UniProtKB - Q9UBF8 (PI4KB_HUMAN)
Phosphatidylinositol 4-kinase beta
PI4KB
Functioni
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
By similarity4 Publications(Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260).
Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).
3 Publications(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
1 PublicationCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H+2 PublicationsEC:2.7.1.672 PublicationsThis reaction proceeds in the forward1 Publication direction.
Cofactori
Activity regulationi
Kineticsi
- KM=1.0 mM for PtdIns1 Publication
- KM=1.0 mM for ATP1 Publication
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- 1-phosphatidylinositol 4-kinase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- phosphatidylinositol kinase activity Source: GO_Central
GO - Biological processi
- lysosome organization Source: MGI
- phosphatidylinositol biosynthetic process Source: Reactome
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol phosphate biosynthetic process Source: GO_Central
- receptor-mediated endocytosis Source: ProtInc
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Host-virus interaction, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.67, 2681 |
PathwayCommonsi | Q9UBF8 |
Reactomei | R-HSA-1660514, Synthesis of PIPs at the Golgi membrane |
SignaLinki | Q9UBF8 |
SIGNORi | Q9UBF8 |
Chemistry databases
SwissLipidsi | SLP:000001947 [Q9UBF8-2] |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 4-kinase betaCurated (EC:2.7.1.672 Publications)Short name: PI4K-beta Short name: PI4Kbeta Short name: PtdIns 4-kinase beta Alternative name(s): NPIK PI4K92 PI4KIII2 Publications |
Gene namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8984, PI4KB |
MIMi | 602758, gene |
neXtProti | NX_Q9UBF8 |
VEuPathDBi | HostDB:ENSG00000143393 |
Subcellular locationi
Mitochondrion
Endoplasmic reticulum
Golgi apparatus
- Golgi apparatus 1 Publication
- Golgi apparatus membrane 3 Publications
Other locations
Note: Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207). GGA2 is also involved in the recruitment (PubMed:28289207).3 Publications
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- rough endoplasmic reticulum membrane Source: UniProtKB-SubCell
Endosome
- endosome Source: ProtInc
Golgi apparatus
- Golgi apparatus Source: MGI
- Golgi membrane Source: UniProtKB
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- membrane Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 40 – 42 | LSV → AAA: Small decrease in C10ORF76-binding. No effect on ACBD3-, nor RAB11B-binding. 1 Publication | 3 | |
Mutagenesisi | 42 | V → A: No loss of interaction with ACBD3. 1 Publication | 1 | |
Mutagenesisi | 43 – 45 | IDP → AAA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication | 3 | |
Mutagenesisi | 43 | I → A: Loss of interaction with ACBD3. 2 Publications | 1 | |
Mutagenesisi | 44 | D → A: Loss of interaction with ACBD3. 1 Publication | 1 | |
Mutagenesisi | 46 – 47 | EV → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication | 2 | |
Mutagenesisi | 47 | V → A: No loss of interaction with ACBD3. 1 Publication | 1 | |
Mutagenesisi | 49 – 50 | QK → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication | 2 | |
Mutagenesisi | 52 | C → A: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication | 1 | |
Mutagenesisi | 53 – 54 | QE → AA: Drastically decreased C10ORF76- and RAB11B-binding. 6-fold increase in ACBD3-binding. 1 Publication | 2 | |
