UniProtKB - Q9UBC2 (EP15R_HUMAN)
Epidermal growth factor receptor substrate 15-like 1
EPS15L1
Functioni
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 172 – 184 | PROSITE-ProRule annotationAdd BLAST | 13 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- calcium ion binding Source: InterPro
GO - Biological processi
- endocytosis Source: GO_Central
- endosomal transport Source: GO_Central
- membrane organization Source: Reactome
- negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Endocytosis |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UBC2 |
Reactomei | R-HSA-182971, EGFR downregulation R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
Protein family/group databases
MoonDBi | Q9UBC2, Curated |
Names & Taxonomyi
Protein namesi | Recommended name: Epidermal growth factor receptor substrate 15-like 1Alternative name(s): Eps15-related protein Short name: Eps15R |
Gene namesi | Name:EPS15L1 Synonyms:EPS15R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127527.13 |
HGNCi | HGNC:24634, EPS15L1 |
neXtProti | NX_Q9UBC2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Other locations
- coated pit By similarity
Note: Localized to plasma membrane coated pits.By similarity
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- clathrin coat of coated pit Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Coated pit, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 58513 |
MalaCardsi | EPS15L1 |
OpenTargetsi | ENSG00000127527 |
Orphaneti | 2440, Isolated split hand-split foot malformation |
PharmGKBi | PA134906266 |
Miscellaneous databases
Pharosi | Q9UBC2, Tbio |
Polymorphism and mutation databases
BioMutai | EPS15L1 |
DMDMi | 61223942 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000146118 | 2 – 864 | Epidermal growth factor receptor substrate 15-like 1Add BLAST | 863 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 74 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 107 | PhosphoserineBy similarity | 1 | |
Modified residuei | 108 | PhosphoserineCombined sources | 1 | |
Modified residuei | 229 | PhosphoserineCombined sources | 1 | |
Modified residuei | 244 | PhosphoserineCombined sources | 1 | |
Modified residuei | 253 | PhosphoserineCombined sources | 1 | |
Modified residuei | 255 | PhosphoserineCombined sources | 1 | |
Modified residuei | 259 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | PhosphoserineBy similarity | 1 | |
Modified residuei | 366 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 371 | PhosphoserineCombined sources | 1 | |
Modified residuei | 374 | PhosphoserineCombined sources | 1 | |
Modified residuei | 377 | PhosphoserineCombined sources | 1 | |
Modified residuei | 560 | PhosphoserineCombined sources | 1 | |
Modified residuei | 564 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 577 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 593 | PhosphoserineCombined sources | 1 | |
Modified residuei | 666 | PhosphoserineCombined sources | 1 | |
Modified residuei | 672 | PhosphoserineCombined sources | 1 | |
Modified residuei | 697 | PhosphoserineCombined sources | 1 | |
Modified residuei | 717 | PhosphoserineCombined sources | 1 | |
Modified residuei | 734 | PhosphoserineCombined sources | 1 | |
Modified residuei | 793 | PhosphoserineCombined sources | 1 | |
Modified residuei | 797 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9UBC2 |
jPOSTi | Q9UBC2 |
MassIVEi | Q9UBC2 |
MaxQBi | Q9UBC2 |
PaxDbi | Q9UBC2 |
PeptideAtlasi | Q9UBC2 |
PRIDEi | Q9UBC2 |
ProteomicsDBi | 466 83933 [Q9UBC2-1] 83934 [Q9UBC2-2] |
PTM databases
iPTMneti | Q9UBC2 |
MetOSitei | Q9UBC2 |
PhosphoSitePlusi | Q9UBC2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127527, Expressed in gastrocnemius and 208 other tissues |
ExpressionAtlasi | Q9UBC2, baseline and differential |
Genevisiblei | Q9UBC2, HS |
Organism-specific databases
HPAi | ENSG00000127527, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) (By similarity).
Interacts with FCHO1.
Interacts with FCHO2.
Interacts (via EH domains) with DAB2.
Interacts with UBQLN1 (via ubiquitin-like domain).
