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Protein

Ammonium transporter Rh type C

Gene

RHCG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.4 Publications

GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: UniProtKB
  • ankyrin binding Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processAmmonia transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-444411 Rhesus glycoproteins mediate ammonium transport

Protein family/group databases

TCDBi1.A.11.4.1 the ammonium transporter channel (amt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type C
Alternative name(s):
Rh glycoprotein kidney
Rhesus blood group family type C glycoprotein
Short name:
Rh family type C glycoprotein
Short name:
Rh type C glycoprotein
Tumor-related protein DRC2
Gene namesi
Name:RHCG
Synonyms:C15orf6, CDRC2, PDRC2, RHGK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140519.12
HGNCiHGNC:18140 RHCG
MIMi605381 gene
neXtProtiNX_Q9UBD6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 60ExtracellularSequence analysisAdd BLAST30
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 85CytoplasmicSequence analysis4
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 123ExtracellularSequence analysisAdd BLAST17
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 148CytoplasmicSequence analysis4
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 177ExtracellularSequence analysis8
Transmembranei178 – 200HelicalSequence analysisAdd BLAST23
Topological domaini201 – 218CytoplasmicSequence analysisAdd BLAST18
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 250ExtracellularSequence analysisAdd BLAST11
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 281CytoplasmicSequence analysis10
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303ExtracellularSequence analysis1
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 345CytoplasmicSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 394ExtracellularSequence analysisAdd BLAST28
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 479CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74F → L: Reduction of ammonia transport. 1 Publication1
Mutagenesisi137V → I: Reduction of ammonia transport. 1 Publication1
Mutagenesisi177D → N: Loss of function. 1 Publication1
Mutagenesisi235F → V: Reduction of ammonia transport. 1 Publication1

Organism-specific databases

DisGeNETi51458
OpenTargetsiENSG00000140519
PharmGKBiPA134876043

Chemistry databases

DrugBankiDB09326 Ammonia N-13

Polymorphism and mutation databases

BioMutaiRHCG
DMDMi74734928

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002835771 – 479Ammonium transporter Rh type CAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UBD6
PeptideAtlasiQ9UBD6
PRIDEiQ9UBD6
ProteomicsDBi83949

PTM databases

iPTMnetiQ9UBD6
PhosphoSitePlusiQ9UBD6

Expressioni

Tissue specificityi

Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.3 Publications

Developmental stagei

Specifically expressed in fetal kidney.1 Publication

Gene expression databases

BgeeiENSG00000140519 Expressed in 116 organ(s), highest expression level in ectocervix
CleanExiHS_RHCG
ExpressionAtlasiQ9UBD6 baseline and differential
GenevisibleiQ9UBD6 HS

Organism-specific databases

HPAiHPA041874
HPA043317

Interactioni

Subunit structurei

Homotrimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15853497,EBI-15853497

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119552, 1 interactor
DIPiDIP-59334N
IntActiQ9UBD6, 15 interactors
STRINGi9606.ENSP00000268122

Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UBD6
SMRiQ9UBD6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UBD6

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796 Eukaryota
ENOG410XTF8 LUCA
GeneTreeiENSGT00390000005787
HOGENOMiHOG000007656
HOVERGENiHBG004374
InParanoidiQ9UBD6
KOiK06580
OMAiDLENEFY
OrthoDBiEOG091G06KX
PhylomeDBiQ9UBD6
TreeFamiTF314450

Family and domain databases

Gene3Di1.10.3430.10, 1 hit
InterProiView protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR024041 NH4_transpt_AmtB-like_dom
IPR002229 RhesusRHD
PfamiView protein in Pfam
PF00909 Ammonium_transp, 1 hit
PRINTSiPR00342 RHESUSRHD

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

Q9UBD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWNTNLRWR LPLTCLLLQV IMVILFGVFV RYDFEADAHW WSERTHKNLS
60 70 80 90 100
DMENEFYYRY PSFQDVHVMV FVGFGFLMTF LQRYGFSAVG FNFLLAAFGI
110 120 130 140 150
QWALLMQGWF HFLQDRYIVV GVENLINADF CVASVCVAFG AVLGKVSPIQ
160 170 180 190 200
LLIMTFFQVT LFAVNEFILL NLLKVKDAGG SMTIHTFGAY FGLTVTRILY
210 220 230 240 250
RRNLEQSKER QNSVYQSDLF AMIGTLFLWM YWPSFNSAIS YHGDSQHRAA
260 270 280 290 300
INTYCSLAAC VLTSVAISSA LHKKGKLDMV HIQNATLAGG VAVGTAAEMM
310 320 330 340 350
LMPYGALIIG FVCGIISTLG FVYLTPFLES RLHIQDTCGI NNLHGIPGII
360 370 380 390 400
GGIVGAVTAA SASLEVYGKE GLVHSFDFQG FNGDWTARTQ GKFQIYGLLV
410 420 430 440 450
TLAMALMGGI IVGLILRLPF WGQPSDENCF EDAVYWEMPE GNSTVYIPED
460 470
PTFKPSGPSV PSVPMVSPLP MASSVPLVP
Length:479
Mass (Da):53,179
Last modified:May 1, 2000 - v1
Checksum:iE5D8024D720D4589
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMF8H0YMF8_HUMAN
Ammonium transporter Rh type C
RHCG hCG_28640
331Annotation score:
H0YKQ3H0YKQ3_HUMAN
Ammonium transporter Rh type C
RHCG
233Annotation score:
H0YMS1H0YMS1_HUMAN
Ammonium transporter Rh type C
RHCG
136Annotation score:
H0YM79H0YM79_HUMAN
Ammonium transporter Rh type C
RHCG
237Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242H → R in AAP81044 (Ref. 6) Curated1
Sequence conflicti442N → D in AAP81044 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031496202R → C. Corresponds to variant dbSNP:rs17807723Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193809 mRNA Translation: AAF19372.1
AF219986
, AF219981, AF219982, AF219983, AF219984, AF219985 Genomic DNA Translation: AAG02171.1
AF081497 mRNA Translation: AAD55748.1
AF284446 Genomic DNA Translation: AAG02414.1
AY257182 mRNA Translation: AAP81044.1
AK290899 mRNA Translation: BAF83588.1
AK313238 mRNA Translation: BAG36049.1
AC013391 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02051.1
BC030965 mRNA Translation: AAH30965.1
CCDSiCCDS10351.1
RefSeqiNP_001307970.1, NM_001321041.1
NP_057405.1, NM_016321.2
UniGeneiHs.459284

Genome annotation databases

EnsembliENST00000268122; ENSP00000268122; ENSG00000140519
GeneIDi51458
KEGGihsa:51458
UCSCiuc002bnz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRHCG_HUMAN
AccessioniPrimary (citable) accession number: Q9UBD6
Secondary accession number(s): A8K4D4, Q6X3Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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