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UniProtKB - Q9UBE0 (SAE1_HUMAN)

Entry version 187 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

SUMO-activating enzyme subunit 1

Gene

SAE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UBE0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3065676, SUMO is conjugated to E1 (UBA2:SAE1)
R-HSA-3065678, SUMO is transferred from E1 to E2 (UBE2I, UBC9)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00886

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SUMO-activating enzyme subunit 1
Alternative name(s):
Ubiquitin-like 1-activating enzyme E1A
Cleaved into the following chain:
SUMO-activating enzyme subunit 1, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAE1
Synonyms:AOS1, SUA1, UBLE1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30660, SAE1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613294, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UBE0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142230.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21R → A: Abolishes ATP-dependent activation of SUMO proteins. 1 Publication1
Mutagenesisi24 – 26RLW → AAA: Abolishes ATP-dependent activation of SUMO proteins. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		10055

Open Targets

More...OpenTargetsi		ENSG00000142230

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162402387

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UBE0, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1615388

DrugCentral

More...DrugCentrali		Q9UBE0

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SAE1

Domain mapping of disease mutations (DMDM)

More...DMDMi		42559897

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949661 – 346SUMO-activating enzyme subunit 1Add BLAST346
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00004232902 – 346SUMO-activating enzyme subunit 1, N-terminally processedAdd BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylvaline; in SUMO-activating enzyme subunit 1, N-terminally processedCombined sources1 Publication1
Modified residuei12PhosphoserineCombined sources1
Modified residuei198N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UBE0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UBE0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UBE0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UBE0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UBE0

PeptideAtlas

More...PeptideAtlasi		Q9UBE0

PRoteomics IDEntifications database

More...PRIDEi		Q9UBE0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24559
33772
83952 [Q9UBE0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UBE0

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UBE0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UBE0

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UBE0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression level increases during S phase and drops in G2 phase (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142230, Expressed in ventricular zone and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UBE0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UBE0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142230, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1.

Interacts with UBE2I.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115366, 86 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2161, SUMO activating enzyme complex
CPX-3042, activated SUMO1-E1 ligase complex
CPX-3044, activated SUMO2-E1 ligase complex
CPX-3045, activated SUMO3-E1 ligase complex
CPX-3076, activated SUMO4-E1 ligase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UBE0

Database of interacting proteins

More...DIPi		DIP-34587N

Protein interaction database and analysis system

More...IntActi		Q9UBE0, 37 interactors

Molecular INTeraction database

More...MINTi		Q9UBE0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000270225

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9UBE0

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UBE0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UBE0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UBE0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2014, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075007

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UBE0

Identification of Orthologs from Complete Genome Data

More...OMAi		MEAPHRN

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UBE0

TreeFam database of animal gene trees

More...TreeFami		TF315037

Family and domain databases

Database of protein disorder

More...DisProti		DP00485

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00397

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000594, ThiF_NAD_FAD-bd
IPR035985, Ubiquitin-activating_enz
IPR000011, UBQ/SUMO-activ_enz_E1-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00899, ThiF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01849, UBIQUITINACT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF69572, SSF69572, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE 
        60         70         80         90        100
IAKNLILAGV KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ 
       110        120        130        140        150
NLNPMVDVKV DTEDIEKKPE SFFTQFDAVC LTCCSRDVIV KVDQICHKNS 
       160        170        180        190        200
IKFFTGDVFG YHGYTFANLG EHEFVEEKTK VAKVSQGVED GPDTKRAKLD 
       210        220        230        240        250
SSETTMVKKK VVFCPVKEAL EVDWSSEKAK AALKRTTSDY FLLQVLLKFR 
       260        270        280        290        300
TDKGRDPSSD TYEEDSELLL QIRNDVLDSL GISPDLLPED FVRYCFSEMA 
       310        320        330        340 
PVCAVVGGIL AQEIVKALSQ RDPPHNNFFF FDGMKGNGIV ECLGPK
Length:346
Mass (Da):38,450
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2B10A69FF2ED746
GO
Isoform 2 (identifier: Q9UBE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-266: VLLKFRTDKGRDPSSDTYEEDS → GTASPRWPQCVRWLEGFWHRKL
     267-346: Missing.

