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Protein

Palmitoyltransferase

Gene

Patsas

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotation, Transferase

Enzyme and pathway databases

SignaLinkiQ9U722

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
Name:PatsasImported
ORF Names:CG6618Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0029137 Patsas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei230 – 250HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 278HelicalUniRule annotationAdd BLAST17
Transmembranei359 – 383HelicalUniRule annotationAdd BLAST25
Transmembranei390 – 409HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ9U722

Expressioni

Gene expression databases

BgeeiFBgn0029137
ExpressionAtlasiQ9U722 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ9U722
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 198ANK_REP_REGIONInterPro annotationAdd BLAST195
Repeati10 – 38ANKPROSITE-ProRule annotationAdd BLAST29
Repeati45 – 77ANKPROSITE-ProRule annotationAdd BLAST33
Repeati78 – 110ANKPROSITE-ProRule annotationAdd BLAST33
Repeati111 – 143ANKPROSITE-ProRule annotationAdd BLAST33
Repeati144 – 164ANKPROSITE-ProRule annotationAdd BLAST21

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotationSAAS annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
OrthoDBiEOG091G0CPB

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF13606 Ank_3, 1 hit
PF01529 DHHC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

Sequencei

Sequence statusi: Complete.

Q9U722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECLSARDRH GYTPAHWIAL NGXVQLMRYL IERTAPIDLP CLGTQGPRPI
60 70 80 90 100
HWACRKGHAS VVQVLLQAGV AVNAADFKGL TPLHLACMYG RTATAAYLLG
110 120 130 140 150
MGALNNLTDI NGDTALHWAA YKGHADLMRL LMYSGVELQK TDNFGSTPLH
160 170 180 190 200
LACLSGNMTC VRLLCEKSQL DLEPRDKNGK TPIMLAQAHQ HQDVVRLLYG
210 220 230 240 250
EVKKKSRWIP SVSESWGWLF GGAGDSKGPL FLFLFSVLLW GYPMYMIRAI
260 270 280 290 300
PITWNILRRS HYCFIYWNAV MWISWAIANR RDPGYIPLSS DAYYRAIKQI
310 320 330 340 350
PYFDKLKKRN VMLTRLCHSC RCLRPLRAKH CRVCNRCVSY FDHHCPFIYN
360 370 380 390 400
CVGLRNRMWF FLFVLSVAVN CSFTIYFACY CVMIEGFTML YVLGLIEAVV
410 420 430 440
FCGLGWILTC TSVSASFPKI LIVLTSFALA DPARLHESHH KRDV
Length:444
Mass (Da):50,444
Last modified:May 1, 2000 - v1
Checksum:i7BCFE02E28B2520C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163011 Genomic DNA Translation: AAF00133.1

Entry informationi

Entry nameiQ9U722_DROME
AccessioniPrimary (citable) accession number: Q9U722
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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