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Entry version 136 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

Monoglyceride lipase faah-4

Gene

faah-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts monoacylglycerides to free fatty acids and glycerol (PubMed:30911178). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-AG), and thereby regulates the degradation of endocannabinoid-related monoacylglycerides (PubMed:30911178). Also hydrolyzes arachidonoyl ethanolamide (anandamide, or AEA), but with low efficiency (PubMed:30911178). Plays a role in the regulation of longevity and resistance to oxidative stress (PubMed:30911178).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the benzodioxole 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester (JZL184).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=19.4 pmol/min/mg enzyme towards arachidonoyl ethanolamide (at 37 degrees Celsius)1 Publication
    2. Vmax=1200.8 pmol/min/mg enzyme towards endocannabinoid 2-arachidonoylglycerol (at 37 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei165Charge relay systemBy similarity1
    Active sitei240Charge relay systemBy similarity1
    Active sitei264Acyl-ester intermediateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Serine esterase
    Biological processLipid degradation, Lipid metabolism

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Monoglyceride lipase faah-4Curated (EC:3.1.1.231 Publication)
    Alternative name(s):
    Fatty acid amide hydrolase 4Curated (EC:3.5.1.991 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:faah-4Imported
    ORF Names:Y56A3A.12Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

    Organism-specific databases

    WormBase

    More...
    WormBasei
    Y56A3A.12a ; CE24467 ; WBGene00013232 ; faah-4
    Y56A3A.12b ; CE24468 ; WBGene00013232 ; faah-4

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Extended lifespan, increased food consumption and increased resistance to oxidative stress induced by paraquat (PubMed:30911178). Increased levels of mono- and polyunsaturated monoacylglycerides, including endocannabinoid 2-arachidonoylglycerol (PubMed:30911178). Lifespan is further extended following treatment with the benzodioxole 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester (JZL184) (PubMed:30911178).1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004488901 – 647Monoglyceride lipase faah-4Add BLAST647

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9U217

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9U217

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    WBGene00013232, Expressed in multi-cellular organism and 5 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9U217, baseline and differential

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q9U217, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    6239.Y56A3A.12a.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9U217

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the amidase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1212, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00970000196598

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_009600_9_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9U217

    KEGG Orthology (KO)

    More...
    KOi
    K15528

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LPNCEEM

    Database of Orthologous Groups

    More...
    OrthoDBi
    852596at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9U217

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.1300.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020556, Amidase_CS
    IPR023631, Amidase_dom
    IPR036928, AS_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01425, Amidase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF75304, SSF75304, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00571, AMIDASES, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform aImported (identifier: Q9U217-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGNNFWSTWS PSQRIFSLIW PATILYLIMK LLIEKMWGKN RGAVERFQTR
    60 70 80 90 100
    REALFDDFKS RSAPASLVNN PRIVKGNETA EQIETTFNEI LKLDLIALKS
    110 120 130 140 150
    ALQTDKYNAY TVLCAFVWRA IDVNSEINCI TEVIREAFNT AEALDDNYAQ
    160 170 180 190 200
    TGEKGQLFGL PFSVKSNFYM ENYDVTVGLA KLLEQPKTTT CPMVQFLSDQ
    210 220 230 240 250
    GAVPFCLTNV PQGLLSYVSS NPIYGTTKNP WDFSRTPGGS SGGEAALLAA
    260 270 280 290 300
    GGAAFGIGSD LAGSLRIPAA FCGLVTLKPT QDRLCVTDTH GGLPGRGRLG
    310 320 330 340 350
    LSFGFYTRSV KEQEFLLGLI VGRSEYLELC PMSSPAKLEK HIEKDQKLVI
    360 370 380 390 400
    GWFVDDGFNP VVPSNRRAVE ETVKSLQAKG HQVVELKLAD VSEEFPPFAV
    410 420 430 440 450
    ADMLFRNVMP DNGAYMSEMY AGEQYDEHMK LFIRLVCLKQ NFLVSFLLRY
    460 470 480 490 500
    GVMPFAKLAL SKRLACIGSA YNSDLAACRQ NQENTDSYKL QWIRYWKSKK
    510 520 530 540 550
    IDALICPSFI TPAQPFEYPA QLSNGAFITG LFNMLDVPAG VVPVSPVNQK
    560 570 580 590 600
    DVDQLIDGFS TEGDLLLKKQ REAARGTTGL PNAVQVVTLP NCEEMCLRVM
    610 620 630 640
    RLVEESAEGV QRLQWRVGAS AAPIDVENTP AGVVSSLEHF ERVNLLH
    Length:647
    Mass (Da):71,729
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4168A44EF8C19B5A
    GO
    Isoform bImported (identifier: Q9U217-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4-35: Missing.

