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Entry version 197 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

DNA (cytosine-5)-methyltransferase 3B

Gene

DNMT3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398).By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by binding to the regulatory factor DNMT3L.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei605S-adenosyl-L-methionineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei651PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri434 – 464GATA-type; atypicalPROSITE-ProRule annotationAdd BLAST31
Zinc fingeri475 – 531PHD-type; atypicalPROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Methyltransferase, Repressor, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.37 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-5334118 DNA methylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UBC3

Protein family/group databases

Restriction enzymes and methylases database

More...
REBASEi
4120 M.HsaDnmt3B

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 3B (EC:2.1.1.37)
Short name:
Dnmt3b
Alternative name(s):
DNA methyltransferase HsaIIIB
Short name:
DNA MTase HsaIIIB
Short name:
M.HsaIIIB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNMT3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2979 DNMT3B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602900 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBC3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency-centromeric instability-facial anomalies syndrome 1 (ICF1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022579270S → P in ICF1. 1 PublicationCorresponds to variant dbSNP:rs121908947EnsemblClinVar.1
Natural variantiVAR_077528585A → T in ICF1. 1 PublicationCorresponds to variant dbSNP:rs750849178Ensembl.1
Natural variantiVAR_011506585A → V in ICF1. 2 Publications1
Natural variantiVAR_011499603A → T in ICF1. 4 PublicationsCorresponds to variant dbSNP:rs121908943EnsemblClinVar.1
Natural variantiVAR_011507606V → A in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs867732105Ensembl.1
Natural variantiVAR_011500663G → S in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs121908942EnsemblClinVar.1
Natural variantiVAR_022580664L → P in ICF1. 1 Publication1
Natural variantiVAR_011508699V → G in ICF1. 2 Publications1
Natural variantiVAR_011501726V → G in ICF1. 4 PublicationsCorresponds to variant dbSNP:rs121908941Ensembl.1
Natural variantiVAR_011509766A → P in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs1191203668Ensembl.1
Natural variantiVAR_011502806E → ESTP in ICF1. 1
Natural variantiVAR_011510814H → R in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs1219696128Ensembl.1
Natural variantiVAR_011503817D → G in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs121908939EnsemblClinVar.1
Natural variantiVAR_011504818V → M in ICF1. 3 PublicationsCorresponds to variant dbSNP:rs121908940EnsemblClinVar.1
Natural variantiVAR_077530836V → M in ICF1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs866792483Ensembl.1
Natural variantiVAR_022581840R → Q in ICF1. 1 PublicationCorresponds to variant dbSNP:rs121908946EnsemblClinVar.1
Facioscapulohumeral muscular dystrophy 2 (FSHD2)1 Publication
The gene represented in this entry may act as a disease modifier. DNMT3B mutations lead to DUX4 expression in somatic tissues, including muscle cells, when an haplotype on chromosome 4 is permissive for DUX4 expression. Ectopic expression of DUX4 in skeletal muscle activates the expression of stem cell and germline genes, and, when overexpressed in somatic cells, DUX4 can ultimately lead to cell death.
Disease descriptionA degenerative muscle disease characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. The onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with impairment of upper extremity elevation. This tends to be followed by facial weakness, primarily involving the orbicularis oris and orbicularis oculi muscles.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077527527C → R in FSHD2. 1 Publication1
Natural variantiVAR_077529691P → L in FSHD2. 1 PublicationCorresponds to variant dbSNP:rs889145646Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1789

MalaCards human disease database

More...
MalaCardsi
DNMT3B
MIMi158901 phenotype
242860 phenotype

Open Targets

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OpenTargetsi
ENSG00000088305

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2268 ICF syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27446

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBC3

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL6095

DrugCentral

More...
DrugCentrali
Q9UBC3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNMT3B

Domain mapping of disease mutations (DMDM)

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DMDMi
17375667

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000880451 – 853DNA (cytosine-5)-methyltransferase 3BAdd BLAST853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei82PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei96PhosphothreonineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei410CitrullineBy similarity1
Cross-linki617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.1 Publication
Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBC3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UBC3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UBC3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UBC3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBC3

PeptideAtlas

More...
PeptideAtlasi
Q9UBC3

PRoteomics IDEntifications database

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PRIDEi
Q9UBC3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
17089
19210
83935 [Q9UBC3-1]
83936 [Q9UBC3-2]
83937 [Q9UBC3-3]
83938 [Q9UBC3-4]
83939 [Q9UBC3-5]
83940 [Q9UBC3-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000088305 Expressed in 137 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBC3 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB069896
HPA001595

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BAZ2A/TIP5, SUV39H1 and CBX4.