Interacts with CAVIN3 (via leucine-zipper domain) (PubMed:19262564).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ9UBC2
With | #Exp. | IntAct |
---|---|---|
CAVIN3 [Q969G5] | 2 | EBI-2556746,EBI-3893101 |
GNG5 [P63218] | 3 | EBI-2556746,EBI-10220734 |
P0DI81 | 3 | EBI-2556746,EBI-5663373 |
Isoform 3 [Q9UBC2-3]
With | #Exp. | IntAct |
---|---|---|
LRRC7 [A1L1C6] | 3 | EBI-11958621,EBI-10171988 |
NDC80 [O14777] | 3 | EBI-11958621,EBI-715849 |
TRAPPC2 - isoform 3 [P0DI81-3] | 3 | EBI-11958621,EBI-11961968 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 121840, 88 interactors |
ELMi | Q9UBC2 |
IntActi | Q9UBC2, 41 interactors |
MINTi | Q9UBC2 |
STRINGi | 9606.ENSP00000393313 |
Miscellaneous databases
RNActi | Q9UBC2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 104 | EH 1PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 127 – 215 | EH 2PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 159 – 194 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 275 – 365 | EH 3PROSITE-ProRule annotationAdd BLAST | 91 | |
Repeati | 618 – 620 | 1 | 3 | |
Repeati | 640 – 642 | 2 | 3 | |
Repeati | 645 – 647 | 3 | 3 | |
Repeati | 650 – 652 | 4 | 3 | |
Repeati | 656 – 658 | 5 | 3 | |
Repeati | 661 – 663 | 6 | 3 | |
Repeati | 667 – 669 | 7 | 3 | |
Repeati | 685 – 687 | 8 | 3 | |
Repeati | 690 – 692 | 9 | 3 | |
Repeati | 709 – 711 | 10 | 3 | |
Repeati | 728 – 730 | 11 | 3 | |
Repeati | 754 – 756 | 12 | 3 | |
Repeati | 806 – 808 | 13 | 3 | |
Repeati | 812 – 814 | 14 | 3 | |
Repeati | 833 – 835 | 15 | 3 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 15 – 368 | Interaction with DAB2By similarityAdd BLAST | 354 | |
Regioni | 618 – 835 | 15 X 3 AA repeats of D-P-FAdd BLAST | 218 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 386 – 553 | Sequence analysisAdd BLAST | 168 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 750 – 816 | Pro-richAdd BLAST | 67 |
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0998, Eukaryota |
GeneTreei | ENSGT00940000155438 |
HOGENOMi | CLU_007270_1_1_1 |
InParanoidi | Q9UBC2 |
OMAi | KIRDQCQ |
OrthoDBi | 597979at2759 |
PhylomeDBi | Q9UBC2 |
TreeFami | TF324293 |
Family and domain databases
CDDi | cd00052, EH, 3 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom |
Pfami | View protein in Pfam PF12763, EF-hand_4, 3 hits |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00027, EH, 3 hits |
SUPFAMi | SSF47473, SSF47473, 3 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 4 hits PS50031, EH, 3 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPLIPLSQ QIPTGNSLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD
60 70 80 90 100
IILGKIWDLA DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSNLNLSMPP
110 120 130 140 150
PKFHDTSSPL MVTPPSAEAH WAVRVEEKAK FDGIFESLLP INGLLSGDKV
160 170 180 190 200
KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD RDEFAVAMHL VYRALEKEPV
210 220 230 240 250
PSALPPSLIP PSKRKKTVFP GAVPVLPASP PPKDSLRSTP SHGSVSSLNS
260 270 280 290 300
TGSLSPKHSL KQTQPTVNWV VPVADKMRFD EIFLKTDLDL DGYVSGQEVK
310 320 330 340 350
EIFMHSGLTQ NLLAHIWALA DTRQTGKLSK DQFALAMYFI QQKVSKGIDP
360 370 380 390 400
PQVLSPDMVP PSERGTPGPD SSGSLGSGEF TGVKELDDIS QEIAQLQREK
410 420 430 440 450
YSLEQDIREK EEAIRQKTSE VQELQNDLDR ETSSLQELEA QKQDAQDRLD
460 470 480 490 500
