRSRSR SFSRHRSCSR SPYSRSRSRS PGSRSSSRSC
610 620 630 640 650
YYYESSHYRH RTHRNSPLYV RSRSRSPYSR RPRYDSYEEY QHERLKREEY
660 670 680 690 700
RREYEKRESE RAKQRERQRQ KAIEERRVIY VGKIRPDTTR TELRDRFEVF
710 720 730 740 750
GEIEECTVNL RDDGDSYGFI TYRYTCDAFA ALENGYTLRR SNETDFELYF
760 770 780 790
CGRKQFFKSN YADLDSNSDD FDPASTKSKY DSLDFDSLLK EAQRSLRR
Length:798
Mass (Da):91,027
Last modified:May 1, 2000 - v1
Checksum:i97DDD3643051A5F1
GO
Isoform NT-7a (identifier: Q9UBK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-271: DPK → LFL
     272-798: Missing.

Show »
Length:271
Mass (Da):30,031
Checksum:i0F7BB8B4136DE6E3
GO
Isoform B5 (identifier: Q9UBK2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDETSPRLEEDWKKVLQREAGWQ

Note: Produced by alternative promoter usage.
Show »
Length:803
Mass (Da):91,713
Checksum:i5AD73310B38C36D8
GO
Isoform B4 (identifier: Q9UBK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDEGYF

Note: Produced by alternative promoter usage.
Show »
Length:786
Mass (Da):89,641
Checksum:i61A006A08CD2862C
GO
Isoform B4-8a (identifier: Q9UBK2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDEGYF
     294-301: LTPPTTPP → VKTNLISK
     302-798: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:289
Mass (Da):31,772
Checksum:i7551B9318C4F7BA9
GO
Isoform B5-NT (identifier: Q9UBK2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDETSPRLEEDWKKVLQREAGWQ
     269-271: DPK → LFL
     272-798: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:276
Mass (Da):30,717
Checksum:i6818E49B958E2F21
GO
Isoform B4-3ext (identifier: Q9UBK2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAWDMCNQDSESVWSDIE → MDEGYF
     144-150: LKKLLLA → VRTLPTV
     151-798: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:138
Mass (Da):14,964
Checksum:i913391C42BA4D8B2
GO
Isoform 8a (identifier: Q9UBK2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-301: LTPPTTPP → VKTNLISK
     302-798: Missing.

Show »
Length:301
Mass (Da):33,157
Checksum:i31AACF20FC3B29F9
GO
Isoform 9 (identifier: Q9UBK2-9) [UniParc]FASTAAdd to basket
Also known as: L-PGG-1alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: Produced by alternative promoter usage. May be involved in gluconeogenesis, liver-specific.
Show »
Length:671
Mass (Da):77,139
Checksum:iD84936587B7C36CF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVW3A0A087WVW3_HUMAN
Peroxisome proliferator-activated r...
PPARGC1A
267Annotation score:
D6RBF3D6RBF3_HUMAN
Peroxisome proliferator-activated r...
PPARGC1A
99Annotation score:
A0A087WTJ3A0A087WTJ3_HUMAN
Peroxisome proliferator-activated r...
PPARGC1A
297Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018450482G → S1 PublicationCorresponds to variant dbSNP:rs8192678Ensembl.1
Natural variantiVAR_018451612T → M. Corresponds to variant dbSNP:rs3736265Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0537701 – 127Missing in isoform 9. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_0537251 – 18MAWDM…WSDIE → MDEGYF in isoform B4, isoform B4-8a and isoform B4-3ext. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0537241 – 18MAWDM…WSDIE → MDETSPRLEEDWKKVLQREA GWQ in isoform B5 and isoform B5-NT. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_053726144 – 150LKKLLLA → VRTLPTV in isoform B4-3ext. 1 Publication7
Alternative sequenceiVSP_053727151 – 798Missing in isoform B4-3ext. 1 PublicationAdd BLAST648
Alternative sequenceiVSP_047684269 – 271DPK → LFL in isoform NT-7a and isoform B5-NT. 2 Publications3
Alternative sequenceiVSP_047685272 – 798Missing in isoform NT-7a and isoform B5-NT. 2 PublicationsAdd BLAST527
Alternative sequenceiVSP_053728294 – 301LTPPTTPP → VKTNLISK in isoform B4-8a and isoform 8a. 2 Publications8
Alternative sequenceiVSP_053729302 – 798Missing in isoform B4-8a and isoform 8a. 2 PublicationsAdd BLAST497

