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Entry version 128 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

Headcase protein homolog

Gene

HECA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UBI9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Headcase protein homolog
Short name:
hHDC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HECA
Synonyms:HDC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112406.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21041, HECA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607977, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51696

Open Targets

More...
OpenTargetsi
ENSG00000112406

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134977625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBI9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HECA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
44887986

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000839341 – 543Headcase protein homologAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei264PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UBI9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UBI9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UBI9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UBI9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBI9

PeptideAtlas

More...
PeptideAtlasi
Q9UBI9

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBI9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83976

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112406, Expressed in amniotic fluid and 248 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBI9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112406, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119682, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356630

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UBI9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBI9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 95Ala/Gly-richAdd BLAST87

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3816, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044928

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027672_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBI9

KEGG Orthology (KO)

More...
KOi
K23049

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKGLNHD

Database of Orthologous Groups

More...
OrthoDBi
1215307at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBI9

TreeFam database of animal gene trees

More...
TreeFami
TF315512

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026066, Headcase
IPR031947, Headcase_mid

The PANTHER Classification System

More...
PANTHERi
PTHR13425, PTHR13425, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16002, Headcase, 1 hit
PF15353, HECA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UBI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNPKNSKGG RKNKRANSSG DEQENGAGAL AAAGAAGAAA GGALAAAAGC
60 70 80 90 100
GAAAAGAPGA GGAAGAGGAG TGAANAAAAA GAAAAGDAKN EAPCATPLIC
110 120 130 140 150
SFGRPVDLEK DDYQKVVCNN EHCPCSTWMH LQCFYEWESS ILVQFNCIGR
160 170 180 190 200
ARSWNEKQCR QNMWTKKGYD LAFRFCSCRC GQGHLKKDTD WYQVKRMQDE
210 220 230 240 250
KKKKSGSEKN TGRPPGEAAE EAKKCRPPNK PQKGPSHDLP RRHSMDRQNS
260 270 280 290 300
QEKAVGAAAY GARSPGGSPG QSPPTGYSIL SPAHFSGPRS SRYLGEFLKN
310 320 330 340 350
AIHLEPHKKA MAGGHVFRNA HFDYSPAGLA VHRGGHFDTP VQFLRRLDLS
360 370 380 390 400
ELLTHIPRHK LNTFHVRMED DAQVGQGEDL RKFILAALSA SHRNVVNCAL
410 420 430 440 450
CHRALPVFEQ FPLVDGTLFL SPSRHDEIEY DVPCHLQGRL MHLYAVCVDC
460 470 480 490 500
LEGVHKIICI KCKSRWDGSW HQLGTMYTYD ILAASPCCQA RLNCKHCGKP
510 520 530 540
VIDVRIGMQY FSEYSNVQQC PHCGNLDYHF VKPFSSFKVL EAY
Length:543
Mass (Da):58,837
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA161B7F4C57EF0D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033496 Genomic DNA Translation: BAA85333.1
AB033492 mRNA Translation: BAA85322.1
AL031772 Genomic DNA Translation: CAB94782.1
BC070068 mRNA Translation: AAH70068.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5194.1

NCBI Reference Sequences

More...
RefSeqi
NP_057301.1, NM_016217.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51696

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51696

UCSC genome browser

More...
UCSCi
uc003qin.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033496 Genomic DNA Translation: BAA85333.1
AB033492 mRNA Translation: BAA85322.1
AL031772 Genomic DNA Translation: CAB94782.1
BC070068 mRNA Translation: AAH70068.1
CCDSiCCDS5194.1
RefSeqiNP_057301.1, NM_016217.2

3D structure databases

SMRiQ9UBI9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119682, 2 interactors
STRINGi9606.ENSP00000356630

PTM databases

iPTMnetiQ9UBI9
PhosphoSitePlusiQ9UBI9

Polymorphism and mutation databases

BioMutaiHECA
DMDMi44887986

Proteomic databases

EPDiQ9UBI9
jPOSTiQ9UBI9
MassIVEiQ9UBI9
MaxQBiQ9UBI9
PaxDbiQ9UBI9
PeptideAtlasiQ9UBI9
PRIDEiQ9UBI9
ProteomicsDBi83976

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33083, 69 antibodies

Genome annotation databases

GeneIDi51696
KEGGihsa:51696
UCSCiuc003qin.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51696
DisGeNETi51696
EuPathDBiHostDB:ENSG00000112406.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HECA
HGNCiHGNC:21041, HECA
HPAiENSG00000112406, Low tissue specificity
MIMi607977, gene
neXtProtiNX_Q9UBI9
OpenTargetsiENSG00000112406
PharmGKBiPA134977625

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3816, Eukaryota
GeneTreeiENSGT00500000044928
HOGENOMiCLU_027672_0_0_1
InParanoidiQ9UBI9
KOiK23049
OMAiQKGLNHD
OrthoDBi1215307at2759
PhylomeDBiQ9UBI9
TreeFamiTF315512

Enzyme and pathway databases

PathwayCommonsiQ9UBI9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51696, 4 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HECA, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51696
PharosiQ9UBI9, Tbio

Protein Ontology

More...
PROi
PR:Q9UBI9
RNActiQ9UBI9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112406, Expressed in amniotic fluid and 248 other tissues
GenevisibleiQ9UBI9, HS

Family and domain databases

InterProiView protein in InterPro
IPR026066, Headcase
IPR031947, Headcase_mid
PANTHERiPTHR13425, PTHR13425, 1 hit
PfamiView protein in Pfam
PF16002, Headcase, 1 hit
PF15353, HECA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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