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UniProtKB - Q9UBB4 (ATX10_HUMAN)

Entry version 182 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein

Ataxin-10

Gene

ATXN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UBB4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UBB4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ataxin-10
Alternative name(s):
Brain protein E46 homolog
Spinocerebellar ataxia type 10 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATXN10
Synonyms:SCA10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10549, ATXN10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611150, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UBB4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130638.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia 10 (SCA10)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).
Related information in OMIM
Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy that leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia.1 Publication

Keywords - Diseasei

Ciliopathy, Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET

More...DisGeNETi		25814

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		ATXN10

MalaCards human disease database

More...MalaCardsi		ATXN10
MIMi603516, phenotype

Open Targets

More...OpenTargetsi		ENSG00000130638

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		98761, Spinocerebellar ataxia type 10

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34959

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UBB4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATXN10

Domain mapping of disease mutations (DMDM)

More...DMDMi		17372671

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000647481 – 475Ataxin-10Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10Omega-N-methylarginineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UBB4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UBB4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UBB4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UBB4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UBB4

PeptideAtlas

More...PeptideAtlasi		Q9UBB4

PRoteomics IDEntifications database

More...PRIDEi		Q9UBB4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83921 [Q9UBB4-1]
83922 [Q9UBB4-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9UBB4

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UBB4

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UBB4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UBB4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UBB4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the central nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130638, Expressed in ventricular zone and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UBB4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UBB4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130638, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (By similarity).

Interacts with OGT (By similarity).

Interacts with GNB2.

Interacts with IQCB1.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9UBB4
With#Exp.IntAct
AP2B1 - isoform 2 [P63010-2]3EBI-702390,EBI-11529439
API5 - isoform 2 [Q9BZZ5-2]3EBI-702390,EBI-10989614
BAK1 [Q16611]3EBI-702390,EBI-519866
CD1C [P29017]3EBI-702390,EBI-2836704
CDC23 [Q9UJX2]3EBI-702390,EBI-396137
CENPV [Q7Z7K6]3EBI-702390,EBI-1210604
COPS3 [Q9UNS2]3EBI-702390,EBI-350590
CWF19L2 [Q2TBE0]3EBI-702390,EBI-5453285
DIP2A - isoform 3 [Q14689-3]3EBI-702390,EBI-25858204
H3C15 [Q71DI3]3EBI-702390,EBI-750650
HNRNPK [P61978]3EBI-702390,EBI-304185
HYAL2 [Q12891]3EBI-702390,EBI-2806068
LPIN1 [Q14693]3EBI-702390,EBI-5278370
LRATD1 [Q96KN4]3EBI-702390,EBI-11477916
MICAL2 [O94851]3EBI-702390,EBI-2804835
MLC1 [Q15049]3EBI-702390,EBI-8475277
MLLT6 [P55198]3EBI-702390,EBI-740216
MYC [P01106]4EBI-702390,EBI-447544
NCOA4 - isoform 3 [Q13772-3]3EBI-702390,EBI-12054609
PHF19 [Q5T6S3]3EBI-702390,EBI-2339674
PIAS1 [O75925]3EBI-702390,EBI-629434
PPP1R12A [O14974]3EBI-702390,EBI-351726
SAMD3 - isoform 2 [Q8N6K7-2]3EBI-702390,EBI-11528848
SLU7 [O95391]3EBI-702390,EBI-750559
SPATA22 [Q8NHS9]3EBI-702390,EBI-7067260
SPATA2L [Q8IUW3]3EBI-702390,EBI-2510414
SULT4A1 - isoform 2 [Q9BR01-2]3EBI-702390,EBI-25831443
TLE1 [Q04724]3EBI-702390,EBI-711424
TWIST2 [Q8WVJ9]3EBI-702390,EBI-1797313
UBQLN2 [Q9UHD9]3EBI-702390,EBI-947187
UBQLN3 [Q9H347]3EBI-702390,EBI-25832660
UBQLNL [Q8IYU4]3EBI-702390,EBI-12295223
UTP14A [Q9BVJ6]3EBI-702390,EBI-473284
VIM [P08670]3EBI-702390,EBI-353844
WDR61 [Q9GZS3]3EBI-702390,EBI-358545
ZKSCAN5 [Q9Y2L8]3EBI-702390,EBI-2876965
ZNF232 [Q9UNY5]3EBI-702390,EBI-749023
ZNF774 [Q6NX45]3EBI-702390,EBI-10251462
Q96E883EBI-702390,EBI-10976904

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117343, 71 interactors

Protein interaction database and analysis system

More...IntActi		Q9UBB4, 84 interactors

Molecular INTeraction database

More...MINTi		Q9UBB4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000252934

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UBB4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ataxin-10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2676, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010377

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_046084_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UBB4

Identification of Orthologs from Complete Genome Data

More...OMAi		KIVAYCS

Database of Orthologous Groups

More...OrthoDBi		1416864at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UBB4

TreeFam database of animal gene trees

More...TreeFami		TF323870

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR019156, Ataxin-10_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09759, Atx10homo_assoc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPRPPPAR LSGVMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV 
        60         70         80         90        100
LDILKKSSHA VELACRDPSQ VENLASSLQL ITECFRCLRN ACIECSVNQN 
       110        120        130        140        150
SIRNLDTIGV AVDLILLFRE LRVEQESLLT AFRCGLQFLG NIASRNEDSQ 
       160        170        180        190        200
SIVWVHAFPE LFLSCLNHPD KKIVAYSSMI LFTSLNHERM KELEENLNIA 
       210        220        230        240        250
IDVIDAYQKH PESEWPFLII TDLFLKSPEL VQAMFPKLNN QERVTLLDLM 
       260        270        280        290        300
IAKITSDEPL TKDDIPVFLR HAELIASTFV DQCKTVLKLA SEEPPDDEEA 
       310        320        330        340        350
LATIRLLDVL CEMTVNTELL GYLQVFPGLL ERVIDLLRVI HVAGKETTNI 
       360        370        380        390        400
FSNCGCVRAE GDISNVANGF KSHLIRLIGN LCYKNKDNQD KVNELDGIPL 
       410        420        430        440        450
ILDNCNISDS NPFLTQWVIY AIRNLTEDNS QNQDLIAKME EQGLADASLL 
       460        470 
KKVGFEVEKK GEKLILKSTR DTPKP
Length:475
Mass (Da):53,489
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD02130EC86D1A3A
GO
Isoform 2 (identifier: Q9UBB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-103: Missing.

