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Entry version 127 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Gigas protein

Gene

gig

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-110523, TOR signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Gigas proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gigImported
Synonyms:gigasImported
ORF Names:CG6975Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0005198, gig

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0005198, Expressed in embryo and 23 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9U9B0, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1586 – 1812Rap-GAPInterPro annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni913 – 935DisorderedSequence analysisAdd BLAST23
Regioni1033 – 1145DisorderedSequence analysisAdd BLAST113
Regioni1218 – 1239DisorderedSequence analysisAdd BLAST22
Regioni1262 – 1302DisorderedSequence analysisAdd BLAST41
Regioni1322 – 1371DisorderedSequence analysisAdd BLAST50
Regioni1417 – 1458DisorderedSequence analysisAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili116 – 136Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1057 – 1103Polar residuesSequence analysisAdd BLAST47
Compositional biasi1119 – 1145Polar residuesSequence analysisAdd BLAST27
Compositional biasi1262 – 1282Polar residuesSequence analysisAdd BLAST21
Compositional biasi1331 – 1371Polar residuesSequence analysisAdd BLAST41
Compositional biasi1417 – 1445Polar residuesSequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR003913, Tuberin
IPR018515, Tuberin-type_domain
IPR027107, Tuberin/Ral-act_asu
IPR024584, Tuberin_N

The PANTHER Classification System

More...
PANTHERi
PTHR10063, PTHR10063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11864, DUF3384, 1 hit
PF02145, Rap_GAP, 1 hit
PF03542, Tuberin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01431, TUBERIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347, SSF111347, 1 hit
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9U9B0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSKDKSKFK LFLKSLPAGY VGERTLRPEF ERELRPEQPV AQRCRMLKEL
60 70 80 90 100
GDTQLHNFNL DESAITILLN LTNDLIVPNK PAETRQIALS FYKRLIHTQY
110 120 130 140 150
KNLTIMREKF FLVIQNHEAR EDLRHLLELL DTLTDNGKDI TNFEEKIGKF
160 170 180 190 200
MLLWIPAITE ANLLTPYLDI LVNLIKFNAA HLDKDILVGI VQNACDLSCS
210 220 230 240 250
VTVNEIGLQC LTILEMVIGY TIFPSEPLPQ CITTLCRTVN HAPYCPSSFK
260 270 280 290 300
IMKNLLGTQL GYHSMKMMCS ILNDRALYDD AHLLRGAVFH LNMNIFGSNI
310 320 330 340 350
IFQVSPMTYA TNVLTAFLRA LDSRQVIVTF EVILSVRMVI TKRQLSEIIW
360 370 380 390 400
DLICDIMSSI VSNIEYYEEV NINKDRLHHL QINFHENIDC IEKLLQQDRS
410 420 430 440 450
QILGNVERIY DLIERVADRR PEASVLALIE YRSRRVTATR PDWLQVLAQF
460 470 480 490 500
VRRYYRMSNV NVRIKTIEAL VQIMDQNRAC YEEEILSRVV LVHLSHIHLE
510 520 530 540 550
SSVQVRVAVA RALSNFATHC DTKRCMDLLD ILEALINRPF EHTRHGSSSG
560 570 580 590 600
EGTLAEVTFG LVNNESEISD IIAAVDGLVK VFAIKLHRLP GIHALKIFNI
610 620 630 640 650
LMDHLELHYE RPKIFEHISV VRYKIFAWLL KARANGSYHI GYPEGSTEVV
660 670 680 690 700
KFSPYLGIDS PLLPQAHPTA ISIRRVCKLI VRCLEHDTDY QVFQLVIREL
710 720 730 740 750
PKVLQNKALV QGNDIEELAN TLLKINLVSN NKFKRPTDEF HALVLPAIAS
760 770 780 790 800
LVIYHESLQP QQHYGIITAL NSRVLTGIAS VCINTMTILI LEMPEALMRK
810 820 830 840 850
LPDVLLQMSK MSDTNALATP VLEFLSLLIH LSKHLFANFT SMHNMYVFAI
860 870 880 890 900
TLPYTKPHRY DHYTVSLAHH VIAGWFLKCK LELRRNCVNY IKSSIQSNAK
910 920 930 940 950
MLSSDIVNLN SLNEDSSNRK RSTSLTERGS RNNANAWNDL EMRPQMNNGL
960 970 980 990 1000
RNFHAELAET CFDFLARHTY SPCPSMPKRL PAAEFLLKDG VSQTWLVGNN
1010 1020 1030 1040 1050
LVTITTSGCP SAPARSGLCE RCAQLGKAPS ISLNSKSLSD AAPPLSPERE
1060 1070 1080 1090 1100
RRYTKVSLQH SSGNESAGST ELTSSSSSNS AAAGGHPHRQ ISNSSTASLD
1110 1120 1130 1140 1150
ALSRRGSNPE ALGSALGEGA HTGSNTSLLG NSLSQSSVSM SPSSGSVVQQ
1160 1170 1180 1190 1200
PVCVRACTGW AEVLVRPPTG NVSWITRIQN PITNDCFGQE LPFNNVVSLF
1210 1220 1230 1240 1250
LPTAHGGVFG PDNTIQAPPH TLADPEPEPE AEVNAATAPQ ASALRSRMVA
1260 1270 1280 1290 1300
KARALQRQEE IHSVGGNGNG NGNGNGSGNA PSTGGAAAIP IPRVPASGKR
1310 1320 1330 1340 1350
GKEAALCGSV SDGEADDDSL AFEDAQSRAR NPVRRVNSSP EMSSSWRQSF
1360 1370 1380 1390 1400
LTNKPTPLSQ EPVKTTADEP QSLLTLKKKT VQYSTKDMRV SCEAIPEEIA
1410 1420 1430 1440 1450
GSTPPSQAAA LALQPESGTL PPKQHSADDV SSHVAGGSNL QAGGSTLKLG
1460 1470 1480 1490 1500
KPPLSPGQPP LLGTGRVTSF GGTSVPQPGA LAKSSSSGSN GTNVGVITSD
1510 1520 1530 1540 1550
YDNGNNGNGD MMRGRSKTIS VVREVNNGNT RPPPASSFRN FGAAKPPINT
1560 1570 1580 1590 1600
KLCMNPSFIF MQLYTTGQLG VTDEPLKVGP ENSSAVSLID LVPPFETHKI
1610 1620 1630 1640 1650
GVLYVGQGQC NNEVEILRNS HGSARYVEFL RNIGTLVSLK EAEQNNLFIM
1660 1670 1680 1690 1700
LDRNGADGKF AYIWKDDILQ VTFHVATLMP TNLQDDPNCN EKKSHIGNDF
1710 1720 1730 1740 1750
VKIIYNESGE EYNLNTISGQ FNYACVIVEP LDLNSNRVYV KARSEISKFV
1760 1770 1780 1790 1800
CHAEYRIVSD RSAPLLARQM ALHANLASLV YQSVQKKHPY ASNWLERLRK
1810 1820 1830 1840
LKRLRSKLIE GLNSQQKSGS ASSGIGINAS AIGSDMDDQR GDFIKYT
Length:1,847
Mass (Da):204,026
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20CC7E972773FA40
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF172995 mRNA Translation: AAD48498.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172995 mRNA Translation: AAD48498.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Organism-specific databases

FlyBaseiFBgn0005198, gig

Enzyme and pathway databases

ReactomeiR-DME-110523, TOR signaling pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
gig, fly

Gene expression databases

BgeeiFBgn0005198, Expressed in embryo and 23 other tissues
ExpressionAtlasiQ9U9B0, baseline and differential

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR003913, Tuberin
IPR018515, Tuberin-type_domain
IPR027107, Tuberin/Ral-act_asu
IPR024584, Tuberin_N
PANTHERiPTHR10063, PTHR10063, 1 hit
PfamiView protein in Pfam
PF11864, DUF3384, 1 hit
PF02145, Rap_GAP, 1 hit
PF03542, Tuberin, 1 hit
PRINTSiPR01431, TUBERIN
SUPFAMiSSF111347, SSF111347, 1 hit
SSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50085, RAPGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9U9B0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U9B0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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