Interacts with UHRF1 (By similarity).

Interacts with DNMT1 and DNMT3A, SETDB1, UBL1, UBE2I9 and ZHX1.

Interacts with the PRC2/EED-EZH2 complex.

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108126, 76 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UBC3

Database of interacting proteins

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DIPi
DIP-30000N

Protein interaction database and analysis system

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IntActi
Q9UBC3, 35 interactors

Molecular INTeraction database

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MINTi
Q9UBC3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000328547

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9UBC3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1853
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBC3

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UBC3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini225 – 283PWWPPROSITE-ProRule annotationAdd BLAST59
Domaini423 – 555ADDPROSITE-ProRule annotationAdd BLAST133
Domaini575 – 853SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST279

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 298Interaction with DNMT1 and DNMT3A1 PublicationAdd BLAST298
Regioni435 – 527Interaction with the PRC2/EED-EZH2 complexBy similarityAdd BLAST93
Regioni582 – 586S-adenosyl-L-methionine bindingBy similarity5
Regioni627 – 629S-adenosyl-L-methionine bindingBy similarity3
Regioni832 – 834S-adenosyl-L-methionine bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PWWP domain is essential for targeting to pericentric heterochromatin.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri434 – 464GATA-type; atypicalPROSITE-ProRule annotationAdd BLAST31
Zinc fingeri475 – 531PHD-type; atypicalPROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGHW Eukaryota
ENOG410XQ4Y LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156928

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230875

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBC3

KEGG Orthology (KO)

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KOi
K17399

Identification of Orthologs from Complete Genome Data

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OMAi
IKPMLDW

Database of Orthologous Groups

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OrthoDBi
539311at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBC3

TreeFam database of animal gene trees

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TreeFami
TF329039

Family and domain databases

Conserved Domains Database

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CDDi
cd11728 ADDz_Dnmt3b, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025766 ADD
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR040552 DNMT3_ADD
IPR030488 DNMT3B_ADD
IPR000313 PWWP_dom
IPR029063 SAM-dependent_MTases
IPR011011 Znf_FYVE_PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17980 ADD_DNMT3, 1 hit
PF00145 DNA_methylase, 1 hit
PF00855 PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00293 PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51533 ADD, 1 hit
PS00094 C5_MTASE_1, 1 hit
PS50812 PWWP, 1 hit
PS51679 SAM_MT_C5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UBC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR
60 70 80 90 100
SSSRLSKREV SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES
110 120 130 140 150
PAVRTRNNNS VSSRERHRPS PRSTRGRQGR NHVDESPVEF PATRSLRRRA
160 170 180 190 200
TASAGTPWPS PPSSYLTIDL TDDTEDTHGT PQSSSTPYAR LAQDSQQGGM
210 220 230 240 250
ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP AMVVSWKATS
260 270 280 290 300
KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK
310 320 330 340 350
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP
360 370 380 390 400
NNTQPVVNKS KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK
410 420 430 440 450
TNCYNNGKDR GDEDQSREQM ASDVANNKSS LEDGCLSCGR KNPVSFHPLF
460 470 480 490 500
EGGLCQTCRD RFLELFYMYD DDGYQSYCTV CCEGRELLLC SNTSCCRCFC
510 520 530 540 550
VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK DWNVRLQAFF
560 570 580 590 600
TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK
610 620 630 640 650
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP
660 670 680 690 700
CNDLSNVNPA RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV
710 720 730 740 750
AMKVGDKRDI SRFLECNPVM IDAIKVSAAH RARYFWGNLP GMNRPVIASK
760 770 780 790 800
NDKLELQDCL EYNRIAKLKK VQTITTKSNS IKQGKNQLFP VVMNGKEDVL
810 820 830 840 850
WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR HLFAPLKDYF

ACE
Length:853
Mass (Da):95,751
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF20A67CF78951532
GO
Isoform 2 (identifier: Q9UBC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-375: Missing.

