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Entry version 155 (26 Feb 2020)
Sequence version 6 (05 Feb 2008)
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Protein

Leucine-rich repeat serine/threonine-protein kinase 1

Gene

lrk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1726ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1847Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi982 – 989GTPSequence analysis8
Nucleotide bindingi1040 – 1044GTPSequence analysis5
Nucleotide bindingi1098 – 1101GTPSequence analysis4
Nucleotide bindingi1700 – 1708ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processStress response
LigandATP-binding, GTP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9TZM3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat serine/threonine-protein kinase 1By similarity (EC:2.7.11.1)
Alternative name(s):
Leucine-rich repeats, ras-like domain, kinase protein 1
PARK8-related kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lrk-1
ORF Names:T27C10.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
T27C10.6 ; CE41939 ; WBGene00003068 ; lrk-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1726K → A: Loss of ability to correctly sort SV proteins. No loss of ability to correctly sort SV proteins; when associated with T-1877. 1 Publication1
Mutagenesisi1877I → T: No loss of ability to correctly sort SV proteins; when associated with A-1726. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003853731 – 2393Leucine-rich repeat serine/threonine-protein kinase 1Add BLAST2393

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9TZM3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9TZM3

PeptideAtlas

More...
PeptideAtlasi
Q9TZM3

PRoteomics IDEntifications database

More...
PRIDEi
Q9TZM3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cell bodies, but not in dendritic or axonal processes, of adult head neurons. Also present in non-neuronal tissues, such as the body wall musculature and the epithelial cells of the nematode vulva.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003068 Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T27C10.6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9TZM3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati56 – 86ANK 1Sequence analysisAdd BLAST31
Repeati90 – 120ANK 2Sequence analysisAdd BLAST31
Repeati123 – 152ANK 3Sequence analysisAdd BLAST30
Repeati197 – 226ANK 4Sequence analysisAdd BLAST30
Repeati230 – 259ANK 5Sequence analysisAdd BLAST30
Repeati264 – 293ANK 6Sequence analysisAdd BLAST30
Repeati317 – 347ANK 7Sequence analysisAdd BLAST31
Repeati361 – 390ANK 8Sequence analysisAdd BLAST30
Repeati407 – 437ANK 9Sequence analysisAdd BLAST31
Repeati439 – 464ANK 10Sequence analysisAdd BLAST26
Repeati532 – 553LRR 1Add BLAST22
Repeati555 – 576LRR 2Add BLAST22
Repeati580 – 600LRR 3Add BLAST21
Repeati604 – 625LRR 4Add BLAST22
Repeati627 – 648LRR 5Add BLAST22
Repeati718 – 739LRR 6Add BLAST22
Repeati742 – 763LRR 7Add BLAST22
Repeati765 – 787LRR 8Add BLAST23
Repeati856 – 877LRR 9Add BLAST22
Repeati883 – 905LRR 10Add BLAST23
Repeati906 – 928LRR 11Add BLAST23
Repeati930 – 952LRR 12Add BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini969 – 1167RocPROSITE-ProRule annotationAdd BLAST199
Domaini1694 – 1992Protein kinasePROSITE-ProRule annotationAdd BLAST299

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.By similarity

Keywords - Domaini

ANK repeat, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0192 Eukaryota
KOG0504 Eukaryota
KOG0619 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165193

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000987_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9TZM3

