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Protein

Tuftelin-interacting protein 11

Gene

TFIP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • biomineral tissue development Source: UniProtKB-KW
  • mRNA splicing, via spliceosome Source: Reactome
  • negative regulation of DNA ligase activity Source: BHF-UCL
  • negative regulation of double-strand break repair via nonhomologous end joining Source: BHF-UCL
  • negative regulation of protein binding Source: BHF-UCL
  • negative regulation of protein complex assembly Source: BHF-UCL
  • protection from non-homologous end joining at telomere Source: BHF-UCL
  • RNA processing Source: UniProtKB
  • spliceosomal complex disassembly Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiomineralization, mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tuftelin-interacting protein 11
Alternative name(s):
Septin and tuftelin-interacting protein 1
Short name:
STIP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFIP11
Synonyms:STIP
ORF Names:HSPC006
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100109.16

Human Gene Nomenclature Database

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HGNCi
HGNC:17165 TFIP11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612747 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBB9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
24144

Open Targets

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OpenTargetsi
ENSG00000100109

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38441

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TFIP11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22096235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725011 – 837Tuftelin-interacting protein 11Add BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineBy similarity1
Modified residuei59PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBB9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UBB9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBB9

PeptideAtlas

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PeptideAtlasi
Q9UBB9

PRoteomics IDEntifications database

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PRIDEi
Q9UBB9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83928
83929 [Q9UBB9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBB9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100109 Expressed in 212 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_TFIP11

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UBB9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBB9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027085

