Putative transcription factor capicua

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer."
    Fores M., Simon-Carrasco L., Ajuria L., Samper N., Gonzalez-Crespo S., Drosten M., Barbacid M., Jimenez G.
    PLoS Genet. 13:e1006622-e1006622(2017) [PubMed] [Europe PMC] [Abstract]
• repressing transcription factor binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.1

    "Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning."
    Jimenez G., Guichet A., Ephrussi A., Casanova J.
    Genes Dev. 14:224-231(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH GRO, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
• RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer."
    Fores M., Simon-Carrasco L., Ajuria L., Samper N., Gonzalez-Crespo S., Drosten M., Barbacid M., Jimenez G.
    PLoS Genet. 13:e1006622-e1006622(2017) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila."
    Ajuria L., Nieva C., Winkler C., Kuo D., Samper N., Andreu M.J., Helman A., Gonzalez-Crespo S., Paroush Z., Courey A.J., Jimenez G.
    Development 138:915-924(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• dorsal/ventral pattern formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling."
    Astigarraga S., Grossman R., Diaz-Delfin J., Caelles C., Paroush Z., Jimenez G.
    EMBO J. 26:668-677(2007) [PubMed] [Europe PMC] [Abstract]
• dorsal appendage formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror."
    Atkey M.R., Lachance J.F., Walczak M., Rebello T., Nilson L.A.
    Development 133:2115-2123(2006) [PubMed] [Europe PMC] [Abstract]
• epidermal growth factor receptor signaling pathway Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling."
    Astigarraga S., Grossman R., Diaz-Delfin J., Caelles C., Paroush Z., Jimenez G.
    EMBO J. 26:668-677(2007) [PubMed] [Europe PMC] [Abstract]
  • "Phosphorylation of Groucho mediates RTK feedback inhibition and prolonged pathway target gene expression."
    Helman A., Cinnamon E., Mezuman S., Hayouka Z., Von Ohlen T., Orian A., Jimenez G., Paroush Z.
    Curr. Biol. 21:1102-1110(2011) [PubMed] [Europe PMC] [Abstract]
  • "Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control."
    Herranz H., Hong X., Cohen S.M.
    Curr. Biol. 22:651-657(2012) [PubMed] [Europe PMC] [Abstract]
• eye morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology."
    Lam Y.C., Bowman A.B., Jafar-Nejad P., Lim J., Richman R., Fryer J.D., Hyun E.D., Duvick L.A., Orr H.T., Botas J., Zoghbi H.Y.
    Cell 127:1335-1347(2006) [PubMed] [Europe PMC] [Abstract]
• imaginal disc-derived wing vein specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology."
    Lam Y.C., Bowman A.B., Jafar-Nejad P., Lim J., Richman R., Fryer J.D., Hyun E.D., Duvick L.A., Orr H.T., Botas J., Zoghbi H.Y.
    Cell 127:1335-1347(2006) [PubMed] [Europe PMC] [Abstract]
  • "A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer."
    Fores M., Simon-Carrasco L., Ajuria L., Samper N., Gonzalez-Crespo S., Drosten M., Barbacid M., Jimenez G.
    PLoS Genet. 13:e1006622-e1006622(2017) [PubMed] [Europe PMC] [Abstract]
• maternal specification of dorsal/ventral axis, oocyte, soma encoded Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer."
    Fores M., Simon-Carrasco L., Ajuria L., Samper N., Gonzalez-Crespo S., Drosten M., Barbacid M., Jimenez G.
    PLoS Genet. 13:e1006622-e1006622(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell growth Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway."
    Tseng A.S., Tapon N., Kanda H., Cigizoglu S., Edelmann L., Pellock B., White K., Hariharan I.K.
    Curr. Biol. 17:728-733(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: FlyBaseInferred from direct assayⁱ
  • "Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila."
    Ajuria L., Nieva C., Winkler C., Kuo D., Samper N., Andreu M.J., Helman A., Gonzalez-Crespo S., Paroush Z., Courey A.J., Jimenez G.
    Development 138:915-924(2011) [PubMed] [Europe PMC] [Abstract]
  • "A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer."
    Fores M., Simon-Carrasco L., Ajuria L., Samper N., Gonzalez-Crespo S., Drosten M., Barbacid M., Jimenez G.
    PLoS Genet. 13:e1006622-e1006622(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains."
    Lohr U., Chung H.R., Beller M., Jackle H.
    Proc. Natl. Acad. Sci. U.S.A. 106:21695-21700(2009) [PubMed] [Europe PMC] [Abstract]
• terminal region determination Source: FlyBaseInferred from mutant phenotypeⁱ
  • Ref.1

