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Protein

Hepatocyte nuclear factor 6

Gene

ONECUT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi283 – 369CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi385 – 444HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
SignaLinkiQ9UBC0

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 6
Short name:
HNF-6
Alternative name(s):
One cut domain family member 1
One cut homeobox 1
Gene namesi
Name:ONECUT1
Synonyms:HNF6, HNF6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000169856.8
HGNCiHGNC:8138 ONECUT1
MIMi604164 gene
neXtProtiNX_Q9UBC0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3175
OpenTargetsiENSG00000169856
PharmGKBiPA31924

Polymorphism and mutation databases

DMDMi13627184

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024021 – 465Hepatocyte nuclear factor 6Add BLAST465

Proteomic databases

PaxDbiQ9UBC0
PeptideAtlasiQ9UBC0
PRIDEiQ9UBC0
ProteomicsDBi83930

PTM databases

iPTMnetiQ9UBC0
PhosphoSitePlusiQ9UBC0

Expressioni

Tissue specificityi

Highly expressed in liver; lower expression in testis and skin.

Gene expression databases

BgeeiENSG00000169856 Expressed in 39 organ(s), highest expression level in body of pancreas
CleanExiHS_ONECUT1
ExpressionAtlasiQ9UBC0 baseline and differential
GenevisibleiQ9UBC0 HS

Organism-specific databases

HPAiHPA003457

Interactioni

Subunit structurei

Binds DNA as a monomer.By similarity

Protein-protein interaction databases

BioGridi109417, 7 interactors
CORUMiQ9UBC0
STRINGi9606.ENSP00000302630

Structurei

3D structure databases

ProteinModelPortaliQ9UBC0
SMRiQ9UBC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 72Poly-His4
Compositional biasi124 – 138Poly-HisAdd BLAST15
Compositional biasi455 – 460Poly-Ser6

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252 Eukaryota
ENOG410YWY4 LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000232114
HOVERGENiHBG005981
InParanoidiQ9UBC0
KOiK08026
OMAiQMEEVNT
OrthoDBiEOG091G0E7H
PhylomeDBiQ9UBC0
TreeFamiTF318206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 1 hit
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS51042 CUT, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UBC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP
60 70 80 90 100
RSMGMASLLD GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP
110 120 130 140 150
TTYTTLTPLQ PLPPISTVSD KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT
160 170 180 190 200
LMRDERGLAS MNNLYTPYHK DVAGMGQSLS PLSSSGLGSI HNSQQGLPHY
210 220 230 240 250
AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG MVPINGLPPH
260 270 280 290 300
HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR
310 320 330 340 350
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM
360 370 380 390 400
WKWLQEPEFQ RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL
410 420 430 440 450
HAIFKENKRP SKELQITISQ QLGLELSTVS NFFMNARRRS LDKWQDEGSS
460
NSGNSSSSSS TCTKA
Length:465
Mass (Da):51,023
Last modified:May 1, 2000 - v1
Checksum:iF47F78957A6ECFC2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQR8U3KQR8_HUMAN
Hepatocyte nuclear factor 6
ONECUT1
182Annotation score:
H0YMS2H0YMS2_HUMAN
Hepatocyte nuclear factor 6
ONECUT1
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220A → T (PubMed:10491763).Curated1
Sequence conflicti220A → T (Ref. 6) Curated1
Sequence conflicti284S → N in AAB61705 (Ref. 6) Curated1
Sequence conflicti288Q → H in AAB61705 (Ref. 6) Curated1
Sequence conflicti318R → K in AAB61705 (Ref. 6) Curated1
Sequence conflicti386K → Q in AAB61705 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01072975P → A1 PublicationCorresponds to variant dbSNP:rs74805019Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035581, AF035580 Genomic DNA Translation: AAD02033.1
U96173 mRNA Translation: AAD00826.1
CH471082 Genomic DNA Translation: EAW77461.1
BC140830 mRNA Translation: AAI40831.1
Y17739 Genomic DNA Translation: CAB50769.1
U77975 mRNA Translation: AAB61705.1
CCDSiCCDS10150.1
RefSeqiNP_004489.1, NM_004498.2
UniGeneiHs.555318
Hs.658573

Genome annotation databases

EnsembliENST00000305901; ENSP00000302630; ENSG00000169856
GeneIDi3175
KEGGihsa:3175
UCSCiuc002aci.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035581, AF035580 Genomic DNA Translation: AAD02033.1
U96173 mRNA Translation: AAD00826.1
CH471082 Genomic DNA Translation: EAW77461.1
BC140830 mRNA Translation: AAI40831.1
Y17739 Genomic DNA Translation: CAB50769.1
U77975 mRNA Translation: AAB61705.1
CCDSiCCDS10150.1
RefSeqiNP_004489.1, NM_004498.2
UniGeneiHs.555318
Hs.658573

3D structure databases

ProteinModelPortaliQ9UBC0
SMRiQ9UBC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109417, 7 interactors
CORUMiQ9UBC0
STRINGi9606.ENSP00000302630

PTM databases

iPTMnetiQ9UBC0
PhosphoSitePlusiQ9UBC0

Polymorphism and mutation databases

DMDMi13627184

Proteomic databases

PaxDbiQ9UBC0
PeptideAtlasiQ9UBC0
PRIDEiQ9UBC0
ProteomicsDBi83930

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305901; ENSP00000302630; ENSG00000169856
GeneIDi3175
KEGGihsa:3175
UCSCiuc002aci.3 human

Organism-specific databases

CTDi3175
DisGeNETi3175
EuPathDBiHostDB:ENSG00000169856.8
GeneCardsiONECUT1
HGNCiHGNC:8138 ONECUT1
HPAiHPA003457
MIMi604164 gene
neXtProtiNX_Q9UBC0
OpenTargetsiENSG00000169856
PharmGKBiPA31924
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2252 Eukaryota
ENOG410YWY4 LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000232114
HOVERGENiHBG005981
InParanoidiQ9UBC0
KOiK08026
OMAiQMEEVNT
OrthoDBiEOG091G0E7H
PhylomeDBiQ9UBC0
TreeFamiTF318206

Enzyme and pathway databases

ReactomeiR-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
SignaLinkiQ9UBC0

Miscellaneous databases

ChiTaRSiONECUT1 human
GenomeRNAii3175
PROiPR:Q9UBC0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169856 Expressed in 39 organ(s), highest expression level in body of pancreas
CleanExiHS_ONECUT1
ExpressionAtlasiQ9UBC0 baseline and differential
GenevisibleiQ9UBC0 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 1 hit
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS51042 CUT, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHNF6_HUMAN
AccessioniPrimary (citable) accession number: Q9UBC0
Secondary accession number(s): B2RTV4, Q99744, Q9UMR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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