Show »
Length:833
Mass (Da):93,407
Checksum:iDAD71DB275947261
GO
Isoform 3 (identifier: Q9UBC3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-375: Missing.
     745-807: Missing.

Show »
Length:770
Mass (Da):86,177
Checksum:iE7777E3879B1D93B
GO
Isoform 4 (identifier: Q9UBC3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-375: Missing.
     744-744: R → S
     745-853: Missing.

Show »
Length:724
Mass (Da):80,845
Checksum:i21173ED0988996FC
GO
Isoform 5 (identifier: Q9UBC3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-375: Missing.
     768-853: LKKVQTITTK...APLKDYFACE → DLWLSCALHR...LRPSEGLLCM

Show »
Length:792
Mass (Da):88,572
Checksum:iC6721C7241B9283A
GO
Isoform 6 (identifier: Q9UBC3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEPSPEPPSLESM
     356-375: Missing.

Show »
Length:845
Mass (Da):94,689
Checksum:iCFA82BB96B59EFBF
GO
Isoform 7 (identifier: Q9UBC3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-144: Missing.
     356-375: Missing.
     744-806: Missing.

Note: No experimental confirmation available.
Show »
Length:694
Mass (Da):77,719
Checksum:i6C59147487ABA6DC
GO
Isoform 8 (identifier: Q9UBC3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-144: Missing.
     356-375: Missing.
     744-806: Missing.

Note: No experimental confirmation available.
Show »
Length:728
Mass (Da):81,311
Checksum:iE4465A68EC2334A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti575I → T in BAG61690 (PubMed:14702039).Curated1
Sequence conflicti583G → D in BAG61753 (PubMed:14702039).Curated1
Sequence conflicti655S → P in BAG61690 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03388554R → P. Corresponds to variant dbSNP:rs17123590Ensembl.1
Natural variantiVAR_022579270S → P in ICF1. 1 PublicationCorresponds to variant dbSNP:rs121908947EnsemblClinVar.1
Natural variantiVAR_077527527C → R in FSHD2. 1 Publication1
Natural variantiVAR_077528585A → T in ICF1. 1 PublicationCorresponds to variant dbSNP:rs750849178Ensembl.1
Natural variantiVAR_011506585A → V in ICF1. 2 Publications1
Natural variantiVAR_011499603A → T in ICF1. 4 PublicationsCorresponds to variant dbSNP:rs121908943EnsemblClinVar.1
Natural variantiVAR_011507606V → A in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs867732105Ensembl.1
Natural variantiVAR_011500663G → S in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs121908942EnsemblClinVar.1
Natural variantiVAR_022580664L → P in ICF1. 1 Publication1
Natural variantiVAR_077529691P → L in FSHD2. 1 PublicationCorresponds to variant dbSNP:rs889145646Ensembl.1
Natural variantiVAR_011508699V → G in ICF1. 2 Publications1
Natural variantiVAR_011501726V → G in ICF1. 4 PublicationsCorresponds to variant dbSNP:rs121908941Ensembl.1
Natural variantiVAR_011509766A → P in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs1191203668Ensembl.1
Natural variantiVAR_011502806E → ESTP in ICF1. 1
Natural variantiVAR_011510814H → R in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs1219696128Ensembl.1
Natural variantiVAR_011503817D → G in ICF1. 2 PublicationsCorresponds to variant dbSNP:rs121908939EnsemblClinVar.1
Natural variantiVAR_011504818V → M in ICF1. 3 PublicationsCorresponds to variant dbSNP:rs121908940EnsemblClinVar.1
Natural variantiVAR_077530836V → M in ICF1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs866792483Ensembl.1
Natural variantiVAR_022581840R → Q in ICF1. 1 PublicationCorresponds to variant dbSNP:rs121908946EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0056361M → MEPSPEPPSLESM in isoform 6. 1 Publication1
Alternative sequenceiVSP_04587469 – 144Missing in isoform 7. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_045875103 – 144Missing in isoform 8. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_005637356 – 375Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8. 4 PublicationsAdd BLAST20
Alternative sequenceiVSP_045876744 – 806Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_005639744R → S in isoform 4. 1 Publication1
Alternative sequenceiVSP_005640745 – 853Missing in isoform 4. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_005638745 – 807Missing in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_005641768 – 853LKKVQ…YFACE → DLWLSCALHRRVQHGPWCPP EAAGKVLERACHPTPLRPSE GLLCM in isoform 5. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF156487 mRNA Translation: AAD53062.1
AF156488 mRNA Translation: AAD53063.1
AF176228 mRNA Translation: AAF04015.1
AF331857 mRNA Translation: AAL57040.1
AK299821 mRNA Translation: BAG61690.1
AK299915 mRNA Translation: BAG61753.1
AL035071 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76351.1
CH471077 Genomic DNA Translation: EAW76352.1
CH471077 Genomic DNA Translation: EAW76353.1
CH471077 Genomic DNA Translation: EAW76354.1
CH471077 Genomic DNA Translation: EAW76356.1
AF129267 mRNA Translation: AAD31432.1
AF129268 mRNA Translation: AAD31433.1
AF129269 mRNA Translation: AAD31434.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13204.1 [Q9UBC3-6]
CCDS13205.1 [Q9UBC3-1]
CCDS13206.1 [Q9UBC3-2]
CCDS13207.1 [Q9UBC3-3]
CCDS56183.1 [Q9UBC3-8]
CCDS56184.1 [Q9UBC3-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001193984.1, NM_001207055.1 [Q9UBC3-8]
NP_001193985.1, NM_001207056.1 [Q9UBC3-7]
NP_008823.1, NM_006892.3 [Q9UBC3-1]
NP_787044.1, NM_175848.1 [Q9UBC3-2]
NP_787045.1, NM_175849.1 [Q9UBC3-3]
NP_787046.1, NM_175850.2 [Q9UBC3-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000201963; ENSP00000201963; ENSG00000088305 [Q9UBC3-6]
ENST00000328111; ENSP00000328547; ENSG00000088305 [Q9UBC3-1]
ENST00000348286; ENSP00000337764; ENSG00000088305 [Q9UBC3-3]
ENST00000353855; ENSP00000313397; ENSG00000088305 [Q9UBC3-2]
ENST00000443239; ENSP00000403169; ENSG00000088305 [Q9UBC3-8]
ENST00000456297; ENSP00000412305; ENSG00000088305 [Q9UBC3-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1789

