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Entry version 140 (26 Feb 2020)
Sequence version 3 (25 Jan 2012)
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Protein

Histone-lysine N-methyltransferase set-26

Gene

set-26

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro (PubMed:24685137). Involved in transcriptional regulation (PubMed:29714684). Plays a role in the negative regulation of lifespan and in heat resistance (PubMed:29714684). Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion (PubMed:22212395, PubMed:29714684). Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline (PubMed:29714684). Together with spr-5, required for transgenerational fertility (PubMed:24685137).3 Publications

Caution

Contrary to other SET-domain containing methyltransferases, set-26 does not have the residues usually involved in cofactor binding: instead of the highly conserved XGXG, Y and NH motifs, set-26 displays AVEA (Ala-948-Ala-951), V (Val-967) and F (Phe-1063) and RR (Arg-1024-Arg-1025) motifs (PubMed:29714684). However, histone methyltransferase activity has been detected in vitro (PubMed:24685137).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri794 – 842PHD-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase set-26Curated (EC:2.1.1.3551 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:set-26Imported
ORF Names:Y51H4A.12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
Y51H4A.12 ; CE25361 ; WBGene00013106 ; set-26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Exhibits prolonged lifespan, increased resistance to heat stress, reduced brood size and changes in gene expression (PubMed:29714684). In a glp-1(e2141) mutant background which lacks a germline, extended lifespan, increased H3 protein levels, decreased levels of trimethylated histone H3 'Lys-9' (H3K9me3) and 'Lys-27' (H3K27me3) and changes in gene expression (PubMed:22212395, PubMed:29714684). In spr-5 null mutants, accelerates the progressive sterility and accumulation of histone H3 'Lys-4' dimethylation (H3K4me2) over generations which is seen in spr-5 mutants (PubMed:24685137). Simultaneous RNAi-mediated knockdown of set-26 and set-9 results in extended lifespan (PubMed:22212395).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004389271 – 1645Histone-lysine N-methyltransferase set-26Add BLAST1645

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9U263

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9U263

PeptideAtlas

More...
PeptideAtlasi
Q9U263

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed both in the germline and in somatic tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00013106 Expressed in multi-cellular organism and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.Y51H4A.12

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini973 – 1064SETPROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1103 – 1217Sequence analysisAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi508 – 606Pro-richPROSITE-ProRule annotationAdd BLAST99
Compositional biasi1069 – 1212Glu-richPROSITE-ProRule annotationAdd BLAST144
Compositional biasi1395 – 1469Lys-richPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHD-type domain binds histone H3 when trimethylated at 'Lys-4' (H3K4me3) in combination with a nearby acetylation (K9ac, K14ac and/or K18ac), but not H3K4me3 alone.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri794 – 842PHD-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMX8 Eukaryota
ENOG4111FV9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168747

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_243457_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9U263