EMDQQKAKLR DMLSDVRQKC QDETQMISSL KTQIQSQESD LKSQEDDLNR
510 520 530 540 550
AKSELNRLQQ EETQLEQSIQ AGRVQLETII KSLKSTQDEI NQARSKLSQL
560 570 580 590 600
HESRQEAHRS LEQYDQVLDG AHGASLTDLA NLSEGVSLAE RGSFGAMDDP
610 620 630 640 650
FKNKALLFSN NTQELHPDPF QTEDPFKSDP FKGADPFKGD PFQNDPFAEQ
660 670 680 690 700
QTTSTDPFGG DPFKESDPFR GSATDDFFKK QTKNDPFTSD PFTKNPSLPS
710 720 730 740 750
KLDPFESSDP FSSSSVSSKG SDPFGTLDPF GSGSFNSAEG FADFSQMSKP
760 770 780 790 800
PPSGPFTSSL GGAGFSDDPF KSKQDTPALP PKKPAPPRPK PPSGKSTPVS
810 820 830 840 850
QLGSADFPEA PDPFQPLGAD SGDPFQSKKG FGDPFSGKDP FVPSSAAKPS
860
KASASGFADF TSVS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R165 | M0R165_HUMAN | Epidermal growth factor receptor su... | EPS15L1 | 756 | Annotation score: | ||
M0R2S2 | M0R2S2_HUMAN | Epidermal growth factor receptor su... | EPS15L1 | 447 | Annotation score: | ||
M0QY01 | M0QY01_HUMAN | Epidermal growth factor receptor su... | EPS15L1 | 71 | Annotation score: | ||
M0R3I1 | M0R3I1_HUMAN | Epidermal growth factor receptor su... | EPS15L1 | 213 | Annotation score: | ||
M0QX30 | M0QX30_HUMAN | Epidermal growth factor receptor su... | EPS15L1 | 90 | Annotation score: | ||
M0R1V5 | M0R1V5_HUMAN | Epidermal growth factor receptor su... | EPS15L1 | 110 | Annotation score: | ||
K7EJR2 | K7EJR2_HUMAN | Epidermal growth factor receptor su... | EPS15L1 | 79 | Annotation score: | ||
M0R330 | M0R330_HUMAN | Epidermal growth factor receptor su... | EPS15L1 | 83 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 680 | K → E in BAG59115 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046904 | 598 – 601 | DDPF → VKVE in isoform 4. 1 Publication | 4 | |
Alternative sequenceiVSP_046905 | 602 – 864 | Missing in isoform 4. 1 PublicationAdd BLAST | 263 | |
Alternative sequenceiVSP_045429 | 750 – 864 | PPPSG…FTSVS → VKVHL in isoform 3. 2 PublicationsAdd BLAST | 115 | |
Alternative sequenceiVSP_042200 | 863 – 864 | VS → FGNEEQQLAWAKRESEKAEQ ERLARLRRQEQEDLELAIAL SKADMPAA in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF110265 mRNA Translation: AAF21930.1 AB015346 mRNA Translation: BAA88118.1 AK024166 mRNA Translation: BAG51266.1 AK296473 mRNA Translation: BAG59115.1 AC008764 Genomic DNA No translation available. AC020917 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84542.1 BC131590 mRNA Translation: AAI31591.1 BC142716 mRNA Translation: AAI42717.1 |
CCDSi | CCDS32944.1 [Q9UBC2-1] CCDS58653.1 [Q9UBC2-3] CCDS58654.1 [Q9UBC2-2] CCDS59363.1 [Q9UBC2-4] |
RefSeqi | NP_001245303.1, NM_001258374.1 [Q9UBC2-2] NP_001245304.1, NM_001258375.1 [Q9UBC2-3] NP_001245305.1, NM_001258376.1 [Q9UBC2-4] NP_067058.1, NM_021235.2 [Q9UBC2-1] |
Genome annotation databases
Ensembli | ENST00000248070; ENSP00000248070; ENSG00000127527 [Q9UBC2-1] ENST00000455140; ENSP00000393313; ENSG00000127527 [Q9UBC2-2] ENST00000535753; ENSP00000440103; ENSG00000127527 [Q9UBC2-3] ENST00000597937; ENSP00000472267; ENSG00000127527 [Q9UBC2-4] ENST00000602022; ENSP00000471981; ENSG00000127527 [Q9UBC2-3] |
GeneIDi | 58513 |
KEGGi | hsa:58513 |
UCSCi | uc002ndx.5, human [Q9UBC2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF110265 mRNA Translation: AAF21930.1 AB015346 mRNA Translation: BAA88118.1 AK024166 mRNA Translation: BAG51266.1 AK296473 mRNA Translation: BAG59115.1 AC008764 Genomic DNA No translation available. AC020917 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84542.1 BC131590 mRNA Translation: AAI31591.1 BC142716 mRNA Translation: AAI42717.1 |