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVHIKIA

Database of Orthologous Groups

More...
OrthoDBi
14978at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9TZM3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR020859 ROC_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF16095 COR, 1 hit
PF13855 LRR_8, 1 hit
PF00069 Pkinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 8 hits
SM00369 LRR_TYP, 7 hits
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 2 hits
SSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS51450 LRR, 10 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS51424 ROC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9TZM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLSSGGPSS SSDVASELDN SDAMQLVRQA VLFENVELLA DLFKVNPWVW
60 70 80 90 100
NRVDRHGRTP LMLAAHNGKL DSLRTILMLS PNSLNLVNDR GKTALHMAAE
110 120 130 140 150
SGETSIVLEL VELGSDPMKS DNEGHCALEL AQMAGHNEVA AKLIDAIQKE
160 170 180 190 200
SEDLNEAHTM IISACISGSA DVVYEISRRF MEKKQSREIL FNGRNEEDET
210 220 230 240 250
ALLIACTNGH IEIVRHLLQF EEHLLQSHVS KDTVIHAAVS SQNVEVLQLC
260 270 280 290 300
LEKFPQLVKS TNNEGSTCLH WAARCGSSEC VSTILNFPFP SEFIIEIDTV
310 320 330 340 350
GAPAYQLALD VNEVDGECRT AMYLAVAEGH LEVVKAMTDF KCTSIDGRQR
360 370 380 390 400
CPFQLDVYCT RGRTPFMLAA FNQNLPLMTL LLDAGADVNL PLAVLDTEYS
410 420 430 440 450
VEEGRCIGSG ALVEAVRSDG LHIVHFLLDR GALDTDNKAL RLAAQGKNEK
460 470 480 490 500
LIRVFLVRLV FADPEYKINK KNIDVGQIQV GQSLLPSSLC PSKAAQLNWN
510 520 530 540 550
SANLEQLQSD WFVAAALHVN PRLRTTRLSL AAITRVDLSD NRLNTFPSIL
560 570 580 590 600
FQMPSLRSLN LADNSIRKIE IPTYYISSTS LEILNLRNNQ LECIAIQFLS
610 620 630 640 650
SLPQLQQLDV SKNELSQLPE YIWLCPALKE LNASYNRLST LPMVARASRG
660 670 680 690 700
ERPRLNNSNN NFNTQSPTQE SNPIVVDDPP NVTSNPLRRQ NVWQASINLS
710 720 730 740 750
KVDDDSLFPD FPVTSSNTLT TINLSFNKFH TFPFCLACTC PRLLILNMSN
760 770 780 790 800
NSMTSLPPMA CVPAHLRTLD LSYNKIQESF IEASPLHVVC HAVPPTTSNG
810 820 830 840 850
SMLPKRRNSP ARQHRSRSKS AVRSQRSLSV SRHHALIDPQ KEEESCVHKR
860 870 880 890 900
HDSLEWLKTL QLAGNRLRSI SVTNAASKVL LPALNVMDIS DNKLLQAPPD
910 920 930 940 950
VARLTLLSML NLSGNTAIKE LPPDYGMLSR LWSLSLKGCS LKEPLESMVN
960 970 980 990 1000
VENCKTVEIV AYLKTILEES KTYHHLRLMI LGSDGVGKSV IWDALCKEAV
1010 1020 1030 1040 1050
QKRQPIHSET GVIRQAEWKF EAKRSKGDKN LGPVGFSVID FGGQREYHST
1060 1070 1080 1090 1100
HQYFLSKRSL NLVLWKITDG DEALAQLDTW LVNIHARAPN STVILVGTNL
1110 1120 1130 1140 1150
DQVASNSSKF GPGYIDIMEQ KVRTRYMVAD ADKSGLPRIV DVILINSTSR
1160 1170 1180 1190 1200
NDVKALLNTI YRTAWEVRMG KERAMEQQIP SSYIALMKVT KELGVEFRKE
1210 1220 1230 1240 1250
GQPAVMTVEA YRERVKKRMI SKFGRPFRDD IEFYAACTFL HDCGELVRFE
1260 1270 1280 1290 1300
DATLRDLIFV DPLWLAEFLT SVVILRSPNL PAGLLSTDAI NPHTRSFKSG
1310 1320 1330 1340 1350
ALLMLKTQLL DLLHKFELAL ATQPRQLLIP SLLPDEYRLR SDFLASAVKI
1360 1370 1380 1390 1400
RMKMSQWNVR CPSPAGSPTK SPLRRTSPTD QNGVGSEDVM LQFTYDDDQL
1410 1420 1430 1440 1450
LRRIYALAYI PSGFWSRLVT RIVGDKNVCA AIESIFMTTS ADRAKIADIA
1460 1470 1480 1490 1500
TKHAKAEWVV WQTGIELHVK GHSLFTLKQF LPLAEVRDID YSAIDMRAKD
1510 1520 1530 1540 1550
EQKRWRTWNQ PSHRPIVEMV VNSLSISAAS QHGRKLSMKT DVEGRSRLLA
1560 1570 1580 1590 1600
MISDLLDTLL EDWYPALGTR FVHSSEGDLL VSRYVLCPQC VRDAERNGSR
1610 1620 1630 1640 1650
SRTSSSASHR RSQDDGELPI TSSSHMKGSR TTGDISKCRG GVVHCFVIEE
1660 1670 1680 1690 1700
CMLAGREYNW VECPSHGGLH MRELAPDTVF ADIENALTIH PDQLKRSRML
1710 1720 1730 1740 1750
GRGAFGFVFR ATVRQPNGEL CEVAQKMLEP VDPGPGGRPS ALAAYKAAAD
1760 1770 1780 1790 1800
KWKRDSMEFA CRAYCTSRQE LSLLSRMKHP NVIGLVGVCT FPLSLVVELA
1810 1820 1830 1840 1850
PLGALNQLLG SHRKAGTKLS LGVIKESAVQ VARALEYLHS AHIIYRDLKS
1860 1870 1880 1890 1900
ENVLGWRFPA PFSPQTDVLL KLGDYGISRS VLPSGGAKGF GGTEGFMAPE
1910 1920 1930 1940 1950
IVRFNGEEEY TQKVDCFSFG MFLYELLTLK FPFESEEHVK ERMLDGARPV
1960 1970 1980 1990 2000
LLPHELLLPT PMLDLLVHCW SAHPESRPSS SQLVGFCAAP EFTHLLDVCE
2010 2020 2030 2040 2050
LGEALPPTQL MAVGITDEID DPDDFEAQLW LSGREMVVMG CTQYGFVDQK
2060 2070 2080 2090 2100
SIELPHRGKY VSKVRDSVWS CDECGQVTVY GISLHETGHL QLPSLNGTLI
2110 2120 2130 2140 2150
CAPELISNDV LILISDKQIV LLKLSESNSV SHLGTIDSPY EIRTATFLGN
2160 2170 2180 2190 2200
GSTRQIWAGH SEGRISIHHI ASNDSFSFSS SLYLPDDKCI VRQLVGSKDA
2210 2220 2230 2240 2250
QKVWIALEKS SKVQMVEVEK RQVTGSLDIR KVMPGSETIH TIDMEMASQN
2260 2270 2280 2290 2300
YVTCIGLLER NDGDQLYIGT SKGLLVIAHA TTLQPLSACR PFEGDITSIC
2310 2320 2330 2340 2350
ILEEPSREEE NTRGKATTLS TASSESGLGW VRERVSETVD RFRSSPATVE
2360 2370 2380 2390
TQGAALVVCI GRQFRSLSHR FVAEEKLADV YSIAVWRTEE WAL
Length:2,393
Mass (Da):266,322
Last modified:February 5, 2008 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0E6BB5780DC9C85
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB297384 mRNA Translation: BAF48647.1
FO081425 Genomic DNA Translation: CCD71547.1

