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Protein

DNA polymerase

Gene

PF3D7_0411900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: GeneDB
  • DNA binding Source: UniProtKB-KW
  • DNA-directed DNA polymerase activity Source: GeneDB
  • nucleotide binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation

Enzyme and pathway databases

ReactomeiR-PFA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-PFA-174411 Polymerase switching on the C-strand of the telomere
R-PFA-174430 Telomere C-strand synthesis initiation
R-PFA-68952 DNA replication initiation
R-PFA-68962 Activation of the pre-replicative complex
R-PFA-69091 Polymerase switching
R-PFA-69166 Removal of the Flap Intermediate
R-PFA-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
ORF Names:PF3D7_0411900Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0411900

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PRIDEiQ9U0H1

Structurei

3D structure databases

ProteinModelPortaliQ9U0H1
SMRiQ9U0H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1026 – 1545DNA_pol_BInterPro annotationAdd BLAST520

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili281 – 308Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000283960
InParanoidiQ9U0H1
KOiK02320
OMAiEAYDDIC
PhylomeDBiQ9U0H1

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 2 hits
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 4 hits
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

Q9U0H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVFDKLKK QRSKECKATD FYEVKNKNDE IYEVVDEEGY MKNKRSLQNF
60 70 80 90 100
IVGGDKDFDS SDDVIVENIN FTLLKKKNVD KEPKVKRNQT LDDFIREKKL
110 120 130 140 150
RKTLSGNKLS KEEIHKTKNI EELMDQNTSS DSDGESRTRK RKTRESYENS
160 170 180 190 200
MYKNMNKSSC YIRSKDYEYN IYDMKHTNEY NKKIIENNNN NNNNYYYYNN
210 220 230 240 250
YNDMSFSNKD LEYSKYTKVK NEKEDIDKHQ PYDIHRDMGS SLKKKENYVK
260 270 280 290 300
QEEQSNMINV GNDDDINEKK NKIHLMKNEL VLKKEIQIKE NEENIKEVKE
310 320 330 340 350
QGSKNNNNKN NNDNNNNNNN VDDFYNDYIL NEMNISPLFI KIENETLKKE
360 370 380 390 400
EKKLKENDIN DKEEDILEND IDSEMLKNKY EQLIKYEENN NLFVNVYVFD
410 420 430 440 450
ICKHRNSIIL FGKTLTKFKK YKSISIFIEN LDRYYYFLLN KNKVYYENGE
460 470 480 490 500
EIKFNHEKFK IHIMSEFLEE FKIIREYHNI KMAKYKIVKR KNLNLSSYDD
510 520 530 540 550
ELYIKVLYSY NNDPIHEKFQ KGSSYLSFYC CNEDIVENFI IKKNFKLPCW
560 570 580 590 600
IKIKNLRKND LSNLTYCYFD CIVEDKKSIL LCDKVHEKKV DTSKNIDEQT
610 620 630 640 650
SPKINNVNSN NNNNNNNNNN NNNNNNNNNN NNNSSNNFGR VIISDDGPKK
660 670 680 690 700
IEQTYQQLSD INLNKLYIKV VSLLNEENVH EIFSICSLVQ IDKLKYINFC
710 720 730 740 750
GISRKCSKKG TMYNYNKTLC KLFDNEKELL HTFLEKIKDL DIDIYIGYNI
760 770 780 790 800
LNFDLEFLIH RCNVHNLNSY ILSRKKKMKK NEKMKVNKFN GTNSTGSMYN
810 820 830 840 850
IIQNIKGRLI VDIYLLCKDS IKLTTYCLDE IIDHVKNKFQ DKSKQVTNKT
860 870 880 890 900
NKSTNLNKTN YTNQQSVVSQ QSVVSQQSVV SQQSVVSQQS VVSQQSVVSQ
910 920 930 940 950
QSVTSQSTQS SQANQPNHTN QSTHMNHVKT EEHIHASNKA TGNHDIPTDV
960 970 980 990 1000
ASTNSHKSSN THINIFKDFL VNNINLINCS NIHLYDAQSI IANNLNTYVN
1010 1020 1030 1040 1050
SQIFCINETV NVCNILQIIE KTRDLTKLSG YIWMRSLLCY TSERVEFFLL
1060 1070 1080 1090 1100
HEYNKKKFIT PLIKKRTKKI ETNQMKNKNT AKYLGGLVLD PLCGYYDTFV
1110 1120 1130 1140 1150
LYLDFNSLYP SIIIEYNVCF STLKLKNCDV SIEDNKLNTK KNGNINNDYE
1160 1170 1180 1190 1200
KNIHSDAEKN IHSDDDKNIH SDDEKNYDND KSYNKLEDDN LLENNVEIDE
1210 1220 1230 1240 1250
FDRSKPGILP CILKSLVEKR SVIKKLISNE KNKEKKELLL IQSLSIKLIS
1260 1270 1280 1290 1300
NSIYGCLGNT NNRFYAKHIA SYITSKGRNL LQHTKFKVEK EFNLKVIYGD
1310 1320 1330 1340 1350
TDSIMIDTGI KANNINNYKE SFKLAHLIKN SINKNYKKLE LDLECIFSKL
1360 1370 1380 1390 1400
LLLKKKKYAC AKVIDNNLEK YEYEMKGINF IKRDFSKISK LIGNEVLRII
1410 1420 1430 1440 1450
FTNRDVDSKN IPVPLENDLS EQIHEYLRTI NQRIQNDEFD LDYYIITKKL
1460 1470 1480 1490 1500
TKNVHEYQDK NSLGHVLVAE RMIKDGYNIC VNKEIQYCVC TSEDASRFYK
1510 1520 1530 1540 1550
KTSEKLNNSQ CCFSINEIKK YNLKIDKEYY IRNQILSPIN RLCQYIEGTS
1560 1570 1580 1590 1600
AEKLSSCFNI YDVKEIKTDK QIEENYLETN VLSLLNESDE RFKDIHLKGF
1610 1620 1630 1640 1650
LVCSNCMHNV KPNIFIKYFK CNKCLTYLSI EQIRNYIFSF IHHLCNTFYK
1660 1670 1680 1690 1700
QLYICQGCTL KTRRIFLKND KNCPNINCEY NKNSLKPLIS KKYIYLILEY
1710 1720 1730 1740 1750
FLFLLKDNLK KIPSNLVEKN KSEQLNETQD TNNENDITSN QKEEAKDPNG
1760 1770 1780 1790 1800
SISNIHDDIN NEHSEKNNHN IYKKNNSNNN NNNNNKDIEN EEYCNDFIVC
1810 1820 1830 1840 1850
LCIDEGFKTY IIHDDINKYK NIKVEAYDDI CKYRELSVNI TKGLKMKYPN
1860 1870 1880 1890 1900
ISNFLSYLNL RNNVFFINYN EERDIIRNSI KYIVHNNIYS QIFFDQVFSI
1910
FHLPLSTHIT EM
Length:1,912
Mass (Da):225,401
Last modified:October 1, 2000 - v2
Checksum:iF8FD8344A71ED00E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844503 Genomic DNA Translation: CAB62892.2
RefSeqiXP_001351430.1, XM_001351394.1