    Show »
    Length:615
    Mass (Da):67,851
    Checksum:i42200672F414360C
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0604644 – 35Missing in isoform b. CuratedAdd BLAST32

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BX284603 Genomic DNA Translation: CAB60524.1
    BX284603 Genomic DNA Translation: CAB60525.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_499544.1, NM_067143.4 [Q9U217-2]
    NP_499545.1, NM_067144.3 [Q9U217-1]

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    Y56A3A.12a.1; Y56A3A.12a.1; WBGene00013232 [Q9U217-1]
    Y56A3A.12a.2; Y56A3A.12a.2; WBGene00013232 [Q9U217-1]
    Y56A3A.12b.1; Y56A3A.12b.1; WBGene00013232 [Q9U217-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    176620

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    cel:CELE_Y56A3A.12

    UCSC genome browser

    More...
    UCSCi
    Y56A3A.12b.1, c. elegans [Q9U217-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX284603 Genomic DNA Translation: CAB60524.1
    BX284603 Genomic DNA Translation: CAB60525.1
    RefSeqiNP_499544.1, NM_067143.4 [Q9U217-2]
    NP_499545.1, NM_067144.3 [Q9U217-1]

    3D structure databases

    SMRiQ9U217
    ModBaseiSearch...

    Protein-protein interaction databases

    IntActiQ9U217, 1 interactor
    STRINGi6239.Y56A3A.12a.1

    Proteomic databases

    EPDiQ9U217
    PaxDbiQ9U217

    Genome annotation databases

    EnsemblMetazoaiY56A3A.12a.1; Y56A3A.12a.1; WBGene00013232 [Q9U217-1]
    Y56A3A.12a.2; Y56A3A.12a.2; WBGene00013232 [Q9U217-1]
    Y56A3A.12b.1; Y56A3A.12b.1; WBGene00013232 [Q9U217-2]
    GeneIDi176620
    KEGGicel:CELE_Y56A3A.12
    UCSCiY56A3A.12b.1, c. elegans [Q9U217-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    176620
    WormBaseiY56A3A.12a ; CE24467 ; WBGene00013232 ; faah-4
    Y56A3A.12b ; CE24468 ; WBGene00013232 ; faah-4

    Phylogenomic databases

    eggNOGiKOG1212, Eukaryota
    GeneTreeiENSGT00970000196598
    HOGENOMiCLU_009600_9_3_1
    InParanoidiQ9U217
    KOiK15528
    OMAiLPNCEEM
    OrthoDBi852596at2759
    PhylomeDBiQ9U217

    Gene expression databases

    BgeeiWBGene00013232, Expressed in multi-cellular organism and 5 other tissues
    ExpressionAtlasiQ9U217, baseline and differential

    Family and domain databases

    Gene3Di3.90.1300.10, 1 hit
    InterProiView protein in InterPro
    IPR020556, Amidase_CS
    IPR023631, Amidase_dom
    IPR036928, AS_sf
    PfamiView protein in Pfam
    PF01425, Amidase, 1 hit
    SUPFAMiSSF75304, SSF75304, 1 hit
    PROSITEiView protein in PROSITE
    PS00571, AMIDASES, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAAH4_CAEEL
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U217
    Secondary accession number(s): Q8I4C5, Q9U216
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2020
    Last sequence update: May 1, 2000
    Last modified: August 12, 2020
    This is version 136 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families
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