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UniProtKB - Q9UBF8 (PI4KB_HUMAN)

Entry version 186 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Phosphatidylinositol 4-kinase beta

Gene

PI4KB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).

By similarity4 Publications

(Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260).

Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).

3 Publications

(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by wortmannin and adenosine (PubMed:11277933). Increased kinase activity upon interaction with NCS1/FREQ (By similarity).By similarity1 Publication
(Microbial infection) Activated by Aichi virus protein 3A, this activation is sensitized by ACBD3.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.0 mM for PtdIns1 Publication
  2. KM=1.0 mM for ATP1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processHost-virus interaction
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS07046-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.7.1.67, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q9UBF8

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-1660514, Synthesis of PIPs at the Golgi membrane

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		Q9UBF8

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000001947 [Q9UBF8-2]

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phosphatidylinositol 4-kinase betaCurated (EC:2.7.1.672 Publications)
    Short name:
    PI4K-beta
    Short name:
    PI4Kbeta
    Short name:
    PtdIns 4-kinase beta
    Alternative name(s):
    NPIK
    PI4K92
    PI4KIII2 Publications
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PI4KBImported
    Synonyms:PIK4CB
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:8984, PI4KB

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		602758, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9UBF8

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000143393.16

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40 – 42LSV → AAA: Small decrease in C10ORF76-binding. No effect on ACBD3-, nor RAB11B-binding. 1 Publication3
    Mutagenesisi42V → A: No loss of interaction with ACBD3. 1 Publication1
    Mutagenesisi43 – 45IDP → AAA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication3
    Mutagenesisi43I → A: Loss of interaction with ACBD3. 2 Publications1
    Mutagenesisi44D → A: Loss of interaction with ACBD3. 1 Publication1
    Mutagenesisi46 – 47EV → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
    Mutagenesisi47V → A: No loss of interaction with ACBD3. 1 Publication1
    Mutagenesisi49 – 50QK → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
    Mutagenesisi52C → A: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication1
    Mutagenesisi53 – 54QE → AA: Drastically decreased C10ORF76- and RAB11B-binding. 6-fold increase in ACBD3-binding. 1 Publication2
    Mutagenesisi55 – 56VL → AA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication2
    Mutagenesisi55V → A: Loss of interaction with ACBD3. 1 Publication1
    Mutagenesisi56L → A: Loss of interaction with ACBD3. 1 Publication1
    Mutagenesisi57 – 59EKV → AAA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication3

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		5298

    Open Targets

    More...    OpenTargetsi    		ENSG00000143393

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA162399420

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q9UBF8, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3268

    Drug and drug target database

    More...    DrugBanki    		DB12010, Fostamatinib

    DrugCentral

    More...    DrugCentrali    		Q9UBF8

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		2149

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		PI4KB

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		38372507

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888292 – 816Phosphatidylinositol 4-kinase betaAdd BLAST815

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
    Modified residuei258PhosphoserineCombined sources1 Publication1
    Modified residuei263Phosphothreonine1 Publication1
    Modified residuei266PhosphoserineCombined sources1 Publication1
    Modified residuei275PhosphoserineBy similarity1
    Modified residuei277PhosphoserineCombined sources1 Publication1
    Modified residuei284PhosphoserineBy similarity1
    Modified residuei294Phosphoserine2 Publications1
    Modified residuei428PhosphoserineCombined sources1
    Modified residuei438Phosphothreonine1 Publication1
    Modified residuei511PhosphoserineCombined sources1 Publication1
    Modified residuei517PhosphothreonineCombined sources1
    Modified residuei519Phosphothreonine1 Publication1
    Isoform 21 Publication (identifier: Q9UBF8-2)
    Modified residuei294PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9UBF8

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q9UBF8

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q9UBF8

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q9UBF8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9UBF8

    PeptideAtlas

    More...    PeptideAtlasi    		Q9UBF8

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9UBF8

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		83959 [Q9UBF8-1]
    83960 [Q9UBF8-2]
    83961 [Q9UBF8-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9UBF8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9UBF8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000143393, Expressed in left lobe of thyroid gland and 242 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9UBF8, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9UBF8, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000143393, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535).

    Interacts with NCS1/FREQ in a calcium-independent manner.

    Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity).

    Interacts with ACBD3 (PubMed:23572552, PubMed:27009356, PubMed:27989622, PubMed:22124328, PubMed:22258260).

    Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552).

    Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (PubMed:28289207).

    By similarity7 Publications

    (Microbial infection) Interacts with Aichi virus protein 3A.

    Part of a complex Aichi virus protein 3A/ACBD3/PI4KB that allows the synthesis of PI4P at the viral RNA replication sites.

