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Entry version 173 (31 Jul 2019)
Sequence version 1 (01 May 2000)
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Protein

Phosphatidylinositol 4-kinase beta

Gene

PI4KB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07046-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.67 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9UBF8

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001947 [Q9UBF8-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase betaCurated (EC:2.7.1.67)
Short name:
PI4K-beta
Short name:
PI4Kbeta
Short name:
PtdIns 4-kinase beta
Alternative name(s):
NPIK
PI4K92
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PI4KBImported
Synonyms:PIK4CB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8984 PI4KB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602758 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40 – 42LSV → AAA: Small decrease in C10ORF76-binding. No effect on ACBD3-, nor RAB11B-binding. 1 Publication3
Mutagenesisi42V → A: No loss of interaction with ACBD3. 1 Publication1
Mutagenesisi43 – 45IDP → AAA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication3
Mutagenesisi43I → A: Loss of interaction with ACBD3. 2 Publications1
Mutagenesisi44D → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi46 – 47EV → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi47V → A: No loss of interaction with ACBD3. 1 Publication1
Mutagenesisi49 – 50QK → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi52C → A: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication1
Mutagenesisi53 – 54QE → AA: Drastically decreased C10ORF76- and RAB11B-binding. 6-fold increase in ACBD3-binding. 1 Publication2
Mutagenesisi55 – 56VL → AA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi55V → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi56L → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi57 – 59EKV → AAA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication3

Organism-specific databases

DisGeNET

More...
DisGeNETi
5298

Open Targets

More...
OpenTargetsi
ENSG00000143393

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399420

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3268

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2149

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PI4KB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38372507

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888292 – 816Phosphatidylinositol 4-kinase betaAdd BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei258PhosphoserineCombined sources1 Publication1
Modified residuei263Phosphothreonine1 Publication1
Modified residuei266PhosphoserineCombined sources1 Publication1
Modified residuei275PhosphoserineBy similarity1
Modified residuei277PhosphoserineCombined sources1 Publication1
Modified residuei284PhosphoserineBy similarity1
Modified residuei294Phosphoserine2 Publications1
Modified residuei428PhosphoserineCombined sources1
Modified residuei438Phosphothreonine1 Publication1
Modified residuei511PhosphoserineCombined sources1 Publication1
Modified residuei517PhosphothreonineCombined sources1
Modified residuei519Phosphothreonine1 Publication1
Isoform 21 Publication (identifier: Q9UBF8-2)
Modified residuei294PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UBF8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UBF8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UBF8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBF8

PeptideAtlas

More...
PeptideAtlasi
Q9UBF8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBF8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83959 [Q9UBF8-1]
83960 [Q9UBF8-2]
83961 [Q9UBF8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBF8

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9UBF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143393 Expressed in 230 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBF8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022071
HPA006280
HPA006281

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535).

Interacts with NCS1/FREQ in a calcium-independent manner.

Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity).

Interacts with ACBD3 (PubMed:27009356, PubMed:27989622, PubMed:23572552).

Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552).

Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (PubMed:28289207).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111316, 22 interactors

Database of interacting proteins

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DIPi
DIP-42267N

Protein interaction database and analysis system

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IntActi
Q9UBF8, 12 interactors

Molecular INTeraction database

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MINTi
Q9UBF8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357869

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UBF8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1816
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBF8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 242PIK helicalPROSITE-ProRule annotationAdd BLAST214
Domaini558 – 765PI3K/PI4KPROSITE-ProRule annotationCuratedAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 68Interaction with ACBD31 PublicationAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0903 Eukaryota
ENOG410XPH3 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00550000074892

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBF8

KEGG Orthology (KO)

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KOi
K19801

Database of Orthologous Groups

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OrthoDBi
1147978at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBF8

