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Protein

Phosphatidylinositol 4-kinase beta

Gene

PI4KB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).By similarity3 Publications

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.1 Publication

Activity regulationi

Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity).By similarity

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • 1-phosphatidylinositol 4-kinase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • phosphatidylinositol biosynthetic process Source: Reactome
  • phosphatidylinositol-mediated signaling Source: GO_Central
  • phosphatidylinositol phosphorylation Source: GO_Central
  • receptor-mediated endocytosis Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07046-MONOMER
BRENDAi2.7.1.67 2681
ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane
SIGNORiQ9UBF8

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase beta (EC:2.7.1.67)
Short name:
PI4K-beta
Short name:
PI4Kbeta
Short name:
PtdIns 4-kinase beta
Alternative name(s):
NPIK
PI4K92
Gene namesi
Name:PI4KB
Synonyms:PIK4CB
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143393.16
HGNCiHGNC:8984 PI4KB
MIMi602758 gene
neXtProtiNX_Q9UBF8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40 – 42LSV → AAA: Small decrease in C10ORF76-binding. No effect on ACBD3-, nor RAB11B-binding. 1 Publication3
Mutagenesisi42V → A: No loss of interaction with ACBD3. 1 Publication1
Mutagenesisi43 – 45IDP → AAA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication3
Mutagenesisi43I → A: Loss of interaction with ACBD3. 2 Publications1
Mutagenesisi44D → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi46 – 47EV → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi47V → A: No loss of interaction with ACBD3. 1 Publication1
Mutagenesisi49 – 50QK → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi52C → A: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication1
Mutagenesisi53 – 54QE → AA: Drastically decreased C10ORF76- and RAB11B-binding. 6-fold increase in ACBD3-binding. 1 Publication2
Mutagenesisi55 – 56VL → AA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi55V → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi56L → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi57 – 59EKV → AAA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication3

Organism-specific databases

DisGeNETi5298
OpenTargetsiENSG00000143393
PharmGKBiPA162399420

Chemistry databases

ChEMBLiCHEMBL3268
GuidetoPHARMACOLOGYi2149

Polymorphism and mutation databases

BioMutaiPI4KB
DMDMi38372507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000888292 – 816Phosphatidylinositol 4-kinase betaAdd BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei258PhosphoserineCombined sources1 Publication1
Modified residuei263Phosphothreonine1 Publication1
Modified residuei266PhosphoserineCombined sources1 Publication1
Modified residuei275PhosphoserineBy similarity1
Modified residuei277PhosphoserineCombined sources1 Publication1
Modified residuei284PhosphoserineBy similarity1
Modified residuei294Phosphoserine2 Publications1
Modified residuei428PhosphoserineCombined sources1
Modified residuei438Phosphothreonine1 Publication1
Modified residuei511PhosphoserineCombined sources1 Publication1
Modified residuei517PhosphothreonineCombined sources1
Modified residuei519Phosphothreonine1 Publication1
Isoform 21 Publication (identifier: Q9UBF8-2)
Modified residuei294PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UBF8
MaxQBiQ9UBF8
PaxDbiQ9UBF8
PeptideAtlasiQ9UBF8
PRIDEiQ9UBF8
ProteomicsDBi83959
83960 [Q9UBF8-2]
83961 [Q9UBF8-3]

PTM databases

iPTMnetiQ9UBF8
PhosphoSitePlusiQ9UBF8

Miscellaneous databases

PMAP-CutDBiQ9UBF8

Expressioni

Tissue specificityi

Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.3 Publications

Gene expression databases

BgeeiENSG00000143393 Expressed in 230 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PI4KB
ExpressionAtlasiQ9UBF8 baseline and differential
GenevisibleiQ9UBF8 HS

Organism-specific databases

HPAiCAB022071
HPA006280
HPA006281

Interactioni

Subunit structurei

Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3 (PubMed:27009356, PubMed:27989622, PubMed:23572552). Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111316, 18 interactors
DIPiDIP-42267N
IntActiQ9UBF8, 12 interactors
MINTiQ9UBF8
STRINGi9606.ENSP00000271657

Chemistry databases

BindingDBiQ9UBF8

Structurei

Secondary structure

1816
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UBF8
SMRiQ9UBF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 242PIK helicalPROSITE-ProRule annotationAdd BLAST214
Domaini558 – 765PI3K/PI4KPROSITE-ProRule annotationCuratedAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 68Interaction with ACBD31 PublicationAdd BLAST67

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0903 Eukaryota
ENOG410XPH3 LUCA
GeneTreeiENSGT00550000074892
HOVERGENiHBG053597
InParanoidiQ9UBF8
KOiK19801
PhylomeDBiQ9UBF8
TreeFamiTF102042