CCDSi | CCDS32944.1 [Q9UBC2-1] CCDS58653.1 [Q9UBC2-3] CCDS58654.1 [Q9UBC2-2] CCDS59363.1 [Q9UBC2-4] |
RefSeqi | NP_001245303.1, NM_001258374.1 [Q9UBC2-2] NP_001245304.1, NM_001258375.1 [Q9UBC2-3] NP_001245305.1, NM_001258376.1 [Q9UBC2-4] NP_067058.1, NM_021235.2 [Q9UBC2-1] |
3D structure databases
SMRi | Q9UBC2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121840, 88 interactors |
ELMi | Q9UBC2 |
IntActi | Q9UBC2, 41 interactors |
MINTi | Q9UBC2 |
STRINGi | 9606.ENSP00000393313 |
Protein family/group databases
MoonDBi | Q9UBC2, Curated |
PTM databases
iPTMneti | Q9UBC2 |
MetOSitei | Q9UBC2 |
PhosphoSitePlusi | Q9UBC2 |
Polymorphism and mutation databases
BioMutai | EPS15L1 |
DMDMi | 61223942 |
Proteomic databases
EPDi | Q9UBC2 |
jPOSTi | Q9UBC2 |
MassIVEi | Q9UBC2 |
MaxQBi | Q9UBC2 |
PaxDbi | Q9UBC2 |
PeptideAtlasi | Q9UBC2 |
PRIDEi | Q9UBC2 |
ProteomicsDBi | 466 83933 [Q9UBC2-1] 83934 [Q9UBC2-2] |
Protocols and materials databases
Antibodypediai | 14142, 193 antibodies |
Genome annotation databases
Ensembli | ENST00000248070; ENSP00000248070; ENSG00000127527 [Q9UBC2-1] ENST00000455140; ENSP00000393313; ENSG00000127527 [Q9UBC2-2] ENST00000535753; ENSP00000440103; ENSG00000127527 [Q9UBC2-3] ENST00000597937; ENSP00000472267; ENSG00000127527 [Q9UBC2-4] ENST00000602022; ENSP00000471981; ENSG00000127527 [Q9UBC2-3] |
GeneIDi | 58513 |
KEGGi | hsa:58513 |
UCSCi | uc002ndx.5, human [Q9UBC2-1] |
Organism-specific databases
CTDi | 58513 |
DisGeNETi | 58513 |
EuPathDBi | HostDB:ENSG00000127527.13 |
GeneCardsi | EPS15L1 |
HGNCi | HGNC:24634, EPS15L1 |
HPAi | ENSG00000127527, Low tissue specificity |
MalaCardsi | EPS15L1 |
neXtProti | NX_Q9UBC2 |
OpenTargetsi | ENSG00000127527 |
Orphaneti | 2440, Isolated split hand-split foot malformation |
PharmGKBi | PA134906266 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0998, Eukaryota |
GeneTreei | ENSGT00940000155438 |
HOGENOMi | CLU_007270_1_1_1 |
InParanoidi | Q9UBC2 |
OMAi | KIRDQCQ |
OrthoDBi | 597979at2759 |
PhylomeDBi | Q9UBC2 |
TreeFami | TF324293 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBC2 |
Reactomei | R-HSA-182971, EGFR downregulation R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
BioGRID-ORCSi | 58513, 22 hits in 849 CRISPR screens |
ChiTaRSi | EPS15L1, human |
GeneWikii | EPS15L1 |
GenomeRNAii | 58513 |
Pharosi | Q9UBC2, Tbio |
PROi | PR:Q9UBC2 |
RNActi | Q9UBC2, protein |
Gene expression databases
Bgeei | ENSG00000127527, Expressed in gastrocnemius and 208 other tissues |
ExpressionAtlasi | Q9UBC2, baseline and differential |
Genevisiblei | Q9UBC2, HS |
Family and domain databases
CDDi | cd00052, EH, 3 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom |
Pfami | View protein in Pfam PF12763, EF-hand_4, 3 hits |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00027, EH, 3 hits |
SUPFAMi | SSF47473, SSF47473, 3 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 4 hits PS50031, EH, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EP15R_HUMAN | |
Accessioni | Q9UBC2Primary (citable) accession number: Q9UBC2 Secondary accession number(s): A2RRF3, A5PL29, B4DKA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM