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Entry version 190 (07 Apr 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene

GNG12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UBI6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296041, Activation of G protein gated Potassium channels
R-HSA-163359, Glucagon signaling in metabolic regulation
R-HSA-202040, G-protein activation
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170, ADP signalling through P2Y purinoceptor 12
R-HSA-392451, G beta:gamma signalling through PI3Kgamma
R-HSA-392851, Prostacyclin signalling through prostacyclin receptor
R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398, Ca2+ pathway
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-418217, G beta:gamma signalling through PLC beta
R-HSA-418555, G alpha (s) signalling events
R-HSA-418592, ADP signalling through P2Y purinoceptor 1
R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-428930, Thromboxane signalling through TP receptor
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657, Presynaptic function of Kainate receptors
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315, G beta:gamma signalling through BTK
R-HSA-8964616, G beta:gamma signalling through CDC42
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9UBI6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UBI6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNG12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19663, GNG12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615405, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBI6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000172380.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55970

Open Targets

More...
OpenTargetsi
ENSG00000172380

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956700

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBI6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GNG12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12229817

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000126672 – 69Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Add BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001266870 – 72Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei26PhosphoserineBy similarity1
Modified residuei42PhosphotyrosineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei69Cysteine methyl ester1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi69S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBI6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UBI6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UBI6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UBI6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBI6

PeptideAtlas

More...
PeptideAtlasi
Q9UBI6

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBI6

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
83975

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9UBI6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBI6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBI6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UBI6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000172380, Expressed in duodenum and 245 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBI6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000172380, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121016, 56 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UBI6

Protein interaction database and analysis system

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IntActi
Q9UBI6, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360021

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UBI6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBI6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4119, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01020000230495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_168377_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBI6

Identification of Orthologs from Complete Genome Data

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OMAi
CSEHARN

Database of Orthologous Groups

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OrthoDBi
1581168at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBI6

TreeFam database of animal gene trees

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TreeFami
TF319909

Family and domain databases

Conserved Domains Database

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CDDi
cd00068, GGL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015898, G-protein_gamma-like_dom
IPR036284, GGL_sf
IPR001770, Gprotein-gamma

The PANTHER Classification System

More...
PANTHERi
PTHR13809, PTHR13809, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00631, G-gamma, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00321, GPROTEING

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00224, GGL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48670, SSF48670, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50058, G_PROTEIN_GAMMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKTASTNN IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD
60 70
PLLIGIPTSE NPFKDKKTCI IL
Length:72
Mass (Da):8,006
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4C489A61697FAA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29R → G in AAH05940 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF188181 Genomic DNA Translation: AAF04571.1
AF123766 mRNA Translation: AAP97245.1
AF119663 mRNA Translation: AAF17220.1
AF365871 mRNA Translation: AAK53385.1
AF493879 mRNA Translation: AAM12593.1
AK293101 mRNA Translation: BAF85790.1
AL832431 mRNA Translation: CAH10645.1
CH471059 Genomic DNA Translation: EAX06484.1
CH471059 Genomic DNA Translation: EAX06485.1
CH471059 Genomic DNA Translation: EAX06486.1
BC005940 mRNA Translation: AAH05940.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30749.1

NCBI Reference Sequences

More...
RefSeqi
NP_061329.3, NM_018841.5
XP_016857298.1, XM_017001809.1
XP_016857299.1, XM_017001810.1
XP_016857300.1, XM_017001811.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370982; ENSP00000360021; ENSG00000172380

