UniProtKB - Q9UBI4 (STML1_HUMAN)
Protein
Stomatin-like protein 1
Gene
STOML1
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202).By similarity1 Publication1 Publication
GO - Biological processi
- lipid transport Source: UniProtKB-KW
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9UBI4 |
Names & Taxonomyi
Protein namesi | Recommended name: Stomatin-like protein 1Short name: SLP-1 Alternative name(s): EPB72-like protein 1 Protein unc-24 homolog Stomatin-related protein Short name: STORP |
Gene namesi | Name:STOML1 Synonyms:SLP1, UNC24 ORF Names:MSTP019 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000067221.13 |
HGNCi | HGNC:14560, STOML1 |
MIMi | 608326, gene |
neXtProti | NX_Q9UBI4 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type III membrane protein
Endosome
- Late endosome membrane 1 Publication
Other locations
- Membrane Curated; Single-pass type III membrane protein Curated
- Membrane raft 1 Publication
- Cytoplasmic vesicle By similarity
Endosome
- late endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 58 – 78 | Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 398 | CytoplasmicSequence analysisAdd BLAST | 320 |
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 7 | Y → A: Plasma membrane localization. 1 Publication | 1 | |
Mutagenesisi | 10 | L → S: Plasma membrane localization. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9399 |
OpenTargetsi | ENSG00000067221 |
PharmGKBi | PA37898 |
Miscellaneous databases
Pharosi | Q9UBI4, Tbio |
Polymorphism and mutation databases
BioMutai | STOML1 |
DMDMi | 60415942 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094029 | 1 – 398 | Stomatin-like protein 1Add BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 28 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9UBI4 |
MassIVEi | Q9UBI4 |
MaxQBi | Q9UBI4 |
PaxDbi | Q9UBI4 |
PeptideAtlasi | Q9UBI4 |
PRIDEi | Q9UBI4 |
ProteomicsDBi | 17957 42124 5218 83973 [Q9UBI4-1] 83974 [Q9UBI4-2] |
PTM databases
iPTMneti | Q9UBI4 |
PhosphoSitePlusi | Q9UBI4 |
Expressioni
Tissue specificityi
Ubiquitously expressed at low levels. Expression is highest in brain.2 Publications
Gene expression databases
Bgeei | ENSG00000067221, Expressed in tendon of biceps brachii and 234 other tissues |
ExpressionAtlasi | Q9UBI4, baseline and differential |
Genevisiblei | Q9UBI4, HS |
Organism-specific databases
HPAi | ENSG00000067221, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ9UBI4
With | #Exp. | IntAct |
---|---|---|
CDK2 [P24941] | 2 | EBI-2681162,EBI-375096 |
FBXW7 - isoform 3 [Q969H0-4] | 3 | EBI-2681162,EBI-6502391 |
STOM [P27105] | 4 | EBI-2681162,EBI-1211440 |
Protein-protein interaction databases
BioGRIDi | 114796, 6 interactors |
IntActi | Q9UBI4, 5 interactors |
STRINGi | 9606.ENSP00000442478 |
Miscellaneous databases
RNActi | Q9UBI4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 287 – 398 | SCP2Add BLAST | 112 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 6 – 10 | Tyrosine-type lysosomal sorting signalSequence analysis1 Publication | 5 |
Sequence similaritiesi
Belongs to the band 7/mec-2 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2621, Eukaryota KOG4170, Eukaryota |
GeneTreei | ENSGT01010000222507 |
HOGENOMi | CLU_049498_0_0_1 |
InParanoidi | Q9UBI4 |
OMAi | SFDYIPN |
OrthoDBi | 1062075at2759 |
PhylomeDBi | Q9UBI4 |
TreeFami | TF105750 |
Family and domain databases
Gene3Di | 3.30.1050.10, 1 hit |
InterProi | View protein in InterPro IPR043202, Band-7_stomatin-like IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR003033, SCP2_sterol-bd_dom IPR036527, SCP2_sterol-bd_dom_sf IPR001972, Stomatin_HflK_HflKC_fam |
PANTHERi | PTHR10264, PTHR10264, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit PF02036, SCP2, 1 hit |
PRINTSi | PR00721, STOMATIN |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit SSF55718, SSF55718, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UBI4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLGRSGYRAL PLGDFDRFQQ SSFGFLGSQK GCLSPERGGV GTGADVPQSW
60 70 80 90 100
PSCLCHGLIS FLGFLLLLVT FPISGWFALK IVPTYERMIV FRLGRIRTPQ
110 120 130 140 150
GPGMVLLLPF IDSFQRVDLR TRAFNVPPCK LASKDGAVLS VGADVQFRIW
160 170 180 190 200
DPVLSVMTVK DLNTATRMTA QNAMTKALLK RPLREIQMEK LKISDQLLLE
210 220 230 240 250
INDVTRAWGL EVDRVELAVE AVLQPPQDSP AGPNLDSTLQ QLALHFLGGS
260 270 280 290 300
MNSMAGGAPS PGPADTVEMV SEVEPPAPQV GARSSPKQPL AEGLLTALQP
310 320 330 340 350
FLSEALVSQV GACYQFNVVL PSGTQSAYFL DLTTGRGRVG HGVPDGIPDV
360 370 380 390
