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Entry version 103 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

Homeobox protein prospero

Gene

pros

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for proper neuronal differentiation of most or all neurons and their precursors in central and peripheral nervous systems, axonal outgrowth and pathfinding. Not required for the specification of neuronal identity. May regulate transcription by binding to DNA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein prospero
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pros
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila virilis (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7244 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0028753, Dvir\pros

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002088851 – 1556Homeobox protein prosperoAdd BLAST1556

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9U6A1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7244.FBpp0237841

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9U6A1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1398 – 1456Prospero-type homeoPROSITE-ProRule annotationAdd BLAST59
Domaini1457 – 1556ProsperoPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1398 – 1556Homeo-ProsperoPROSITE-ProRule annotationAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1090 – 1097Nuclear localization signalBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 12Poly-Ala9
Compositional biasi19 – 36Asn-richAdd BLAST18
Compositional biasi150 – 172Asn-richAdd BLAST23
Compositional biasi206 – 209Poly-Ala4
Compositional biasi237 – 292Gln-richAdd BLAST56
Compositional biasi305 – 309Poly-Asn5
Compositional biasi349 – 381Ser-richAdd BLAST33
Compositional biasi443 – 473Asp-richAdd BLAST31
Compositional biasi544 – 547Poly-Ala4
Compositional biasi574 – 1080Gln-richAdd BLAST507
Compositional biasi888 – 906Asn-richAdd BLAST19
Compositional biasi1027 – 1030Poly-Ala4
Compositional biasi1045 – 1054Poly-Gln10
Compositional biasi1057 – 1062Poly-Gln6
Compositional biasi1132 – 1189Thr-richAdd BLAST58
Compositional biasi1140 – 1145Poly-Ala6
Compositional biasi1154 – 1163Poly-Gln10
Compositional biasi1183 – 1189Poly-Thr7
Compositional biasi1330 – 1337Poly-Gln8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.PROSITE-ProRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Prospero homeodomain family.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3779, Eukaryota

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.500, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023082, Homeo_prospero_dom
IPR037131, Homeo_prospero_dom_sf
IPR009057, Homeobox-like_sf
IPR039350, Prospero_homeodomain