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-1105213,EBI-743598
AIMP2Q131555EBI-1105213,EBI-745226
ARMCX1Q9P2913EBI-1105213,EBI-2843626
ATP5POP480473EBI-1105213,EBI-355815
AXIN1A0A0S2Z4M13EBI-1105213,EBI-16429430
AXIN1O151693EBI-1105213,EBI-710484
BMFQ96LC95EBI-1105213,EBI-3919268
C1orf109Q9NX045EBI-1105213,EBI-8643161
C2CD6Q53TS83EBI-1105213,EBI-739879
CARD9Q9H2573EBI-1105213,EBI-751319
CCDC116Q8IYX33EBI-1105213,EBI-744311
CCDC121Q6ZUS55EBI-1105213,EBI-2836982
CCDC146Q8IYE0-23EBI-1105213,EBI-10247802
CCDC151A5D8V75EBI-1105213,EBI-8466445
CCDC151A5D8V7-23EBI-1105213,EBI-10173824
CCDC196A0A1B0GWI13EBI-1105213,EBI-10181422
CCDC42Q96M953EBI-1105213,EBI-747041
CCDC68Q9H2F95EBI-1105213,EBI-2813327
CCHCR1Q8TD31-37EBI-1105213,EBI-10175300
CCND3P302813EBI-1105213,EBI-375013
CCNG1P519593EBI-1105213,EBI-3905829
CCNL1Q9UK583EBI-1105213,EBI-2836773
CENPUQ71F233EBI-1105213,EBI-2515234
CEP57Q86XR83EBI-1105213,EBI-308614
CEP57L1Q8IYX83EBI-1105213,EBI-1104570
CFAP206Q8IYR03EBI-1105213,EBI-749051
COQ8AQ8NI6010EBI-1105213,EBI-745535
COX5BP106063EBI-1105213,EBI-1053725
EIF3AQ24JU43EBI-1105213,EBI-10239221
FAM13CQ8NE313EBI-1105213,EBI-751248
FAM156AQ8NDB63EBI-1105213,EBI-749727
FAM161AQ3B8207EBI-1105213,EBI-719941
FAM50BQ9Y2473EBI-1105213,EBI-742802
GCC1Q96CN93EBI-1105213,EBI-746252
GCFC2P163834EBI-1105213,EBI-954074
GEMP550405EBI-1105213,EBI-744104
GNG4B1APZ03EBI-1105213,EBI-10175453
GOLGA1Q928055EBI-1105213,EBI-6164177
GPS2Q132275EBI-1105213,EBI-713355
HAUS1Q96CS23EBI-1105213,EBI-2514791
HMG20BQ9P0W23EBI-1105213,EBI-713401
HOOK1Q9UJC35EBI-1105213,EBI-746704
IKBIPQ70UQ03EBI-1105213,EBI-2557212
IMP3Q9NV313EBI-1105213,EBI-747481
KANSL1Q7Z3B34EBI-1105213,EBI-740244
KRT20P359006EBI-1105213,EBI-742094
KRT6AP025388EBI-1105213,EBI-702198
KRT6BP042595EBI-1105213,EBI-740907
KRT6CP486683EBI-1105213,EBI-2564105
KRT8P057873EBI-1105213,EBI-297852
LATS1Q6PJG33EBI-1105213,EBI-10253976
LCA5Q86VQ03EBI-1105213,EBI-6658186
LCA5LO954473EBI-1105213,EBI-8473670
LENG1Q96BZ83EBI-1105213,EBI-726510
LIN37Q96GY33EBI-1105213,EBI-748884
LMO1P258005EBI-1105213,EBI-8639312
LMO4P619685EBI-1105213,EBI-2798728
LOC729862Q0VAF83EBI-1105213,EBI-10226726
LOC729862Q0VAF93EBI-1105213,EBI-10226748
METTL17Q9H7H04EBI-1105213,EBI-749353
MTFR2Q6P4443EBI-1105213,EBI-10252703
NDC80O147775EBI-1105213,EBI-715849
NFU1Q9UMS05EBI-1105213,EBI-725252
OIP5O434825EBI-1105213,EBI-536879
PBX4Q9BYU15EBI-1105213,EBI-10302990
PDE4DIPQ8TBR03EBI-1105213,EBI-10240575
POLLQ9UGP5-23EBI-1105213,EBI-10320765
POLR1CO151604EBI-1105213,EBI-1055079
PPP1R18Q6NYC83EBI-1105213,EBI-2557469
PRPF31Q8WWY310EBI-1105213,EBI-1567797
PSTPIP1A0A0S2Z5283EBI-1105213,EBI-16430249
RCOR3Q9P2K33EBI-1105213,EBI-743428
RHNO1Q9BSD35EBI-1105213,EBI-9658624
RNF6A0A0S2Z4G93EBI-1105213,EBI-16428950
RRP7AQ9Y3A43EBI-1105213,EBI-7223720
RXRBP28702-33EBI-1105213,EBI-16429492
S100PP258153EBI-1105213,EBI-743700
SAP30BPQ9UHR53EBI-1105213,EBI-751683
SCNM1Q9BWG64EBI-1105213,EBI-748391
SFR1Q86XK33EBI-1105213,EBI-1104535
SH2D4AQ9H7885EBI-1105213,EBI-747035
SH2D4AQ9H788-23EBI-1105213,EBI-10308083
SH3GLB1Q9Y3715EBI-1105213,EBI-2623095
SMARCE1Q969G35EBI-1105213,EBI-455078
SNRPBP14678-25EBI-1105213,EBI-372475
SNW1Q135735EBI-1105213,EBI-632715
SNX20Q7Z6143EBI-1105213,EBI-744896
SSX2IPQ9Y2D83EBI-1105213,EBI-2212028
STRNO438153EBI-1105213,EBI-1046642
TCAF1Q9Y4C23EBI-1105213,EBI-750484
TFPTA0A024R4Q54EBI-1105213,EBI-11527449
TFPTP0C1Z6-23EBI-1105213,EBI-10178002
THAP7Q9BT495EBI-1105213,EBI-741350
THAP8Q8NA923EBI-1105213,EBI-717429
TNNT1P138053EBI-1105213,EBI-726527
TRAF3IP3Q9Y2283EBI-1105213,EBI-765817
TSHZ3Q63HK55EBI-1105213,EBI-9053916
TSPYL4Q9UJ043EBI-1105213,EBI-308511
TXLNAP402225EBI-1105213,EBI-359793
VPS37CA5D8V63EBI-1105213,EBI-2559305
ZC2HC1CQ53FD03EBI-1105213,EBI-740767
ZFYVE26Q68DK2-53EBI-1105213,EBI-8656416
ZGPATA0A0S2Z6H03EBI-1105213,EBI-16428984
ZGPATQ8N5A53EBI-1105213,EBI-3439227
ZGPATQ8N5A5-28EBI-1105213,EBI-10183064
ZMAT2Q96NC03EBI-1105213,EBI-2682299
ZNF417Q8TAU34EBI-1105213,EBI-740727
ZSCAN12O433093EBI-1105213,EBI-1210440

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117294, 149 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UBB9

Protein interaction database and analysis system

More...
IntActi
Q9UBB9, 243 interactors

Molecular INTeraction database

More...
MINTi
Q9UBB9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383892

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UBB9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBB9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 195G-patchPROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 50Required for interaction with DHX151 PublicationAdd BLAST50
Regioni710 – 734Required for nuclear speckle localizationBy similarityAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi700 – 705Nuclear localization signalBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 19Poly-Asp5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFP11/STIP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2184 Eukaryota
ENOG410XP4Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230470

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055868

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBB9

KEGG Orthology (KO)

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KOi
K13103

Identification of Orthologs from Complete Genome Data

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OMAi
VWEWHEL

Database of Orthologous Groups

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OrthoDBi
EOG091G04T2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBB9