TreeFam database of animal gene trees

More...
TreeFami
TF102042

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR015433 PI_Kinase

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9UBF8-1) [UniParc]FASTAAdd to basket
Also known as: NPIK-B1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK
60 70 80 90 100
ACQEVLEKVK LLHGGVAVSS RGTPLELVNG DGVDSEIRCL DDPPAQIREE
110 120 130 140 150
EDEMGAAVAS GTAKGARRRR QNNSAKQSWL LRLFESKLFD ISMAISYLYN
160 170 180 190 200
SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL NMYIHMDEDV GDAIKPYIVH
210 220 230 240 250
RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI LSDELKPAHR
260 270 280 290 300
KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN
310 320 330 340 350
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ
360 370 380 390 400
RLISELSLLN HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY
410 420 430 440 450
VEVLECENFD TTSVPARIPE NRIRSTRSVE NLPECGITHE QRAGSFSTVP
460 470 480 490 500
NYDNDDEAWS VDDIGELQVE LPEVHTNSCD NISQFSVDSI TSQESKEPVF
510 520 530 540 550
IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK VRRIREGSPY
560 570 580 590 600
GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI
610 620 630 640 650
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ
660 670 680 690 700
RNFVQSCAGY CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN
710 720 730 740 750
LGFETSAFKL TTEFVDVMGG LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI
760 770 780 790 800
VEIMQQGSQL PCFHGSSTIR NLKERFHMSM TEEQLQLLVE QMVDGSMRSI
810
TTKLYDGFQY LTNGIM
Length:816
Mass (Da):91,379
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAD8791729BB4308
GO
Isoform 21 Publication (identifier: Q9UBF8-2) [UniParc]FASTAAdd to basket
Also known as: NPIK-C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     304-318: Missing.

Show »
Length:801
Mass (Da):89,807
Checksum:i22E1ABA37AA9A2BD
GO
Isoform 3 (identifier: Q9UBF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Show »
Length:484
Mass (Da):54,976
Checksum:i395A9DF64FC58A8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1S8A0A0B4J1S8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
828Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVV8A6PVV8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCW3H0YCW3_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F8H0Y4F8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSL0A0A0A0MSL0_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W860F8W860_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL47E9PL47_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA21661 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW53450 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti216L → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti339L → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti340A → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti370P → S in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti446F → S in BAG57793 (PubMed:14702039).Curated1
Sequence conflicti754M → L in BAG57793 (PubMed:14702039).Curated1
Sequence conflicti796S → G in BAG57793 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371331 – 332Missing in isoform 3. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_050627304 – 318Missing in isoform 2. 3 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ011121 mRNA Translation: CAA09495.1
AJ011122 mRNA No translation available.
AJ011123 mRNA Translation: CAA09496.1
AB005910 mRNA Translation: BAA21661.1 Different initiation.
U81802 mRNA Translation: AAC51156.1
AK294606 mRNA Translation: BAG57793.1
AL391069 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53449.1
CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems.
BC000029 mRNA Translation: AAH00029.1
BC040300 mRNA Translation: AAH40300.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55637.1 [Q9UBF8-3]
CCDS55638.1 [Q9UBF8-2]
CCDS81376.1 [Q9UBF8-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC5706

NCBI Reference Sequences

More...
RefSeqi
NP_001185702.1, NM_001198773.2 [Q9UBF8-2]
NP_001185703.1, NM_001198774.1 [Q9UBF8-2]
NP_001185704.1, NM_001198775.2 [Q9UBF8-3]
NP_001317650.1, NM_001330721.1 [Q9UBF8-1]
NP_002642.1, NM_002651.3
XP_016856979.1, XM_017001490.1
XP_016856980.1, XM_017001491.1
XP_016856981.1, XM_017001492.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5298