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1789

UCSC genome browser

More...
UCSCi
uc002wyc.3 human [Q9UBC3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

DNMT3Bbase

DNMT3B mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156487 mRNA Translation: AAD53062.1
AF156488 mRNA Translation: AAD53063.1
AF176228 mRNA Translation: AAF04015.1
AF331857 mRNA Translation: AAL57040.1
AK299821 mRNA Translation: BAG61690.1
AK299915 mRNA Translation: BAG61753.1
AL035071 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76351.1
CH471077 Genomic DNA Translation: EAW76352.1
CH471077 Genomic DNA Translation: EAW76353.1
CH471077 Genomic DNA Translation: EAW76354.1
CH471077 Genomic DNA Translation: EAW76356.1
AF129267 mRNA Translation: AAD31432.1
AF129268 mRNA Translation: AAD31433.1
AF129269 mRNA Translation: AAD31434.1
CCDSiCCDS13204.1 [Q9UBC3-6]
CCDS13205.1 [Q9UBC3-1]
CCDS13206.1 [Q9UBC3-2]
CCDS13207.1 [Q9UBC3-3]
CCDS56183.1 [Q9UBC3-8]
CCDS56184.1 [Q9UBC3-7]
RefSeqiNP_001193984.1, NM_001207055.1 [Q9UBC3-8]
NP_001193985.1, NM_001207056.1 [Q9UBC3-7]
NP_008823.1, NM_006892.3 [Q9UBC3-1]
NP_787044.1, NM_175848.1 [Q9UBC3-2]
NP_787045.1, NM_175849.1 [Q9UBC3-3]
NP_787046.1, NM_175850.2 [Q9UBC3-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FLGX-ray1.80A206-355[»]
3QKJX-ray2.04A/B/C/D206-355[»]
5CIUX-ray2.24A/B206-355[»]
5NR3X-ray2.30A/B206-355[»]
5NRRX-ray1.70A/B206-355[»]
5NRSX-ray2.30A/B206-355[»]
5NRVX-ray2.08A/D206-355[»]
5NV0X-ray2.40A/B206-355[»]
5NV2X-ray2.03A/B206-355[»]
5NV7X-ray2.57A/B206-355[»]
5NVOX-ray2.40A/B206-355[»]
SMRiQ9UBC3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108126, 76 interactors
CORUMiQ9UBC3
DIPiDIP-30000N
IntActiQ9UBC3, 35 interactors
MINTiQ9UBC3
STRINGi9606.ENSP00000328547