    3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		111316, 27 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-42267N

    Protein interaction database and analysis system

    More...    IntActi    		Q9UBF8, 27 interactors

    Molecular INTeraction database

    More...    MINTi    		Q9UBF8

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000357869

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q9UBF8

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9UBF8, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1816
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9UBF8

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 242PIK helicalPROSITE-ProRule annotationAdd BLAST214
    Domaini558 – 765PI3K/PI4KPROSITE-ProRule annotationCuratedAdd BLAST208

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
    Regioni41 – 67Interaction with ACBD31 Publication2 PublicationsAdd BLAST27
    Regioni101 – 120DisorderedSequence analysisAdd BLAST20
    Regioni248 – 318DisorderedSequence analysisAdd BLAST71

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi277 – 294Polar residuesSequence analysisAdd BLAST18

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0903, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00550000074892

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9UBF8

    Database of Orthologous Groups

    More...    OrthoDBi    		1147978at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9UBF8

    TreeFam database of animal gene trees

    More...    TreeFami    		TF102042

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.1070.11, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR011009, Kinase-like_dom_sf
    IPR000403, PI3/4_kinase_cat_dom
    IPR036940, PI3/4_kinase_cat_sf
    IPR018936, PI3/4_kinase_CS
    IPR001263, PI3K_accessory_dom
    IPR015433, PI_Kinase

    The PANTHER Classification System

    More...    PANTHERi    		PTHR10048, PTHR10048, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00454, PI3_PI4_kinase, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00146, PI3Kc, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF56112, SSF56112, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00915, PI3_4_KINASE_1, 1 hit
    PS00916, PI3_4_KINASE_2, 1 hit
    PS50290, PI3_4_KINASE_3, 1 hit
    PS51545, PIK_HELICAL, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 11 Publication (identifier: Q9UBF8-1) [UniParc]FASTAAdd to basket
    Also known as: NPIK-B1 Publication

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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            10         20         30         40         50
    MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK 
            60         70         80         90        100
    ACQEVLEKVK LLHGGVAVSS RGTPLELVNG DGVDSEIRCL DDPPAQIREE 
           110        120        130        140        150
    EDEMGAAVAS GTAKGARRRR QNNSAKQSWL LRLFESKLFD ISMAISYLYN 
           160        170        180        190        200
    SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL NMYIHMDEDV GDAIKPYIVH 
           210        220        230        240        250
    RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI LSDELKPAHR 
           260        270        280        290        300
    KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN 
           310        320        330        340        350
    EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ 
           360        370        380        390        400
    RLISELSLLN HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY 
           410        420        430        440        450
    VEVLECENFD TTSVPARIPE NRIRSTRSVE NLPECGITHE QRAGSFSTVP 
           460        470        480        490        500
    NYDNDDEAWS VDDIGELQVE LPEVHTNSCD NISQFSVDSI TSQESKEPVF 
           510        520        530        540        550
    IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK VRRIREGSPY 
           560        570        580        590        600
    GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI 
           610        620        630        640        650
    LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ 
           660        670        680        690        700
    RNFVQSCAGY CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN 
           710        720        730        740        750
    LGFETSAFKL TTEFVDVMGG LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI 
           760        770        780        790        800
    VEIMQQGSQL PCFHGSSTIR NLKERFHMSM TEEQLQLLVE QMVDGSMRSI 
           810 
    TTKLYDGFQY LTNGIM
    Length:816
    Mass (Da):91,379
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAD8791729BB4308
    GO
    Isoform 21 Publication (identifier: Q9UBF8-2) [UniParc]FASTAAdd to basket
    Also known as: NPIK-C1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         304-318: Missing.

    Show »
    Length:801
    Mass (Da):89,807
    Checksum:i22E1ABA37AA9A2BD
    GO
    Isoform 3 (identifier: Q9UBF8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-332: Missing.