Genome annotation databases

EnsemblProtistsiCAB62892; CAB62892; PF3D7_0411900
GeneDBiPF3D7_0411900.1:pep
GeneIDi812588
KEGGipfa:PF3D7_0411900

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844503 Genomic DNA Translation: CAB62892.2
RefSeqiXP_001351430.1, XM_001351394.1

3D structure databases

ProteinModelPortaliQ9U0H1
SMRiQ9U0H1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9U0H1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAB62892; CAB62892; PF3D7_0411900
GeneDBiPF3D7_0411900.1:pep
GeneIDi812588
KEGGipfa:PF3D7_0411900

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0411900

Phylogenomic databases

HOGENOMiHOG000283960
InParanoidiQ9U0H1
KOiK02320
OMAiEAYDDIC
PhylomeDBiQ9U0H1

Enzyme and pathway databases

ReactomeiR-PFA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-PFA-174411 Polymerase switching on the C-strand of the telomere
R-PFA-174430 Telomere C-strand synthesis initiation
R-PFA-68952 DNA replication initiation
R-PFA-68962 Activation of the pre-replicative complex
R-PFA-69091 Polymerase switching
R-PFA-69166 Removal of the Flap Intermediate
R-PFA-69183 Processive synthesis on the lagging strand

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 2 hits
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 4 hits
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9U0H1_PLAF7
AccessioniPrimary (citable) accession number: Q9U0H1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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