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Protein

NF-kappa-B inhibitor-like protein 1

Gene

NFKBIL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cellular response to lipopolysaccharide Source: UniProtKB
  • cytoplasmic sequestering of transcription factor Source: ProtInc
  • I-kappaB kinase/NF-kappaB signaling Source: GO_Central
  • negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of toll-like receptor signaling pathway Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NF-kappa-B inhibitor-like protein 1
Alternative name(s):
Inhibitor of kappa B-like protein
Short name:
I-kappa-B-like protein
Short name:
IkappaBL
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFKBIL1
Synonyms:IKBL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204498.10

Human Gene Nomenclature Database

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HGNCi
HGNC:7800 NFKBIL1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601022 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Rheumatoid arthritis (RA)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
See also OMIM:180300

Organism-specific databases

DisGeNET

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DisGeNETi
4795

MalaCards human disease database

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MalaCardsi
NFKBIL1
MIMi180300 phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31604

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NFKBIL1

Domain mapping of disease mutations (DMDM)

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DMDMi
44888077

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000670091 – 381NF-kappa-B inhibitor-like protein 1Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei150PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBC1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UBC1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBC1

PeptideAtlas

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PeptideAtlasi
Q9UBC1

PRoteomics IDEntifications database

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PRIDEi
Q9UBC1

ProteomicsDB human proteome resource

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ProteomicsDBi
83931
83932 [Q9UBC1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UBC1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UBC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000204498 Expressed in 152 organ(s), highest expression level in body of stomach

CleanEx database of gene expression profiles

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CleanExi
HS_NFKBIL1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBC1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBC1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CACTIN (via N-terminal domain); the interaction occurs in a proinflammatory-independent manner.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110862, 34 interactors

Protein interaction database and analysis system

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IntActi
Q9UBC1, 13 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365318

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UBC1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBC1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati64 – 93ANK 1Add BLAST30
Repeati97 – 130ANK 2Add BLAST34

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IZ7E Eukaryota
ENOG4111NZ2 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000043101

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG048799

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBC1

KEGG Orthology (KO)

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KOi
K09256

Database of Orthologous Groups

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OrthoDBi
EOG091G0HSG

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBC1

TreeFam database of animal gene trees

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TreeFami
TF333242

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038753 NFKBIL1

The PANTHER Classification System

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PANTHERi
PTHR15263 PTHR15263, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNPSPQVPE EEASTSVCRP KSSMASTSRR QRRERRFRRY LSAGRLVRAQ
60 70 80 90 100
ALLQRHPGLD VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT
110 120 130 140 150
ALHAAARQGP DAYTDFFLPL LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS
160 170 180 190 200
AEEEEEDDAS KEREWRQKLQ GELEDEWQEV MGRFEGDASH ETQEPESFSA
210 220 230 240 250
WSDRLAREHA QKCQQQQREA EGSCRPPRAE GSSQSWRQQE EEQRLFRERA
260 270 280 290 300
RAKEEELRES RARRAQEALG DREPKPTRAG PREEHPRGAG RGSLWRFGDV
310 320 330 340 350
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL RRYLRVQQVR WHPDRFLQRF
360 370 380
RSQIETWELG RVMGAVTALS QALNRHAEAL K
Length:381
Mass (Da):43,204
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF466991A92A93F4C
GO
Isoform 2 (identifier: Q9UBC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:358
Mass (Da):40,774
Checksum:iB2DF68E09AA28AA2
GO
Isoform 3 (identifier: Q9UBC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-185: Missing.