    "Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning."
    Jimenez G., Guichet A., Ephrussi A., Casanova J.
    Genes Dev. 14:224-231(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH GRO, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
  • "A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer."
    Fores M., Simon-Carrasco L., Ajuria L., Samper N., Gonzalez-Crespo S., Drosten M., Barbacid M., Jimenez G.
    PLoS Genet. 13:e1006622-e1006622(2017) [PubMed] [Europe PMC] [Abstract]
• torso signaling pathway Source: FlyBaseInferred from direct assayⁱ
  • "Torso RTK controls Capicua degradation by changing its subcellular localization."
    Grimm O., Sanchez Zini V., Kim Y., Casanova J., Shvartsman S.Y., Wieschaus E.
    Development 139:3962-3968(2012) [PubMed] [Europe PMC] [Abstract]
• wing disc dorsal/ventral pattern formation Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing."
    Bejarano F., Luque C.M., Herranz H., Sorrosal G., Rafel N., Pham T.T., Milan M.
    Genetics 178:307-323(2008) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• repressing transcription factor binding Source: FlyBaseInferred from physical interactionⁱ
  • Ref.1

    "Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning."
    Jimenez G., Guichet A., Ephrussi A., Casanova J.
    Genes Dev. 14:224-231(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH GRO, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MNAFQDFELG AKLYLQCLLS LSSSRSATPS YTSPVNHAGA SPLNAIAHSP 
        60         70         80         90        100
VNVSATHRQN FFTPIANQSQ QQQQQQPVAV PLDSKWKTTP SPVLYNANNN 
       110        120        130        140        150
SSNNNTSSSN NNNNSNWEVG SNSNTHVAAT AAATSTVGAQ PLPPQTTPVS 
       160        170        180        190        200
LVMHAPPPQQ QPLQQQHHHH QPPPPPPASL PAPSAPPTSG SSSSHNSVGH 
       210        220        230        240        250
ATSVIRISSS QQQHQQQQQH QQQAHPHVVV SGGQTFHPVI VDATQLSVPL 
       260        270        280        290        300
PPTTVSFHQP NTPTSTAASV ASMSQDKMLA KNGYNAPWFK LLPHMTPMSK 
       310        320        330        340        350
ASPAPVTPTL TTSASSYNVV MMQQQQQHQQ LQQQQQLQQQ QQSPPQMPLN 
       360        370        380        390        400
HNNNHLIVSA PLSSPGKPLN CSMNDAKVAA AAAAAAVANQ RQKQQQEEPD 
       410        420        430        440        450
DQLDDDVFET TTPGISANSK KQTAAMRLPT HNSNIRKLEE CHDDGAAGAP 
       460        470        480        490        500
ATSAAKRRSQ SLSALQQQQQ QQQQAGAAGT AAGQPANKKI RRPMNAFMIF 
       510        520        530        540        550
SKKHRKMVHK KHPNQDNRTV SKILGEWWYA LKPEQKAQYH ELASSVKDAH 
       560        570        580        590        600
FKLHPEWKWC SKDRRKSSTS TATPGGKASG AAGTGDAKQR LVSVDGSDSL 
