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Entry version 147 (16 Jan 2019)
Sequence version 3 (16 Dec 2008)
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Protein
Submitted name:

Uncharacterized protein

Gene

mrp-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi659 – 666ATPPROSITE-ProRule annotation8
Nucleotide bindingi1316 – 1323ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

  • response to methylmercury Source: WormBase
  • transmembrane transport Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-CEL-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-CEL-382556 ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrp-7Imported
ORF Names:CELE_Y43F8C.12Imported, Y43F8C.12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
Y43F8C.12 ; CE43255 ; WBGene00003413 ; mrp-7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 51HelicalSequence analysisAdd BLAST25
Transmembranei63 – 86HelicalSequence analysisAdd BLAST24
Transmembranei92 – 114HelicalSequence analysisAdd BLAST23
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei166 – 188HelicalSequence analysisAdd BLAST23
Transmembranei345 – 366HelicalSequence analysisAdd BLAST22
Transmembranei445 – 466HelicalSequence analysisAdd BLAST22
Transmembranei527 – 549HelicalSequence analysisAdd BLAST23
Transmembranei555 – 571HelicalSequence analysisAdd BLAST17
Transmembranei955 – 982HelicalSequence analysisAdd BLAST28
Transmembranei1002 – 1026HelicalSequence analysisAdd BLAST25
Transmembranei1077 – 1096HelicalSequence analysisAdd BLAST20
Transmembranei1102 – 1120HelicalSequence analysisAdd BLAST19
Transmembranei1185 – 1206HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9U2G5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9U2G5

PeptideAtlas

More...
PeptideAtlasi
Q9U2G5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003413 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.Y43F8C.12

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9U2G5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini305 – 587ABC transmembrane type-1InterPro annotationAdd BLAST283
Domaini622 – 849ABC transporterInterPro annotationAdd BLAST228
Domaini959 – 1245ABC transmembrane type-1InterPro annotationAdd BLAST287
Domaini1282 – 1516ABC transporterInterPro annotationAdd BLAST235