Mutagenesisi | 55 – 56 | VL → AA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication | 2 | |
Mutagenesisi | 55 | V → A: Loss of interaction with ACBD3. 1 Publication | 1 | |
Mutagenesisi | 56 | L → A: Loss of interaction with ACBD3. 1 Publication | 1 | |
Mutagenesisi | 57 – 59 | EKV → AAA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 5298 |
OpenTargetsi | ENSG00000143393 |
PharmGKBi | PA162399420 |
Miscellaneous databases
Pharosi | Q9UBF8, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3268 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9UBF8 |
GuidetoPHARMACOLOGYi | 2149 |
Genetic variation databases
BioMutai | PI4KB |
DMDMi | 38372507 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000088829 | 2 – 816 | Phosphatidylinositol 4-kinase betaAdd BLAST | 815 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylglycine1 Publication | 1 | ||
Modified residuei | 258 | PhosphoserineCombined sources1 Publication | 1 | ||
Modified residuei | 263 | Phosphothreonine1 Publication | 1 | ||
Modified residuei | 266 | PhosphoserineCombined sources1 Publication | 1 | ||
Modified residuei | 275 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 277 | PhosphoserineCombined sources1 Publication | 1 | ||
Modified residuei | 284 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 294 | Phosphoserine2 Publications | 1 | ||
Modified residuei | 428 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 438 | Phosphothreonine1 Publication | 1 | ||
Modified residuei | 511 | PhosphoserineCombined sources1 Publication | 1 | ||
Modified residuei | 517 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 519 | Phosphothreonine1 Publication | 1 | ||
Isoform 21 Publication (identifier: Q9UBF8-2) | |||||
Modified residuei | 294 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9UBF8 |
jPOSTi | Q9UBF8 |
MassIVEi | Q9UBF8 |
MaxQBi | Q9UBF8 |
PaxDbi | Q9UBF8 |
PeptideAtlasi | Q9UBF8 |
PRIDEi | Q9UBF8 |
ProteomicsDBi | 83959 [Q9UBF8-1] 83960 [Q9UBF8-2] 83961 [Q9UBF8-3] |
PTM databases
GlyGeni | Q9UBF8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UBF8 |
PhosphoSitePlusi | Q9UBF8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000143393, Expressed in left lobe of thyroid gland and 242 other tissues |
ExpressionAtlasi | Q9UBF8, baseline and differential |
Genevisiblei | Q9UBF8, HS |
Organism-specific databases
HPAi | ENSG00000143393, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535).
Interacts with NCS1/FREQ in a calcium-independent manner.
Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity).
Interacts with ACBD3 (PubMed:23572552, PubMed:27009356, PubMed:27989622, PubMed:22124328, PubMed:22258260).
Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552).
Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (PubMed:28289207).
Interacts with ATG9A (PubMed:30917996).
By similarity8 Publications(Microbial infection) Interacts with Aichi virus protein 3A.
Part of a complex Aichi virus protein 3A/ACBD3/PI4KB that allows the synthesis of PI4P at the viral RNA replication sites.
3 PublicationsBinary interactionsi
Q9UBF8
Isoform 2 [Q9UBF8-2]
With | #Exp. | IntAct |
---|---|---|
RAB11A [P62491] | 5 | EBI-16107849,EBI-745098 |
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111316, 45 interactors |
DIPi | DIP-42267N |
IntActi | Q9UBF8, 27 interactors |
MINTi | Q9UBF8 |