       610        620        630        640        650
EHDMCPSTPG GSGSCGGQGI SSDLQGDIIP LTIDNYNSTC DEAPTTISMK 
       660        670        680        690        700
GNGNGKLMKN ELPSDEDEQM LVVEEEQQQQ TVKKIDLHCR ERVNDSDMDD 
       710        720        730        740        750
TPFDYRKQQP EANQRSAEEH STSGANGQAI NAPPLSGGER EITLKPKAIK 
       760        770        780        790        800
AHPVLESNML PYTQMSIYTQ YTSPKNPIGV TPFQPTGGAF KSMPISPKGS 
       810        820        830        840        850
GGKPEDAGSL QAHIKQEDIK QEPPSPYKLN NGSGSASGGG VVSAPPPNSG 
       860        870        880        890        900
SVGAIFNFNV PTATALSQKQ FHYPMHHPHR SPTDLRDEEA DREEITQGTK 
       910        920        930        940        950
SGESSEKDKP ALDDQERDEV EEEDEDEEDD DEDDEDDEQF MQELASVNAS 
       960        970        980        990       1000
AGFDDLVPYA MPKVVITPTP TPPPVATIVT PIKRKQFTIV RSLTPLQPSN 
      1010       1020       1030       1040       1050
SPHQQLKHLH QRRGETPPTV ITRVPTPTIN HFTIIRTQQH PHTHPHNTPP 
      1060       1070       1080       1090       1100
PLFFKQKVQG SPVIATVTTS TLSSSSSNPA NNEAPNKFSN FPTQHQPTTT 
      1110       1120       1130       1140       1150
TTISCNTNNN ATPIIRKLLT LQEGAELGGS HKGTGRAAIL YDALVLDTLH 
      1160       1170       1180       1190       1200
GQDEEEEEDE GNAEKQENPK VAGKEQVTTS QPATMLLITD VNAYNQQHVA 
      1210       1220       1230       1240       1250
GNAATPVSGA ATLRPVSFIS INACNKITLP ANARILTAAT ATSTAAGAAV 
      1260       1270       1280       1290       1300
TSQAGATLTV MTKASAATNH SSSNASDITI TAASAAPVPT SGSSIVMINS 
      1310       1320       1330       1340       1350
TTNPSTSSNS TSCSAAAHQA CVPSSPAGMG LGHAANIATP PASAPAQIMG 
      1360       1370       1380       1390       1400
GGPASQKMFF AMTHPYTLLQ RSHQPGTPSL EHLQLDAFAP GGYTLRNHNG 
      1410       1420       1430       1440       1450
LSSLPPPVSA QPTMLLHGYP PSHGVEPPAR SPSYKSMPST PKSATYLMSA 
      1460       1470       1480       1490       1500
PPERGMDGGM SGCASAAASG GDESDIDADG QQFILAPTPA QLGRAPLQRR 
      1510       1520       1530       1540       1550
KNLSQSKSES NVSFGANLGA SNGQHISRKL HSPTMMESSS PIIGHVNSSN 
      1560       1570       1580       1590       1600
LSSALPTPTS STTTPNSDEQ LPLTPTTSSS NSNLNQQQPK SPMKGAPGST 
      1610       1620       1630       1640       1650
AAALKKKNDE MNNSVLKQVD FEKKYKALPQ FQPEDCQSPS AIAVPSSPRV 
      1660       1670       1680       1690       1700
YGTNYRKKNT APPPVQKLMC EDDSIDEPAS APPTTTQRFF GPDFNNELKE 
      1710       1720       1730       1740       1750
LESSDQTGRS PRTPKTPLQS ARSDASEKGH RKVLETRRSL VLQLFAEHGN 
      1760       1770       1780       1790       1800
FPTAQATMAF QSKHSDVFPR KQDLQLKIRE VRQKLLGQAS CTPHSAGPNT 
      1810       1820       1830 
PSDSNSSSTT LSASSTSLNM QTTSAADVFQ YY                    