TreeFam database of animal gene trees

More...
TreeFami
TF314887

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000467 G_patch_dom
IPR022783 GCFC_dom
IPR024933 STIP
IPR022159 STIP/TFIP11_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01585 G-patch, 1 hit
PF07842 GCFC, 1 hit
PF12457 TIP_N, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF017706 TFIP11, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00443 G_patch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50174 G_PATCH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSHLYRDG EGRIDDDDDE RENFEITDWD LQNEFNPNRQ RHWQTKEEAT
60 70 80 90 100
YGVWAERDSD DERPSFGGKR ARDYSAPVNF ISAGLKKGAA EEAELEDSDD
110 120 130 140 150
EEKPVKQDDF PKDFGPRKLK TGGNFKPSQK GFAGGTKSFM DFGSWERHTK
160 170 180 190 200
GIGQKLLQKM GYVPGRGLGK NAQGIINPIE AKQRKGKGAV GAYGSERTTQ
210 220 230 240 250
SMQDFPVVDS EEEAEEEFQK ELSQWRKDPS GSKKKPKYSY KTVEELKAKG
260 270 280 290 300
RISKKLTAPQ KELSQVKVID MTGREQKVYY SYSQISHKHN VPDDGLPLQS
310 320 330 340 350
QQLPQSGKEA KAPGFALPEL EHNLQLLIDL TEQEIIQNDR QLQYERDMVV
360 370 380 390 400
NLFHELEKMT EVLDHEERVI SNLSKVLEMV EECERRMQPD CSNPLTLDEC
410 420 430 440 450
ARIFETLQDK YYEEYRMSDR VDLAVAIVYP LMKEYFKEWD PLKDCTYGTE
460 470 480 490 500
IISKWKSLLE NDQLLSHGGQ DLSADAFHRL IWEVWMPFVR NIVTQWQPRN
510 520 530 540 550
CDPMVDFLDS WVHIIPVWIL DNILDQLIFP KLQKEVENWN PLTDTVPIHS
560 570 580 590 600
WIHPWLPLMQ ARLEPLYSPI RSKLSSALQK WHPSDSSAKL ILQPWKDVFT
610 620 630 640 650
PGSWEAFMVK NIVPKLGMCL GELVINPHQQ HMDAFYWVID WEGMISVSSL
660 670 680 690 700
VGLLEKHFFP KWLQVLCSWL SNSPNYEEIT KWYLGWKSMF SDQVLAHPSV
710 720 730 740 750
KDKFNEALDI MNRAVSSNVG AYMQPGAREN IAYLTHTERR KDFQYEAMQE
760 770 780 790 800
RREAENMAQR GIGVAASSVP MNFKDLIETK AEEHNIVFMP VIGKRHEGKQ
810 820 830
LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK
Length:837
Mass (Da):96,820
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4C44F8411517289
GO
Isoform 2 (identifier: Q9UBB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-641: Missing.
     642-663: EGMISVSSLVGLLEKHFFPKWL → MATSEILPSFVATMDASNFSFW

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):22,431
Checksum:i0E4DBC70BB97D704
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4U8H0Y4U8_HUMAN
Tuftelin-interacting protein 11
TFIP11
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SQZ1F6SQZ1_HUMAN
Tuftelin-interacting protein 11
TFIP11
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XM96F6XM96_HUMAN
Tuftelin-interacting protein 11
TFIP11
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UKU9F6UKU9_HUMAN
Tuftelin-interacting protein 11
TFIP11
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UQ07F6UQ07_HUMAN
Tuftelin-interacting protein 11
TFIP11
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054069177N → S. Corresponds to variant dbSNP:rs6005062Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0039981 – 641Missing in isoform 2. 1 PublicationAdd BLAST641
Alternative sequenceiVSP_003999642 – 663EGMIS…FPKWL → MATSEILPSFVATMDASNFS FW in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF070662 mRNA Translation: AAD20968.1
AL080147 mRNA Translation: CAB45740.1
AL050258 mRNA Translation: CAB43360.1
BT007274 mRNA Translation: AAP35938.1
CT841511 mRNA Translation: CAJ86441.1
Z95115, Z99714 Genomic DNA Translation: CAI17979.1
Z99714, Z95115 Genomic DNA Translation: CAI17878.1
CH471095 Genomic DNA Translation: EAW59723.1
BC011599 mRNA Translation: AAH11599.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13838.1 [Q9UBB9-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T12531

NCBI Reference Sequences

More...
RefSeqi
NP_001008697.1, NM_001008697.2 [Q9UBB9-1]
NP_001333786.1, NM_001346857.1 [Q9UBB9-1]
NP_001333787.1, NM_001346858.1 [Q9UBB9-1]
NP_001333788.1, NM_001346859.1 [Q9UBB9-1]
NP_001333790.1, NM_001346861.1 [Q9UBB9-1]
NP_036275.1, NM_012143.3 [Q9UBB9-1]
XP_011528381.1, XM_011530079.1
XP_016884224.1, XM_017028735.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.20225

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000405938; ENSP00000384297; ENSG00000100109 [Q9UBB9-1]
ENST00000407148; ENSP00000385861; ENSG00000100109 [Q9UBB9-1]
ENST00000407431; ENSP00000383892; ENSG00000100109 [Q9UBB9-1]
ENST00000407690; ENSP00000384421; ENSG00000100109 [Q9UBB9-1]
ENST00000619735; ENSP00000480171; ENSG00000100109 [Q9UBB9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:24144

UCSC genome browser

More...
UCSCi
uc003acr.4 human [Q9UBB9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070662 mRNA Translation: AAD20968.1
AL080147 mRNA Translation: CAB45740.1
AL050258 mRNA Translation: CAB43360.1
BT007274 mRNA Translation: AAP35938.1
CT841511 mRNA Translation: CAJ86441.1
Z95115, Z99714 Genomic DNA Translation: CAI17979.1
Z99714, Z95115 Genomic DNA Translation: CAI17878.1
CH471095 Genomic DNA Translation: EAW59723.1
BC011599 mRNA Translation: AAH11599.1
CCDSiCCDS13838.1 [Q9UBB9-1]
PIRiT12531
RefSeqiNP_001008697.1, NM_001008697.2 [Q9UBB9-1]
NP_001333786.1, NM_001346857.1 [Q9UBB9-1]
NP_001333787.1, NM_001346858.1 [Q9UBB9-1]
NP_001333788.1, NM_001346859.1 [Q9UBB9-1]
NP_001333790.1, NM_001346861.1 [Q9UBB9-1]
NP_036275.1, NM_012143.3 [Q9UBB9-1]
XP_011528381.1, XM_011530079.1
XP_016884224.1, XM_017028735.1
UniGeneiHs.20225

3D structure databases

ProteinModelPortaliQ9UBB9
SMRiQ9UBB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117294, 149 interactors
CORUMiQ9UBB9
IntActiQ9UBB9, 243 interactors
MINTiQ9UBB9
STRINGi9606.ENSP00000383892

PTM databases

iPTMnetiQ9UBB9
PhosphoSitePlusiQ9UBB9

Polymorphism and mutation databases

BioMutaiTFIP11
DMDMi22096235

Proteomic databases

EPDiQ9UBB9
MaxQBiQ9UBB9
PaxDbiQ9UBB9
PeptideAtlasiQ9UBB9
PRIDEiQ9UBB9
ProteomicsDBi83928
83929 [Q9UBB9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
24144
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405938; ENSP00000384297; ENSG00000100109 [Q9UBB9-1]
ENST00000407148; ENSP00000385861; ENSG00000100109 [Q9UBB9-1]
ENST00000407431; ENSP00000383892; ENSG00000100109 [Q9UBB9-1]
ENST00000407690; ENSP00000384421; ENSG00000100109 [Q9UBB9-1]
ENST00000619735; ENSP00000480171; ENSG00000100109 [Q9UBB9-1]
GeneIDi24144
KEGGihsa:24144
UCSCiuc003acr.4 human [Q9UBB9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
24144
DisGeNETi24144
EuPathDBiHostDB:ENSG00000100109.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TFIP11
HGNCiHGNC:17165 TFIP11
HPAiHPA027085
MIMi612747 gene
neXtProtiNX_Q9UBB9
OpenTargetsiENSG00000100109
PharmGKBiPA38441

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2184 Eukaryota
ENOG410XP4Y LUCA
GeneTreeiENSGT00390000012739
HOGENOMiHOG000230470
HOVERGENiHBG055868
InParanoidiQ9UBB9
KOiK13103
OMAiVWEWHEL
OrthoDBiEOG091G04T2
PhylomeDBiQ9UBB9
TreeFamiTF314887

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TFIP11 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TFIP11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
24144

Protein Ontology

More...
PROi
PR:Q9UBB9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100109 Expressed in 212 organ(s), highest expression level in testis
CleanExiHS_TFIP11
ExpressionAtlasiQ9UBB9 baseline and differential
GenevisibleiQ9UBB9 HS

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR022783 GCFC_dom
IPR024933 STIP
IPR022159 STIP/TFIP11_N
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF07842 GCFC, 1 hit
PF12457 TIP_N, 1 hit
PIRSFiPIRSF017706 TFIP11, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFP11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBB9
Secondary accession number(s): O95908
, Q20WL0, Q5H8V8, Q9UGV7, Q9Y2Q8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: December 5, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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