Show »
Length:411
Mass (Da):46,286
Checksum:i4CC979B21A9AC137
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PQD2A0A1W2PQD2_HUMAN
Ataxin-10
ATXN10
395Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AHE3B1AHE3_HUMAN
Ataxin-10
ATXN10
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AHE4B1AHE4_HUMAN
Ataxin-10
ATXN10
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04252640 – 103Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL050282 mRNA Translation: CAB43383.1
AF119662 mRNA Translation: AAF17219.1
CR457381 mRNA Translation: CAG33662.1
CR456568 mRNA Translation: CAG30454.1
AK294348 mRNA Translation: BAG57616.1
Z84478 Genomic DNA No translation available.
Z93784 Genomic DNA No translation available.
Z95331 Genomic DNA No translation available.
BC007508 mRNA Translation: AAH07508.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14070.1 [Q9UBB4-1]
CCDS54540.1 [Q9UBB4-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T08753

NCBI Reference Sequences

More...RefSeqi		NP_001161093.1, NM_001167621.1 [Q9UBB4-2]
NP_037368.1, NM_013236.3 [Q9UBB4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000252934; ENSP00000252934; ENSG00000130638 [Q9UBB4-1]
ENST00000381061; ENSP00000370449; ENSG00000130638 [Q9UBB4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25814

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25814

UCSC genome browser

More...UCSCi		uc003bgm.3, human [Q9UBB4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050282 mRNA Translation: CAB43383.1
AF119662 mRNA Translation: AAF17219.1
CR457381 mRNA Translation: CAG33662.1
CR456568 mRNA Translation: CAG30454.1
AK294348 mRNA Translation: BAG57616.1
Z84478 Genomic DNA No translation available.
Z93784 Genomic DNA No translation available.
Z95331 Genomic DNA No translation available.
BC007508 mRNA Translation: AAH07508.1
CCDSiCCDS14070.1 [Q9UBB4-1]
CCDS54540.1 [Q9UBB4-2]
PIRiT08753
RefSeqiNP_001161093.1, NM_001167621.1 [Q9UBB4-2]
NP_037368.1, NM_013236.3 [Q9UBB4-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117343, 71 interactors
IntActiQ9UBB4, 84 interactors
MINTiQ9UBB4
STRINGi9606.ENSP00000252934

PTM databases

CarbonylDBiQ9UBB4
iPTMnetiQ9UBB4
MetOSiteiQ9UBB4
PhosphoSitePlusiQ9UBB4
SwissPalmiQ9UBB4

Genetic variation databases

BioMutaiATXN10
DMDMi17372671

Proteomic databases

EPDiQ9UBB4
jPOSTiQ9UBB4
MassIVEiQ9UBB4
MaxQBiQ9UBB4
PaxDbiQ9UBB4
PeptideAtlasiQ9UBB4
PRIDEiQ9UBB4
ProteomicsDBi83921 [Q9UBB4-1]
83922 [Q9UBB4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27938, 186 antibodies

The DNASU plasmid repository

More...DNASUi		25814

Genome annotation databases

EnsembliENST00000252934; ENSP00000252934; ENSG00000130638 [Q9UBB4-1]
ENST00000381061; ENSP00000370449; ENSG00000130638 [Q9UBB4-2]
GeneIDi25814
KEGGihsa:25814
UCSCiuc003bgm.3, human [Q9UBB4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25814
DisGeNETi25814

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATXN10
GeneReviewsiATXN10
HGNCiHGNC:10549, ATXN10
HPAiENSG00000130638, Low tissue specificity
MalaCardsiATXN10
MIMi603516, phenotype
611150, gene
neXtProtiNX_Q9UBB4
OpenTargetsiENSG00000130638
Orphaneti98761, Spinocerebellar ataxia type 10
PharmGKBiPA34959
VEuPathDBiHostDB:ENSG00000130638.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2676, Eukaryota
GeneTreeiENSGT00390000010377
HOGENOMiCLU_046084_1_0_1
InParanoidiQ9UBB4
OMAiKIVAYCS
OrthoDBi1416864at2759
PhylomeDBiQ9UBB4
TreeFamiTF323870

Enzyme and pathway databases

PathwayCommonsiQ9UBB4
SIGNORiQ9UBB4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25814, 340 hits in 889 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATXN10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATXN10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25814
PharosiQ9UBB4, Tbio

Protein Ontology

More...PROi		PR:Q9UBB4
RNActiQ9UBB4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130638, Expressed in ventricular zone and 244 other tissues
ExpressionAtlasiQ9UBB4, baseline and differential
GenevisibleiQ9UBB4, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR019156, Ataxin-10_domain
PfamiView protein in Pfam
PF09759, Atx10homo_assoc, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATX10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBB4
Secondary accession number(s): A6NLC4
, B4DG05, O14998, O15009, Q6I9X4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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