UniProtKB - Q9U4F3 (SURF1_DROME)
Protein
SURF1-like protein
Gene
Surf1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Probably involved in the biogenesis of the COX complex.2 Publications
GO - Biological processi
- instar larval development Source: FlyBase
- mitochondrial cytochrome c oxidase assembly Source: UniProtKB
- mitochondrial respirasome assembly Source: UniProtKB
- phototaxis Source: FlyBase
- respiratory chain complex IV assembly Source: FlyBase
- visual behavior Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-5628897, TP53 Regulates Metabolic Genes R-DME-611105, Respiratory electron transport |
Names & Taxonomyi
Protein namesi | Recommended name: SURF1-like protein |
Gene namesi | Name:Surf1 ORF Names:CG9943 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0029117, Surf1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 60 – 82 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 271 – 291 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Disruption phenotypei
Lethal at larval stage (PubMed:16172499). Larvae show reduced locomotor speed and response to light (PubMed:16172499). Results in smaller muscle fibers with mitochondria defects (PubMed:16172499). RNAi-mediated knockdown is lethal at larval stage (PubMed:25164807). RNAi-mediated knockdown in the developing CNS, in the eye and antenna disk from early larval stages shows increased lifespan with reduction of COX activity, increased succinate dehydrogenase (SDH) activity, reduced locomotor speed and response to light (PubMed:16172499, PubMed:25164807). RNAi-mediated knockdown in mesodermal derivatives from early embryonic stages to pupal metamorphosis is lethal at pupal stage with muscles showing enlarged and disorganized mitochondria and reduced activity of all mitochondrial respiratory chain complexes (PubMed:25164807).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215657 | 1 – 300 | SURF1-like proteinAdd BLAST | 300 |
Proteomic databases
PaxDbi | Q9U4F3 |
PRIDEi | Q9U4F3 |
Expressioni
Gene expression databases
Bgeei | FBgn0029117, Expressed in adult abdomen (Drosophila) and 33 other tissues |
ExpressionAtlasi | Q9U4F3, baseline and differential |
Genevisiblei | Q9U4F3, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 69086, 2 interactors |
STRINGi | 7227.FBpp0076607 |
Family & Domainsi
Sequence similaritiesi
Belongs to the SURF1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1563, Eukaryota |
GeneTreei | ENSGT00530000064194 |
HOGENOMi | CLU_047737_4_0_1 |
InParanoidi | Q9U4F3 |
OMAi | WYSRDVA |
OrthoDBi | 923657at2759 |
PhylomeDBi | Q9U4F3 |
Family and domain databases
CDDi | cd06662, SURF1, 1 hit |
InterProi | View protein in InterPro IPR002994, Surf1/Shy1 |
Pfami | View protein in Pfam PF02104, SURF1, 1 hit |
PROSITEi | View protein in PROSITE PS50895, SURF1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9U4F3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIRLGNQMCR QVAFNIQTVF RNPGTANNPR LITRKMTQQR PPVNWTTSIP
60 70 80 90 100
NQAAKDKEKI APLGWFLLLI PATTFGLGCW QVKRKIWKEQ LIKDLNKQLS
110 120 130 140 150
TAPVALPDDL TDLAQMEYRL VKIRGRFLHD KEMRLGPRSL IRPDGVETQG
160 170 180 190 200
GLFSQRDSGN GYLIVTPFQL ADRDDIVLVN RGWVSRKQVE PETRPLGQQQ
210 220 230 240 250
AEVELTAVVR KGEARPQFTP DHKGNVYLYR DLARMCAATG AAPVFLDAVY
260 270 280 290 300
DPQTAAHAPI GGQTRVTLRN DHLSYLVTWF SLSAATSFLW YRQIVKRIPF
Sequence cautioni
The sequence AAM50675 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182954 mRNA Translation: AAF19610.1 AE014296 Genomic DNA Translation: AAF50632.2 AY118815 mRNA Translation: AAM50675.1 Different initiation. |
RefSeqi | NP_524758.1, NM_080019.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0076897; FBpp0076607; FBgn0029117 |
GeneIDi | 44498 |
KEGGi | dme:Dmel_CG9943 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182954 mRNA Translation: AAF19610.1 AE014296 Genomic DNA Translation: AAF50632.2 AY118815 mRNA Translation: AAM50675.1 Different initiation. |
RefSeqi | NP_524758.1, NM_080019.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 69086, 2 interactors |
STRINGi | 7227.FBpp0076607 |
Proteomic databases
PaxDbi | Q9U4F3 |
PRIDEi | Q9U4F3 |
Genome annotation databases
EnsemblMetazoai | FBtr0076897; FBpp0076607; FBgn0029117 |
GeneIDi | 44498 |
KEGGi | dme:Dmel_CG9943 |
Organism-specific databases
CTDi | 6834 |
FlyBasei | FBgn0029117, Surf1 |
Phylogenomic databases
eggNOGi | KOG1563, Eukaryota |
GeneTreei | ENSGT00530000064194 |
HOGENOMi | CLU_047737_4_0_1 |
InParanoidi | Q9U4F3 |
OMAi | WYSRDVA |
OrthoDBi | 923657at2759 |
PhylomeDBi | Q9U4F3 |
Enzyme and pathway databases
Reactomei | R-DME-5628897, TP53 Regulates Metabolic Genes R-DME-611105, Respiratory electron transport |
Miscellaneous databases
BioGRID-ORCSi | 44498, 0 hits in 1 CRISPR screen |
GenomeRNAii | 44498 |
PROi | PR:Q9U4F3 |
Gene expression databases
Bgeei | FBgn0029117, Expressed in adult abdomen (Drosophila) and 33 other tissues |
ExpressionAtlasi | Q9U4F3, baseline and differential |
Genevisiblei | Q9U4F3, DM |
Family and domain databases
CDDi | cd06662, SURF1, 1 hit |
InterProi | View protein in InterPro IPR002994, Surf1/Shy1 |
Pfami | View protein in Pfam PF02104, SURF1, 1 hit |
PROSITEi | View protein in PROSITE PS50895, SURF1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SURF1_DROME | |
Accessioni | Q9U4F3Primary (citable) accession number: Q9U4F3 Secondary accession number(s): Q8MSH4, Q9VRZ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 13, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families