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Protein

Phospholipid-transporting ATPase tat-1

Gene

tat-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet (PubMed:18436785, PubMed:21170358, PubMed:23427264). Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes (PubMed:18436785). Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintainence and control of the membrane surface charge (PubMed:23427264). Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo and this is likely with its chaperone protein chat-1 (PubMed:21170358, PubMed:23427264).3 Publications

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3884-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-6798695 Neutrophil degranulation
R-CEL-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.8.15 the p-type atpase (p-atpase) superfamily

Chemistry databases

SwissLipidsiSLP:000000331

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPase tat-1 (EC:7.6.2.1)
Gene namesi
Name:tat-1
ORF Names:Y49E10.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY49E10.11a ; CE28133 ; WBGene00013034 ; tat-1
Y49E10.11b ; CE36241 ; WBGene00013034 ; tat-1
Y49E10.11c ; CE44010 ; WBGene00013034 ; tat-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Transmembranei901 – 921HelicalSequence analysisAdd BLAST21
Transmembranei935 – 955HelicalSequence analysisAdd BLAST21
Transmembranei972 – 992HelicalSequence analysisAdd BLAST21
Transmembranei1013 – 1033HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Results in abnormal formation of intestinal vacuoles.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004248521 – 1139Phospholipid-transporting ATPase tat-1Add BLAST1139

Proteomic databases

EPDiQ9U280
PaxDbiQ9U280
PeptideAtlasiQ9U280

Expressioni

Gene expression databases

BgeeiWBGene00013034 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Interactioni

Protein-protein interaction databases

BioGridi41845, 1 interactor
STRINGi6239.Y49E10.11c.2

Structurei

3D structure databases

ProteinModelPortaliQ9U280
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00910000144008
HOGENOMiHOG000202528
KOiK14802
OMAiMLRDSNG
PhylomeDBiQ9U280

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q9U280-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTEARDNNR HIHLGKVRDP HHQHAQRFCS NRISTCKYNG FSFLPRFLYE
60 70 80 90 100
QFRRYNNIFF LAIALLQQIP DVSPTGRYTT AVPFLIILSV SALKEIFEDV
110 120 130 140 150
KRRRSDNKVN AFSVEILVDG HWIEKQWKDV SVGDFIRIDN DSLFPADLLL
160 170 180 190 200
LASSEQQGMA YIETSNLDGE TNLKIKQALD ITSTMTSPEK LSQFESEITC
210 220 230 240 250
EPPSRHVNEF NGNIEINGVA RHFGIDQLLL RGARLKNTAW IFGAVIYTGH
260 270 280 290 300
DSKLLMNSKR APLKSGTIDV QTNYRIIFLF FVLVALALIS ATGSEIWRGN
310 320 330 340 350
NIPQAWYLSF LEHDPKGSFL WGVLTFFILY NNLIPISLQV TLEVVRFFQA
360 370 380 390 400
IYINNDIEMY DVNSDSCAIA RTSNLNEELG QVKFIMSDKT GTLTRNVMKF
410 420 430 440 450
KRLSIGSRNY GNNEDDEFAD ASLIEDYRQG DEHSTSILEV LKMMAVCHTV
460 470 480 490 500
VPENKDGQLI YQSSSPDEAA LVRGAASQSV SFHTRQPQKV ICNVFGEDET
510 520 530 540 550
IEILDVIDFT SDRKRMSVIV RDGAGGDIKL YTKGADTVIF ERLEHGKEQE
560 570 580 590 600
EAVEYCTEHL EDYASFGYRT LCFSMRHLTE QEYSQWAPEY KKAILAIDNR
610 620 630 640 650
AKLLADAAEK LERNMILVGA TAIEDKLQEW VPETIQALMA ADIRVWMLTG
660 670 680 690 700
DKRETAINIA HSCALCHTNT ELLIVDKTTY EETYQKLEQF VARAIELEKQ
710 720 730 740 750
EKGFAMVIDG KSLLHALTGE ARKHFGDLAL RCHAVVCCRM SPMQKAEVVE
760 770 780 790 800
MVRKLAKHVV LAIGDGANDV AMIQAANVGV GISGEEGLQA ASASDYAIPR
810 820 830 840 850
FHFLRRLLLV HGAWNHDRSV KVILYSFYKN ICLYIIELWF AMFSAWSGQT
860 870 880 890 900
IFERWTIGMF NVIFTAWPPV VLGLFDHPVP AEQIMKYPAL YASFQNRAFS
910 920 930 940 950
IGNFSLWIGL AIVHSLSLFF LTYATMEHQV VWDNGLTGGW LMLGNCAYTF
960 970 980 990 1000
VVATVCFKAL LECDSWTWPV VVACIGSIGL WIVFVIVYSL VFPHIGGIGA
1010 1020 1030 1040 1050
DMAGMAAIMM SSYTFWLALL FIPLATLLWD LVIKSLFTIA MPTPRELAVM
1060 1070 1080 1090 1100
YNKRTTSFNG FERLASYSSN VLENMRLLTS SLRGSTTGST RSRTASEASL
1110 1120 1130
ALAEQTRYGF AFSQDESSAV AQTELIRNVD STREKPTGR
Length:1,139
Mass (Da):128,411
Last modified:October 1, 2001 - v3
Checksum:i4EB9BABE669824AC
GO
Isoform b (identifier: Q9U280-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1066-1089: SYSSNVLENMRLLTSSLRGSTTGS → RKHVHLHTIIVAIERRLKAVCEWV
     1090-1139: Missing.