STRINGi | 9606.ENSP00000357869 |
Chemistry databases
BindingDBi | Q9UBF8 |
Miscellaneous databases
RNActi | Q9UBF8, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9UBF8 |
SMRi | Q9UBF8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 242 | PIK helicalPROSITE-ProRule annotationAdd BLAST | 214 | |
Domaini | 535 – 801 | PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST | 267 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 41 – 67 | Interaction with ACBD31 Publication2 PublicationsAdd BLAST | 27 | |
Regioni | 101 – 120 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 248 – 318 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 541 – 547 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 668 – 676 | Catalytic loopPROSITE-ProRule annotation | 9 | |
Regioni | 687 – 711 | Activation loopPROSITE-ProRule annotationAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 277 – 294 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0903, Eukaryota |
GeneTreei | ENSGT00550000074892 |
InParanoidi | Q9UBF8 |
OMAi | GNKMFSF |
OrthoDBi | 1147978at2759 |
PhylomeDBi | Q9UBF8 |
TreeFami | TF102042 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR001263, PI3K_accessory_dom IPR015433, PI_Kinase |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit |
SMARTi | View protein in SMART SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51545, PIK_HELICAL, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK
60 70 80 90 100
ACQEVLEKVK LLHGGVAVSS RGTPLELVNG DGVDSEIRCL DDPPAQIREE
110 120 130 140 150
EDEMGAAVAS GTAKGARRRR QNNSAKQSWL LRLFESKLFD ISMAISYLYN
160 170 180 190 200
SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL NMYIHMDEDV GDAIKPYIVH
210 220 230 240 250
RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI LSDELKPAHR
260 270 280 290 300
KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN
310 320 330 340 350
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ
360 370 380 390 400
RLISELSLLN HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY
410 420 430 440 450
VEVLECENFD TTSVPARIPE NRIRSTRSVE NLPECGITHE QRAGSFSTVP
460 470 480 490 500
NYDNDDEAWS VDDIGELQVE LPEVHTNSCD NISQFSVDSI TSQESKEPVF
510 520 530 540 550
IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK VRRIREGSPY
560 570 580 590 600
GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI
610 620 630 640 650
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ
660 670 680 690 700
RNFVQSCAGY CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN
710 720 730 740 750
LGFETSAFKL TTEFVDVMGG LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI
760 770 780 790 800
VEIMQQGSQL PCFHGSSTIR NLKERFHMSM TEEQLQLLVE QMVDGSMRSI
810
TTKLYDGFQY LTNGIM
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J1S8 | A0A0B4J1S8_HUMAN | Phosphatidylinositol 4-kinase beta | PI4KB | 828 | Annotation score: | ||
A6PVV8 | A6PVV8_HUMAN | Phosphatidylinositol 4-kinase beta | PI4KB | 227 | Annotation score: | ||
H0YCW3 | H0YCW3_HUMAN | Phosphatidylinositol 4-kinase beta | PI4KB | 183 | Annotation score: | ||
H0Y4F8 | H0Y4F8_HUMAN | Phosphatidylinositol 4-kinase beta | PI4KB | 73 | Annotation score: | ||
A0A0A0MSL0 | A0A0A0MSL0_HUMAN | Phosphatidylinositol 4-kinase beta | PI4KB | 280 | Annotation score: | ||
E9PL47 | E9PL47_HUMAN | Phosphatidylinositol 4-kinase beta | PI4KB | 95 | Annotation score: | ||
F8W860 | F8W860_HUMAN | Phosphatidylinositol 4-kinase beta | PI4KB | 191 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | L → V in AAC51156 (PubMed:9020160).Curated | 1 | |
Sequence conflicti | 339 | L → V in AAC51156 (PubMed:9020160).Curated | 1 | |
Sequence conflicti | 340 | A → V in AAC51156 (PubMed:9020160).Curated | 1 | |
Sequence conflicti | 370 | P → S in AAC51156 (PubMed:9020160).Curated | 1 | |
Sequence conflicti | 446 | F → S in BAG57793 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 754 | M → L in BAG57793 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 796 | S → G in BAG57793 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037133 | 1 – 332 | Missing in isoform 3. 1 PublicationAdd BLAST | 332 | |
Alternative sequenceiVSP_050627 | 304 – 318 | Missing in isoform 2. 3 PublicationsAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ011121 mRNA Translation: CAA09495.1 AJ011122 mRNA No translation available. AJ011123 mRNA Translation: CAA09496.1 AB005910 mRNA Translation: BAA21661.1 Different initiation. U81802 mRNA Translation: AAC51156.1 AK294606 mRNA Translation: BAG57793.1 AL391069 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53449.1 CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems. BC000029 mRNA Translation: AAH00029.1 BC040300 mRNA Translation: AAH40300.1 |
CCDSi | CCDS55637.1 [Q9UBF8-3] CCDS55638.1 [Q9UBF8-2] CCDS81376.1 [Q9UBF8-1] |
PIRi | JC5706 |
RefSeqi | NP_001185702.1, NM_001198773.2 [Q9UBF8-2] NP_001185703.1, NM_001198774.1 [Q9UBF8-2] NP_001185704.1, NM_001198775.2 [Q9UBF8-3] NP_001317650.1, NM_001330721.1 [Q9UBF8-1] NP_002642.1, NM_002651.3 XP_016856979.1, XM_017001490.1 XP_016856980.1, XM_017001491.1 XP_016856981.1, XM_017001492.1 |
Genome annotation databases
Ensembli | ENST00000368872.5; ENSP00000357866.1; ENSG00000143393.17 [Q9UBF8-2] ENST00000368873.6; ENSP00000357867.1; ENSG00000143393.17 ENST00000368874.8; ENSP00000357868.4; ENSG00000143393.17 [Q9UBF8-2] ENST00000529142.5; ENSP00000433149.1; ENSG00000143393.17 [Q9UBF8-3] |
GeneIDi | 5298 |
KEGGi | hsa:5298 |
MANE-Selecti | ENST00000368873.6; ENSP00000357867.1; NM_001369623.2; NP_001356552.1 |
UCSCi | uc001ext.4, human [Q9UBF8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ011121 mRNA Translation: CAA09495.1 AJ011122 mRNA No translation available. AJ011123 mRNA Translation: CAA09496.1 AB005910 mRNA Translation: BAA21661.1 Different initiation. U81802 mRNA Translation: AAC51156.1 AK294606 mRNA Translation: BAG57793.1 AL391069 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53449.1 CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems. BC000029 mRNA Translation: AAH00029.1 BC040300 mRNA Translation: AAH40300.1 |
CCDSi | CCDS55637.1 [Q9UBF8-3] CCDS55638.1 [Q9UBF8-2] CCDS81376.1 [Q9UBF8-1] |
PIRi | JC5706 |
RefSeqi | NP_001185702.1, NM_001198773.2 [Q9UBF8-2] NP_001185703.1, NM_001198774.1 [Q9UBF8-2] NP_001185704.1, NM_001198775.2 [Q9UBF8-3] NP_001317650.1, NM_001330721.1 [Q9UBF8-1] NP_002642.1, NM_002651.3 XP_016856979.1, XM_017001490.1 XP_016856980.1, XM_017001491.1 XP_016856981.1, XM_017001492.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2N73 | NMR | - | B | 1-68 | [»] | |
4D0L | X-ray | 2.94 | A/C/E | 121-799 | [»] | |
4D0M | X-ray | 6.00 | A/C/G/I/M/O/Q/S/W/Y/c/g | 121-799 | [»] | |
4WAE | X-ray | 3.32 | A | 128-799 | [»] | |
4WAG | X-ray | 3.41 | A | 128-799 | [»] | |
5C46 | X-ray | 2.65 | E | 121-799 | [»] | |
5C4G | X-ray | 3.20 | E | 121-799 | [»] | |
5EUQ | X-ray | 3.20 | E | 121-248 | [»] | |
