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Entry version 174 (18 Sep 2019)
Sequence version 1 (01 May 2000)
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Protein

Serine/threonine kinase NLK

Gene

lit-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T-cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction.5 Publications

Miscellaneous

Worms lacking nlk exhibit defects in body wall muscle, endoderm development and pop-1 asymmetry.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei269ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei366Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi246 – 254ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-4086398 Ca2+ pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9U9Y8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine kinase NLKBy similarity (EC:2.7.11.24)
Alternative name(s):
Loss of intestine protein 1
Nemo-like kinaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lit-1Imported
Synonyms:nlkBy similarity
ORF Names:W06F12.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
W06F12.1a ; CE29476 ; WBGene00003048 ; lit-1
W06F12.1b ; CE29477 ; WBGene00003048 ; lit-1
W06F12.1c ; CE29478 ; WBGene00003048 ; lit-1
W06F12.1d ; CE37160 ; WBGene00003048 ; lit-1
W06F12.1e ; CE37161 ; WBGene00003048 ; lit-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi357L → S in t1512; intestine cells absent but have an excess of pharyngeal cells, symmetrical localization of pop-1 and symmetrical T-cell division. 2 Publications1
Mutagenesisi400T → A: No detectable kinase activity. 1 Publication1
Mutagenesisi402E → K in t1534; reduced body-wall muscle. 1 Publication1
Mutagenesisi541C → Y in or131; loss of pop-1 asymmetry and protruding vulva phenotype and defects in gonadal migration and development. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003728021 – 634Serine/threonine kinase NLKAdd BLAST634

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9U9Y8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9U9Y8

PeptideAtlas

More...
PeptideAtlasi
Q9U9Y8

PRoteomics IDEntifications database

More...
PRIDEi
Q9U9Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in larval and adult pharynx and seam and vulval cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003048 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with wrm-1 (via N-terminus); activates lit-1 kinase activity and the lit-1/wrm-1 dimer phosphorylates pop-1 which promotes pop-1 interaction with par-5 and translocation of pop-1 from the nucleus to the cytoplasm.

Interacts with pop-1 (phosphorylated on 'Ser-118' and 'Ser-127'); dependent on lit-1/wrm-1 complex.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
41974, 64 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1130 Beta-catenin-lit-1 complex

Database of interacting proteins

More...
DIPi
DIP-25624N

Protein interaction database and analysis system

More...
IntActi
Q9U9Y8, 42 interactors

STRING: functional protein association networks

More...
STRINGi
6239.W06F12.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9U9Y8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini240 – 531Protein kinasePROSITE-ProRule annotationAdd BLAST292

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 216Gln-richSequence analysisAdd BLAST137
Compositional biasi102 – 188His-richSequence analysisAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0664 Eukaryota
ENOG410XRAQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168938

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9U9Y8

KEGG Orthology (KO)

More...
KOi
K04468

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIDYFED

Database of Orthologous Groups

More...
OrthoDBi
741207at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9U9Y8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a1 Publication (identifier: Q9U9Y8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSWGRGKDA YYLYISREQE EDDDDSLSFY SSQKDTEDEF CGCLFPDPEI
60 70 80 90 100
PGSSSSSGCS SSSTELYDLA AAHAALISRQ QQILSQAIPI IPEHQLAAVA
110 120 130 140 150
AHHQHHQQLH PSVQYQLVAA ATHHNHHQPQ AAQPHYSAVV PRSDVIQQPP
160 170 180 190 200
HFALHHHLQN LVQQQQQQQA HHHHQQLVGE MALVSHTHPA AVGSTTCYEK
210 220 230 240 250
NQQKQQQVQQ IPTQPQVAHV SSNAILAAAQ PFYPPPVQDS QPDRPIGYGA
260 270 280 290 300
FGVVWSVTDP RSGKRVALKK MPNVFQNLAS CKRVFREIKM LSSFRHDNVL
310 320 330 340 350
SLLDILQPAN PSFFQELYVL TELMQSDLHK IIVSPQALTP DHVKVFVYQI
360 370 380 390 400
LRGLKYLHTA NILHRDIKPG NLLVNSNCIL KICDFGLART WDQRDRLNMT
410 420 430 440 450
HEVVTQYYRA PELLMGARRY TGAVDIWSVG CIFAELLQRK ILFQAAGPIE
460 470 480 490 500
QLQMIIDLLG TPSQEAMKYA CEGAKNHVLR AGLRAPDTQR LYKIASPDDK
510 520 530 540 550
NHEAVDLLQK LLHFDPDKRI SVEEALQHRY LEEGRLRFHS CMCSCCYTKP
560 570 580 590 600
NMPSRLFAQD LDPRHESPFD PKWEKDMSRL SMFELREKMY QFVMDRPALY
610 620 630
GVALCINPQS AAYKNFASSS VAQASELPPS PQAW
Length:634
Mass (Da):71,777
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9F2EA7E3E2CE7F5
GO
Isoform b1 Publication (identifier: Q9U9Y8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
     173-178: HHQQLV → MRDMIY

Show »
Length:462
Mass (Da):52,603
Checksum:iD030A48CA8F2968C
GO
Isoform c1 Publication (identifier: Q9U9Y8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-197: Missing.
     198-216: YEKNQQKQQQVQQIPTQPQ → MILIAIIESFIEYLRKIVW

Note: No experimental confirmation available.Curated
Show »
Length:437
Mass (Da):49,951
Checksum:i21C9CF88553F20D3
GO
Isoform d1 Publication (identifier: Q9U9Y8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     34-51: KDTEDEFCGCLFPDPEIP → MGRNQEGQFNGAGNSESA

Note: No experimental confirmation available.Curated
Show »
Length:601
Mass (Da):67,652
Checksum:i311EED6DED5AA170
GO
Isoform e1 Publication (identifier: Q9U9Y8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: Missing.

Show »
Length:454
Mass (Da):51,607
Checksum:iD951AB8C0CAC9394
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0528451 – 197Missing in isoform c. 1 PublicationAdd BLAST197
Alternative sequenceiVSP_0528461 – 180Missing in isoform e. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_0528471 – 172Missing in isoform b. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0528481 – 33Missing in isoform d. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_05284934 – 51KDTED…DPEIP → MGRNQEGQFNGAGNSESA in isoform d. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_052850173 – 178HHQQLV → MRDMIY in isoform b. 1 Publication6
Alternative sequenceiVSP_052851198 – 216YEKNQ…PTQPQ → MILIAIIESFIEYLRKIVW in isoform c. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF143243 mRNA Translation: AAD37360.1
AF143244 mRNA Translation: AAD37361.1
AF145376 mRNA Translation: AAD39815.1
Z83244 Genomic DNA Translation: CAB05827.2
Z83244 Genomic DNA Translation: CAB60300.2
Z83244 Genomic DNA Translation: CAD18878.1
Z83244 Genomic DNA Translation: CAH10803.1
Z83244, Z92822 Genomic DNA Translation: CAH10804.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T26240

NCBI Reference Sequences

More...
RefSeqi
NP_001022805.1, NM_001027634.2 [Q9U9Y8-1]
NP_001022806.1, NM_001027635.2 [Q9U9Y8-2]
NP_001022807.1, NM_001027636.2 [Q9U9Y8-3]
NP_001022808.1, NM_001027637.3 [Q9U9Y8-4]
NP_001022809.1, NM_001027638.3 [Q9U9Y8-5]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W06F12.1a.1; W06F12.1a.1; WBGene00003048 [Q9U9Y8-1]
W06F12.1b.1; W06F12.1b.1; WBGene00003048 [Q9U9Y8-2]
W06F12.1b.2; W06F12.1b.2; WBGene00003048 [Q9U9Y8-2]
W06F12.1c.1; W06F12.1c.1; WBGene00003048 [Q9U9Y8-3]
W06F12.1d.1; W06F12.1d.1; WBGene00003048 [Q9U9Y8-4]
W06F12.1e.1; W06F12.1e.1; WBGene00003048 [Q9U9Y8-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
176808

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W06F12.1

UCSC genome browser

More...
UCSCi
W06F12.1d c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143243 mRNA Translation: AAD37360.1
AF143244 mRNA Translation: AAD37361.1
AF145376 mRNA Translation: AAD39815.1
Z83244 Genomic DNA Translation: CAB05827.2
Z83244 Genomic DNA Translation: CAB60300.2
Z83244 Genomic DNA Translation: CAD18878.1
Z83244 Genomic DNA Translation: CAH10803.1
Z83244, Z92822 Genomic DNA Translation: CAH10804.1
PIRiT26240
RefSeqiNP_001022805.1, NM_001027634.2 [Q9U9Y8-1]
NP_001022806.1, NM_001027635.2 [Q9U9Y8-2]
NP_001022807.1, NM_001027636.2 [Q9U9Y8-3]
NP_001022808.1, NM_001027637.3 [Q9U9Y8-4]
NP_001022809.1, NM_001027638.3 [Q9U9Y8-5]

3D structure databases

SMRiQ9U9Y8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi41974, 64 interactors
ComplexPortaliCPX-1130 Beta-catenin-lit-1 complex
DIPiDIP-25624N
IntActiQ9U9Y8, 42 interactors
STRINGi6239.W06F12.1a

Proteomic databases

EPDiQ9U9Y8
PaxDbiQ9U9Y8
PeptideAtlasiQ9U9Y8
PRIDEiQ9U9Y8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW06F12.1a.1; W06F12.1a.1; WBGene00003048 [Q9U9Y8-1]
W06F12.1b.1; W06F12.1b.1; WBGene00003048 [Q9U9Y8-2]
W06F12.1b.2; W06F12.1b.2; WBGene00003048 [Q9U9Y8-2]
W06F12.1c.1; W06F12.1c.1; WBGene00003048 [Q9U9Y8-3]
W06F12.1d.1; W06F12.1d.1; WBGene00003048 [Q9U9Y8-4]
W06F12.1e.1; W06F12.1e.1; WBGene00003048 [Q9U9Y8-5]
GeneIDi176808
KEGGicel:CELE_W06F12.1
UCSCiW06F12.1d c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176808
WormBaseiW06F12.1a ; CE29476 ; WBGene00003048 ; lit-1
W06F12.1b ; CE29477 ; WBGene00003048 ; lit-1
W06F12.1c ; CE29478 ; WBGene00003048 ; lit-1
W06F12.1d ; CE37160 ; WBGene00003048 ; lit-1
W06F12.1e ; CE37161 ; WBGene00003048 ; lit-1

Phylogenomic databases

eggNOGiKOG0664 Eukaryota
ENOG410XRAQ LUCA
GeneTreeiENSGT00940000168938
InParanoidiQ9U9Y8
KOiK04468
OMAiHIDYFED
OrthoDBi741207at2759
PhylomeDBiQ9U9Y8

Enzyme and pathway databases

ReactomeiR-CEL-4086398 Ca2+ pathway
SignaLinkiQ9U9Y8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9U9Y8

Gene expression databases

BgeeiWBGene00003048 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLK_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U9Y8
Secondary accession number(s): O62395
, Q69YW9, Q8WQB7, Q9U343, Q9UA07, Q9Y198
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: September 18, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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