Show »
Length:1,089
Mass (Da):123,285
Checksum:iFBAC22424A7B34AE
GO
Isoform c (identifier: Q9U280-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1139: YSSNVLENMR...DSTREKPTGR → SWAAYQGPTK...DEEDGSGTRL

Show »
Length:1,192
Mass (Da):134,455
Checksum:i43C75FDB38B500F2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535221066 – 1089SYSSN…STTGS → RKHVHLHTIIVAIERRLKAV CEWV in isoform b. CuratedAdd BLAST24
Alternative sequenceiVSP_0535231067 – 1139YSSNV…KPTGR → SWAAYQGPTKDGAHVFANRF SLRKRIQPTSTTAASHPSAT SPPPNGYVEKSQLNGKNGKH HRAKSPDYGSTELSTWSTRD EHEVEYKIPRGRKERSSYTN RAFIAEDNNVTSIVVNDEED GSGTRL in isoform c. CuratedAdd BLAST73
Alternative sequenceiVSP_0535241090 – 1139Missing in isoform b. CuratedAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98866 Genomic DNA Translation: CAB11550.4
Z98866 Genomic DNA Translation: CAE54923.1
Z98866 Genomic DNA Translation: CAX51688.2
PIRiD88601
T27057
RefSeqiNP_001022894.1, NM_001027723.2 [Q9U280-1]
NP_001022895.1, NM_001027724.2 [Q9U280-2]
NP_001255165.1, NM_001268236.1 [Q9U280-3]
UniGeneiCel.17289

Genome annotation databases

EnsemblMetazoaiY49E10.11a.1; Y49E10.11a.1; WBGene00013034 [Q9U280-1]
Y49E10.11a.2; Y49E10.11a.2; WBGene00013034 [Q9U280-1]
Y49E10.11b.1; Y49E10.11b.1; WBGene00013034 [Q9U280-2]
Y49E10.11b.2; Y49E10.11b.2; WBGene00013034 [Q9U280-2]
Y49E10.11c.1; Y49E10.11c.1; WBGene00013034 [Q9U280-3]
Y49E10.11c.2; Y49E10.11c.2; WBGene00013034 [Q9U280-3]
GeneIDi176666
KEGGicel:CELE_Y49E10.11
UCSCiY49E10.11a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98866 Genomic DNA Translation: CAB11550.4
Z98866 Genomic DNA Translation: CAE54923.1
Z98866 Genomic DNA Translation: CAX51688.2
PIRiD88601
T27057
RefSeqiNP_001022894.1, NM_001027723.2 [Q9U280-1]
NP_001022895.1, NM_001027724.2 [Q9U280-2]
NP_001255165.1, NM_001268236.1 [Q9U280-3]
UniGeneiCel.17289

3D structure databases

ProteinModelPortaliQ9U280
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41845, 1 interactor
STRINGi6239.Y49E10.11c.2

Chemistry databases

SwissLipidsiSLP:000000331

Protein family/group databases

TCDBi3.A.3.8.15 the p-type atpase (p-atpase) superfamily

Proteomic databases

EPDiQ9U280
PaxDbiQ9U280
PeptideAtlasiQ9U280

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY49E10.11a.1; Y49E10.11a.1; WBGene00013034 [Q9U280-1]
Y49E10.11a.2; Y49E10.11a.2; WBGene00013034 [Q9U280-1]
Y49E10.11b.1; Y49E10.11b.1; WBGene00013034 [Q9U280-2]
Y49E10.11b.2; Y49E10.11b.2; WBGene00013034 [Q9U280-2]
Y49E10.11c.1; Y49E10.11c.1; WBGene00013034 [Q9U280-3]
Y49E10.11c.2; Y49E10.11c.2; WBGene00013034 [Q9U280-3]
GeneIDi176666
KEGGicel:CELE_Y49E10.11
UCSCiY49E10.11a c. elegans

Organism-specific databases

CTDi176666
WormBaseiY49E10.11a ; CE28133 ; WBGene00013034 ; tat-1
Y49E10.11b ; CE36241 ; WBGene00013034 ; tat-1
Y49E10.11c ; CE44010 ; WBGene00013034 ; tat-1

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00910000144008
HOGENOMiHOG000202528
KOiK14802
OMAiMLRDSNG
PhylomeDBiQ9U280

Enzyme and pathway databases

ReactomeiR-CEL-6798695 Neutrophil degranulation
R-CEL-936837 Ion transport by P-type ATPases

Miscellaneous databases

PROiPR:Q9U280

Gene expression databases

BgeeiWBGene00013034 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAT1_CAEEL
AccessioniPrimary (citable) accession number: Q9U280
Secondary accession number(s): C0P289, Q7JK70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: October 1, 2001
Last modified: November 7, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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