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Entry version 131 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

B30.2/SPRY domain-containing protein

Gene

hrpu-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
B30.2/SPRY domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hrpu-1Imported
ORF Names:CELE_Y41E3.11Imported, Y41E3.11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
Y41E3.11b ; CE18379 ; WBGene00012769 ; hrpu-1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q9U2H8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00012769, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9U2H8, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9U2H8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 380B30.2/SPRYInterPro annotationAdd BLAST207

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 94DisorderedSequence analysisAdd BLAST94
Regioni610 – 677DisorderedSequence analysisAdd BLAST68
Regioni732 – 813DisorderedSequence analysisAdd BLAST82
Regioni888 – 917DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 91AcidicSequence analysisAdd BLAST58
Compositional biasi637 – 674PolarSequence analysisAdd BLAST38
Compositional biasi737 – 805PolarSequence analysisAdd BLAST69
Compositional biasi894 – 917Pro-richSequence analysisAdd BLAST24

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR027417, P-loop_NTPase
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00622, SPRY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9U2H8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELGDGDGEY NPEDSAIGQD ESEIVWEYQP IMTRMEDEEE EMEENEGDDE
60 70 80 90 100
DEDEMVMDDE EEDDDEDEEE ATNLDAPEAP EALEAQEDPE ELNVLEQNPM
110 120 130 140 150
ELLKRALPLL HSSTVTEQPK HDYAQLELPI TESLLKRTDD EQPEEVYYHG
160 170 180 190 200
DPVPEVDENE LYEIAAGIKP KKKEKKALVQ IPEEERVPAD SETIELDYYN
210 220 230 240 250
ADILVKSAEK DIWQIEPFNQ DGLALMWGGI RSNFGIKLPF KQTGKDASHR
260 270 280 290 300
LAFQIQIDSY QSIQHLPTEF MADGGDVRIG FSLASTASLI LGESPGSWCI
310 320 330 340 350
SASGKRAANN HFSDFGKLFD IGDVVTCIFD LSVGTISYQI NGENVGSPFE
360 370 380 390 400
SLQFREGDVI FPTICTKNAN INVNMGQELT DEKWKIPEDR DWMFITEMDR
410 420 430 440 450
AHLVRSHTAP AAKKDCTVLM TVGLPGVGKT TWVRRYLAEH PHEHWTLISA
460 470 480 490 500
DVVMDAMKVN GVPRIRLPTL KRPDFLRGII GKSMNRLILL APRRRKNYIL
510 520 530 540 550
DMTNCFAEKR KRKLMAFEEF NRKCMLFVPD EDTHQKRLIK QEHEENEKLD
560 570 580 590 600
TDAMMQHKAA MSLPIVAEGE PCEELIFIDP PAGCEQIAFD RVGKMNYDCR
610 620 630 640 650
SWLVIPGRRR GGGGYNNHHN RGDRGGGGGN YHHGGYHQYN RPSTSGPPSG
660 670 680 690 700
GAQYSPRGSS SSTMNITHTT FPSVPSPLVR EEPTIILPPV KIGLPVVVST
710 720 730 740 750
ADDSSSPTVA AAVVVAGNNQ FSFPPPPVVM AAPASAAPQT PIQQQQKIQQ
760 770 780 790 800
VQQPKKVEVS QPLTLNTSSL PRKSTDSSAG PLSIVSSAGG RSSSFTQQSP
810 820 830 840 850
RFATTPIPSV IPPTTTPVQQ IPVMMNISQP PPQIMMSIPP PSMMVQHMRQ
860 870 880 890 900
PPVVFPIDVT VPPPNFSAPP PMLPASAGIP PHLLMYHHHQ MSAPPPPTTT
910
PQQAPQFSYP PPQFAPR
Length:917
Mass (Da):101,813
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11CEB5511CBEC22C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9WRU1B9WRU1_CAEEL
B30.2/SPRY domain-containing protei...
hrpu-1 CELE_Y41E3.11, Y41E3.11
1,667Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GUI4F5GUI4_CAEEL
B30.2/SPRY domain-containing protei...
hrpu-1 CELE_Y41E3.11, Y41E3.11
692Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GUI5F5GUI5_CAEEL
B30.2/SPRY domain-containing protei...
hrpu-1 CELE_Y41E3.11, Y41E3.11
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAB63361.1

NCBI Reference Sequences

More...
RefSeqi
NP_001255854.1, NM_001268925.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y41E3.11b.1; Y41E3.11b.1; WBGene00012769
Y41E3.11b.2; Y41E3.11b.2; WBGene00012769

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178421

UCSC genome browser

More...
UCSCi
Y41E3.11, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAB63361.1
RefSeqiNP_001255854.1, NM_001268925.1

3D structure databases

SMRiQ9U2H8
ModBaseiSearch...

Proteomic databases

PeptideAtlasiQ9U2H8

Genome annotation databases

EnsemblMetazoaiY41E3.11b.1; Y41E3.11b.1; WBGene00012769
Y41E3.11b.2; Y41E3.11b.2; WBGene00012769
GeneIDi178421
UCSCiY41E3.11, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178421
WormBaseiY41E3.11b ; CE18379 ; WBGene00012769 ; hrpu-1

Gene expression databases

BgeeiWBGene00012769, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiQ9U2H8, baseline and differential

Family and domain databases

Gene3Di2.60.120.920, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR027417, P-loop_NTPase
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF00622, SPRY, 1 hit
SMARTiView protein in SMART
SM00449, SPRY, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9U2H8_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U2H8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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