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM00146 PI3Kc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9UBF8-1) [UniParc]FASTAAdd to basket
Also known as: NPIK-B1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK
60 70 80 90 100
ACQEVLEKVK LLHGGVAVSS RGTPLELVNG DGVDSEIRCL DDPPAQIREE
110 120 130 140 150
EDEMGAAVAS GTAKGARRRR QNNSAKQSWL LRLFESKLFD ISMAISYLYN
160 170 180 190 200
SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL NMYIHMDEDV GDAIKPYIVH
210 220 230 240 250
RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI LSDELKPAHR
260 270 280 290 300
KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN
310 320 330 340 350
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ
360 370 380 390 400
RLISELSLLN HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY
410 420 430 440 450
VEVLECENFD TTSVPARIPE NRIRSTRSVE NLPECGITHE QRAGSFSTVP
460 470 480 490 500
NYDNDDEAWS VDDIGELQVE LPEVHTNSCD NISQFSVDSI TSQESKEPVF
510 520 530 540 550
IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK VRRIREGSPY
560 570 580 590 600
GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI
610 620 630 640 650
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ
660 670 680 690 700
RNFVQSCAGY CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN
710 720 730 740 750
LGFETSAFKL TTEFVDVMGG LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI
760 770 780 790 800
VEIMQQGSQL PCFHGSSTIR NLKERFHMSM TEEQLQLLVE QMVDGSMRSI
810
TTKLYDGFQY LTNGIM
Length:816
Mass (Da):91,379
Last modified:May 1, 2000 - v1
Checksum:iCAD8791729BB4308
GO
Isoform 21 Publication (identifier: Q9UBF8-2) [UniParc]FASTAAdd to basket
Also known as: NPIK-C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     304-318: Missing.

Show »
Length:801
Mass (Da):89,807
Checksum:i22E1ABA37AA9A2BD
GO
Isoform 3 (identifier: Q9UBF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Show »
Length:484
Mass (Da):54,976
Checksum:i395A9DF64FC58A8C
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1S8A0A0B4J1S8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
828Annotation score:
A6PVV8A6PVV8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
227Annotation score:
H0YCW3H0YCW3_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
183Annotation score:
H0Y4F8H0Y4F8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
73Annotation score:
F8W860F8W860_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
191Annotation score:
E9PL47E9PL47_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
95Annotation score:
A0A0A0MSL0A0A0A0MSL0_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
280Annotation score:

Sequence cautioni

The sequence BAA21661 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW53450 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216L → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti339L → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti340A → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti370P → S in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti446F → S in BAG57793 (PubMed:14702039).Curated1
Sequence conflicti754M → L in BAG57793 (PubMed:14702039).Curated1
Sequence conflicti796S → G in BAG57793 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0371331 – 332Missing in isoform 3. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_050627304 – 318Missing in isoform 2. 3 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011121 mRNA Translation: CAA09495.1
AJ011122 mRNA No translation available.
AJ011123 mRNA Translation: CAA09496.1
AB005910 mRNA Translation: BAA21661.1 Different initiation.
U81802 mRNA Translation: AAC51156.1
AK294606 mRNA Translation: BAG57793.1
AL391069 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53449.1
CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems.
BC000029 mRNA Translation: AAH00029.1
BC040300 mRNA Translation: AAH40300.1
CCDSiCCDS55637.1 [Q9UBF8-3]
CCDS55638.1 [Q9UBF8-2]
CCDS81376.1 [Q9UBF8-1]
PIRiJC5706
RefSeqiNP_001185702.1, NM_001198773.2 [Q9UBF8-2]
NP_001185703.1, NM_001198774.1 [Q9UBF8-2]
NP_001185704.1, NM_001198775.2 [Q9UBF8-3]
NP_001317650.1, NM_001330721.1 [Q9UBF8-1]
NP_002642.1, NM_002651.3
XP_016856979.1, XM_017001490.1 [Q9UBF8-1]
XP_016856980.1, XM_017001491.1 [Q9UBF8-1]
XP_016856981.1, XM_017001492.1 [Q9UBF8-2]
UniGeneiHs.632465