    Show »
    Length:484
    Mass (Da):54,976
    Checksum:i395A9DF64FC58A8C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    A0A0B4J1S8A0A0B4J1S8_HUMAN
    Phosphatidylinositol 4-kinase beta
    PI4KB
    		828Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A6PVV8A6PVV8_HUMAN
    Phosphatidylinositol 4-kinase beta
    PI4KB
    		227Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YCW3H0YCW3_HUMAN
    Phosphatidylinositol 4-kinase beta
    PI4KB
    		183Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y4F8H0Y4F8_HUMAN
    Phosphatidylinositol 4-kinase beta
    PI4KB
    		73Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0A0MSL0A0A0A0MSL0_HUMAN
    Phosphatidylinositol 4-kinase beta
    PI4KB
    		280Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PL47E9PL47_HUMAN
    Phosphatidylinositol 4-kinase beta
    PI4KB
    		95Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8W860F8W860_HUMAN
    Phosphatidylinositol 4-kinase beta
    PI4KB
    		191Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA21661 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
    The sequence EAW53450 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti216L → V in AAC51156 (PubMed:9020160).Curated1
    Sequence conflicti339L → V in AAC51156 (PubMed:9020160).Curated1
    Sequence conflicti340A → V in AAC51156 (PubMed:9020160).Curated1
    Sequence conflicti370P → S in AAC51156 (PubMed:9020160).Curated1
    Sequence conflicti446F → S in BAG57793 (PubMed:14702039).Curated1
    Sequence conflicti754M → L in BAG57793 (PubMed:14702039).Curated1
    Sequence conflicti796S → G in BAG57793 (PubMed:14702039).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371331 – 332Missing in isoform 3. 1 PublicationAdd BLAST332
    Alternative sequenceiVSP_050627304 – 318Missing in isoform 2. 3 PublicationsAdd BLAST15

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AJ011121 mRNA Translation: CAA09495.1
    AJ011122 mRNA No translation available.
    AJ011123 mRNA Translation: CAA09496.1
    AB005910 mRNA Translation: BAA21661.1 Different initiation.
    U81802 mRNA Translation: AAC51156.1
    AK294606 mRNA Translation: BAG57793.1
    AL391069 Genomic DNA No translation available.
    CH471121 Genomic DNA Translation: EAW53449.1
    CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems.
    BC000029 mRNA Translation: AAH00029.1
    BC040300 mRNA Translation: AAH40300.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS55637.1 [Q9UBF8-3]
    CCDS55638.1 [Q9UBF8-2]
    CCDS81376.1 [Q9UBF8-1]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		JC5706

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001185702.1, NM_001198773.2 [Q9UBF8-2]
    NP_001185703.1, NM_001198774.1 [Q9UBF8-2]
    NP_001185704.1, NM_001198775.2 [Q9UBF8-3]
    NP_001317650.1, NM_001330721.1 [Q9UBF8-1]
    NP_002642.1, NM_002651.3
    XP_016856979.1, XM_017001490.1
    XP_016856980.1, XM_017001491.1
    XP_016856981.1, XM_017001492.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000368872; ENSP00000357866; ENSG00000143393 [Q9UBF8-2]
    ENST00000368873; ENSP00000357867; ENSG00000143393 [Q9UBF8-1]
    ENST00000368874; ENSP00000357868; ENSG00000143393 [Q9UBF8-2]
    ENST00000529142; ENSP00000433149; ENSG00000143393 [Q9UBF8-3]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		5298

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:5298

    UCSC genome browser

    More...    UCSCi    		uc001ext.4, human [Q9UBF8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AJ011121 mRNA Translation: CAA09495.1
    AJ011122 mRNA No translation available.
    AJ011123 mRNA Translation: CAA09496.1
    AB005910 mRNA Translation: BAA21661.1 Different initiation.
    U81802 mRNA Translation: AAC51156.1
    AK294606 mRNA Translation: BAG57793.1
    AL391069 Genomic DNA No translation available.
    CH471121 Genomic DNA Translation: EAW53449.1
    CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems.
    BC000029 mRNA Translation: AAH00029.1
    BC040300 mRNA Translation: AAH40300.1
    CCDSiCCDS55637.1 [Q9UBF8-3]
    CCDS55638.1 [Q9UBF8-2]
    CCDS81376.1 [Q9UBF8-1]
    PIRiJC5706
    RefSeqiNP_001185702.1, NM_001198773.2 [Q9UBF8-2]
    NP_001185703.1, NM_001198774.1 [Q9UBF8-2]
    NP_001185704.1, NM_001198775.2 [Q9UBF8-3]
    NP_001317650.1, NM_001330721.1 [Q9UBF8-1]
    NP_002642.1, NM_002651.3
    XP_016856979.1, XM_017001490.1
    XP_016856980.1, XM_017001491.1
    XP_016856981.1, XM_017001492.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2N73NMR-B1-68[»]
    4D0LX-ray2.94A/C/E121-799[»]
    4D0MX-ray6.00A/C/G/I/M/O/Q/S/W/Y/c/g121-799[»]
    4WAEX-ray3.32A128-799[»]
    4WAGX-ray3.41A128-799[»]
    5C46X-ray2.65E121-799[»]
    5C4GX-ray3.20E121-799[»]
    5EUQX-ray3.20E121-248[»]
    E523-799[»]
    5FBLX-ray3.37A128-799[»]
    5FBQX-ray3.79A128-799[»]
    5FBRX-ray3.28A128-799[»]
    5FBVX-ray3.29A128-799[»]
    5FBWX-ray3.49A128-799[»]
    5LX2X-ray2.58B292-297[»]
    5NASX-ray2.08C/D289-297[»]
    6GL3X-ray2.77A/B317-428[»]
    A/B532-798[»]
    SMRiQ9UBF8
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi111316, 27 interactors
    DIPiDIP-42267N
    IntActiQ9UBF8, 27 interactors
    MINTiQ9UBF8
    STRINGi9606.ENSP00000357869