Identification of Orthologs from Complete Genome Data

More...
OMAi
IHPQEGP

Database of Orthologous Groups

More...
OrthoDBi
790990at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00628 PHD, 1 hit
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01359 ZF_PHD_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9U263-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGEHTLPA DEELFEQPPL QQQQPEIAEP IVMAQEPIQG VSEDPQASEA
60 70 80 90 100
THEAPDNYPV DHQMENQEFY QEPQIPEPQQ IPQIPVFQPA AYNPPNYVAP
110 120 130 140 150
QQRANNFGEP AAAADSRPLT EEEQLAAERP TEDTVWIDSD DDTDVEEAIL
160 170 180 190 200
RANFWLPYSD HNYDPPDPAD RIILPTEGPF PCIAGLDEDC NIVKQWMPED
210 220 230 240 250
AVGPGSPGTQ YRRNQQTGGG LPSTSVAPQQ QQLPVRHNIQ NRPMVAAQPF
260 270 280 290 300
SIGGNQVEYG GIGGMDSRMQ QRGVVRDGPQ YRVMNDFGNG LPMRGQLPPR
310 320 330 340 350
NSPAANAINR VREQQQQMYH QAGARGSLQQ RVPAPAAPTP GSYQHIVNAV
360 370 380 390 400
PVGGANPMRR VPPQARPGMI GGAANNNRAR PIHVTRPMDT QEFEHPVAPA
410 420 430 440 450
AAAPPRRVVD VAPHRMTPEQ RQELQQMNRQ RAAPQFPAAA AQRSAEKIVI
460 470 480 490 500
QQRPGASSSR APRPSMAQED LLRSPTRRLS ERVPQEHQTP VLEPRRFQVK
510 520 530 540 550
VTDTYSTPIP KASDQLPAQL TEEDPPEESA AAAAPEDVPD AAPEDPPKGI
560 570 580 590 600
LKPTPPHRMT QEEKNAHFAR LTTDKEKPTS SASILPQDAA PPHVPPPPPP
610 620 630 640 650
PLVLRPHHQD ETLAMVQSVF ESKPRQPDTP KDKEAISKIA DLLRFSADEF
660 670 680 690 700
TGQSGSSAAA RQRTVSGSAA RAQTYQMHHQ QQQQHHHQMP MDQRKRHSSG
710 720 730 740 750
RYDALMGAMP LQQQPPPPPP SQFQHTDSIA HRPRGRPKGT RHPSVAVQPQ
760 770 780 790 800
RSGGARTLPP RAQTVAMSAR NGANAKNSDS ESEGIDEAAE ESWTMRCHCG
810 820 830 840 850
MDHGDGDTIE CEGCKTWQHM ACMGLTLKSN TSKYKCEMCL PRRLPVSKAE
860 870 880 890 900
AAREQERILN RLRAAAKKQK RKSEPVEQKQ KSQPSTSRKS APMALQQQPA
910 920 930 940 950
EPRVAQLNDY SKQASALLFG MEQTAGADTL LAESRLHKKA RRMFVEEAVE
960 970 980 990 1000
ALVTTDLVQI RQVILEVNGH VSMSNEVKRQ PGGGNCIFMY DGLMKGTAGE
1010 1020 1030 1040 1050
DMGDGQELVC IDTKRKGNDT KFTRRSCVPN CVLKHVLGSN ATLGIMIVAT
1060 1070 1080 1090 1100
KDITRNTEVT LPFDADWRES EVELECAEHM KELQACPFES ERRRFAAERH
1110 1120 1130 1140 1150
RAMDHKKREA EEARRADEER RRLEEEVRRE RAAKTKQMDE AEKARLEAEK
1160 1170 1180 1190 1200
AAEKEKKAKE REEAKERKKM EVEASAAAAP ESSNSITARE ERRIQQAEEM
1210 1220 1230 1240 1250
FRRQEEEGKR KEARRRSKSV TPGVLEAAGT AAREDAPEAS IPAPAPSPPA
1260 1270 1280 1290 1300
SRRSVSRTTQ PSTSSFATPT EPPAKNKRMR SVVPPKSEPA SSAKRVRATT
1310 1320 1330 1340 1350
VATPKDTTAS NDSRKRKSSA TGKTPVAKRS KNVVPTSFGL ALIEKELREQ
1360 1370 1380 1390 1400
ARDSTVLEMI LPDYIMKEKR SGLLAGQSPD FSEVRAQIEE ENRMKERFTK
1410 1420 1430 1440 1450
REAKKKAVEK AKEKEKKEHR KEPKKANEPG PAPKSEKAVE KAVEKVEKKP
1460 1470 1480 1490 1500
KSPQKPPAKP TAQKPPLKKT EEVDGIEREA SESSSKESSV APEEKKNPKK
1510 1520 1530 1540 1550
ITFAEYNSRR SQKREAGECS TPPAVTRRGF IPSTEGEDLV NVELSAIPLD
1560 1570 1580 1590 1600
DHPSSSNTAP TTTIAPSVGG APKPTSVVVK SPSTRSRTRG AASESVDDAP
1610 1620 1630 1640
AEHSMSLQDR VFSMFGSTVD APAPPPPPPA SAETNSRRSR STRWN
Length:1,645
Mass (Da):181,666
Last modified:January 25, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74BF8830788BED57
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAB63382.3

NCBI Reference Sequences

More...
RefSeqi
NP_502971.3, NM_070570.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y51H4A.12.1; Y51H4A.12.1; WBGene00013106

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y51H4A.12

UCSC genome browser

More...
UCSCi
Y51H4A.12 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAB63382.3
RefSeqiNP_502971.3, NM_070570.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.Y51H4A.12

Proteomic databases

EPDiQ9U263
PaxDbiQ9U263
PeptideAtlasiQ9U263

Genome annotation databases

EnsemblMetazoaiY51H4A.12.1; Y51H4A.12.1; WBGene00013106
GeneIDi178463
KEGGicel:CELE_Y51H4A.12
UCSCiY51H4A.12 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178463
WormBaseiY51H4A.12 ; CE25361 ; WBGene00013106 ; set-26

Phylogenomic databases

eggNOGiENOG410IMX8 Eukaryota
ENOG4111FV9 LUCA
GeneTreeiENSGT00940000168747
HOGENOMiCLU_243457_0_0_1
InParanoidiQ9U263
OMAiIHPQEGP
OrthoDBi790990at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9U263

Gene expression databases

BgeeiWBGene00013106 Expressed in multi-cellular organism and 2 other tissues

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET26_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U263
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: January 25, 2012
Last modified: February 26, 2020
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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