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):41,368
Checksum:i872AAC6A001FACB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5STV6Q5STV6_HUMAN
NF-kappa-B inhibitor-like protein 1
NFKBIL1
358Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRT5A0A0A0MRT5_HUMAN
NF-kappa-B inhibitor-like protein 1
NFKBIL1
366Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z390F2Z390_HUMAN
NF-kappa-B inhibitor-like protein 1
NFKBIL1
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA04A0A140TA04_HUMAN
NF-kappa-B inhibitor-like protein 1
NFKBIL1
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG62473 differs from that shown. Reason: Erroneous termination at position 255. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48R → Q in BAG62473 (Ref. 7) Curated1
Sequence conflicti238 – 239QQ → HE in CAA54867 (PubMed:8081366).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017798224C → R Polymorphism found in the MHC 7.1 haplotype (HLA-A3,B7,DR15) population. 3 PublicationsCorresponds to variant dbSNP:rs3130062Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0410751 – 23Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_046261171 – 185Missing in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X77909 mRNA Translation: CAA54867.1
AB000876 Genomic DNA No translation available.
AB000882 Genomic DNA No translation available.
AF097419 mRNA Translation: AAD38108.1
AF097420 mRNA Translation: AAD38109.1
AF097421 mRNA Translation: AAD38110.1
AF097422 mRNA Translation: AAD38111.1
AF097423 mRNA Translation: AAD38112.1
AF097424 mRNA Translation: AAD38113.1
AF097425 mRNA Translation: AAD38114.1
AF097426 mRNA Translation: AAD38115.1
AF097427 mRNA Translation: AAD38116.1
AF097428 mRNA Translation: AAD38117.1
AF097429 mRNA Translation: AAD38118.1
Y14768 Genomic DNA Translation: CAA75072.1
AK300818 mRNA Translation: BAG62473.1 Sequence problems.
BA000025 Genomic DNA Translation: BAB63398.1
AB088115 Genomic DNA Translation: BAC54951.1
AC004181 Genomic DNA No translation available.
AL662847 Genomic DNA No translation available.
AL662801 Genomic DNA No translation available.
BX001040 Genomic DNA No translation available.
AL929587 Genomic DNA No translation available.
BX248516 Genomic DNA No translation available.
CR753892 Genomic DNA No translation available.
CR942185 Genomic DNA No translation available.
BX927320 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03417.1
CH471081 Genomic DNA Translation: EAX03418.1
BC143671 mRNA Translation: AAI43672.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4700.1 [Q9UBC1-1]
CCDS47399.1 [Q9UBC1-3]
CCDS47400.1 [Q9UBC1-2]

Protein sequence database of the Protein Information Resource

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PIRi
S60561

NCBI Reference Sequences

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RefSeqi
NP_001138433.1, NM_001144961.1
NP_001138434.1, NM_001144962.1
NP_001138435.1, NM_001144963.1
NP_004998.3, NM_005007.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.2764

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000376148; ENSP00000365318; ENSG00000204498
ENST00000383500; ENSP00000372992; ENSG00000206440 [Q9UBC1-3]
ENST00000400279; ENSP00000383137; ENSG00000206440 [Q9UBC1-2]
ENST00000400285; ENSP00000383142; ENSG00000206440 [Q9UBC1-1]
ENST00000414391; ENSP00000414084; ENSG00000234530 [Q9UBC1-3]
ENST00000419122; ENSP00000394486; ENSG00000234530 [Q9UBC1-1]
ENST00000419623; ENSP00000414206; ENSG00000236346 [Q9UBC1-3]
ENST00000421396; ENSP00000399871; ENSG00000235125 [Q9UBC1-3]
ENST00000424652; ENSP00000395544; ENSG00000236346 [Q9UBC1-1]
ENST00000428467; ENSP00000407809; ENSG00000236346 [Q9UBC1-2]
ENST00000430501; ENSP00000404901; ENSG00000236196 [Q9UBC1-3]
ENST00000430961; ENSP00000411174; ENSG00000235125 [Q9UBC1-2]
ENST00000432160; ENSP00000411611; ENSG00000227565 [Q9UBC1-1]
ENST00000434332; ENSP00000413952; ENSG00000234530 [Q9UBC1-2]
ENST00000442947; ENSP00000396656; ENSG00000235125 [Q9UBC1-1]
ENST00000451911; ENSP00000413643; ENSG00000227565 [Q9UBC1-3]
ENST00000453377; ENSP00000395977; ENSG00000227565 [Q9UBC1-2]
ENST00000455376; ENSP00000408426; ENSG00000236196 [Q9UBC1-1]
ENST00000456607; ENSP00000401830; ENSG00000236196 [Q9UBC1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4795

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4795

UCSC genome browser

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UCSCi
uc003nub.4 human [Q9UBC1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77909 mRNA Translation: CAA54867.1
AB000876 Genomic DNA No translation available.
AB000882 Genomic DNA No translation available.
AF097419 mRNA Translation: AAD38108.1
AF097420 mRNA Translation: AAD38109.1
AF097421 mRNA Translation: AAD38110.1
AF097422 mRNA Translation: AAD38111.1
AF097423 mRNA Translation: AAD38112.1
AF097424 mRNA Translation: AAD38113.1
AF097425 mRNA Translation: AAD38114.1
AF097426 mRNA Translation: AAD38115.1
AF097427 mRNA Translation: AAD38116.1
AF097428 mRNA Translation: AAD38117.1
AF097429 mRNA Translation: AAD38118.1
Y14768 Genomic DNA Translation: CAA75072.1
AK300818 mRNA Translation: BAG62473.1 Sequence problems.
BA000025 Genomic DNA Translation: BAB63398.1
AB088115 Genomic DNA Translation: BAC54951.1
AC004181 Genomic DNA No translation available.
AL662847 Genomic DNA No translation available.
AL662801 Genomic DNA No translation available.
BX001040 Genomic DNA No translation available.
AL929587 Genomic DNA No translation available.
BX248516 Genomic DNA No translation available.
CR753892 Genomic DNA No translation available.
CR942185 Genomic DNA No translation available.
BX927320 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03417.1
CH471081 Genomic DNA Translation: EAX03418.1
BC143671 mRNA Translation: AAI43672.1
CCDSiCCDS4700.1 [Q9UBC1-1]
CCDS47399.1 [Q9UBC1-3]
CCDS47400.1 [Q9UBC1-2]
PIRiS60561
RefSeqiNP_001138433.1, NM_001144961.1
NP_001138434.1, NM_001144962.1
NP_001138435.1, NM_001144963.1
NP_004998.3, NM_005007.3
UniGeneiHs.2764

