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Entry version 121 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Numb-associated kinase

Gene

Nak

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9U485

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Numb-associated kinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NakImported
ORF Names:CG10637Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0015772, Nak

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
VectorBase:FBgn0015772

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9U485

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0015772, Expressed in oviduct (Drosophila) and 48 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9U485, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9U485

Protein interaction database and analysis system

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IntActi
Q9U485, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 316Protein kinaseInterPro annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31
Regioni369 – 412DisorderedSequence analysisAdd BLAST44
Regioni489 – 509DisorderedSequence analysisAdd BLAST21
Regioni785 – 818DisorderedSequence analysisAdd BLAST34
Regioni888 – 929DisorderedSequence analysisAdd BLAST42
Regioni976 – 1042DisorderedSequence analysisAdd BLAST67
Regioni1063 – 1086DisorderedSequence analysisAdd BLAST24
Regioni1384 – 1433DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 31Polar residuesSequence analysisAdd BLAST17
Compositional biasi369 – 383Polar residuesSequence analysisAdd BLAST15
Compositional biasi393 – 407Pro residuesSequence analysisAdd BLAST15
Compositional biasi902 – 921Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1004 – 1019Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1020 – 1039Polar residuesSequence analysisAdd BLAST20
Compositional biasi1384 – 1399Polar residuesSequence analysisAdd BLAST16

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004433_0_0_1

Identification of Orthologs from Complete Genome Data

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OMAi
QDQDENR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9U485-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKILSKFER NENSRLENPP NSSSSSSSNE KNSFVGKVFT VGRVTVTVED
60 70 80 90 100
VLAEGGFAMV FLARGNGGGS SSATKYALKR MYVNNEHDLN VAKREIQIAS
110 120 130 140 150
NLSGHKNIIG YVDSSITPTG NGVCEVLLLM PYCKHHMLAM MNARLHVGFT
160 170 180 190 200
EPEVLNIFCD IAEAVSRLHY CQTPIIHRDL KVENILQTDA GNFVLCDFGS
210 220 230 240 250
ATAKTLNPQQ HGVTVVQEEI QKYTTLSYRA PEMIDLYGGK SITTKADIWA
260 270 280 290 300
LGCMLYKLCF FSLPFGESTL AIQNGQFSIP DSSKYSKGMH QLIKYMLEPD
310 320 330 340 350
MEKRPNIWQV CEVAFRLAGK DNPVQNLHKT PIPNFDLLVV PPFESEAKRI
360 370 380 390 400
SAAASKAAKA QNVSVVEAGT SVAPRSRPKG SSSVHGGNPL GLGLPPSPSP
410 420 430 440 450
RQNITSPQPQ PQPVVEQFQA NFPAMPPAVP PPPQAVTPAA PAASKLFESS
460 470 480 490 500
GYPDPFNEPA AAVIPTEFLP AAEEPNKEEV PQDLNVIAGT PTKSMLTPPK
510 520 530 540 550
PSGGGGHRRN VSDTSAFNKT FANETSQFLA PFNNNLAAMG DGQQTLASAA
560 570 580 590 600
SNPGIYASST ANSAAVSISE LMKPGQTAVE KRVEAWNPFE EEQPFSQMTE
610 620 630 640 650
DHIFEAEFDK IRQRGSQGSI TAKSASTTST LTPTEQIPSA VVAPVTAAPG
660 670 680 690 700
AVPPPPIAAA VSPYPSQVSE DPFGSAPFSL PPGLREKASS LRKTGAKFIG
710 720 730 740 750
VSSGGTGGGV ATPIGLVAGG ANTATSSNSS KWMLSPTLEV SSEEKTSLIS
760 770 780 790 800
KLKTDSECGI PGAVGGAGEG VSGYVKLPVE DRNKYEKLRS KDQPTSDDSD
810 820 830 840 850
SEASEFFQQD SDEGGGGIFR QMQMVTSNLP ETIHKIQQVA YHKVDKTAHL
860 870 880 890 900
PIVKKLRDKT KKPTTAAHQA AQQLNLMAAA VAAQAEEAAK AAESDGDSIG
910 920 930 940 950
SASDLRAEDD DLFDENPRQT QAKQRRPLPT EMDGISESVK TCSSSAYHAE
960 970 980 990 1000
CESVTTHEDD VRSRVVVKVR MRKKDRALVT ATGDPSAPSE ELSPTSSDLL
1010 1020 1030 1040 1050
HKFGDRPLLL DDELDYGSGE SKSSTESPVA PTLPTNPDVQ ESEEDVFALA
1060 1070 1080 1090 1100
PFKLPVGVPL KRKTKPKAKP KPAEPEMWTS TPVKSAAVGD PSTNFASFPA
1110 1120 1130 1140 1150
NVTPTNNVGN SAQLDEFNAP IFNPFQENAQ NTQSGETNQC DLFGLEPFPQ
1160 1170 1180 1190 1200
VIRTIEQNPQ HHQIHQFPSH NNNNNVIKVP ASVSVALPAS VPVSVSVNSS
1210 1220 1230 1240 1250
APQLVTINHS IIINKTPEPP MNYNNNNNNN NQTAKSTGTS SVYVNVPSFS
1260 1270 1280 1290 1300
SMSTSSCSIN QPQSSPAAVI PVQAPLPVPV PAPVSVPAVP VPIPAVVTHL
1310 1320 1330 1340 1350
RPLLPIADNA YVQISQDRCS DFTPDDEEEP VVLRDADVVA DGIGIPTPAK
1360 1370 1380 1390 1400
PKKEKSNLAV RVLPGKLTQK VKGHSYKKVS AAALGSTSSL SSGSKQKHQR
1410 1420 1430 1440 1450
LQYQSHDDDD DEQDQDENRG AGGGRNFQSN TIQNSAKTGF SNMSFEDFPS
1460 1470 1480 1490
DQEMDRLSRT IPFEVVRNEK MLLEAEKKFG SLKRRNNLFS
Length:1,490
Mass (Da):159,797
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i816F66B9D7E4B7A8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF197910 mRNA Translation: AAF15596.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197910 mRNA Translation: AAF15596.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ELMiQ9U485
IntActiQ9U485, 1 interactor

Proteomic databases

PRIDEiQ9U485

Organism-specific databases

FlyBaseiFBgn0015772, Nak
VEuPathDBiVectorBase:FBgn0015772

Phylogenomic databases

HOGENOMiCLU_004433_0_0_1
OMAiQDQDENR

Enzyme and pathway databases

SignaLinkiQ9U485

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Atpalpha, fly

Gene expression databases

BgeeiFBgn0015772, Expressed in oviduct (Drosophila) and 48 other tissues
ExpressionAtlasiQ9U485, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9U485_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U485
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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