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5298

UCSC genome browser

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UCSCi
uc001ext.4 human [Q9UBF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011121 mRNA Translation: CAA09495.1
AJ011122 mRNA No translation available.
AJ011123 mRNA Translation: CAA09496.1
AB005910 mRNA Translation: BAA21661.1 Different initiation.
U81802 mRNA Translation: AAC51156.1
AK294606 mRNA Translation: BAG57793.1
AL391069 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53449.1
CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems.
BC000029 mRNA Translation: AAH00029.1
BC040300 mRNA Translation: AAH40300.1
CCDSiCCDS55637.1 [Q9UBF8-3]
CCDS55638.1 [Q9UBF8-2]
CCDS81376.1 [Q9UBF8-1]
PIRiJC5706
RefSeqiNP_001185702.1, NM_001198773.2 [Q9UBF8-2]
NP_001185703.1, NM_001198774.1 [Q9UBF8-2]
NP_001185704.1, NM_001198775.2 [Q9UBF8-3]
NP_001317650.1, NM_001330721.1 [Q9UBF8-1]
NP_002642.1, NM_002651.3
XP_016856979.1, XM_017001490.1
XP_016856980.1, XM_017001491.1
XP_016856981.1, XM_017001492.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N73NMR-B1-68[»]
4D0LX-ray2.94A/C/E121-799[»]
4D0MX-ray6.00A/C/G/I/M/O/Q/S/W/Y/c/g121-799[»]
4WAEX-ray3.32A128-799[»]
4WAGX-ray3.41A128-799[»]
5C46X-ray2.65E121-799[»]
5C4GX-ray3.20E121-799[»]
5EUQX-ray3.20E121-248[»]
E523-799[»]
5FBLX-ray3.37A128-799[»]
5FBQX-ray3.79A128-799[»]
5FBRX-ray3.28A128-799[»]
5FBVX-ray3.29A128-799[»]
5FBWX-ray3.49A128-799[»]
5LX2X-ray2.58B292-297[»]
5NASX-ray2.08C/D289-297[»]
6GL3X-ray2.77A/B317-428[»]
A/B532-798[»]
SMRiQ9UBF8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111316, 22 interactors
DIPiDIP-42267N
IntActiQ9UBF8, 12 interactors
MINTiQ9UBF8
STRINGi9606.ENSP00000357869

Chemistry databases

BindingDBiQ9UBF8
ChEMBLiCHEMBL3268
GuidetoPHARMACOLOGYi2149
SwissLipidsiSLP:000001947 [Q9UBF8-2]

PTM databases

iPTMnetiQ9UBF8
PhosphoSitePlusiQ9UBF8

Polymorphism and mutation databases

BioMutaiPI4KB
DMDMi38372507

Proteomic databases

EPDiQ9UBF8
jPOSTiQ9UBF8
MaxQBiQ9UBF8
PaxDbiQ9UBF8
PeptideAtlasiQ9UBF8
PRIDEiQ9UBF8
ProteomicsDBi83959 [Q9UBF8-1]
83960 [Q9UBF8-2]
83961 [Q9UBF8-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5298
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5298
KEGGihsa:5298
UCSCiuc001ext.4 human [Q9UBF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5298
DisGeNETi5298

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PI4KB
HGNCiHGNC:8984 PI4KB
HPAiCAB022071
HPA006280
HPA006281
MIMi602758 gene
neXtProtiNX_Q9UBF8
OpenTargetsiENSG00000143393
PharmGKBiPA162399420

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0903 Eukaryota
ENOG410XPH3 LUCA
GeneTreeiENSGT00550000074892
InParanoidiQ9UBF8
KOiK19801
OrthoDBi1147978at2759
PhylomeDBiQ9UBF8
TreeFamiTF102042

Enzyme and pathway databases

BioCyciMetaCyc:HS07046-MONOMER
BRENDAi2.7.1.67 2681
ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane
SIGNORiQ9UBF8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PI4KB human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PI4KB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5298
PMAP-CutDBiQ9UBF8

Protein Ontology

More...
PROi
PR:Q9UBF8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143393 Expressed in 230 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ9UBF8 baseline and differential
GenevisibleiQ9UBF8 HS

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR015433 PI_Kinase
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM00146 PI3Kc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI4KB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBF8
Secondary accession number(s): B4DGI2
, O15096, P78405, Q5VWB9, Q5VWC0, Q5VWC1, Q9BWR6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 2000
Last modified: July 31, 2019
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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