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108205
, AF108193, AF108194, AF108195, AF108196, AF108197, AF108198, AF108199, AF108200, AF108201, AF108202, AF108203, AF108204 Genomic DNA Translation: AAF19083.1
AF106698 mRNA Translation: AAF18573.1
AF159714 mRNA Translation: AAD51615.1
AF186379 mRNA Translation: AAD56250.1
HQ695733 mRNA Translation: ADW77180.1
JQ772116 mRNA Translation: AFK29753.1
JQ772117 mRNA Translation: AFK29754.1
JQ772118 mRNA Translation: AFK29755.1
JQ772119 mRNA Translation: AFK29756.1
JQ772120 mRNA Translation: AFK29757.1
AB061325 mRNA Translation: BAE46508.1
EU280319 Genomic DNA Translation: ABX44665.1
AK296591 mRNA Translation: BAH12392.1
AC092834 Genomic DNA Translation: AAY41058.1
AC097508 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92811.1
CCDSiCCDS3429.1 [Q9UBK2-1]
CCDS87211.1 [Q9UBK2-9]
RefSeqiNP_001317680.1, NM_001330751.1 [Q9UBK2-3]
NP_001317681.1, NM_001330752.1 [Q9UBK2-4]
NP_001317682.1, NM_001330753.1 [Q9UBK2-9]
NP_037393.1, NM_013261.4 [Q9UBK2-1]
XP_011512073.1, XM_011513771.1 [Q9UBK2-9]
UniGeneiHs.527078

Genome annotation databases

EnsembliENST00000264867; ENSP00000264867; ENSG00000109819 [Q9UBK2-1]
ENST00000506055; ENSP00000423075; ENSG00000109819 [Q9UBK2-2]
ENST00000513205; ENSP00000421632; ENSG00000109819 [Q9UBK2-8]
ENST00000613098; ENSP00000481498; ENSG00000109819 [Q9UBK2-9]
GeneIDi10891
KEGGihsa:10891
UCSCiuc003gqs.3 human [Q9UBK2-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108205
, AF108193, AF108194, AF108195, AF108196, AF108197, AF108198, AF108199, AF108200, AF108201, AF108202, AF108203, AF108204 Genomic DNA Translation: AAF19083.1
AF106698 mRNA Translation: AAF18573.1
AF159714 mRNA Translation: AAD51615.1
AF186379 mRNA Translation: AAD56250.1
HQ695733 mRNA Translation: ADW77180.1
JQ772116 mRNA Translation: AFK29753.1
JQ772117 mRNA Translation: AFK29754.1
JQ772118 mRNA Translation: AFK29755.1
JQ772119 mRNA Translation: AFK29756.1
JQ772120 mRNA Translation: AFK29757.1
AB061325 mRNA Translation: BAE46508.1
EU280319 Genomic DNA Translation: ABX44665.1
AK296591 mRNA Translation: BAH12392.1
AC092834 Genomic DNA Translation: AAY41058.1
AC097508 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92811.1
CCDSiCCDS3429.1 [Q9UBK2-1]
CCDS87211.1 [Q9UBK2-9]
RefSeqiNP_001317680.1, NM_001330751.1 [Q9UBK2-3]
NP_001317681.1, NM_001330752.1 [Q9UBK2-4]
NP_001317682.1, NM_001330753.1 [Q9UBK2-9]
NP_037393.1, NM_013261.4 [Q9UBK2-1]
XP_011512073.1, XM_011513771.1 [Q9UBK2-9]
UniGeneiHs.527078

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB7X-ray2.50P205-216[»]
3B1MX-ray1.60B136-154[»]
3CS8X-ray2.30B141-152[»]
3D24X-ray2.11B/D198-219[»]
3U9QX-ray1.52B142-150[»]
3V9TX-ray1.65C136-154[»]
3V9VX-ray1.60C136-154[»]
4QJRX-ray2.40B139-152[»]
4QK4X-ray2.81B139-152[»]
5Q0IX-ray1.70B141-152[»]
5TWOX-ray1.93B138-152[»]
5UNJX-ray1.96C139-152[»]
ProteinModelPortaliQ9UBK2
SMRiQ9UBK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116097, 66 interactors
CORUMiQ9UBK2
DIPiDIP-38449N
ELMiQ9UBK2
IntActiQ9UBK2, 18 interactors
MINTiQ9UBK2
STRINGi9606.ENSP00000264867

Chemistry databases

ChEMBLiCHEMBL6116

PTM databases

iPTMnetiQ9UBK2
PhosphoSitePlusiQ9UBK2

Polymorphism and mutation databases

BioMutaiPPARGC1A
DMDMi47117335

Proteomic databases

MaxQBiQ9UBK2
PaxDbiQ9UBK2
PeptideAtlasiQ9UBK2
PRIDEiQ9UBK2
ProteomicsDBi83978

Protocols and materials databases

DNASUi10891
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264867; ENSP00000264867; ENSG00000109819 [Q9UBK2-1]
ENST00000506055; ENSP00000423075; ENSG00000109819 [Q9UBK2-2]
ENST00000513205; ENSP00000421632; ENSG00000109819 [Q9UBK2-8]
ENST00000613098; ENSP00000481498; ENSG00000109819 [Q9UBK2-9]
GeneIDi10891
KEGGihsa:10891
UCSCiuc003gqs.3 human [Q9UBK2-1]

Organism-specific databases

CTDi10891
DisGeNETi10891
EuPathDBiHostDB:ENSG00000109819.8
GeneCardsiPPARGC1A
HGNCiHGNC:9237 PPARGC1A
HPAiHPA063136
MalaCardsiPPARGC1A
MIMi604517 gene
neXtProtiNX_Q9UBK2
OpenTargetsiENSG00000109819
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33558
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVU Eukaryota
ENOG410YQI0 LUCA
GeneTreeiENSGT00530000063196
HOGENOMiHOG000082404
HOVERGENiHBG053678
InParanoidiQ9UBK2
KOiK07202
OMAiENGYTLR
OrthoDBiEOG091G029M
PhylomeDBiQ9UBK2
TreeFamiTF343068

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400253 Circadian Clock
R-HSA-8939902 Regulation of RUNX2 expression and activity
SIGNORiQ9UBK2

Miscellaneous databases

ChiTaRSiPPARGC1A human
EvolutionaryTraceiQ9UBK2
GeneWikiiPPARGC1A
GenomeRNAii10891
PROiPR:Q9UBK2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109819 Expressed in 205 organ(s), highest expression level in right atrium auricular region
CleanExiHS_PPARGC1A
ExpressionAtlasiQ9UBK2 baseline and differential
GenevisibleiQ9UBK2 HS

Family and domain databases

CDDicd12623 RRM_PPARGC1A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034625 PGC-1alpha
IPR034833 PPARGC1A_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF10 PTHR15528:SF10, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRGC1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBK2
Secondary accession number(s): B7Z406
, G8DM16, I3RTT5, I3RTT6, I3RTT7, I3RTT8, I3RTT9, Q3LIG1, Q4W5M7, Q9UN32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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