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Entry version 140 (07 Oct 2020)
Sequence version 1 (01 May 2000)
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Protein

Calcium release-activated calcium channel protein 1

Gene

Orai

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores. Regulates transcription factor NFAT nuclear import.2 Publications

Miscellaneous

In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.52.1.5, the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium release-activated calcium channel protein 11 PublicationImported
Alternative name(s):
Protein orai1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Orai1 PublicationImported
Synonyms:CRACM11 Publication, olf186-F1 Publication
ORF Names:CG11430Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0041585, Orai

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 163CytoplasmicSequence analysisAdd BLAST163
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei164 – 181HelicalSequence analysisAdd BLAST18
Topological domaini182 – 191ExtracellularSequence analysis10
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 248CytoplasmicSequence analysisAdd BLAST36
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 277ExtracellularSequence analysis8
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 351CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343881 – 351Calcium release-activated calcium channel protein 1Add BLAST351

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9U6B8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0041585, Expressed in embryonic/larval hemocyte (Drosophila) and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9U6B8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9U6B8, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62725, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-59770N

Protein interaction database and analysis system

More...
IntActi
Q9U6B8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0113106

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9U6B8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi109 – 114Poly-Pro6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4298, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_062509_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9U6B8

KEGG Orthology (KO)

More...
KOi
K16056

Identification of Orthologs from Complete Genome Data

More...
OMAi
HNNARNN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.140.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012446, CRAC_channel
IPR038350, Orai_sf

The PANTHER Classification System

More...
PANTHERi
PTHR31501, PTHR31501, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07856, Orai-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform AImported (identifier: Q9U6B8-1) [UniParc]FASTAAdd to basket
Also known as: BImported, FImported

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVWTTANNS GLETPTKSPI TSSVPRAARS SAVITTGNHQ QHHFQHVVAA
60 70 80 90 100
AVAAATSVAT GHQFQQQFPL HAHPHPQHHS NSPTGSGSNS NNSAGFQRTS
110 120 130 140 150
ISNSLLQFPP PPPPSSQNQA KPRGHHRTAS SSMSQSGEDL HSPTYLSWRK
160 170 180 190 200
LQLSRAKLKA SSKTSALLSG FAMVAMVEVQ LDHDTNVPPG MLIAFAICTT
210 220 230 240 250
LLVAVHMLAL MISTCILPNI ETVCNLHSIS LVHESPHERL HWYIETAWAF
260 270 280 290 300
STLLGLILFL LEIAILCWVK FYDLSPPAAW SACVVLIPVM IIFMAFAIHF
310 320 330 340 350
YRSLVSHKYE VTVSGIRELE MLKEQMEQDH LEHHNNIRNN GMNYGASGDI

V
Length:351
Mass (Da):38,507
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i328A586D251D3335
GO
Isoform EImported (identifier: Q9U6B8-3) [UniParc]FASTAAdd to basket
Also known as: GImported

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: MSVWTTANNS...PPPSSQNQAK → MPPFEEGESK...YQQNQSYRFQ

Show »
Length:507
Mass (Da):55,693
Checksum:iD810DF0A0AC4ABE0
GO
Isoform CCurated (identifier: Q9U6B8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-132: PRGHHRTASSS → AGRTVQIDCRI
     133-351: Missing.

Show »
Length:132
Mass (Da):13,927
Checksum:iE98C39548A114A5F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2QCH2E2QCH2_DROME
Olf186-F, isoform B
Orai BcDNA:LD03241, CRACM1, Dmel\CG11430, DOrai, dOrai
351Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28A → S in ABF54966 (PubMed:16751269).Curated1
Sequence conflicti75H → HPH in ABF54966 (PubMed:16751269).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0183131 – 121MSVWT…QNQAK → MPPFEEGESKPEEQIPLKPP RRHKKMKSADQEAAQTPAED HEEEQLLPGSGTSNLRYARA NLSQSSLMLSHQQGSFESST ERTASSETLDVMPISRRYQV HPQPNRLGIRQPASALASAL HATARLAASVDAYTAAATAT AATGDYGDYMRPQPNLGHAH QLPLTQTTQTAQPLHHQLPA HQLGNLRASNFVGSSRYLYH SQFNSNSPQTRRFTAQRDGS PAYAASVAAASAAAAASAVA PIAPLAPLASIASPPFAAQP PPFQLRTYQQNQSYRFQ in isoform E. 1 PublicationAdd BLAST121
Alternative sequenceiVSP_021772122 – 132PRGHHRTASSS → AGRTVQIDCRI in isoform C. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_021773133 – 351Missing in isoform C. 1 PublicationAdd BLAST219