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55970

UCSC genome browser

More...
UCSCi
uc001dea.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188181 Genomic DNA Translation: AAF04571.1
AF123766 mRNA Translation: AAP97245.1
AF119663 mRNA Translation: AAF17220.1
AF365871 mRNA Translation: AAK53385.1
AF493879 mRNA Translation: AAM12593.1
AK293101 mRNA Translation: BAF85790.1
AL832431 mRNA Translation: CAH10645.1
CH471059 Genomic DNA Translation: EAX06484.1
CH471059 Genomic DNA Translation: EAX06485.1
CH471059 Genomic DNA Translation: EAX06486.1
BC005940 mRNA Translation: AAH05940.1
CCDSiCCDS30749.1
RefSeqiNP_061329.3, NM_018841.5
XP_016857298.1, XM_017001809.1
XP_016857299.1, XM_017001810.1
XP_016857300.1, XM_017001811.1

3D structure databases

SMRiQ9UBI6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121016, 56 interactors
CORUMiQ9UBI6
IntActiQ9UBI6, 22 interactors
STRINGi9606.ENSP00000360021

PTM databases

iPTMnetiQ9UBI6
PhosphoSitePlusiQ9UBI6
SwissPalmiQ9UBI6

Genetic variation databases

BioMutaiGNG12
DMDMi12229817

Proteomic databases

EPDiQ9UBI6
jPOSTiQ9UBI6
MassIVEiQ9UBI6
MaxQBiQ9UBI6
PaxDbiQ9UBI6
PeptideAtlasiQ9UBI6
PRIDEiQ9UBI6
ProteomicsDBi83975
TopDownProteomicsiQ9UBI6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33413, 59 antibodies

The DNASU plasmid repository

More...
DNASUi
55970

Genome annotation databases

EnsembliENST00000370982; ENSP00000360021; ENSG00000172380
GeneIDi55970
KEGGihsa:55970
UCSCiuc001dea.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55970
DisGeNETi55970

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GNG12
HGNCiHGNC:19663, GNG12
HPAiENSG00000172380, Low tissue specificity
MIMi615405, gene
neXtProtiNX_Q9UBI6
OpenTargetsiENSG00000172380
PharmGKBiPA134956700
VEuPathDBiHostDB:ENSG00000172380.5

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4119, Eukaryota
GeneTreeiENSGT01020000230495
HOGENOMiCLU_168377_3_1_1
InParanoidiQ9UBI6
OMAiCSEHARN
OrthoDBi1581168at2759
PhylomeDBiQ9UBI6
TreeFamiTF319909

Enzyme and pathway databases

PathwayCommonsiQ9UBI6
ReactomeiR-HSA-1296041, Activation of G protein gated Potassium channels
R-HSA-163359, Glucagon signaling in metabolic regulation
R-HSA-202040, G-protein activation
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170, ADP signalling through P2Y purinoceptor 12
R-HSA-392451, G beta:gamma signalling through PI3Kgamma
R-HSA-392851, Prostacyclin signalling through prostacyclin receptor
R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398, Ca2+ pathway
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-418217, G beta:gamma signalling through PLC beta
R-HSA-418555, G alpha (s) signalling events
R-HSA-418592, ADP signalling through P2Y purinoceptor 1
R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-428930, Thromboxane signalling through TP receptor
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657, Presynaptic function of Kainate receptors
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315, G beta:gamma signalling through BTK
R-HSA-8964616, G beta:gamma signalling through CDC42
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiQ9UBI6
SIGNORiQ9UBI6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55970, 7 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GNG12, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GNG12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55970
PharosiQ9UBI6, Tbio

Protein Ontology

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PROi
PR:Q9UBI6
RNActiQ9UBI6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000172380, Expressed in duodenum and 245 other tissues
GenevisibleiQ9UBI6, HS

Family and domain databases

CDDicd00068, GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898, G-protein_gamma-like_dom
IPR036284, GGL_sf
IPR001770, Gprotein-gamma
PANTHERiPTHR13809, PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631, G-gamma, 1 hit
PRINTSiPR00321, GPROTEING
SMARTiView protein in SMART
SM00224, GGL, 1 hit
SUPFAMiSSF48670, SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058, G_PROTEIN_GAMMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBG12_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBI6
Secondary accession number(s): Q69YP5, Q9BRV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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