Show »
Length:266
Mass (Da):29,811
Checksum:i058AD8B9B2A2EEBB
GO
Isoform 3 (identifier: Q9UBE0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-299: VLLKFRTDKG...DFVRYCFSEM → GPVSAGPSSQ...PTCIPCPLPS
     300-346: Missing.

Show »
Length:299
Mass (Da):33,063
Checksum:i35D1828B2957CCBA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX65M0QX65_HUMAN
SUMO-activating enzyme subunit 1
SAE1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZS6M0QZS6_HUMAN
SUMO-activating enzyme subunit 1
SAE1
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYM8M0QYM8_HUMAN
SUMO-activating enzyme subunit 1
SAE1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R054M0R054_HUMAN
SUMO-activating enzyme subunit 1
SAE1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R286M0R286_HUMAN
SUMO-activating enzyme subunit 1
SAE1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK93A0A590UK93_HUMAN
SUMO-activating enzyme subunit 1
SAE1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KNJ4B3KNJ4_HUMAN
SUMO-1 activating enzyme subunit 1,...
SAE1 hCG_20373
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UKC5A0A590UKC5_HUMAN
SUMO-activating enzyme subunit 1
SAE1
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYP2M0QYP2_HUMAN
SUMO-activating enzyme subunit 1
SAE1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R375M0R375_HUMAN
SUMO-activating enzyme subunit 1
SAE1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115I → M in BAG51064 (Ref. 6) Curated1
Sequence conflicti158V → A in AAF29104 (PubMed:11042152).Curated1
Sequence conflicti178 – 180KTK → ETD in AAF29104 (PubMed:11042152).Curated3
Sequence conflicti186Q → H in AAF29104 (PubMed:11042152).Curated1
Sequence conflicti273R → G in AAD12785 (PubMed:9920803).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045372245 – 299VLLKF…CFSEM → GPVSAGPSSQQLLLLRWHEG EWDCGVPWPQVNSRFGSPRD ANCSMPTCIPCPLPS in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_045373245 – 266VLLKF…YEEDS → GTASPRWPQCVRWLEGFWHR KL in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_045374267 – 346Missing in isoform 2. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_045375300 – 346Missing in isoform 3. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF090385 mRNA Translation: AAD12785.2
AF046025 mRNA Translation: AAD23902.2
AF110956 mRNA Translation: AAD24433.1
AF161489 mRNA Translation: AAF29104.1
AL560234 mRNA No translation available.
BT007290 mRNA Translation: AAP35954.1
AK021978 mRNA Translation: BAG51064.1
AK315624 mRNA Translation: BAG37992.1
AC008532 Genomic DNA No translation available.
AC008755 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57461.1
CH471126 Genomic DNA Translation: EAW57463.1
BC000344 mRNA Translation: AAH00344.1
BC003611 mRNA Translation: AAH03611.1
BC018271 mRNA Translation: AAH18271.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12696.1 [Q9UBE0-1]
CCDS54284.1 [Q9UBE0-2]
CCDS54285.1 [Q9UBE0-3]

NCBI Reference Sequences

More...RefSeqi		NP_001139185.1, NM_001145713.1 [Q9UBE0-3]
NP_001139186.1, NM_001145714.1 [Q9UBE0-2]
NP_005491.1, NM_005500.2 [Q9UBE0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000270225; ENSP00000270225; ENSG00000142230 [Q9UBE0-1]
ENST00000392776; ENSP00000440818; ENSG00000142230 [Q9UBE0-2]
ENST00000413379; ENSP00000416557; ENSG00000142230 [Q9UBE0-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10055

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10055

UCSC genome browser

More...UCSCi		uc002pgc.4, human [Q9UBE0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090385 mRNA Translation: AAD12785.2
AF046025 mRNA Translation: AAD23902.2
AF110956 mRNA Translation: AAD24433.1
AF161489 mRNA Translation: AAF29104.1
AL560234 mRNA No translation available.
BT007290 mRNA Translation: AAP35954.1
AK021978 mRNA Translation: BAG51064.1
AK315624 mRNA Translation: BAG37992.1
AC008532 Genomic DNA No translation available.
AC008755 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57461.1
CH471126 Genomic DNA Translation: EAW57463.1
BC000344 mRNA Translation: AAH00344.1
BC003611 mRNA Translation: AAH03611.1
BC018271 mRNA Translation: AAH18271.1
CCDSiCCDS12696.1 [Q9UBE0-1]
CCDS54284.1 [Q9UBE0-2]
CCDS54285.1 [Q9UBE0-3]
RefSeqiNP_001139185.1, NM_001145713.1 [Q9UBE0-3]
NP_001139186.1, NM_001145714.1 [Q9UBE0-2]
NP_005491.1, NM_005500.2 [Q9UBE0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y8QX-ray2.25A/C1-346[»]
1Y8RX-ray2.75A/D1-346[»]
3KYCX-ray2.45A1-346[»]
3KYDX-ray2.61A1-346[»]
6CWYX-ray2.46C1-346[»]
6CWZX-ray3.10C1-346[»]
SMRiQ9UBE0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115366, 86 interactors
ComplexPortaliCPX-2161, SUMO activating enzyme complex
CPX-3042, activated SUMO1-E1 ligase complex
CPX-3044, activated SUMO2-E1 ligase complex
CPX-3045, activated SUMO3-E1 ligase complex
CPX-3076, activated SUMO4-E1 ligase complex
CORUMiQ9UBE0
DIPiDIP-34587N
IntActiQ9UBE0, 37 interactors
MINTiQ9UBE0
STRINGi9606.ENSP00000270225

Chemistry databases

BindingDBiQ9UBE0
ChEMBLiCHEMBL1615388
DrugCentraliQ9UBE0

PTM databases

iPTMnetiQ9UBE0
MetOSiteiQ9UBE0
PhosphoSitePlusiQ9UBE0
SwissPalmiQ9UBE0

Genetic variation databases

BioMutaiSAE1
DMDMi42559897

Proteomic databases

EPDiQ9UBE0
jPOSTiQ9UBE0
MassIVEiQ9UBE0
MaxQBiQ9UBE0
PaxDbiQ9UBE0
PeptideAtlasiQ9UBE0
PRIDEiQ9UBE0
ProteomicsDBi24559
33772
83952 [Q9UBE0-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18168, 526 antibodies

The DNASU plasmid repository

More...DNASUi		10055

Genome annotation databases

EnsembliENST00000270225; ENSP00000270225; ENSG00000142230 [Q9UBE0-1]
ENST00000392776; ENSP00000440818; ENSG00000142230 [Q9UBE0-2]
ENST00000413379; ENSP00000416557; ENSG00000142230 [Q9UBE0-3]
GeneIDi10055
KEGGihsa:10055
UCSCiuc002pgc.4, human [Q9UBE0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10055
DisGeNETi10055

GeneCards: human genes, protein and diseases

More...GeneCardsi		SAE1
HGNCiHGNC:30660, SAE1
HPAiENSG00000142230, Low tissue specificity
MIMi613294, gene
neXtProtiNX_Q9UBE0
OpenTargetsiENSG00000142230
PharmGKBiPA162402387
VEuPathDBiHostDB:ENSG00000142230.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2014, Eukaryota
GeneTreeiENSGT00550000075007
InParanoidiQ9UBE0
OMAiMEAPHRN
PhylomeDBiQ9UBE0
TreeFamiTF315037

Enzyme and pathway databases

UniPathwayiUPA00886
PathwayCommonsiQ9UBE0
ReactomeiR-HSA-3065676, SUMO is conjugated to E1 (UBA2:SAE1)
R-HSA-3065678, SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10055, 712 hits in 1010 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SAE1, human
EvolutionaryTraceiQ9UBE0

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SAE1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10055
PharosiQ9UBE0, Tbio

Protein Ontology

More...PROi		PR:Q9UBE0
RNActiQ9UBE0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142230, Expressed in ventricular zone and 236 other tissues
ExpressionAtlasiQ9UBE0, baseline and differential
GenevisibleiQ9UBE0, HS

Family and domain databases

DisProtiDP00485
IDEALiIID00397
InterProiView protein in InterPro
IPR000594, ThiF_NAD_FAD-bd
IPR035985, Ubiquitin-activating_enz
IPR000011, UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF00899, ThiF, 1 hit
PRINTSiPR01849, UBIQUITINACT
SUPFAMiSSF69572, SSF69572, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBE0
Secondary accession number(s): B2RDP5
, B3KMQ2, F5GXX7, G3XAK6, O95717, Q9P020
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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