    Chemistry databases

    BindingDBiQ9UBF8
    ChEMBLiCHEMBL3268
    DrugBankiDB12010, Fostamatinib
    DrugCentraliQ9UBF8
    GuidetoPHARMACOLOGYi2149
    SwissLipidsiSLP:000001947 [Q9UBF8-2]

    PTM databases

    iPTMnetiQ9UBF8
    PhosphoSitePlusiQ9UBF8

    Genetic variation databases

    BioMutaiPI4KB
    DMDMi38372507

    Proteomic databases

    EPDiQ9UBF8
    jPOSTiQ9UBF8
    MassIVEiQ9UBF8
    MaxQBiQ9UBF8
    PaxDbiQ9UBF8
    PeptideAtlasiQ9UBF8
    PRIDEiQ9UBF8
    ProteomicsDBi83959 [Q9UBF8-1]
    83960 [Q9UBF8-2]
    83961 [Q9UBF8-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		1666, 131 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		5298

    Genome annotation databases

    EnsembliENST00000368872; ENSP00000357866; ENSG00000143393 [Q9UBF8-2]
    ENST00000368873; ENSP00000357867; ENSG00000143393 [Q9UBF8-1]
    ENST00000368874; ENSP00000357868; ENSG00000143393 [Q9UBF8-2]
    ENST00000529142; ENSP00000433149; ENSG00000143393 [Q9UBF8-3]
    GeneIDi5298
    KEGGihsa:5298
    UCSCiuc001ext.4, human [Q9UBF8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		5298
    DisGeNETi5298

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		PI4KB
    HGNCiHGNC:8984, PI4KB
    HPAiENSG00000143393, Low tissue specificity
    MIMi602758, gene
    neXtProtiNX_Q9UBF8
    OpenTargetsiENSG00000143393
    PharmGKBiPA162399420
    VEuPathDBiHostDB:ENSG00000143393.16

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0903, Eukaryota
    GeneTreeiENSGT00550000074892
    InParanoidiQ9UBF8
    OrthoDBi1147978at2759
    PhylomeDBiQ9UBF8
    TreeFamiTF102042

    Enzyme and pathway databases

    BioCyciMetaCyc:HS07046-MONOMER
    BRENDAi2.7.1.67, 2681
    PathwayCommonsiQ9UBF8
    ReactomeiR-HSA-1660514, Synthesis of PIPs at the Golgi membrane
    SIGNORiQ9UBF8

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		5298, 171 hits in 996 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		PI4KB, human

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		PI4KB

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		5298
    PharosiQ9UBF8, Tchem

    Protein Ontology

    More...    PROi    		PR:Q9UBF8
    RNActiQ9UBF8, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000143393, Expressed in left lobe of thyroid gland and 242 other tissues
    ExpressionAtlasiQ9UBF8, baseline and differential
    GenevisibleiQ9UBF8, HS

    Family and domain databases

    Gene3Di1.10.1070.11, 1 hit
    InterProiView protein in InterPro
    IPR011009, Kinase-like_dom_sf
    IPR000403, PI3/4_kinase_cat_dom
    IPR036940, PI3/4_kinase_cat_sf
    IPR018936, PI3/4_kinase_CS
    IPR001263, PI3K_accessory_dom
    IPR015433, PI_Kinase
    PANTHERiPTHR10048, PTHR10048, 1 hit
    PfamiView protein in Pfam
    PF00454, PI3_PI4_kinase, 1 hit
    SMARTiView protein in SMART
    SM00146, PI3Kc, 1 hit
    SUPFAMiSSF56112, SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS00915, PI3_4_KINASE_1, 1 hit
    PS00916, PI3_4_KINASE_2, 1 hit
    PS50290, PI3_4_KINASE_3, 1 hit
    PS51545, PIK_HELICAL, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI4KB_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBF8
    Secondary accession number(s): B4DGI2
    , O15096, P78405, Q5VWB9, Q5VWC0, Q5VWC1, Q9BWR6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: May 1, 2000
    Last modified: June 2, 2021
    This is version 186 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
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