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Entry version 163 (13 Feb 2019)
Sequence version 1 (01 May 2000)
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Protein

Interleukin-36 receptor antagonist protein

Gene

IL36RN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-1 receptor antagonist activity Source: ProtInc
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processImmunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9014826 Interleukin-36 pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-36 receptor antagonist protein
Short name:
IL-36Ra1 Publication
Alternative name(s):
FIL1 delta
IL-1-related protein 3
Short name:
IL-1RP3
Interleukin-1 HY1
Short name:
IL-1HY1
Interleukin-1 delta
Short name:
IL-1 delta
Interleukin-1 family member 5
Short name:
IL-1F5
Interleukin-1 receptor antagonist homolog 1
Short name:
IL-1ra homolog 1
Interleukin-1-like protein 1
Short name:
IL-1L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL36RN
Synonyms:FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3
ORF Names:UNQ1896/PRO4342
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136695.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15561 IL36RN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605507 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBH0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Psoriasis 14, pustular (PSORS14)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.
See also OMIM:614204
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06664627L → P in PSORS14; expression of the protein is severely impaired compared to wild-type; the mutant protein is substantially less able to inhibit IL1RL2 signaling than wild-type. 1 PublicationCorresponds to variant dbSNP:rs387906914EnsemblClinVar.1
Natural variantiVAR_06664748R → W in PSORS14. 1 PublicationCorresponds to variant dbSNP:rs151325121EnsemblClinVar.1
Natural variantiVAR_066648113S → L in PSORS14. 1 PublicationCorresponds to variant dbSNP:rs144478519EnsemblClinVar.1
Natural variantiVAR_068972123T → R in PSORS14; shows impaired expression of the mutant protein which fails to antagonize the IL-36 signaling pathway. 1 PublicationCorresponds to variant dbSNP:rs397514629EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
26525

MalaCards human disease database

More...
MalaCardsi
IL36RN
MIMi614204 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136695

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
163931 Acrodermatitis continua of Hallopeau
404546 DITRA
247353 Generalized pustular psoriasis
163927 Pustulosis palmaris et plantaris

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38388

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL36RN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25008600

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001536422 – 155Interleukin-36 receptor antagonist proteinAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi8 ↔ 154By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBH0

PeptideAtlas

More...
PeptideAtlasi
Q9UBH0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBH0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83968

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBH0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By phorbol ester (PMA) and bacterial lipopolysaccharides (LPS) treatment in macrophage cell line. By Aspergillus fumigatus conidia in peripheral blood mnonocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136695 Expressed in 105 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UBH0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBH0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034542

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117728, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UBH0, 17 interactors

Molecular INTeraction database

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MINTi
Q9UBH0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259212

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P0JX-ray2.30A/B2-135[»]
A/B147-155[»]
4P0KX-ray1.70A2-49[»]
A55-135[»]
A147-155[»]
4P0LX-ray1.55A2-49[»]
A55-135[»]
A147-155[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UBH0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBH0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZIW Eukaryota
ENOG41116AA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141028

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052099

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBH0

KEGG Orthology (KO)

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KOi
K05483

Identification of Orthologs from Complete Genome Data

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OMAi
SCGTGQE

Database of Orthologous Groups

More...
OrthoDBi
1410755at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBH0

TreeFam database of animal gene trees

More...
TreeFami
TF300203

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR027171 IL-36RA
IPR008996 IL1/FGF

The PANTHER Classification System

More...
PANTHERi
PTHR45145 PTHR45145, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00340 IL1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50353 SSF50353, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UBH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL
60 70 80 90 100
DASLSPVILG VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF
110 120 130 140 150
YRRDMGLTSS FESAAYPGWF LCTVPEADQP VRLTQLPENG GWNAPITDFY

FQQCD
Length:155
Mass (Da):16,962
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB96DB5EFA2612E25
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTH1C9JTH1_HUMAN
Interleukin-1
IL36RN
117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPW9U3KPW9_HUMAN
Interleukin-36 receptor antagonist ...
IL36RN
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06664627L → P in PSORS14; expression of the protein is severely impaired compared to wild-type; the mutant protein is substantially less able to inhibit IL1RL2 signaling than wild-type. 1 PublicationCorresponds to variant dbSNP:rs387906914EnsemblClinVar.1
Natural variantiVAR_02323947N → S1 PublicationCorresponds to variant dbSNP:rs28938777EnsemblClinVar.1
Natural variantiVAR_06664748R → W in PSORS14. 1 PublicationCorresponds to variant dbSNP:rs151325121EnsemblClinVar.1
Natural variantiVAR_066648113S → L in PSORS14. 1 PublicationCorresponds to variant dbSNP:rs144478519EnsemblClinVar.1
Natural variantiVAR_068972123T → R in PSORS14; shows impaired expression of the mutant protein which fails to antagonize the IL-36 signaling pathway. 1 PublicationCorresponds to variant dbSNP:rs397514629EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF201830 mRNA Translation: AAF25210.1
AF186094 mRNA Translation: AAF02757.1
AJ242737 mRNA Translation: CAB59822.1
AJ242738 mRNA Translation: CAB59823.1
AJ271338 Genomic DNA Translation: CAB67704.1
AF216693 Genomic DNA Translation: AAF76981.1
AF230377 mRNA Translation: AAF91274.1
BN000002 Genomic DNA Translation: CAD29877.1
AY359117 mRNA Translation: AAQ89475.1
AK290249 mRNA Translation: BAF82938.1
AY972853 Genomic DNA Translation: AAX59031.1
AC016724 Genomic DNA Translation: AAY14990.1
CH471217 Genomic DNA Translation: EAW73617.1
BC024747 mRNA Translation: AAH24747.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2111.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7104