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ503470 mRNA Translation: ABF54966.1
AF188634 mRNA Translation: AAF01457.1
AE013599 Genomic DNA Translation: AAF57780.2
AE013599 Genomic DNA Translation: AAS64814.2
AE013599 Genomic DNA Translation: ACL83150.1
AE013599 Genomic DNA Translation: AGB93595.1
AY071273 mRNA Translation: AAL48895.1
BT001876 mRNA Translation: AAN71648.1
BT003591 mRNA Translation: AAO39594.1

NCBI Reference Sequences

More...
RefSeqi
NP_001137696.1, NM_001144224.2 [Q9U6B8-3]
NP_001261063.1, NM_001274134.1 [Q9U6B8-3]
NP_611273.1, NM_137429.3 [Q9U6B8-1]
NP_725727.1, NM_170626.2 [Q9U6B8-1]
NP_995881.2, NM_206159.2 [Q9U6B8-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086795; FBpp0085974; FBgn0041585 [Q9U6B8-1]
FBtr0086797; FBpp0085976; FBgn0041585 [Q9U6B8-1]
FBtr0114614; FBpp0113106; FBgn0041585 [Q9U6B8-3]
FBtr0336698; FBpp0307679; FBgn0041585 [Q9U6B8-1]
FBtr0336699; FBpp0307680; FBgn0041585 [Q9U6B8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37040

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11430

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ503470 mRNA Translation: ABF54966.1
AF188634 mRNA Translation: AAF01457.1
AE013599 Genomic DNA Translation: AAF57780.2
AE013599 Genomic DNA Translation: AAS64814.2
AE013599 Genomic DNA Translation: ACL83150.1
AE013599 Genomic DNA Translation: AGB93595.1
AY071273 mRNA Translation: AAL48895.1
BT001876 mRNA Translation: AAN71648.1
BT003591 mRNA Translation: AAO39594.1
RefSeqiNP_001137696.1, NM_001144224.2 [Q9U6B8-3]
NP_001261063.1, NM_001274134.1 [Q9U6B8-3]
NP_611273.1, NM_137429.3 [Q9U6B8-1]
NP_725727.1, NM_170626.2 [Q9U6B8-1]
NP_995881.2, NM_206159.2 [Q9U6B8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HKRX-ray3.35A/B133-341[»]
4HKSX-ray3.35A/B133-341[»]
6AKIX-ray4.50A/B/C/D/E/F/O/P/Q/R/S/T132-341[»]
6BBFX-ray6.71A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X133-341[»]
6BBGX-ray6.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X133-341[»]
6BBHX-ray6.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X133-341[»]
6BBIX-ray4.35A/B/C133-341[»]
SMRiQ9U6B8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi62725, 5 interactors
DIPiDIP-59770N
IntActiQ9U6B8, 1 interactor
STRINGi7227.FBpp0113106

Protein family/group databases

TCDBi1.A.52.1.5, the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

Proteomic databases

PaxDbiQ9U6B8

Genome annotation databases

EnsemblMetazoaiFBtr0086795; FBpp0085974; FBgn0041585 [Q9U6B8-1]
FBtr0086797; FBpp0085976; FBgn0041585 [Q9U6B8-1]
FBtr0114614; FBpp0113106; FBgn0041585 [Q9U6B8-3]
FBtr0336698; FBpp0307679; FBgn0041585 [Q9U6B8-1]
FBtr0336699; FBpp0307680; FBgn0041585 [Q9U6B8-3]
GeneIDi37040
KEGGidme:Dmel_CG11430

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37040
FlyBaseiFBgn0041585, Orai

Phylogenomic databases

eggNOGiKOG4298, Eukaryota
GeneTreeiENSGT00390000015354
HOGENOMiCLU_062509_0_0_1
InParanoidiQ9U6B8
KOiK16056
OMAiHNNARNN

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
37040, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37040

Protein Ontology

More...
PROi
PR:Q9U6B8

Gene expression databases

BgeeiFBgn0041585, Expressed in embryonic/larval hemocyte (Drosophila) and 40 other tissues
ExpressionAtlasiQ9U6B8, baseline and differential
GenevisibleiQ9U6B8, DM

Family and domain databases

Gene3Di1.20.140.140, 1 hit
InterProiView protein in InterPro
IPR012446, CRAC_channel
IPR038350, Orai_sf
PANTHERiPTHR31501, PTHR31501, 1 hit
PfamiView protein in Pfam
PF07856, Orai-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRCM1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U6B8
Secondary accession number(s): B7YZJ7
, Q0E937, Q1HCN1, Q7JQY5, Q7KRH6, Q8IGA6, Q9V892
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 1, 2000
Last modified: October 7, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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