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166156

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9U2G5

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVLANFA

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9U2G5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9U2G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSSFCGDGH PFSTGLPNVS ICAQHTVLVW VPAAFFLLTL PFLSAQCHLT
60 70 80 90 100
AQRFARLPFS AHFIIKLLLV AFLAANSLAT WCYVLFSKNS YAAAYYVYPG
110 120 130 140 150
LWVLVWTGTF LVHLIRLRCG LVSSGIQHVT SLIFLLCGAP EFYQWIRMEN
160 170 180 190 200
SNSFPNDLTT TDSAQFLSIA YLSWYSALIL YTFSLCFADP RGAKTDDEKA
210 220 230 240 250
SSKSAASPEL QSSFLNRLTL WWFNSIPWTG ARRDLEIDDI FELNERSGTE
260 270 280 290 300
FLSELWESFW EPKRLKYIHD TSIWAKKDPS EQEKDPVVIP SVVSSLFMMF
310 320 330 340 350
RWEFLLASTL KFVSDTMQFA SPFLLHELLN FISAKNAPFW KGMALSILMF
360 370 380 390 400
SVSELRSLIL NGYFYIMFRM GTKIQTSLTA AVYKKTLLIS NSARRDRTVG
410 420 430 440 450
EIVNLMAIDV ERFQMITPQI QQFWSCPYQI TFALVYLFIT LGYSALPGVV
460 470 480 490 500
IMVIFVPMNI ISSMIVRKWQ IEQMKLKDER TKMVNEVLNG IKVVKLYAWE
510 520 530 540 550
VPMEAYIDEI RTKELALIKK SAMVRNILDS FNTASPFLVA LFSFGTFVLS
560 570 580 590 600
NPSHLLTPQI AFVSLALFNQ LRSPMTMIAL LINQAVQAVV SNKRLKEFLV
610 620 630 640 650
AEELDEKCVD RSVNIERSHN AVRVENLTAS WDPEEAAGEK TLQDVDLTAP
660 670 680 690 700
RNSLIAVVGK VGSGKSSLLQ ALLGEMGKLR GRIGVNGRVA YVPQQPWIQN
710 720 730 740 750
MTLRDNITFG RPFDRKRYDQ VLYACALKAD IKILPAGDQT EIGEKGINLS
760 770 780 790 800
GGQKARVSLA RAVYQNLDVY LLDDPLSAVD AHVGRHIFEK VIGPNGLLRE
810 820 830 840 850
KTRILVTHGL TYTKMADEIL VMLEGKIEES GTFEHLIKRR GLFFDFMEEY
860 870 880 890 900
KSGSDNSSEA GGSQDDDFEA IGGEIQDYMN PEDVVLTVTN DLDETIRTPE
910 920 930 940 950
LTTQISTMSS PEKPPTGTSP AAATESQNKL IKKEGIAQGK VEIATYQLYV
960 970 980 990 1000
KAAGYLLSIA FIGFFIVYMT LQILRSFWLS AWSDEYDPDS PSAHPMAKGW
1010 1020 1030 1040 1050
RLGVYGALGF SETACFFVAL LALVFVGQRA SKNLHGPLIH NLMRSPMSFY
1060 1070 1080 1090 1100
DTTPLGRILN RCAKDIETID MMLPMNFRYL VMCVLQVAFT LIVIIISTPL
1110 1120 1130 1140 1150
FAVVILPLAL IYLIFLRYYV PTSRQLKRLE SVHRSPIYSH FGETIQGAAS
1160 1170 1180 1190 1200
IRAFGKVDEF RQDSGRILDT FIRCRYSSLV SNRWLAVRLE FVGNCIIFFA
1210 1220 1230 1240 1250
ALFAVLSKEF GWITSPGVIG VSVSYALNIT EVLNFAVRQV SEIEANIVSV
1260 1270 1280 1290 1300
ERVNEYTNTP NEAPWRIEGR EPAPGWPSRG VVKFDGYSTR YREGLDLVLH
1310 1320 1330 1340 1350
DISADVAAGE KIGIVGRTGA GKSSFALALF RMIEAAGGRI VIDDVEVSQI
1360 1370 1380 1390 1400
GLHDLRSNIT IIPQDPVLFS GTLRFNLDPF FTYSDDQIWR ALELAHLKHF
1410 1420 1430 1440 1450
AAGLPDGLLY KISEAGENLS VGQRQLVALA RALLRHTRVL VLDEATAAVD
1460 1470 1480 1490 1500
VATDALIQET IREEFKECTV FTIAHRLNTI MDYDRIMVLD KGSILEFDTP
1510 1520
DALMADKNSA FAKMVADAAE QDKHE
Length:1,525
Mass (Da):171,048
Last modified:December 16, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A2CA935E9249CFD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA21622.4

NCBI Reference Sequences

More...
RefSeqi
NP_507812.3, NM_075411.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.17468

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y43F8C.12; Y43F8C.12; WBGene00003413

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y43F8C.12

UCSC genome browser

More...
UCSCi
Y43F8C.12 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA21622.4
RefSeqiNP_507812.3, NM_075411.4
UniGeneiCel.17468

3D structure databases

SMRiQ9U2G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y43F8C.12

Proteomic databases

EPDiQ9U2G5
PaxDbiQ9U2G5
PeptideAtlasiQ9U2G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY43F8C.12; Y43F8C.12; WBGene00003413
GeneIDi180289
KEGGicel:CELE_Y43F8C.12
UCSCiY43F8C.12 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180289
WormBaseiY43F8C.12 ; CE43255 ; WBGene00003413 ; mrp-7

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000166156
InParanoidiQ9U2G5
OMAiHVLANFA
OrthoDBi138195at2759
PhylomeDBiQ9U2G5

Enzyme and pathway databases

ReactomeiR-CEL-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-CEL-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-CEL-382556 ABC-family proteins mediated transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9U2G5

Gene expression databases

BgeeiWBGene00003413 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9U2G5_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U2G5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: December 16, 2008
Last modified: January 16, 2019
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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