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Protein

Coatomer subunit gamma-2

Gene

COPG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: Reactome
  • intracellular protein transport Source: InterPro
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-2
Alternative name(s):
Gamma-2-coat protein
Short name:
Gamma-2-COP
Gene namesi
Name:COPG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000158623.14
HGNCiHGNC:2237 COPG2
MIMi604355 gene
neXtProtiNX_Q9UBF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26958
OpenTargetsiENSG00000158623
PharmGKBiPA26753

Polymorphism and mutation databases

BioMutaiCOPG2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938621 – 871Coatomer subunit gamma-2Add BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBF2
MaxQBiQ9UBF2
PaxDbiQ9UBF2
PeptideAtlasiQ9UBF2
PRIDEiQ9UBF2
ProteomicsDBi83955

PTM databases

iPTMnetiQ9UBF2
PhosphoSitePlusiQ9UBF2

Expressioni

Gene expression databases

BgeeiENSG00000158623
CleanExiHS_COPG2
ExpressionAtlasiQ9UBF2 baseline and differential
GenevisibleiQ9UBF2 HS

Organism-specific databases

HPAiHPA045712

Interactioni

Subunit structurei

Oligomeric complex. Binds to CDC42. Interacts with JAGN1.1 Publication

Protein-protein interaction databases

BioGridi117926, 38 interactors
IntActiQ9UBF2, 17 interactors
MINTiQ9UBF2
STRINGi9606.ENSP00000393912

Structurei

3D structure databases

ProteinModelPortaliQ9UBF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 101HEAT 1Add BLAST38
Repeati283 – 320HEAT 2Add BLAST38
Repeati321 – 355HEAT 3Add BLAST35
Repeati356 – 392HEAT 4Add BLAST37
Repeati395 – 430HEAT 5Add BLAST36
Repeati467 – 504HEAT 6Add BLAST38

Sequence similaritiesi

Belongs to the COPG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1078 Eukaryota
COG5240 LUCA
GeneTreeiENSGT00390000016313
HOVERGENiHBG004368
InParanoidiQ9UBF2
KOiK17267
OMAiSYEVLCC
OrthoDBiEOG091G0HWQ
PhylomeDBiQ9UBF2

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1480, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR032154 Coatomer_g_Cpla
IPR017106 Coatomer_gsu
IPR013040 Coatomer_gsu_app_Ig-like_dom
IPR037067 Coatomer_gsu_app_sf
IPR012295 TBP_dom_sf
PANTHERiPTHR10261 PTHR10261, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF16381 Coatomer_g_Cpla, 1 hit
PF08752 COP-gamma_platf, 1 hit
PIRSFiPIRSF037093 Coatomer_gamma_subunit, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK
60 70 80 90 100
ILYLLNQGEH FGTTEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE
110 120 130 140 150
DVIIVTSSLT KDMTGKEDVY RGPAIRALCR ITDGTMLQAI ERYMKQAIVD
160 170 180 190 200
KVSSVSSSAL VSSLHMMKIS YDVVKRWINE AQEAASSDNI MVQYHALGVL
210 220 230 240 250
YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL KETEDGHESP
260 270 280 290 300
LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK
310 320 330 340 350
PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK
360 370 380 390 400
TGSESSVDRL MKQISSFVSE ISDEFKVVVV QAISALCQKY PRKHSVMMTF
410 420 430 440 450
LSNMLRDDGG FEYKRAIVDC IISIVEENPE SKEAGLAHLC EFIEDCEHTV
460 470 480 490 500
LATKILHLLG KEGPRTPVPS KYIRFIFNRV VLENEAVRAA AVSALAKFGA
510 520 530 540 550
QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM ALNATYIFNG
560 570 580 590 600
LTVSVPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK AEITLVATKP
610 620 630 640 650
EKLAPSRQDI FQEQLAAIPE FLNIGPLFKS SEPVQLTEAE TEYFVRCIKH
660 670 680 690 700
MFTNHIVFQF DCTNTLNDQL LEKVTVQMEP SDSYEVLSCI PAPSLPYNQP
710 720 730 740 750
GICYTLVRLP DDDPTAVAGS FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL
760 770 780 790 800
EDLEVTVSDH IQKVLKPNFA AAWEEVGDTF EKEETFALSS TKTLEEAVNN
810 820 830 840 850
IITFLGMQPC ERSDKVPENK NSHSLYLAGI FRGGYDLLVR SRLALADGVT
860 870
MQVTVRSKER TPVDVILASV G
Length:871
Mass (Da):97,622
Last modified:May 1, 2000 - v1
Checksum:iD361A0E74069CBEB
GO
Isoform 2 (identifier: Q9UBF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     717-726: VAGSFSCTMK → GTNPQKGGDT
     727-871: Missing.

Note: No experimental confirmation available.
Show »
Length:726
Mass (Da):81,483
Checksum:i808D4BC052AE37D6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060181547I → L. Corresponds to variant dbSNP:rs10128Ensembl.1
Natural variantiVAR_060182626P → L. Corresponds to variant dbSNP:rs17333054Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055534717 – 726VAGSFSCTMK → GTNPQKGGDT in isoform 2. 1 Publication10
Alternative sequenceiVSP_055535727 – 871Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207598 mRNA Translation: AAF19433.1
AF157833 mRNA Translation: AAF14271.1
AB047847 mRNA Translation: BAB17658.1
AK291409 mRNA Translation: BAF84098.1
AC090520 Genomic DNA No translation available.
AC009274 Genomic DNA No translation available.
AC007938 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24085.1
CH471070 Genomic DNA Translation: EAW83769.1
BC017443 mRNA Translation: AAH17443.2
BC110796 mRNA Translation: AAI10797.1
CCDSiCCDS75662.1 [Q9UBF2-1]
CCDS78275.1 [Q9UBF2-2]
RefSeqiNP_001276962.1, NM_001290033.1 [Q9UBF2-2]
NP_036265.3, NM_012133.5 [Q9UBF2-1]
UniGeneiHs.6421

Genome annotation databases

EnsembliENST00000330992; ENSP00000331218; ENSG00000158623 [Q9UBF2-2]
ENST00000425248; ENSP00000402346; ENSG00000158623 [Q9UBF2-1]
GeneIDi26958
KEGGihsa:26958
UCSCiuc033ahl.2 human [Q9UBF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOPG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBF2
Secondary accession number(s): A6NH74
, Q2NLA0, Q54AC3, Q8WVW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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