Genome annotation databases

EnsembliENST00000368872; ENSP00000357866; ENSG00000143393 [Q9UBF8-2]
ENST00000368873; ENSP00000357867; ENSG00000143393 [Q9UBF8-1]
ENST00000368874; ENSP00000357868; ENSG00000143393 [Q9UBF8-2]
ENST00000529142; ENSP00000433149; ENSG00000143393 [Q9UBF8-3]
GeneIDi5298
KEGGihsa:5298
UCSCiuc001ext.4 human [Q9UBF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011121 mRNA Translation: CAA09495.1
AJ011122 mRNA No translation available.
AJ011123 mRNA Translation: CAA09496.1
AB005910 mRNA Translation: BAA21661.1 Different initiation.
U81802 mRNA Translation: AAC51156.1
AK294606 mRNA Translation: BAG57793.1
AL391069 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53449.1
CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems.
BC000029 mRNA Translation: AAH00029.1
BC040300 mRNA Translation: AAH40300.1
CCDSiCCDS55637.1 [Q9UBF8-3]
CCDS55638.1 [Q9UBF8-2]
CCDS81376.1 [Q9UBF8-1]
PIRiJC5706
RefSeqiNP_001185702.1, NM_001198773.2 [Q9UBF8-2]
NP_001185703.1, NM_001198774.1 [Q9UBF8-2]
NP_001185704.1, NM_001198775.2 [Q9UBF8-3]
NP_001317650.1, NM_001330721.1 [Q9UBF8-1]
NP_002642.1, NM_002651.3
XP_016856979.1, XM_017001490.1 [Q9UBF8-1]
XP_016856980.1, XM_017001491.1 [Q9UBF8-1]
XP_016856981.1, XM_017001492.1 [Q9UBF8-2]
UniGeneiHs.632465

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N73NMR-B1-68[»]
4D0LX-ray2.94A/C/E121-799[»]
4D0MX-ray6.00A/C/G/I/M/O/Q/S/W/Y/c/g121-799[»]
4WAEX-ray3.32A128-799[»]
4WAGX-ray3.41A128-799[»]
5C46X-ray2.65E121-799[»]
5C4GX-ray3.20E121-799[»]
5EUQX-ray3.20E121-248[»]
E523-799[»]
5FBLX-ray3.37A128-799[»]
5FBQX-ray3.79A128-799[»]
5FBRX-ray3.28A128-799[»]
5FBVX-ray3.29A128-799[»]
5FBWX-ray3.49A128-799[»]
5LX2X-ray2.58B292-297[»]
5NASX-ray2.08C/D289-297[»]
6GL3X-ray2.77A/B317-428[»]
A/B532-798[»]
ProteinModelPortaliQ9UBF8
SMRiQ9UBF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111316, 18 interactors
DIPiDIP-42267N
IntActiQ9UBF8, 12 interactors
MINTiQ9UBF8
STRINGi9606.ENSP00000271657

Chemistry databases

BindingDBiQ9UBF8
ChEMBLiCHEMBL3268
GuidetoPHARMACOLOGYi2149

PTM databases

iPTMnetiQ9UBF8
PhosphoSitePlusiQ9UBF8

Polymorphism and mutation databases

BioMutaiPI4KB
DMDMi38372507

Proteomic databases

EPDiQ9UBF8
MaxQBiQ9UBF8
PaxDbiQ9UBF8
PeptideAtlasiQ9UBF8
PRIDEiQ9UBF8
ProteomicsDBi83959
83960 [Q9UBF8-2]
83961 [Q9UBF8-3]

Protocols and materials databases

DNASUi5298
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368872; ENSP00000357866; ENSG00000143393 [Q9UBF8-2]
ENST00000368873; ENSP00000357867; ENSG00000143393 [Q9UBF8-1]
ENST00000368874; ENSP00000357868; ENSG00000143393 [Q9UBF8-2]
ENST00000529142; ENSP00000433149; ENSG00000143393 [Q9UBF8-3]
GeneIDi5298
KEGGihsa:5298
UCSCiuc001ext.4 human [Q9UBF8-1]

Organism-specific databases

CTDi5298
DisGeNETi5298
EuPathDBiHostDB:ENSG00000143393.16
GeneCardsiPI4KB
H-InvDBiHIX0001056
HGNCiHGNC:8984 PI4KB
HPAiCAB022071
HPA006280
HPA006281
MIMi602758 gene
neXtProtiNX_Q9UBF8
OpenTargetsiENSG00000143393
PharmGKBiPA162399420
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0903 Eukaryota
ENOG410XPH3 LUCA
GeneTreeiENSGT00550000074892
HOVERGENiHBG053597
InParanoidiQ9UBF8
KOiK19801
PhylomeDBiQ9UBF8
TreeFamiTF102042

Enzyme and pathway databases

BioCyciMetaCyc:HS07046-MONOMER
BRENDAi2.7.1.67 2681
ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane
SIGNORiQ9UBF8

Miscellaneous databases

ChiTaRSiPI4KB human
GeneWikiiPI4KB
GenomeRNAii5298
PMAP-CutDBiQ9UBF8
PROiPR:Q9UBF8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143393 Expressed in 230 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PI4KB
ExpressionAtlasiQ9UBF8 baseline and differential
GenevisibleiQ9UBF8 HS

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM00146 PI3Kc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPI4KB_HUMAN
AccessioniPrimary (citable) accession number: Q9UBF8
Secondary accession number(s): B4DGI2
, O15096, P78405, Q5VWB9, Q5VWC0, Q5VWC1, Q9BWR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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