        10         20         30         40         50
MNAFQDFELG AKLYLQCLLS LSSSRSATPS YTSPVNHAGA SPLNAIAHSP 
        60         70         80         90        100
VNVSATHRQN FFTPIANQSQ QQQQQQPVAV PLDSKWKTTP SPVLYNANNN 
       110        120        130        140        150
SSNNNTSSSN NNNNSNWEVG SNSNTHVAAT AAATSTVGAQ PLPPQTTPVS 
       160        170        180        190        200
LVMHAPPPQQ QPLQQQHHHH QPPPPPPASL PAPSAPPTSG SSSSHNSVGH 
       210        220        230        240        250
ATSVIRISSS QQQHQQQQQH QQQAHPHVVV SGGQTFHPVI VDATQLSVPL 
       260        270        280        290        300
PPTTVSFHQP NTPTSTAASV ASMSQDKMLA KNGYNAPWFK LLPHMTPMSK 
       310        320        330        340        350
ASPAPVTPTL TTSASSYNVV MMQQQQQHQQ LQQQQQLQQQ QQSPPQMPLN 
       360        370        380        390        400
HNNNHLIVSA PLSSPGKPLN CSMNDAKVAA AAAAAAVANQ RQKQQQEEPD 
       410        420        430        440        450
DQLDDDVFET TTPGISANSK KQTAAMRLPT HNSNIRKLEE CHDDGAAGAP 
       460        470        480        490        500
ATSAAKRRSQ SLSALQQQQQ QQQQAGAAGT AAGQPANKKI RRPMNAFMIF 
       510        520        530        540        550
SKKHRKMVHK KHPNQDNRTV SKILGEWWYA LKPEQKAQYH ELASSVKDAH 
       560        570        580        590        600
FKLHPEWKWC SKDRRKSSTS TATPGGKASG AAGTGDAKQR LVSVDGSDSL 
       610        620        630        640        650
EHDMCPSTPG GSGSCGGQGI SSDLQGDIIP LTIDNYNSTC DEAPTTISMK 
       660        670        680        690        700
GNGNGKLMKN ELPSDEDEQM LVVEEEQQQQ TVKKIDLHCR ERVNDSDMDD 
       710        720        730        740        750
TPFDYRKQQP EANQRSAEEH STSGANGQAI NAPPLSGGER EITLKPKAIK 
       760        770        780        790        800
AHPVLESNML PYTQMSIYTQ YTSPKNPIGV TPFQPTGGAF KSMPISPKGS 
       810        820        830        840        850
GGKPEDAGSL QAHIKQEDIK QEPPSPYKLN NGSGSASGGG VVSAPPPNSG 
       860        870        880        890        900
SVGAIFNFNV PTATALSQKQ FHYPMHHPHR SPTDLRAAHQ ACVPSSPAGM 
       910        920        930        940        950
GLGHAANIAT PPASAPAQIM GGGPASQKMF FAMTHPYTLL QRSHQPGTPS 
       960        970        980        990       1000
LEHLQLDAFA PGGYTLRNHN GLSSLPPPVS AQPTMLLHGY PPSHGVEPPA 
      1010       1020       1030       1040       1050
RSPSYKSMPS TPKSATYLMS APPERGMDGG MSGCASAAAS GGDESDIDAD 
      1060       1070       1080       1090       1100
GQQFILAPTP AQLGRAPLQR RKNLSQSKSE SNVSFGANLG ASNGQHISRK 
      1110       1120       1130       1140       1150
LHSPTMMESS SPIIGHVNSS NLSSALPTPT SSTTTPNSDE QLPLTPTTSS 
      1160       1170       1180       1190       1200
SNSNLNQQQP KSPMKGAPGS TAAALKKKND EMNNSVLKQV DFEKKYKALP 
      1210       1220       1230       1240       1250
QFQPEDCQSP SAIAVPSSPR VYGTNYRKKN TAPPPVQKLM CEDDSIDEPA 
      1260       1270       1280       1290       1300
SAPPTTTQRF FGPDFNNELK ELESSDQTGR SPRTPKTPLQ SARSDASEKG 
      1310       1320       1330       1340       1350
HRKVLETRRS LVLQLFAEHG NFPTAQATMA FQSKHSDVFP RKQDLQLKIR 
      1360       1370       1380       1390       1400
EVRQKLLGQA SCTPHSAGPN TPSDSNSSST TLSASSTSLN MQTTSAADVF 

QYY                                                    

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase