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UniProtKB - Q9UBF8 (PI4KB_HUMAN)

Entry version 180 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

Phosphatidylinositol 4-kinase beta

Gene

PI4KB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).By similarity3 Publications
(Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity).By similarity
(Microbial infection) Activated by Aichi virus protein 3A, this activation is sensitized by ACBD3.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS07046-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.67 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660514 Synthesis of PIPs at the Golgi membrane

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UBF8

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001947 [Q9UBF8-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase betaCurated (EC:2.7.1.67)
Short name:
PI4K-beta
Short name:
PI4Kbeta
Short name:
PtdIns 4-kinase beta
Alternative name(s):
NPIK
PI4K92
PI4KIII2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PI4KBImported
Synonyms:PIK4CB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000143393.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:8984 PI4KB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602758 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UBF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40 – 42LSV → AAA: Small decrease in C10ORF76-binding. No effect on ACBD3-, nor RAB11B-binding. 1 Publication3
Mutagenesisi42V → A: No loss of interaction with ACBD3. 1 Publication1
Mutagenesisi43 – 45IDP → AAA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication3
Mutagenesisi43I → A: Loss of interaction with ACBD3. 2 Publications1
Mutagenesisi44D → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi46 – 47EV → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi47V → A: No loss of interaction with ACBD3. 1 Publication1
Mutagenesisi49 – 50QK → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi52C → A: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication1
Mutagenesisi53 – 54QE → AA: Drastically decreased C10ORF76- and RAB11B-binding. 6-fold increase in ACBD3-binding. 1 Publication2
Mutagenesisi55 – 56VL → AA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi55V → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi56L → A: Loss of interaction with ACBD3. 1 Publication1
Mutagenesisi57 – 59EKV → AAA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		5298

Open Targets

More...OpenTargetsi		ENSG00000143393

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162399420

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UBF8 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3268

Drug and drug target database

More...DrugBanki		DB12010 Fostamatinib

DrugCentral

More...DrugCentrali		Q9UBF8

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2149

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PI4KB

Domain mapping of disease mutations (DMDM)

More...DMDMi		38372507

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888292 – 816Phosphatidylinositol 4-kinase betaAdd BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei258PhosphoserineCombined sources1 Publication1
Modified residuei263Phosphothreonine1 Publication1
Modified residuei266PhosphoserineCombined sources1 Publication1
Modified residuei275PhosphoserineBy similarity1
Modified residuei277PhosphoserineCombined sources1 Publication1
Modified residuei284PhosphoserineBy similarity1
Modified residuei294Phosphoserine2 Publications1
Modified residuei428PhosphoserineCombined sources1
Modified residuei438Phosphothreonine1 Publication1
Modified residuei511PhosphoserineCombined sources1 Publication1
Modified residuei517PhosphothreonineCombined sources1
Modified residuei519Phosphothreonine1 Publication1
Isoform 21 Publication (identifier: Q9UBF8-2)
Modified residuei294PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UBF8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UBF8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UBF8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UBF8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UBF8

PeptideAtlas

More...PeptideAtlasi		Q9UBF8

PRoteomics IDEntifications database

More...PRIDEi		Q9UBF8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83959 [Q9UBF8-1]
83960 [Q9UBF8-2]
83961 [Q9UBF8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UBF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UBF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143393 Expressed in left lobe of thyroid gland and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UBF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UBF8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143393 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535).

Interacts with NCS1/FREQ in a calcium-independent manner.

Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity).

Interacts with ACBD3 (PubMed:23572552, PubMed:27009356, PubMed:27989622, PubMed:22124328, PubMed:22258260).

Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552).

Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (PubMed:28289207).

By similarity7 Publications

(Microbial infection) Interacts with Aichi virus protein 3A.

Part of a complex Aichi virus protein 3A/ACBD3/PI4KB that allows the synthesis of PI4P at the viral RNA replication sites.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111316, 23 interactors

Database of interacting proteins

More...DIPi		DIP-42267N

Protein interaction database and analysis system

More...IntActi		Q9UBF8, 25 interactors

Molecular INTeraction database

More...MINTi		Q9UBF8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357869

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9UBF8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UBF8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1816
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UBF8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 242PIK helicalPROSITE-ProRule annotationAdd BLAST214
Domaini558 – 765PI3K/PI4KPROSITE-ProRule annotationCuratedAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 67Interaction with ACBD31 Publication2 PublicationsAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0903 Eukaryota
ENOG410XPH3 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074892

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UBF8

KEGG Orthology (KO)

More...KOi		K19801

Database of Orthologous Groups

More...OrthoDBi		1147978at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UBF8

TreeFam database of animal gene trees

More...TreeFami		TF102042

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR015433 PI_Kinase

The PANTHER Classification System

More...PANTHERi		PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9UBF8-1) [UniParc]FASTAAdd to basket
Also known as: NPIK-B1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK 
        60         70         80         90        100
ACQEVLEKVK LLHGGVAVSS RGTPLELVNG DGVDSEIRCL DDPPAQIREE 
       110        120        130        140        150
EDEMGAAVAS GTAKGARRRR QNNSAKQSWL LRLFESKLFD ISMAISYLYN 
       160        170        180        190        200
SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL NMYIHMDEDV GDAIKPYIVH 
       210        220        230        240        250
RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI LSDELKPAHR 
       260        270        280        290        300
KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN 
       310        320        330        340        350
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ 
       360        370        380        390        400
RLISELSLLN HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY 
       410        420        430        440        450
VEVLECENFD TTSVPARIPE NRIRSTRSVE NLPECGITHE QRAGSFSTVP 
       460        470        480        490        500
NYDNDDEAWS VDDIGELQVE LPEVHTNSCD NISQFSVDSI TSQESKEPVF 
       510        520        530        540        550
IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK VRRIREGSPY 
       560        570        580        590        600
GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI 
       610        620        630        640        650
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ 
       660        670        680        690        700
RNFVQSCAGY CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN 
       710        720        730        740        750
LGFETSAFKL TTEFVDVMGG LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI 
       760        770        780        790        800
VEIMQQGSQL PCFHGSSTIR NLKERFHMSM TEEQLQLLVE QMVDGSMRSI 
       810 
TTKLYDGFQY LTNGIM
Length:816
Mass (Da):91,379
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAD8791729BB4308
GO
Isoform 21 Publication (identifier: Q9UBF8-2) [UniParc]FASTAAdd to basket
Also known as: NPIK-C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     304-318: Missing.

Show »
Length:801
Mass (Da):89,807
Checksum:i22E1ABA37AA9A2BD
GO
Isoform 3 (identifier: Q9UBF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Show »
Length:484
Mass (Da):54,976
Checksum:i395A9DF64FC58A8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1S8A0A0B4J1S8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
828Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCW3H0YCW3_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVV8A6PVV8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F8H0Y4F8_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSL0A0A0A0MSL0_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W860F8W860_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL47E9PL47_HUMAN
Phosphatidylinositol 4-kinase beta
PI4KB
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA21661 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence EAW53450 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti216L → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti339L → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti340A → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti370P → S in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti446F → S in BAG57793 (PubMed:14702039).Curated1
Sequence conflicti754M → L in BAG57793 (PubMed:14702039).Curated1
Sequence conflicti796S → G in BAG57793 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371331 – 332Missing in isoform 3. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_050627304 – 318Missing in isoform 2. 3 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ011121 mRNA Translation: CAA09495.1
AJ011122 mRNA No translation available.
AJ011123 mRNA Translation: CAA09496.1
AB005910 mRNA Translation: BAA21661.1 Different initiation.
U81802 mRNA Translation: AAC51156.1
AK294606 mRNA Translation: BAG57793.1
AL391069 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53449.1
CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems.
BC000029 mRNA Translation: AAH00029.1
BC040300 mRNA Translation: AAH40300.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55637.1 [Q9UBF8-3]
CCDS55638.1 [Q9UBF8-2]
CCDS81376.1 [Q9UBF8-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5706

NCBI Reference Sequences

More...RefSeqi		NP_001185702.1, NM_001198773.2 [Q9UBF8-2]
NP_001185703.1, NM_001198774.1 [Q9UBF8-2]
NP_001185704.1, NM_001198775.2 [Q9UBF8-3]
NP_001317650.1, NM_001330721.1 [Q9UBF8-1]
NP_002642.1, NM_002651.3
XP_016856979.1, XM_017001490.1
XP_016856980.1, XM_017001491.1
XP_016856981.1, XM_017001492.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5298

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5298

UCSC genome browser

More...UCSCi		uc001ext.4 human [Q9UBF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011121 mRNA Translation: CAA09495.1
AJ011122 mRNA No translation available.
AJ011123 mRNA Translation: CAA09496.1
AB005910 mRNA Translation: BAA21661.1 Different initiation.
U81802 mRNA Translation: AAC51156.1
AK294606 mRNA Translation: BAG57793.1
AL391069 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53449.1
CH471121 Genomic DNA Translation: EAW53450.1 Sequence problems.
BC000029 mRNA Translation: AAH00029.1
BC040300 mRNA Translation: AAH40300.1
CCDSiCCDS55637.1 [Q9UBF8-3]
CCDS55638.1 [Q9UBF8-2]
CCDS81376.1 [Q9UBF8-1]
PIRiJC5706
RefSeqiNP_001185702.1, NM_001198773.2 [Q9UBF8-2]
NP_001185703.1, NM_001198774.1 [Q9UBF8-2]
NP_001185704.1, NM_001198775.2 [Q9UBF8-3]
NP_001317650.1, NM_001330721.1 [Q9UBF8-1]
NP_002642.1, NM_002651.3
XP_016856979.1, XM_017001490.1
XP_016856980.1, XM_017001491.1
XP_016856981.1, XM_017001492.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N73NMR-B1-68[»]
4D0LX-ray2.94A/C/E121-799[»]
4D0MX-ray6.00A/C/G/I/M/O/Q/S/W/Y/c/g121-799[»]
4WAEX-ray3.32A128-799[»]
4WAGX-ray3.41A128-799[»]
5C46X-ray2.65E121-799[»]
5C4GX-ray3.20E121-799[»]
5EUQX-ray3.20E121-248[»]
E523-799[»]
5FBLX-ray3.37A128-799[»]
5FBQX-ray3.79A128-799[»]
5FBRX-ray3.28A128-799[»]
5FBVX-ray3.29A128-799[»]
5FBWX-ray3.49A128-799[»]
5LX2X-ray2.58B292-297[»]
5NASX-ray2.08C/D289-297[»]
6GL3X-ray2.77A/B317-428[»]
A/B532-798[»]
SMRiQ9UBF8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111316, 23 interactors
DIPiDIP-42267N
IntActiQ9UBF8, 25 interactors
MINTiQ9UBF8
STRINGi9606.ENSP00000357869

Chemistry databases

BindingDBiQ9UBF8
ChEMBLiCHEMBL3268
DrugBankiDB12010 Fostamatinib
DrugCentraliQ9UBF8
GuidetoPHARMACOLOGYi2149
SwissLipidsiSLP:000001947 [Q9UBF8-2]

PTM databases

iPTMnetiQ9UBF8
PhosphoSitePlusiQ9UBF8

Polymorphism and mutation databases

BioMutaiPI4KB
DMDMi38372507

Proteomic databases

EPDiQ9UBF8
jPOSTiQ9UBF8
MassIVEiQ9UBF8
MaxQBiQ9UBF8
PaxDbiQ9UBF8
PeptideAtlasiQ9UBF8
PRIDEiQ9UBF8
ProteomicsDBi83959 [Q9UBF8-1]
83960 [Q9UBF8-2]
83961 [Q9UBF8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1666 128 antibodies

The DNASU plasmid repository

More...DNASUi		5298

Genome annotation databases

GeneIDi5298
KEGGihsa:5298
UCSCiuc001ext.4 human [Q9UBF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5298
DisGeNETi5298
EuPathDBiHostDB:ENSG00000143393.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		PI4KB
HGNCiHGNC:8984 PI4KB
HPAiENSG00000143393 Low tissue specificity
MIMi602758 gene
neXtProtiNX_Q9UBF8
OpenTargetsiENSG00000143393
PharmGKBiPA162399420

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0903 Eukaryota
ENOG410XPH3 LUCA
GeneTreeiENSGT00550000074892
InParanoidiQ9UBF8
KOiK19801
OrthoDBi1147978at2759
PhylomeDBiQ9UBF8
TreeFamiTF102042

Enzyme and pathway databases

BioCyciMetaCyc:HS07046-MONOMER
BRENDAi2.7.1.67 2681
ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane
SIGNORiQ9UBF8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5298 153 hits in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PI4KB human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PI4KB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5298
PharosiQ9UBF8 Tchem

Protein Ontology

More...PROi		PR:Q9UBF8
RNActiQ9UBF8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143393 Expressed in left lobe of thyroid gland and 229 other tissues
ExpressionAtlasiQ9UBF8 baseline and differential
GenevisibleiQ9UBF8 HS

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR015433 PI_Kinase
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM00146 PI3Kc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI4KB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBF8
Secondary accession number(s): B4DGI2
, O15096, P78405, Q5VWB9, Q5VWC0, Q5VWC1, Q9BWR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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