3D structure databases

ProteinModelPortaliQ9UBC1
SMRiQ9UBC1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110862, 34 interactors
IntActiQ9UBC1, 13 interactors
STRINGi9606.ENSP00000365318

PTM databases

iPTMnetiQ9UBC1
PhosphoSitePlusiQ9UBC1

Polymorphism and mutation databases

BioMutaiNFKBIL1
DMDMi44888077

Proteomic databases

EPDiQ9UBC1
MaxQBiQ9UBC1
PaxDbiQ9UBC1
PeptideAtlasiQ9UBC1
PRIDEiQ9UBC1
ProteomicsDBi83931
83932 [Q9UBC1-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4795
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376148; ENSP00000365318; ENSG00000204498
ENST00000383500; ENSP00000372992; ENSG00000206440 [Q9UBC1-3]
ENST00000400279; ENSP00000383137; ENSG00000206440 [Q9UBC1-2]
ENST00000400285; ENSP00000383142; ENSG00000206440 [Q9UBC1-1]
ENST00000414391; ENSP00000414084; ENSG00000234530 [Q9UBC1-3]
ENST00000419122; ENSP00000394486; ENSG00000234530 [Q9UBC1-1]
ENST00000419623; ENSP00000414206; ENSG00000236346 [Q9UBC1-3]
ENST00000421396; ENSP00000399871; ENSG00000235125 [Q9UBC1-3]
ENST00000424652; ENSP00000395544; ENSG00000236346 [Q9UBC1-1]
ENST00000428467; ENSP00000407809; ENSG00000236346 [Q9UBC1-2]
ENST00000430501; ENSP00000404901; ENSG00000236196 [Q9UBC1-3]
ENST00000430961; ENSP00000411174; ENSG00000235125 [Q9UBC1-2]
ENST00000432160; ENSP00000411611; ENSG00000227565 [Q9UBC1-1]
ENST00000434332; ENSP00000413952; ENSG00000234530 [Q9UBC1-2]
ENST00000442947; ENSP00000396656; ENSG00000235125 [Q9UBC1-1]
ENST00000451911; ENSP00000413643; ENSG00000227565 [Q9UBC1-3]
ENST00000453377; ENSP00000395977; ENSG00000227565 [Q9UBC1-2]
ENST00000455376; ENSP00000408426; ENSG00000236196 [Q9UBC1-1]
ENST00000456607; ENSP00000401830; ENSG00000236196 [Q9UBC1-2]
GeneIDi4795
KEGGihsa:4795
UCSCiuc003nub.4 human [Q9UBC1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4795
DisGeNETi4795
EuPathDBiHostDB:ENSG00000204498.10

GeneCards: human genes, protein and diseases

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GeneCardsi
NFKBIL1
HGNCiHGNC:7800 NFKBIL1
MalaCardsiNFKBIL1
MIMi180300 phenotype
601022 gene
neXtProtiNX_Q9UBC1
PharmGKBiPA31604

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IZ7E Eukaryota
ENOG4111NZ2 LUCA
HOGENOMiHOG000043101
HOVERGENiHBG048799
InParanoidiQ9UBC1
KOiK09256
OrthoDBiEOG091G0HSG
PhylomeDBiQ9UBC1
TreeFamiTF333242

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NFKBIL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4795

Protein Ontology

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PROi
PR:Q9UBC1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204498 Expressed in 152 organ(s), highest expression level in body of stomach
CleanExiHS_NFKBIL1
ExpressionAtlasiQ9UBC1 baseline and differential
GenevisibleiQ9UBC1 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038753 NFKBIL1
PANTHERiPTHR15263 PTHR15263, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKBL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBC1
Secondary accession number(s): A6NL91
, B4DUW1, Q14625, Q5HYU4, Q5RJ72, Q5ST96, Q5STV4, Q5STV5, Q9UBX4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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