VVEMAEADLR ALLCRELRPL GAYMSGRLKV KGDLAMAMKL EAVLRALK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BQA9 | H3BQA9_HUMAN | Stomatin-like protein 1 | STOML1 | 137 | Annotation score: | ||
H3BST3 | H3BST3_HUMAN | Stomatin-like protein 1 | STOML1 | 310 | Annotation score: | ||
H3BPC1 | H3BPC1_HUMAN | Stomatin-like protein 1 | STOML1 | 91 | Annotation score: | ||
H3BVF2 | H3BVF2_HUMAN | Stomatin-like protein 1 | STOML1 | 92 | Annotation score: |
Sequence cautioni
The sequence AAD42031 differs from that shown. Reason: Frameshift.Curated
The sequence CAA76271 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | W → G in CAG46886 (Ref. 5) Curated | 1 | |
Sequence conflicti | 222 | V → L in AAL39002 (Ref. 3) Curated | 1 | |
Sequence conflicti | 291 | A → T in CAG46886 (Ref. 5) Curated | 1 | |
Sequence conflicti | 369 | P → R in CAA76271 (PubMed:9931417).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054648 | 1 – 44 | MLGRS…VGTGA → MP in isoform 5. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_012654 | 80 – 129 | Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST | 50 | |
Alternative sequenceiVSP_054649 | 264 | Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 4 Publications | 1 | |
Alternative sequenceiVSP_054650 | 265 – 334 | Missing in isoform 6. 1 PublicationAdd BLAST | 70 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000316900; ENSP00000319323; ENSG00000067221 [Q9UBI4-5] ENST00000316911; ENSP00000319384; ENSG00000067221 [Q9UBI4-2] ENST00000359750; ENSP00000352788; ENSG00000067221 [Q9UBI4-6] ENST00000541638; ENSP00000442478; ENSG00000067221 [Q9UBI4-1] ENST00000564777; ENSP00000456343; ENSG00000067221 [Q9UBI4-4] |
GeneIDi | 9399 |
KEGGi | hsa:9399 |
UCSCi | uc002awe.5, human [Q9UBI4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q9UBI4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114796, 6 interactors |
IntActi | Q9UBI4, 5 interactors |
STRINGi | 9606.ENSP00000442478 |
PTM databases
iPTMneti | Q9UBI4 |
PhosphoSitePlusi | Q9UBI4 |
Polymorphism and mutation databases
BioMutai | STOML1 |
DMDMi | 60415942 |
Proteomic databases
jPOSTi | Q9UBI4 |
MassIVEi | Q9UBI4 |
MaxQBi | Q9UBI4 |
PaxDbi | Q9UBI4 |
PeptideAtlasi | Q9UBI4 |
PRIDEi | Q9UBI4 |
ProteomicsDBi | 17957 42124 5218 83973 [Q9UBI4-1] 83974 [Q9UBI4-2] |
Protocols and materials databases
Antibodypediai | 26821, 123 antibodies |
Genome annotation databases
Ensembli | ENST00000316900; ENSP00000319323; ENSG00000067221 [Q9UBI4-5] ENST00000316911; ENSP00000319384; ENSG00000067221 [Q9UBI4-2] ENST00000359750; ENSP00000352788; ENSG00000067221 [Q9UBI4-6] ENST00000541638; ENSP00000442478; ENSG00000067221 [Q9UBI4-1] ENST00000564777; ENSP00000456343; ENSG00000067221 [Q9UBI4-4] |
GeneIDi | 9399 |
KEGGi | hsa:9399 |
UCSCi | uc002awe.5, human [Q9UBI4-1] |
Organism-specific databases
CTDi | 9399 |
DisGeNETi | 9399 |
EuPathDBi | HostDB:ENSG00000067221.13 |
GeneCardsi | STOML1 |
HGNCi | HGNC:14560, STOML1 |
HPAi | ENSG00000067221, Tissue enhanced (brain) |
MIMi | 608326, gene |
neXtProti | NX_Q9UBI4 |
OpenTargetsi | ENSG00000067221 |
PharmGKBi | PA37898 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2621, Eukaryota KOG4170, Eukaryota |
GeneTreei | ENSGT01010000222507 |
HOGENOMi | CLU_049498_0_0_1 |
InParanoidi | Q9UBI4 |
OMAi | SFDYIPN |
OrthoDBi | 1062075at2759 |
PhylomeDBi | Q9UBI4 |
TreeFami | TF105750 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBI4 |
Miscellaneous databases
BioGRID-ORCSi | 9399, 2 hits in 845 CRISPR screens |
ChiTaRSi | STOML1, human |
GeneWikii | STOML1 |
GenomeRNAii | 9399 |
Pharosi | Q9UBI4, Tbio |
PROi | PR:Q9UBI4 |
RNActi | Q9UBI4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000067221, Expressed in tendon of biceps brachii and 234 other tissues |
ExpressionAtlasi | Q9UBI4, baseline and differential |
Genevisiblei | Q9UBI4, HS |
Family and domain databases
Gene3Di | 3.30.1050.10, 1 hit |
InterProi | View protein in InterPro IPR043202, Band-7_stomatin-like IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR003033, SCP2_sterol-bd_dom IPR036527, SCP2_sterol-bd_dom_sf IPR001972, Stomatin_HflK_HflKC_fam |
PANTHERi | PTHR10264, PTHR10264, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit PF02036, SCP2, 1 hit |
PRINTSi | PR00721, STOMATIN |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit SSF55718, SSF55718, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STML1_HUMAN | |
Accessioni | Q9UBI4Primary (citable) accession number: Q9UBI4 Secondary accession number(s): B3KQN0 Q9Y6H9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM