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Entry version 153 (16 Oct 2019)
Sequence version 2 (03 Mar 2009)
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Protein

Putative transcription factor capicua

Gene

cic

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor required for the specification of numerous cell types during embryonic development. Required for terminal patterning of early embryos. May associate with gro to repress tll and hkb, restricting their expression to embryonic terminal poles where they initiate correct development of head and tail structures. Required for dorsoventral patterning of oocytes and early embryos. Cooperates with dl to repress zen and other dorsal specific genes within the embryo and promotes expression of the ventralizing factor pip in ovarian follicle cells. Required during wing development for the specification of intervein areas, where it mediates localized repression of vein specific genes such as aos, dpp and vvl.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi490 – 558HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9U1H0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative transcription factor capicua
Alternative name(s):
Protein fettucine
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cic
Synonyms:fet
ORF Names:CG43122
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0262582 cic

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000486001 – 1832Putative transcription factor capicuaAdd BLAST1832

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41Phosphoserine1 Publication1
Modified residuei49Phosphoserine1 Publication1
Modified residuei1716Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9U1H0

PRoteomics IDEntifications database

More...
PRIDEi
Q9U1H0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9U1H0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the central region of embryos. Also expressed in ovarian follicle cells, the wing imaginal disks and the wing pouch.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed maternally in stage 1-3 blastoderm embryos.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Subject to local inactivation by the RAS-RAF-MAPK signal transduction pathway, which leads to relief of target gene repression. This pathway may be locally activated by a variety of ligands and receptor tyrosine kinases (RTKs) according to the developmental stage and tissue. In terminal patterning, activation of tor by the locally processed ligand trk may promote cic inactivation specifically at the embryonic terminal poles. In the developing wing, activation of Egfr by vn may lead to cic inactivation specifically in prospective vein tissue.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0262582 Expressed in 36 organ(s), highest expression level in cleaving embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9U1H0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9U1H0 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with gro.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
72791, 12 interactors

Database of interacting proteins

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DIPi
DIP-23664N

Protein interaction database and analysis system

More...
IntActi
Q9U1H0, 14 interactors

Molecular INTeraction database

More...
MINTi
Q9U1H0

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293566

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9U1H0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni834 – 1832Interaction with groAdd BLAST999

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 124Asn-richAdd BLAST29
Compositional biasi141 – 187Pro-richAdd BLAST47
Compositional biasi211 – 223Gln-richAdd BLAST13
Compositional biasi323 – 346Gln-richAdd BLAST24
Compositional biasi460 – 474Gln-richAdd BLAST15
Compositional biasi908 – 937Asp-richAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2746 Eukaryota
ENOG410YJCA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159960

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9U1H0

KEGG Orthology (KO)

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KOi
K20225

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00505 HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: Q9U1H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNAFQDFELG AKLYLQCLLS LSSSRSATPS YTSPVNHAGA SPLNAIAHSP
60 70 80 90 100
VNVSATHRQN FFTPIANQSQ QQQQQQPVAV PLDSKWKTTP SPVLYNANNN
110 120 130 140 150
SSNNNTSSSN NNNNSNWEVG SNSNTHVAAT AAATSTVGAQ PLPPQTTPVS
160 170 180 190 200
LVMHAPPPQQ QPLQQQHHHH QPPPPPPASL PAPSAPPTSG SSSSHNSVGH
210 220 230 240 250
ATSVIRISSS QQQHQQQQQH QQQAHPHVVV SGGQTFHPVI VDATQLSVPL
260 270 280 290 300
PPTTVSFHQP NTPTSTAASV ASMSQDKMLA KNGYNAPWFK LLPHMTPMSK
310 320 330 340 350
ASPAPVTPTL TTSASSYNVV MMQQQQQHQQ LQQQQQLQQQ QQSPPQMPLN
360 370 380 390 400
HNNNHLIVSA PLSSPGKPLN CSMNDAKVAA AAAAAAVANQ RQKQQQEEPD
410 420 430 440 450
DQLDDDVFET TTPGISANSK KQTAAMRLPT HNSNIRKLEE CHDDGAAGAP
460 470 480 490 500
ATSAAKRRSQ SLSALQQQQQ QQQQAGAAGT AAGQPANKKI RRPMNAFMIF
510 520 530 540 550
SKKHRKMVHK KHPNQDNRTV SKILGEWWYA LKPEQKAQYH ELASSVKDAH
560 570 580 590 600
FKLHPEWKWC SKDRRKSSTS TATPGGKASG AAGTGDAKQR LVSVDGSDSL
610 620 630 640 650
EHDMCPSTPG GSGSCGGQGI SSDLQGDIIP LTIDNYNSTC DEAPTTISMK
660 670 680 690 700
GNGNGKLMKN ELPSDEDEQM LVVEEEQQQQ TVKKIDLHCR ERVNDSDMDD
710 720 730 740 750
TPFDYRKQQP EANQRSAEEH STSGANGQAI NAPPLSGGER EITLKPKAIK
760 770 780 790 800
AHPVLESNML PYTQMSIYTQ YTSPKNPIGV TPFQPTGGAF KSMPISPKGS
810 820 830 840 850
GGKPEDAGSL QAHIKQEDIK QEPPSPYKLN NGSGSASGGG VVSAPPPNSG
860 870 880 890 900
SVGAIFNFNV PTATALSQKQ FHYPMHHPHR SPTDLRDEEA DREEITQGTK
910 920 930 940 950
SGESSEKDKP ALDDQERDEV EEEDEDEEDD DEDDEDDEQF MQELASVNAS
960 970 980 990 1000
AGFDDLVPYA MPKVVITPTP TPPPVATIVT PIKRKQFTIV RSLTPLQPSN
1010 1020 1030 1040 1050
SPHQQLKHLH QRRGETPPTV ITRVPTPTIN HFTIIRTQQH PHTHPHNTPP
1060 1070 1080 1090 1100
PLFFKQKVQG SPVIATVTTS TLSSSSSNPA NNEAPNKFSN FPTQHQPTTT
1110 1120 1130 1140 1150
TTISCNTNNN ATPIIRKLLT LQEGAELGGS HKGTGRAAIL YDALVLDTLH
1160 1170 1180 1190 1200
GQDEEEEEDE GNAEKQENPK VAGKEQVTTS QPATMLLITD VNAYNQQHVA
1210 1220 1230 1240 1250
GNAATPVSGA ATLRPVSFIS INACNKITLP ANARILTAAT ATSTAAGAAV
1260 1270 1280 1290 1300
TSQAGATLTV MTKASAATNH SSSNASDITI TAASAAPVPT SGSSIVMINS
1310 1320 1330 1340 1350
TTNPSTSSNS TSCSAAAHQA CVPSSPAGMG LGHAANIATP PASAPAQIMG
1360 1370 1380 1390 1400
GGPASQKMFF AMTHPYTLLQ RSHQPGTPSL EHLQLDAFAP GGYTLRNHNG
1410 1420 1430 1440 1450
LSSLPPPVSA QPTMLLHGYP PSHGVEPPAR SPSYKSMPST PKSATYLMSA
1460 1470 1480 1490 1500
PPERGMDGGM SGCASAAASG GDESDIDADG QQFILAPTPA QLGRAPLQRR
1510 1520 1530 1540 1550
KNLSQSKSES NVSFGANLGA SNGQHISRKL HSPTMMESSS PIIGHVNSSN
1560 1570 1580 1590 1600
LSSALPTPTS STTTPNSDEQ LPLTPTTSSS NSNLNQQQPK SPMKGAPGST
1610 1620 1630 1640 1650
AAALKKKNDE MNNSVLKQVD FEKKYKALPQ FQPEDCQSPS AIAVPSSPRV
1660 1670 1680 1690 1700
YGTNYRKKNT APPPVQKLMC EDDSIDEPAS APPTTTQRFF GPDFNNELKE
1710 1720 1730 1740 1750
LESSDQTGRS PRTPKTPLQS ARSDASEKGH RKVLETRRSL VLQLFAEHGN
1760 1770 1780 1790 1800
FPTAQATMAF QSKHSDVFPR KQDLQLKIRE VRQKLLGQAS CTPHSAGPNT
1810 1820 1830
PSDSNSSSTT LSASSTSLNM QTTSAADVFQ YY
Note: No experimental confirmation available.
Length:1,832
Mass (Da):195,662
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D2A2A8537BFB4D8
GO
Isoform A (identifier: Q9U1H0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-1315: Missing.

Show »
Length:1,403
Mass (Da):150,129
Checksum:i068209695B4C18AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K698A0A0B4K698_DROME
Capicua, isoform D
cic CG5060, CG5067, CIC, Cic, cics
2,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGD7A0A0B4KGD7_DROME
Capicua, isoform G
cic CG5060, CG5067, CIC, Cic, cics
2,150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6D6A0A0B4K6D6_DROME
Capicua, isoform H
cic CG5060, CG5067, CIC, Cic, cics
1,275Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K778A0A0B4K778_DROME
Capicua, isoform C
cic CG5060, CG5067, CIC, Cic, cics
1,427Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABC86297 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036477887 – 1315Missing in isoform A. 2 PublicationsAdd BLAST429

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ252268 mRNA Translation: CAB66144.1
AE014297 Genomic DNA Translation: AAF55751.3
AE014297 Genomic DNA Translation: ABW08708.1
BT044183 mRNA Translation: ACH92248.1
BT024235 mRNA Translation: ABC86297.1 Frameshift.

NCBI Reference Sequences

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RefSeqi
NP_001097843.1, NM_001104373.2 [Q9U1H0-1]
NP_524992.1, NM_080253.4 [Q9U1H0-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0305026; FBpp0293563; FBgn0262582 [Q9U1H0-2]
FBtr0305027; FBpp0293564; FBgn0262582 [Q9U1H0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53560

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG43122

UCSC genome browser

More...
UCSCi
CG5067-RB d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ252268 mRNA Translation: CAB66144.1
AE014297 Genomic DNA Translation: AAF55751.3
AE014297 Genomic DNA Translation: ABW08708.1
BT044183 mRNA Translation: ACH92248.1
BT024235 mRNA Translation: ABC86297.1 Frameshift.
RefSeqiNP_001097843.1, NM_001104373.2 [Q9U1H0-1]
NP_524992.1, NM_080253.4 [Q9U1H0-2]

3D structure databases

SMRiQ9U1H0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi72791, 12 interactors
DIPiDIP-23664N
IntActiQ9U1H0, 14 interactors
MINTiQ9U1H0
STRINGi7227.FBpp0293566

PTM databases

iPTMnetiQ9U1H0

Proteomic databases

PaxDbiQ9U1H0
PRIDEiQ9U1H0

Genome annotation databases

EnsemblMetazoaiFBtr0305026; FBpp0293563; FBgn0262582 [Q9U1H0-2]
FBtr0305027; FBpp0293564; FBgn0262582 [Q9U1H0-1]
GeneIDi53560
KEGGidme:Dmel_CG43122
UCSCiCG5067-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23152
FlyBaseiFBgn0262582 cic

Phylogenomic databases

eggNOGiKOG2746 Eukaryota
ENOG410YJCA LUCA
GeneTreeiENSGT00940000159960
InParanoidiQ9U1H0
KOiK20225

Enzyme and pathway databases

SignaLinkiQ9U1H0

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
53560

Protein Ontology

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PROi
PR:Q9U1H0

Gene expression databases

BgeeiFBgn0262582 Expressed in 36 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ9U1H0 baseline and differential
GenevisibleiQ9U1H0 DM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIC_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9U1H0
Secondary accession number(s): A8JR51
, B5RIQ9, Q29R05, Q9VDN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 3, 2009
Last modified: October 16, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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