NCBI Reference Sequences

More...
RefSeqi
NP_036407.1, NM_012275.2
NP_775262.1, NM_173170.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.516301

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000346807; ENSP00000259212; ENSG00000136695
ENST00000393200; ENSP00000376896; ENSG00000136695

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26525

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26525

UCSC genome browser

More...
UCSCi
uc002tis.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-1 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201830 mRNA Translation: AAF25210.1
AF186094 mRNA Translation: AAF02757.1
AJ242737 mRNA Translation: CAB59822.1
AJ242738 mRNA Translation: CAB59823.1
AJ271338 Genomic DNA Translation: CAB67704.1
AF216693 Genomic DNA Translation: AAF76981.1
AF230377 mRNA Translation: AAF91274.1
BN000002 Genomic DNA Translation: CAD29877.1
AY359117 mRNA Translation: AAQ89475.1
AK290249 mRNA Translation: BAF82938.1
AY972853 Genomic DNA Translation: AAX59031.1
AC016724 Genomic DNA Translation: AAY14990.1
CH471217 Genomic DNA Translation: EAW73617.1
BC024747 mRNA Translation: AAH24747.1
CCDSiCCDS2111.1
PIRiJC7104
RefSeqiNP_036407.1, NM_012275.2
NP_775262.1, NM_173170.1
UniGeneiHs.516301

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P0JX-ray2.30A/B2-135[»]
A/B147-155[»]
4P0KX-ray1.70A2-49[»]
A55-135[»]
A147-155[»]
4P0LX-ray1.55A2-49[»]
A55-135[»]
A147-155[»]
ProteinModelPortaliQ9UBH0
SMRiQ9UBH0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117728, 16 interactors
IntActiQ9UBH0, 17 interactors
MINTiQ9UBH0
STRINGi9606.ENSP00000259212

PTM databases

iPTMnetiQ9UBH0
PhosphoSitePlusiQ9UBH0

Polymorphism and mutation databases

BioMutaiIL36RN
DMDMi25008600

Proteomic databases

PaxDbiQ9UBH0
PeptideAtlasiQ9UBH0
PRIDEiQ9UBH0
ProteomicsDBi83968

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
26525
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346807; ENSP00000259212; ENSG00000136695
ENST00000393200; ENSP00000376896; ENSG00000136695
GeneIDi26525
KEGGihsa:26525
UCSCiuc002tis.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26525
DisGeNETi26525
EuPathDBiHostDB:ENSG00000136695.14

GeneCards: human genes, protein and diseases

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GeneCardsi
IL36RN
HGNCiHGNC:15561 IL36RN
HPAiHPA034542
MalaCardsiIL36RN
MIMi605507 gene
614204 phenotype
neXtProtiNX_Q9UBH0
OpenTargetsiENSG00000136695
Orphaneti163931 Acrodermatitis continua of Hallopeau
404546 DITRA
247353 Generalized pustular psoriasis
163927 Pustulosis palmaris et plantaris
PharmGKBiPA38388

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZIW Eukaryota
ENOG41116AA LUCA
GeneTreeiENSGT00900000141028
HOVERGENiHBG052099
InParanoidiQ9UBH0
KOiK05483
OMAiSCGTGQE
OrthoDBi1410755at2759
PhylomeDBiQ9UBH0
TreeFamiTF300203

Enzyme and pathway databases

ReactomeiR-HSA-9014826 Interleukin-36 pathway

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IL1F5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26525

Protein Ontology

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PROi
PR:Q9UBH0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136695 Expressed in 105 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ9UBH0 baseline and differential
GenevisibleiQ9UBH0 HS

Family and domain databases

InterProiView protein in InterPro
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR027171 IL-36RA
IPR008996 IL1/FGF
PANTHERiPTHR45145 PTHR45145, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI36RA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBH0
Secondary accession number(s): A8K2I4, Q56AT9, Q7RTZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: February 13, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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