NCBI Reference Sequences

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RefSeqi
NP_492839.4, NM_060438.6

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
T27C10.6.1; T27C10.6.1; WBGene00003068

Database of genes from NCBI RefSeq genomes

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GeneIDi
172995

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T27C10.6

UCSC genome browser

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UCSCi
T27C10.6 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB297384 mRNA Translation: BAF48647.1
FO081425 Genomic DNA Translation: CCD71547.1
RefSeqiNP_492839.4, NM_060438.6

3D structure databases

SMRiQ9TZM3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.T27C10.6

Proteomic databases

EPDiQ9TZM3
PaxDbiQ9TZM3
PeptideAtlasiQ9TZM3
PRIDEiQ9TZM3

Genome annotation databases

EnsemblMetazoaiT27C10.6.1; T27C10.6.1; WBGene00003068
GeneIDi172995
KEGGicel:CELE_T27C10.6
UCSCiT27C10.6 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
172995
WormBaseiT27C10.6 ; CE41939 ; WBGene00003068 ; lrk-1

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
KOG0504 Eukaryota
KOG0619 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000165193
HOGENOMiCLU_000987_0_0_1
InParanoidiQ9TZM3
OMAiHVHIKIA
OrthoDBi14978at2759
PhylomeDBiQ9TZM3

Enzyme and pathway databases

SignaLinkiQ9TZM3

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9TZM3

Gene expression databases

BgeeiWBGene00003068 Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

Family and domain databases

Gene3Di1.25.40.20, 2 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR020859 ROC_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16095 COR, 1 hit
PF13855 LRR_8, 1 hit
PF00069 Pkinase, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 8 hits
SM00369 LRR_TYP, 7 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48403 SSF48403, 2 hits
SSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS51450 LRR, 10 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS51424 ROC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRK1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TZM3
Secondary accession number(s): A3KFB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 5, 2008
Last modified: February 26, 2020
This is version 155 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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