UniProtKB - Q9UBC7 (GALP_HUMAN)
Protein
Galanin-like peptide
Gene
GALP
Organism
Homo sapiens (Human)
Status
Functioni
Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
Isoform 2: Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).1 Publication
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- behavioral response to starvation Source: GO_Central
- defense response to Gram-negative bacterium Source: UniProtKB
- modification of morphology or physiology of other organism Source: UniProtKB
- neuropeptide signaling pathway Source: UniProtKB-KW
- regulation of appetite Source: Ensembl
- response to insulin Source: Ensembl
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Hormone, Neuropeptide |
Enzyme and pathway databases
SIGNORi | Q9UBC7 |
Names & Taxonomyi
Protein namesi | Recommended name: Galanin-like peptide |
Gene namesi | Name:GALP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197487.8 |
HGNCi | HGNC:24840 GALP |
MIMi | 611178 gene |
neXtProti | NX_Q9UBC7 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 85569 |
OpenTargetsi | ENSG00000197487 |
PharmGKBi | PA162389277 |
Polymorphism and mutation databases
BioMutai | GALP |
DMDMi | 20138432 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000010463 | 25 – 84 | Galanin-like peptideAdd BLAST | 60 | |
PropeptideiPRO_0000010464 | 87 – 116 | By similarityAdd BLAST | 30 |
Keywords - PTMi
Cleavage on pair of basic residuesProteomic databases
MaxQBi | Q9UBC7 |
PaxDbi | Q9UBC7 |
PeptideAtlasi | Q9UBC7 |
PRIDEi | Q9UBC7 |
ProteomicsDBi | 83942 83943 [Q9UBC7-2] |
PTM databases
iPTMneti | Q9UBC7 |
PhosphoSitePlusi | Q9UBC7 |
Expressioni
Tissue specificityi
Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.
Gene expression databases
Bgeei | ENSG00000197487 Expressed in 28 organ(s), highest expression level in liver |
Genevisiblei | Q9UBC7 HS |
Organism-specific databases
HPAi | HPA053938 |
Interactioni
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | Q9UBC7, 2 interactors |
STRINGi | 9606.ENSP00000349884 |
Family & Domainsi
Sequence similaritiesi
Belongs to the galanin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410JE0F Eukaryota ENOG4111D06 LUCA |
GeneTreei | ENSGT00390000016349 |
HOGENOMi | HOG000112691 |
HOVERGENi | HBG018628 |
InParanoidi | Q9UBC7 |
OMAi | QMGDQDR |
OrthoDBi | 1502468at2759 |
PhylomeDBi | Q9UBC7 |
TreeFami | TF339481 |
Family and domain databases
InterProi | View protein in InterPro IPR008174 Galanin IPR039244 GALP |
PANTHERi | PTHR20950 PTHR20950, 1 hit |
Pfami | View protein in Pfam PF01296 Galanin, 1 hit |
PROSITEi | View protein in PROSITE PS00861 GALANIN, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9UBC7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAPPSVPLVL LLVLLLSLAE TPASAPAHRG RGGWTLNSAG YLLGPVLHLP
60 70 80 90 100
QMGDQDGKRE TALEILDLWK AIDGLPYSHP PQPSKRNVME TFAKPEIGDL
110
GMLSMKIPKE EDVLKS
Isoform 2 (identifier: Q9UBC7-2) [UniParc]FASTAAdd to basket
Also known as: Alarin, del/E3
The sequence of this isoform differs from the canonical sequence as follows:
30-115: GRGGWTLNSA...KIPKEEDVLK → SSTFPKWVTKTERGRQPLR
Note: Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentiation in neuroblastic tumor tissues. Vasoactive peptide.
