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Protein

Small proline-rich protein 3

Gene

SPRR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes.

GO - Molecular functioni

  • structural molecule activity Source: GO_Central

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: UniProtKB
  • keratinocyte differentiation Source: GO_Central
  • peptide cross-linking Source: GO_Central
  • wound healing Source: UniProtKB

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 3
Alternative name(s):
22 kDa pancornulin
Cornifin beta
Esophagin
Gene namesi
Name:SPRR3
Synonyms:SPRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163209.14
HGNCiHGNC:11268 SPRR3
MIMi182271 gene
neXtProtiNX_Q9UBC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6707
OpenTargetsiENSG00000163209
PharmGKBiPA36097

Polymorphism and mutation databases

BioMutaiSPRR3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001500032 – 169Small proline-rich protein 3Add BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UBC9
MaxQBiQ9UBC9
PaxDbiQ9UBC9
PeptideAtlasiQ9UBC9
PRIDEiQ9UBC9
ProteomicsDBi83944

PTM databases

iPTMnetiQ9UBC9
PhosphoSitePlusiQ9UBC9

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiENSG00000163209 Expressed in 119 organ(s), highest expression level in vagina
CleanExiHS_SPRR3
ExpressionAtlasiQ9UBC9 baseline and differential
GenevisibleiQ9UBC9 HS

Interactioni

Protein-protein interaction databases

BioGridi112585, 8 interactors
STRINGi9606.ENSP00000295367

Structurei

3D structure databases

ProteinModelPortaliQ9UBC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 5018
Repeati51 – 5828
Repeati59 – 6638
Repeati67 – 7448
Repeati75 – 8258
Repeati83 – 9068
Repeati91 – 9878
Repeati99 – 10688
Repeati107 – 11498
Repeati115 – 122108
Repeati123 – 130118
Repeati131 – 138128
Repeati139 – 146138
Repeati147 – 154148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 15414 X 8 AA approximate tandem repeatsAdd BLAST112

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KDVU Eukaryota
ENOG410Y7EH LUCA
GeneTreeiENSGT00730000111065
HOVERGENiHBG079213
InParanoidiQ9UBC9
OMAiYTTIPGP
OrthoDBiEOG091G0YCF
PhylomeDBiQ9UBC9
TreeFamiTF338205

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UBC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN
60 70 80 90 100
TKIPEPGCTK VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK
110 120 130 140 150
VPEPGYTKVP EPGSIKVPDQ GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP
160
EPCPSTVTPG PAQQKTKQK
Length:169
Mass (Da):18,154
Last modified:February 11, 2002 - v2
Checksum:iB8E522AF798F1ECB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AN48B1AN48_HUMAN
Small proline-rich protein 3
SPRR3
158Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19Q → H in AAM74559 (PubMed:8809402).Curated1
Sequence conflicti61 – 68Missing no nucleotide entry (PubMed:8018055).Curated8
Sequence conflicti61 – 68Missing in CAB65098 (PubMed:11230159).Curated8
Sequence conflicti61 – 68Missing in AAH17802 (PubMed:16710414).Curated8

Mass spectrometryi

Molecular mass is 17239 Da from positions 2 - 169. Determined by ESI. Variants Del 98-Cys--Pro-105 and Val-149.1 Publication
Molecular mass is 18065 Da from positions 2 - 169. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06525598 – 105Missing . 8
Natural variantiVAR_023377149L → V3 PublicationsCorresponds to variant dbSNP:rs1055935Ensembl.1
Natural variantiVAR_053048156T → M. Corresponds to variant dbSNP:rs2075740Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077374 Genomic DNA Translation: AAD11938.1
AY118269 mRNA Translation: AAM74559.1
AJ243667 mRNA Translation: CAB65098.1
DQ017955 Genomic DNA Translation: AAY26394.1
AK311823 mRNA Translation: BAG34765.1
EF553525 mRNA Translation: ABQ66270.1
AL356867 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53353.1
CH471121 Genomic DNA Translation: EAW53354.1
BC017802 mRNA Translation: AAH17802.1
CCDSiCCDS1033.1
RefSeqiNP_001091058.1, NM_001097589.1
NP_005407.1, NM_005416.2
UniGeneiHs.139322

Genome annotation databases

EnsembliENST00000295367; ENSP00000295367; ENSG00000163209
ENST00000331860; ENSP00000330391; ENSG00000163209
GeneIDi6707
KEGGihsa:6707
UCSCiuc001fax.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077374 Genomic DNA Translation: AAD11938.1
AY118269 mRNA Translation: AAM74559.1
AJ243667 mRNA Translation: CAB65098.1
DQ017955 Genomic DNA Translation: AAY26394.1
AK311823 mRNA Translation: BAG34765.1
EF553525 mRNA Translation: ABQ66270.1
AL356867 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53353.1
CH471121 Genomic DNA Translation: EAW53354.1
BC017802 mRNA Translation: AAH17802.1
CCDSiCCDS1033.1
RefSeqiNP_001091058.1, NM_001097589.1
NP_005407.1, NM_005416.2
UniGeneiHs.139322

3D structure databases

ProteinModelPortaliQ9UBC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112585, 8 interactors
STRINGi9606.ENSP00000295367

PTM databases

iPTMnetiQ9UBC9
PhosphoSitePlusiQ9UBC9

Polymorphism and mutation databases

BioMutaiSPRR3

Proteomic databases

EPDiQ9UBC9
MaxQBiQ9UBC9
PaxDbiQ9UBC9
PeptideAtlasiQ9UBC9
PRIDEiQ9UBC9
ProteomicsDBi83944

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295367; ENSP00000295367; ENSG00000163209
ENST00000331860; ENSP00000330391; ENSG00000163209
GeneIDi6707
KEGGihsa:6707
UCSCiuc001fax.5 human

Organism-specific databases

CTDi6707
DisGeNETi6707
EuPathDBiHostDB:ENSG00000163209.14
GeneCardsiSPRR3
H-InvDBiHIX0001078
HGNCiHGNC:11268 SPRR3
MIMi182271 gene
neXtProtiNX_Q9UBC9
OpenTargetsiENSG00000163209
PharmGKBiPA36097
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDVU Eukaryota
ENOG410Y7EH LUCA
GeneTreeiENSGT00730000111065
HOVERGENiHBG079213
InParanoidiQ9UBC9
OMAiYTTIPGP
OrthoDBiEOG091G0YCF
PhylomeDBiQ9UBC9
TreeFamiTF338205

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiSPRR3 human
GeneWikiiSPRR3
GenomeRNAii6707
PROiPR:Q9UBC9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163209 Expressed in 119 organ(s), highest expression level in vagina
CleanExiHS_SPRR3
ExpressionAtlasiQ9UBC9 baseline and differential
GenevisibleiQ9UBC9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSPRR3_HUMAN
AccessioniPrimary (citable) accession number: Q9UBC9
Secondary accession number(s): A5YKK8
, B2R4G8, D3DV32, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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