Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 124 (26 Feb 2020)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Nup54 domain-containing protein

Gene

npp-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-159227 Transport of the SLBP independent Mature mRNA
R-CEL-159230 Transport of the SLBP Dependant Mature mRNA
R-CEL-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins
R-CEL-3232142 SUMOylation of ubiquitinylation proteins
R-CEL-3301854 Nuclear Pore Complex (NPC) Disassembly
R-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-4085377 SUMOylation of SUMOylation proteins
R-CEL-4551638 SUMOylation of chromatin organization proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nup54 domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:npp-1Imported
ORF Names:CELE_K07F5.13Imported, K07F5.13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
K07F5.13c ; CE23858 ; WBGene00003787 ; npp-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9U3B9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9U3B9

PeptideAtlas

More...
PeptideAtlasi
Q9U3B9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003787 Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.K07F5.13c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9U3B9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini443 – 576Nup54InterPro annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 73DisorderedSequence analysisAdd BLAST73
Regioni146 – 167DisorderedSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3091 Eukaryota
ENOG410XPU5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013620

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9U3B9

KEGG Orthology (KO)

More...
KOi
K14308

Database of Orthologous Groups

More...
OrthoDBi
1506658at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9U3B9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024864 Nup54/Nup57/Nup44
IPR025712 Nup54_alpha-helical_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13000 PTHR13000, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13874 Nup54, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9U3B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFGSSTPQ KQAFTFPTPN APTTSSGTLF GSTTPSKPLF GSTAQASSTP
60 70 80 90 100
SLFGTTNTST PSGGLFGKTG TSTTTTSTAG TLFGAAPTTS TATPSLFGAS
110 120 130 140 150
TTGLFGTSST TSGGLGGIGS TQQTAKSPVA TRLAAFKSGT LGAGSLSGNT
160 170 180 190 200
PTSFATPSAL PGTNAPQSSF LSPANNLNVA PAAYRPPYST FGGSTPFGAA
210 220 230 240 250
STGTAAGSTL FGSSTAKPAT GGFFGSSSGS TLGGLGATQQ QQQPVVQQQQ
260 270 280 290 300
VIQQYHPFVK AVGDPKLFGN DNDGVVAKLN QVAAGLGVGK APYKDGNQLL
310 320 330 340 350
SFSMEGNLFE RFVGIGYNRI SERTDDEGFV TLVLRHPITN LNTEERRDKI
360 370 380 390 400
LEIIKAILGG GPNVEVRYAP GTSMRTLSDG CTEICIIAKE GGFVAGAIKL
410 420 430 440 450
AQILNDAPKM TQLESQLQVD KTRVLPKVGM SKAQRDRYLE TVPDGIDERI
460 470 480 490 500
WRQAIKENPA PNKLLPVPVR GWEALRDRQK AQVGESKLFH EAINALGNRV
510 520 530 540 550
EEANHEHADA VVKMEIIRNR HKTLSYRIVR VMLAQWIVSR YSRQIDTDED
560 570 580 590 600
VIEAKADTLL AQMNRHNQVK FYVDKFYEIL ESKPDKLQES MWKMFDMTIE
610 620 630
DEHYARRVLT KFVNICSGLY ESTHQQIESL EACRRALEG
Length:639
Mass (Da):68,264
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i122EF6EFEB8B25DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q21295Q21295_CAEEL
Nup54 domain-containing protein
npp-1 CELE_K07F5.13, K07F5.13
612Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9U3C1Q9U3C1_CAEEL
Nup54 domain-containing protein
npp-1 CELE_K07F5.13, K07F5.13
549Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAB54280.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T23424

NCBI Reference Sequences

More...
RefSeqi
NP_501770.1, NM_069369.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K07F5.13c.1; K07F5.13c.1; WBGene00003787

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_K07F5.13

UCSC genome browser

More...
UCSCi
K07F5.13b.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAB54280.1
PIRiT23424
RefSeqiNP_501770.1, NM_069369.3

3D structure databases

SMRiQ9U3B9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.K07F5.13c

Proteomic databases

EPDiQ9U3B9
PaxDbiQ9U3B9
PeptideAtlasiQ9U3B9

Genome annotation databases

EnsemblMetazoaiK07F5.13c.1; K07F5.13c.1; WBGene00003787
GeneIDi177836
KEGGicel:CELE_K07F5.13
UCSCiK07F5.13b.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177836
WormBaseiK07F5.13c ; CE23858 ; WBGene00003787 ; npp-1

Phylogenomic databases

eggNOGiKOG3091 Eukaryota
ENOG410XPU5 LUCA
GeneTreeiENSGT00390000013620
InParanoidiQ9U3B9
KOiK14308
OrthoDBi1506658at2759
PhylomeDBiQ9U3B9

Enzyme and pathway databases

ReactomeiR-CEL-159227 Transport of the SLBP independent Mature mRNA
R-CEL-159230 Transport of the SLBP Dependant Mature mRNA
R-CEL-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins
R-CEL-3232142 SUMOylation of ubiquitinylation proteins
R-CEL-3301854 Nuclear Pore Complex (NPC) Disassembly
R-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-4085377 SUMOylation of SUMOylation proteins
R-CEL-4551638 SUMOylation of chromatin organization proteins

Gene expression databases

BgeeiWBGene00003787 Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR024864 Nup54/Nup57/Nup44
IPR025712 Nup54_alpha-helical_dom
PANTHERiPTHR13000 PTHR13000, 1 hit
PfamiView protein in Pfam
PF13874 Nup54, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9U3B9_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U3B9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 26, 2020
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again