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Protein

COMM domain-containing protein 3

Gene

COMMD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).1 Publication2 Publications

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 3
Alternative name(s):
Protein Bup
Protein PIL
Gene namesi
Name:COMMD3
Synonyms:BUP, C10orf8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148444.15
HGNCiHGNC:23332 COMMD3
MIMi616700 gene
neXtProtiNX_Q9UBI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23412
OpenTargetsiENSG00000148444
PharmGKBiPA134864927

Polymorphism and mutation databases

BioMutaiCOMMD3
DMDMi51316114

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773891 – 195COMM domain-containing protein 3Add BLAST195

Proteomic databases

EPDiQ9UBI1
MaxQBiQ9UBI1
PaxDbiQ9UBI1
PeptideAtlasiQ9UBI1
PRIDEiQ9UBI1
ProteomicsDBi83972
TopDownProteomicsiQ9UBI1

PTM databases

iPTMnetiQ9UBI1
PhosphoSitePlusiQ9UBI1

Expressioni

Tissue specificityi

Widely expressed with highest expression in thymus.1 Publication

Gene expression databases

BgeeiENSG00000148444 Expressed in 222 organ(s), highest expression level in body of pancreas
CleanExiHS_COMMD3
ExpressionAtlasiQ9UBI1 baseline and differential
GenevisibleiQ9UBI1 HS

Organism-specific databases

HPAiHPA036584

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4A, CUL4B, CUL5.5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116984, 39 interactors
CORUMiQ9UBI1
IntActiQ9UBI1, 12 interactors
MINTiQ9UBI1
STRINGi9606.ENSP00000366032

Structurei

3D structure databases

ProteinModelPortaliQ9UBI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 193COMMPROSITE-ProRule annotationAdd BLAST70

Phylogenomic databases

eggNOGiENOG410IKHX Eukaryota
ENOG4111PD7 LUCA
GeneTreeiENSGT00390000015971
HOGENOMiHOG000231902
HOVERGENiHBG051068
InParanoidiQ9UBI1
KOiK22559
OMAiVSWRLQY
OrthoDBiEOG091G0O9G
PhylomeDBiQ9UBI1
TreeFamiTF329267

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037355 COMMD3
PANTHERiPTHR31159 PTHR31159, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9UBI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD
60 70 80 90 100
LKHIDPVVLK HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF
110 120 130 140 150
CTEYQNNKNS LEILLGSIGR SLPHITDVSW RLEYQIKTNQ LHRMYRPAYL
160 170 180 190
VTLSVQNTDS PSYPEISFSC SMEQLQDLVG KLKDASKSLE RATQL
Length:195
Mass (Da):22,151
Last modified:May 1, 2000 - v1
Checksum:iAC757941FC17F757
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4E5H0Y4E5_HUMAN
COMM domain-containing protein 3
COMMD3
149Annotation score:
H0Y4W0H0Y4W0_HUMAN
COMM domain-containing protein 3
COMMD3
163Annotation score:
H0Y6Z9H0Y6Z9_HUMAN
COMM domain-containing protein 3
COMMD3
177Annotation score:
R4GNF2R4GNF2_HUMAN
COMM domain-containing protein 3
COMMD3
74Annotation score:
R4GN06R4GN06_HUMAN
COMM domain-containing protein 3
COMMD3
48Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06112118R → G. Corresponds to variant dbSNP:rs11552445Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542159 mRNA Translation: AAS22241.1
AF201948 mRNA Translation: AAF17240.1
AF078848 mRNA Translation: AAD44480.1
AL158211 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86149.1
CH471072 Genomic DNA Translation: EAW86155.1
BC022898 mRNA Translation: AAH22898.1
CCDSiCCDS7137.1
RefSeqiNP_036203.1, NM_012071.3
UniGeneiHs.534398

Genome annotation databases

EnsembliENST00000376836; ENSP00000366032; ENSG00000148444
GeneIDi23412
KEGGihsa:23412
UCSCiuc001irf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542159 mRNA Translation: AAS22241.1
AF201948 mRNA Translation: AAF17240.1
AF078848 mRNA Translation: AAD44480.1
AL158211 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86149.1
CH471072 Genomic DNA Translation: EAW86155.1
BC022898 mRNA Translation: AAH22898.1
CCDSiCCDS7137.1
RefSeqiNP_036203.1, NM_012071.3
UniGeneiHs.534398

3D structure databases

ProteinModelPortaliQ9UBI1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116984, 39 interactors
CORUMiQ9UBI1
IntActiQ9UBI1, 12 interactors
MINTiQ9UBI1
STRINGi9606.ENSP00000366032

PTM databases

iPTMnetiQ9UBI1
PhosphoSitePlusiQ9UBI1

Polymorphism and mutation databases

BioMutaiCOMMD3
DMDMi51316114

Proteomic databases

EPDiQ9UBI1
MaxQBiQ9UBI1
PaxDbiQ9UBI1
PeptideAtlasiQ9UBI1
PRIDEiQ9UBI1
ProteomicsDBi83972
TopDownProteomicsiQ9UBI1

Protocols and materials databases

DNASUi23412
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376836; ENSP00000366032; ENSG00000148444
GeneIDi23412
KEGGihsa:23412
UCSCiuc001irf.4 human

Organism-specific databases

CTDi23412
DisGeNETi23412
EuPathDBiHostDB:ENSG00000148444.15
GeneCardsiCOMMD3
HGNCiHGNC:23332 COMMD3
HPAiHPA036584
MIMi616700 gene
neXtProtiNX_Q9UBI1
OpenTargetsiENSG00000148444
PharmGKBiPA134864927
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKHX Eukaryota
ENOG4111PD7 LUCA
GeneTreeiENSGT00390000015971
HOGENOMiHOG000231902
HOVERGENiHBG051068
InParanoidiQ9UBI1
KOiK22559
OMAiVSWRLQY
OrthoDBiEOG091G0O9G
PhylomeDBiQ9UBI1
TreeFamiTF329267

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSiCOMMD3 human
GenomeRNAii23412
PROiPR:Q9UBI1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148444 Expressed in 222 organ(s), highest expression level in body of pancreas
CleanExiHS_COMMD3
ExpressionAtlasiQ9UBI1 baseline and differential
GenevisibleiQ9UBI1 HS

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037355 COMMD3
PANTHERiPTHR31159 PTHR31159, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD3_HUMAN
AccessioniPrimary (citable) accession number: Q9UBI1
Secondary accession number(s): D3DRU7, Q5T8Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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