Show »Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020426 | 72 | I → M. Corresponds to variant dbSNP:rs3745833Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030460 | 30 – 115 | GRGGW…EDVLK → SSTFPKWVTKTERGRQPLR in isoform 2. 1 PublicationAdd BLAST | 86 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF188492 mRNA Translation: AAF19724.1 AF188493 mRNA Translation: AAF19725.1 AY329637 mRNA Translation: AAQ99038.1 |
CCDSi | CCDS12940.1 [Q9UBC7-1] CCDS46202.1 [Q9UBC7-2] |
RefSeqi | NP_001139018.1, NM_001145546.1 [Q9UBC7-2] NP_149097.1, NM_033106.3 [Q9UBC7-1] |
UniGenei | Hs.283915 |
Genome annotation databases
Ensembli | ENST00000357330; ENSP00000349884; ENSG00000197487 [Q9UBC7-1] ENST00000440823; ENSP00000411521; ENSG00000197487 [Q9UBC7-2] ENST00000590002; ENSP00000464698; ENSG00000197487 [Q9UBC7-2] |
GeneIDi | 85569 |
KEGGi | hsa:85569 |
UCSCi | uc002qmo.1 human [Q9UBC7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF188492 mRNA Translation: AAF19724.1 AF188493 mRNA Translation: AAF19725.1 AY329637 mRNA Translation: AAQ99038.1 |
CCDSi | CCDS12940.1 [Q9UBC7-1] CCDS46202.1 [Q9UBC7-2] |
RefSeqi | NP_001139018.1, NM_001145546.1 [Q9UBC7-2] NP_149097.1, NM_033106.3 [Q9UBC7-1] |
UniGenei | Hs.283915 |
3D structure databases
ProteinModelPortali | Q9UBC7 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | Q9UBC7, 2 interactors |
STRINGi | 9606.ENSP00000349884 |
PTM databases
iPTMneti | Q9UBC7 |
PhosphoSitePlusi | Q9UBC7 |
Polymorphism and mutation databases
BioMutai | GALP |
DMDMi | 20138432 |
Proteomic databases
MaxQBi | Q9UBC7 |
PaxDbi | Q9UBC7 |
PeptideAtlasi | Q9UBC7 |
PRIDEi | Q9UBC7 |
ProteomicsDBi | 83942 83943 [Q9UBC7-2] |
Protocols and materials databases
DNASUi | 85569 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000357330; ENSP00000349884; ENSG00000197487 [Q9UBC7-1] ENST00000440823; ENSP00000411521; ENSG00000197487 [Q9UBC7-2] ENST00000590002; ENSP00000464698; ENSG00000197487 [Q9UBC7-2] |
GeneIDi | 85569 |
KEGGi | hsa:85569 |
UCSCi | uc002qmo.1 human [Q9UBC7-1] |
Organism-specific databases
CTDi | 85569 |
DisGeNETi | 85569 |
EuPathDBi | HostDB:ENSG00000197487.8 |
GeneCardsi | GALP |
HGNCi | HGNC:24840 GALP |
HPAi | HPA053938 |
MIMi | 611178 gene |
neXtProti | NX_Q9UBC7 |
OpenTargetsi | ENSG00000197487 |
PharmGKBi | PA162389277 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410JE0F Eukaryota ENOG4111D06 LUCA |
GeneTreei | ENSGT00390000016349 |
HOGENOMi | HOG000112691 |
HOVERGENi | HBG018628 |
InParanoidi | Q9UBC7 |
OMAi | QMGDQDR |
OrthoDBi | 1502468at2759 |
PhylomeDBi | Q9UBC7 |
TreeFami | TF339481 |
Enzyme and pathway databases
SIGNORi | Q9UBC7 |
Miscellaneous databases
GenomeRNAii | 85569 |
PROi | PR:Q9UBC7 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197487 Expressed in 28 organ(s), highest expression level in liver |
Genevisiblei | Q9UBC7 HS |
Family and domain databases
InterProi | View protein in InterPro IPR008174 Galanin IPR039244 GALP |
PANTHERi | PTHR20950 PTHR20950, 1 hit |
Pfami | View protein in Pfam PF01296 Galanin, 1 hit |
PROSITEi | View protein in PROSITE PS00861 GALANIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | GALP_HUMAN | |
Accessioni | Q9UBC7Primary (citable) accession number: Q9UBC7 Secondary accession number(s): A1KXL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 13, 2019 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations