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Entry version 157 (02 Dec 2020)
Sequence version 2 (25 Mar 2003)
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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei985NucleophilePROSITE-ProRule annotation1
Active sitei1105Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi174 – 301cNMP 1Add BLAST128
Nucleotide bindingi482 – 609cNMP 2Add BLAST128
Nucleotide bindingi598 – 727cNMP 3Add BLAST130

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase
Biological processLipid degradation, Lipid metabolism, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6814848, Glycerophospholipid catabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Short name:
DSWS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sws
ORF Names:CG2212
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003656, sws

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34LumenalSequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 1425CytoplasmicSequence analysisAdd BLAST1370

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Progressive degeneration of the adult nervous system, associated with apoptotic cell death, glial hyperwrapping, and neuronal apoptosis. Also, vacuolization in the neuropil.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi133R → A: Has no effect on nervous system function but reduces binding to Pka-C3. 1 Publication1
Mutagenesisi648G → R in allele sws-5; age-dependent neurodegeneration. 1 Publication1
Mutagenesisi956G → D in allele sws-4; age-dependent neurodegeneration. 1 Publication1
Mutagenesisi985S → D: Loss of enzymatic activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001725271 – 1425Neuropathy target esterase swsAdd BLAST1425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei444Phosphoserine1 Publication1
Modified residuei453Phosphoserine1 Publication1
Modified residuei1160Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9U969

PRoteomics IDEntifications database

More...
PRIDEi
Q9U969

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9U969

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform A and isoform B are expressed in the entire brain cortex; cortical cell bodies of adult brain. Sws and Pka-C3 are colocalized in all neurons.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform A is expressed in all developmental stages with highest levels in young embryos and adults. Isoform B is detected only in adult head.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003656, Expressed in egg cell and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9U969, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9U969, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58188, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9U969, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071077

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9U969

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini952 – 1118PNPLAPROSITE-ProRule annotationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi956 – 961GXGXXGPROSITE-ProRule annotation6
Motifi983 – 987GXSXGPROSITE-ProRule annotation5
Motifi1105 – 1107DGA/GPROSITE-ProRule annotation3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NTE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2968, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168388

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000960_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9U969

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHLWRYC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9U969

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038, CAP_ED, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR001423, LysoPLipase_patatin_CS
IPR002641, PNPLA_dom
IPR014710, RmlC-like_jellyroll

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027, cNMP_binding, 3 hits
PF01734, Patatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100, cNMP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206, SSF51206, 3 hits
SSF52151, SSF52151, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042, CNMP_BINDING_3, 3 hits
PS51635, PNPLA, 1 hit
PS01237, UPF0028, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: Q9U969-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATVYMYFA LVMMSLLFIA
60 70 80 90 100
WFLYFKRMAR LRLRDEIARS ISTVTNSSGD MRGLRFRKRD KMLFYGRRML
110 120 130 140 150
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY
160 170 180 190 200
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY
210 220 230 240 250
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID
260 270 280 290 300
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI
310 320 330 340 350
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQAPN
360 370 380 390 400
GPPMVISQMN LMQSAVSGTG SSGVSVTVTR PPSSPSRHSR EEHTLSDPNP
410 420 430 440 450
NPDGSFHGTT NLFTEVHGDA PNADLFHQQQ QQHSVGNLST RRSSITLMAP
460 470 480 490 500
DGSHSCLQTP GVTTSIDMRL VQSSAVDSLR KELGLSEEDS HIIEPFVELR
510 520 530 540 550
ELEPNVTLIT EGNADDVCVW FVMTGTLAVY QSNQDATRAK QDKSDMLIHF
560 570 580 590 600
VHPGEIVGGL AMLTGEASAY TIRSRSITRI AFIRRAAIYQ IMRQRPRIVL
610 620 630 640 650
DLGNGVVRRL SPLVRQCDYA LDWIFLESGR AVYRQDESSD STYIVLSGRM
660 670 680 690 700
RSVITHPGGK KEIVGEYGKG DLVGIVEMIT ETSRTTTVMA VRDSELAKLP
710 720 730 740 750
EGLFNAIKLR YPIVVTKLIS FLSHRFLGSM QTRSGSGAPG APVEANPVTH
760 770 780 790 800
KYSTVALVPI TDEVPMTPFT YELYHSLCAI GPVLRLTSDV VRKQLGSNIF
810 820 830 840 850
EAANEYRLTS WLAQQEDRNI ITLYQCDSSL SAWTQRCMRQ ADVILIVGLG
860 870 880 890 900
DRSHLVGKFE REIDRLAMRT QKELVLLYPE ASNAKPANTL SWLNARPWVT
910 920 930 940 950
KHHHVLCVKR IFTRKSQYRI NDLYSRVLLS EPNMHSDFSR LARWLTGNSI
960 970 980 990 1000
GLVLGGGGAR GAAHIGMLKA IQEAGIPVDM VGGVSIGALM GALWCSERNI
1010 1020 1030 1040 1050
TTVTQKAREW SKKMTKWFLQ LLDLTYPITS MFSGREFNKT IHDTFGDVSI
1060 1070 1080 1090 1100
EDLWIPYFTL TTDITASCHR IHTNGSLWRY VRSSMSLSGY MPPLCDPKDG
1110 1120 1130 1140 1150
HLLLDGGYVN NLPADVMHNL GAAHIIAIDV GSQDDTDLTN YGDDLSGWWL
1160 1170 1180 1190 1200
LYKKWNPFTS PVKVPDLPDI QSRLAYVSCV RQLEEVKNSD YCEYIRPPID
1210 1220 1230 1240 1250
KYKTLAFGSF DEIRDVGYVF GKNYFESMAK AGRLGRFNQW FNKEPPKRVN
1260 1270 1280 1290 1300
HASLNEYTFI DLAQIVCRLP ETYAVNTAEL FSEDEDCDGY ISEPTTLNTD
1310 1320 1330 1340 1350
RRRIQVSRAG NSLSFSETEM DSDVELDLKL ERKTDKSTQS SPPSNSRSDM
1360 1370 1380 1390 1400
RGKEEARHMS NWHWGVKHKD ETGSGATEAT KTQTGQEQEL QQEQQDQGAT
1410 1420
AEQLVDKDKE ENKENRSSPN NETKN
Length:1,425
Mass (Da):160,573
Last modified:March 25, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7FEE533B1C2B628
GO
Isoform B (identifier: Q9U969-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-1084: Missing.
     1087-1098: LSGYMPPLCDPK → IAGVFPPFCDYR
     1107-1112: GYVNNL → CYTNNV

Show »
Length:341
Mass (Da):38,784
Checksum:i27425E1327272860
GO
Isoform C (identifier: Q9U969-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1087-1098: LSGYMPPLCDPK → IAGVFPPFCDYR
     1107-1112: GYVNNL → CYTNNV

Show »
Length:1,425
Mass (Da):160,671
Checksum:i98FBA2A5E1A368D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JJF4E1JJF4_DROME
Neuropathy target esterase sws
sws Dmel\CG2212, olfE, PNPLA6, SWS, Sws
1,425Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL28979 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18I → T in CAB51772 (PubMed:9295388).Curated1
Sequence conflicti314L → F in ABV82201 (Ref. 4) Curated1
Sequence conflicti452G → P in CAB51772 (PubMed:9295388).Curated1
Sequence conflicti785R → H in CAB51772 (PubMed:9295388).Curated1
Sequence conflicti1076S → H in ABV82201 (Ref. 4) Curated1
Sequence conflicti1081 – 1083VRS → CRA in ABV82201 (Ref. 4) Curated3
Sequence conflicti1377T → N in CAB51772 (PubMed:9295388).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0383981 – 1084Missing in isoform B. CuratedAdd BLAST1084
Alternative sequenceiVSP_0383991087 – 1098LSGYM…LCDPK → IAGVFPPFCDYR in isoform B and isoform C. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0384001107 – 1112GYVNNL → CYTNNV in isoform B and isoform C. 1 Publication6

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z97187 mRNA Translation: CAB51772.1
AE014298 Genomic DNA Translation: AAF46305.3
AE014298 Genomic DNA Translation: AAN09223.1
BT030819 mRNA Translation: ABV82201.1
AY061431 mRNA Translation: AAL28979.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_511075.3, NM_078520.3 [Q9U969-1]
NP_727225.1, NM_167141.3 [Q9U969-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0071125; FBpp0071077; FBgn0003656 [Q9U969-1]
FBtr0071126; FBpp0071078; FBgn0003656 [Q9U969-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
31716

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG2212

UCSC genome browser

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UCSCi
CG2212-RB, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97187 mRNA Translation: CAB51772.1
AE014298 Genomic DNA Translation: AAF46305.3
AE014298 Genomic DNA Translation: AAN09223.1
BT030819 mRNA Translation: ABV82201.1
AY061431 mRNA Translation: AAL28979.1 Different initiation.
RefSeqiNP_511075.3, NM_078520.3 [Q9U969-1]
NP_727225.1, NM_167141.3 [Q9U969-2]

3D structure databases

SMRiQ9U969
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi58188, 5 interactors
IntActiQ9U969, 2 interactors
STRINGi7227.FBpp0071077

PTM databases

iPTMnetiQ9U969

Proteomic databases

PaxDbiQ9U969
PRIDEiQ9U969

Genome annotation databases

EnsemblMetazoaiFBtr0071125; FBpp0071077; FBgn0003656 [Q9U969-1]
FBtr0071126; FBpp0071078; FBgn0003656 [Q9U969-2]
GeneIDi31716
KEGGidme:Dmel_CG2212
UCSCiCG2212-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
31716
FlyBaseiFBgn0003656, sws

Phylogenomic databases

eggNOGiKOG2968, Eukaryota
GeneTreeiENSGT00940000168388
HOGENOMiCLU_000960_1_0_1
InParanoidiQ9U969
OMAiGHLWRYC
PhylomeDBiQ9U969

Enzyme and pathway databases

ReactomeiR-DME-6814848, Glycerophospholipid catabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
31716, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31716

Protein Ontology

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PROi
PR:Q9U969

Gene expression databases

BgeeiFBgn0003656, Expressed in egg cell and 39 other tissues
ExpressionAtlasiQ9U969, baseline and differential
GenevisibleiQ9U969, DM

Family and domain databases

CDDicd00038, CAP_ED, 3 hits
Gene3Di2.60.120.10, 3 hits
InterProiView protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR001423, LysoPLipase_patatin_CS
IPR002641, PNPLA_dom
IPR014710, RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027, cNMP_binding, 3 hits
PF01734, Patatin, 1 hit
SMARTiView protein in SMART
SM00100, cNMP, 3 hits
SUPFAMiSSF51206, SSF51206, 3 hits
SSF52151, SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042, CNMP_BINDING_3, 3 hits
PS51635, PNPLA, 1 hit
PS01237, UPF0028, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSWS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U969
Secondary accession number(s): A8E6M7
, Q8IRN7, Q95RE9, Q9W3M0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 25, 2003
Last modified: December 2, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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