Chemistry databases

BindingDBiQ9UBC3
ChEMBLiCHEMBL6095
DrugCentraliQ9UBC3

Protein family/group databases

REBASEi4120 M.HsaDnmt3B

PTM databases

iPTMnetiQ9UBC3
PhosphoSitePlusiQ9UBC3

Polymorphism and mutation databases

BioMutaiDNMT3B
DMDMi17375667

Proteomic databases

EPDiQ9UBC3
jPOSTiQ9UBC3
MassIVEiQ9UBC3
MaxQBiQ9UBC3
PaxDbiQ9UBC3
PeptideAtlasiQ9UBC3
PRIDEiQ9UBC3
ProteomicsDBi17089
19210
83935 [Q9UBC3-1]
83936 [Q9UBC3-2]
83937 [Q9UBC3-3]
83938 [Q9UBC3-4]
83939 [Q9UBC3-5]
83940 [Q9UBC3-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1789

Genome annotation databases

EnsembliENST00000201963; ENSP00000201963; ENSG00000088305 [Q9UBC3-6]
ENST00000328111; ENSP00000328547; ENSG00000088305 [Q9UBC3-1]
ENST00000348286; ENSP00000337764; ENSG00000088305 [Q9UBC3-3]
ENST00000353855; ENSP00000313397; ENSG00000088305 [Q9UBC3-2]
ENST00000443239; ENSP00000403169; ENSG00000088305 [Q9UBC3-8]
ENST00000456297; ENSP00000412305; ENSG00000088305 [Q9UBC3-7]
GeneIDi1789
KEGGihsa:1789
UCSCiuc002wyc.3 human [Q9UBC3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1789
DisGeNETi1789

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNMT3B
HGNCiHGNC:2979 DNMT3B
HPAiCAB069896
HPA001595
MalaCardsiDNMT3B
MIMi158901 phenotype
242860 phenotype
602900 gene
neXtProtiNX_Q9UBC3
OpenTargetsiENSG00000088305
Orphaneti2268 ICF syndrome
PharmGKBiPA27446

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGHW Eukaryota
ENOG410XQ4Y LUCA
GeneTreeiENSGT00940000156928
HOGENOMiHOG000230875
InParanoidiQ9UBC3
KOiK17399
OMAiIKPMLDW
OrthoDBi539311at2759
PhylomeDBiQ9UBC3
TreeFamiTF329039

Enzyme and pathway databases

BRENDAi2.1.1.37 2681
ReactomeiR-HSA-212300 PRC2 methylates histones and DNA
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-5334118 DNA methylation
SIGNORiQ9UBC3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNMT3B human
EvolutionaryTraceiQ9UBC3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DNMT3B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1789
PharosiQ9UBC3

Protein Ontology

More...
PROi
PR:Q9UBC3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088305 Expressed in 137 organ(s), highest expression level in secondary oocyte
GenevisibleiQ9UBC3 HS

Family and domain databases

CDDicd11728 ADDz_Dnmt3b, 1 hit
InterProiView protein in InterPro
IPR025766 ADD
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR040552 DNMT3_ADD
IPR030488 DNMT3B_ADD
IPR000313 PWWP_dom
IPR029063 SAM-dependent_MTases
IPR011011 Znf_FYVE_PHD
PfamiView protein in Pfam
PF17980 ADD_DNMT3, 1 hit
PF00145 DNA_methylase, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51533 ADD, 1 hit
PS00094 C5_MTASE_1, 1 hit
PS50812 PWWP, 1 hit
PS51679 SAM_MT_C5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNM3B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBC3
Secondary accession number(s): A2A2E2
, B4DSM8, B4DSU1, E1P5M6, E1P5M7, E7EN63, E9PBF2, Q9UBD4, Q9UJQ5, Q9UKA6, Q9UNE5, Q9Y5R9, Q9Y5S0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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