The PANTHER Classification System

More...
PANTHERi
PTHR12198, PTHR12198, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05044, HPD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51818, HOMEO_PROSPERO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9U6A1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAAAAAAG AAGGALYTNN NITNNNNNNS NNNNSNITSS SNLSPTAATI
60 70 80 90 100
ATTAAATTAT ALSGSISPGS RESASSLLSA AFGNLFGGSS GENVKRAVRA
110 120 130 140 150
TNEAGPGCHQ WAAQSLDNAM LAAAMETATS ADLLNAAGLV SSLNTSKLLN
160 170 180 190 200
NVNNNNNNNT PLSNGNNNNN NNASISPGSA HSSTTKGGSS RRVSNCSDRS
210 220 230 240 250
LDGNLAAAAT TAATDAAGGS PPRAASVSSL NGGASTQTKQ QQLQHDLMAH
260 270 280 290 300
HMLRNILQGK KELMQLDQEL RTAMQQQQQQ QQQQQNHEKH QQELHSKLNN
310 320 330 340 350
NTTTNNNNNV VSESINLIED SEMPEIKIKS EPELMASATQ APHSPHGGSS
360 370 380 390 400
NSSSSHSHNS SNNSIASNGS LRRKSSDSLD SMQREERATP ATTVEPQLQN
410 420 430 440 450
EVLPTKKEAV DDMLDEVELL GLSGHGHSRN SDLESLASPS HSDMLLLDNS
460 470 480 490 500
KDEVLDNDDI IEDDEDDDDD DDDCIETKRE SNTSGSNCLK KPGMELKRAR
510 520 530 540 550
VEHIVSSMRC SPSATAQAGQ LQVNGCKKRK LYQPQQHAME RYVAAAAGLN
560 570 580 590 600
FGLNLQSMML DQEDSESNEL ESPQIQQKRV EKNALKSQLR SMQEQLAEMQ
610 620 630 640 650
QKYVQLCSRM EQESECQELD NEHEQDMDSM EQEQEQELEQ EQEQEPEPLQ
660 670 680 690 700
QHNDDIELSH SPTLSKSTPK ESSERAGSSS PYIEATEQQQ LLRAAATMLL
710 720 730 740 750
PPRPICSLQM MSKMMSSKLQ HQHNPLVGVA HPALPQGFPP LLQHMGDMSH
760 770 780 790 800
AAAMYQQFFF EQEARMAKEA AEQQQQQQQQ QQQQQQQQQQ QQQQQEQQRR
810 820 830 840 850
YEQEQEQQRR MEEQQQQLHR QQQHLQQLQQ QQQQMEHHVA AAVPRVQLHP
860 870 880 890 900
PARLPTRMGG AAAAAAAAAH SVLKSELSEK FQMLRQHNSS SNSNNSSSNN
910 920 930 940 950
NNSNNNSSMM RMSGTDLEGL ADVLKSEITT SLSALVDTIV TRFVHQRRLF
960 970 980 990 1000
SKQADSVTAA AEQLNKDLML ASQILDRKSP RTKVVADRGL SGNSGHPGAQ
1010 1020 1030 1040 1050
NGPTPATQSA AAMFQAPKTP QGMNPVAAAA LYNSMASPFC LPPDQQQQQQ
1060 1070 1080 1090 1100
QQQQAAQQQQ QQAVQQQHQS AQQTQQQLEQ NEALSLVVTP KKKRHKVTDT
1110 1120 1130 1140 1150
RITPRTVSRI LASGWRCAAQ WTGSCRSSCC RTTTTTTTTA AAAAATTTAA
1160 1170 1180 1190 1200
ATEQQWQQQQ QQQCNAGTEP NGSRPGRRHI LSTATTTTTH DAGVFAHLSG
1210 1220 1230 1240 1250
HTKSIAARIQ SLFAVQSILQ SACGAGPHGP PHGGQPTAAQ LHHQHHHQMQ
1260 1270 1280 1290 1300
LSSSPPGSLG ALMDSRDSPP LPHPPTMLHP ALLAAAHHGG SPDYKTCLRA
1310 1320 1330 1340 1350
VMDAQDRQSE CNSADMTFDG MQPTISFLKQ QQQQQSQLSG AHSVPMVNLW
1360 1370 1380 1390 1400
SLAPTHTLGT NVETSWVETA LTIITIYHTI YDIYTFSNHC ESLTPLHSST
1410 1420 1430 1440 1450
LTPMHLRKAK LMFFWVRYPS SAVLKMYFPD IKFNKNNTAQ LVKWFSNFRE
1460 1470 1480 1490 1500
FYYIQMEKYA RQAVTEGIKT PDDLLIAGDS ELYRVLNLHY NRNNHIEVPQ
1510 1520 1530 1540 1550
NFRFVVEQTL REFFRAIQGG KDTEQSWKKS IYKIISRMDD PVPEYFKSPN

FLEQLE
Length:1,556
Mass (Da):171,030
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FEACFEA2D73E644
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF190405 Genomic DNA Translation: AAF06660.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190405 Genomic DNA Translation: AAF06660.1

3D structure databases

SMRiQ9U6A1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7244.FBpp0237841

Proteomic databases

PRIDEiQ9U6A1

Organism-specific databases

FlyBaseiFBgn0028753, Dvir\pros

Phylogenomic databases

eggNOGiKOG3779, Eukaryota

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
pros, fly

Family and domain databases

Gene3Di1.10.10.500, 1 hit
InterProiView protein in InterPro
IPR023082, Homeo_prospero_dom
IPR037131, Homeo_prospero_dom_sf
IPR009057, Homeobox-like_sf
IPR039350, Prospero_homeodomain
PANTHERiPTHR12198, PTHR12198, 2 hits
PfamiView protein in Pfam
PF05044, HPD, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51818, HOMEO_PROSPERO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROS_DROVI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U6A1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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