E | 523-799 | [»] | ||||
5FBL | X-ray | 3.37 | A | 128-799 | [»] | |
5FBQ | X-ray | 3.79 | A | 128-799 | [»] | |
5FBR | X-ray | 3.28 | A | 128-799 | [»] | |
5FBV | X-ray | 3.29 | A | 128-799 | [»] | |
5FBW | X-ray | 3.49 | A | 128-799 | [»] | |
5LX2 | X-ray | 2.58 | B | 292-297 | [»] | |
5NAS | X-ray | 2.08 | C/D | 289-297 | [»] | |
6GL3 | X-ray | 2.77 | A/B | 317-428 | [»] | |
A/B | 532-798 | [»] | ||||
AlphaFoldDBi | Q9UBF8 | |||||
SMRi | Q9UBF8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111316, 45 interactors |
DIPi | DIP-42267N |
IntActi | Q9UBF8, 27 interactors |
MINTi | Q9UBF8 |
STRINGi | 9606.ENSP00000357869 |
Chemistry databases
BindingDBi | Q9UBF8 |
ChEMBLi | CHEMBL3268 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9UBF8 |
GuidetoPHARMACOLOGYi | 2149 |
SwissLipidsi | SLP:000001947 [Q9UBF8-2] |
PTM databases
GlyGeni | Q9UBF8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UBF8 |
PhosphoSitePlusi | Q9UBF8 |
Genetic variation databases
BioMutai | PI4KB |
DMDMi | 38372507 |
Proteomic databases
EPDi | Q9UBF8 |
jPOSTi | Q9UBF8 |
MassIVEi | Q9UBF8 |
MaxQBi | Q9UBF8 |
PaxDbi | Q9UBF8 |
PeptideAtlasi | Q9UBF8 |
PRIDEi | Q9UBF8 |
ProteomicsDBi | 83959 [Q9UBF8-1] 83960 [Q9UBF8-2] 83961 [Q9UBF8-3] |
Protocols and materials databases
Antibodypediai | 1666, 133 antibodies from 29 providers |
DNASUi | 5298 |
Genome annotation databases
Ensembli | ENST00000368872.5; ENSP00000357866.1; ENSG00000143393.17 [Q9UBF8-2] ENST00000368873.6; ENSP00000357867.1; ENSG00000143393.17 ENST00000368874.8; ENSP00000357868.4; ENSG00000143393.17 [Q9UBF8-2] ENST00000529142.5; ENSP00000433149.1; ENSG00000143393.17 [Q9UBF8-3] |
GeneIDi | 5298 |
KEGGi | hsa:5298 |
MANE-Selecti | ENST00000368873.6; ENSP00000357867.1; NM_001369623.2; NP_001356552.1 |
UCSCi | uc001ext.4, human [Q9UBF8-1] |
Organism-specific databases
CTDi | 5298 |
DisGeNETi | 5298 |
GeneCardsi | PI4KB |
HGNCi | HGNC:8984, PI4KB |
HPAi | ENSG00000143393, Low tissue specificity |
MIMi | 602758, gene |
neXtProti | NX_Q9UBF8 |
OpenTargetsi | ENSG00000143393 |
PharmGKBi | PA162399420 |
VEuPathDBi | HostDB:ENSG00000143393 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0903, Eukaryota |
GeneTreei | ENSGT00550000074892 |
InParanoidi | Q9UBF8 |
OMAi | GNKMFSF |
OrthoDBi | 1147978at2759 |
PhylomeDBi | Q9UBF8 |
TreeFami | TF102042 |
Enzyme and pathway databases
BRENDAi | 2.7.1.67, 2681 |
PathwayCommonsi | Q9UBF8 |
Reactomei | R-HSA-1660514, Synthesis of PIPs at the Golgi membrane |
SignaLinki | Q9UBF8 |
SIGNORi | Q9UBF8 |
Miscellaneous databases
BioGRID-ORCSi | 5298, 179 hits in 1083 CRISPR screens |
ChiTaRSi | PI4KB, human |
GeneWikii | PI4KB |
GenomeRNAii | 5298 |
Pharosi | Q9UBF8, Tchem |
PROi | PR:Q9UBF8 |
RNActi | Q9UBF8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143393, Expressed in left lobe of thyroid gland and 242 other tissues |
ExpressionAtlasi | Q9UBF8, baseline and differential |
Genevisiblei | Q9UBF8, HS |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR001263, PI3K_accessory_dom IPR015433, PI_Kinase |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit |
SMARTi | View protein in SMART SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51545, PIK_HELICAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PI4KB_HUMAN | |
Accessioni | Q9UBF8Primary (citable) accession number: Q9UBF8 Secondary accession number(s): B4DGI2 Q9BWR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families