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Protein
Submitted name:

HAlF transporter (PGP related)

Gene

haf-4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi533 – 540ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • lipid metabolic process Source: WormBase
  • lysosomal transport Source: WormBase
  • multicellular organism growth Source: WormBase
  • peptide transport Source: InterPro

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-382556 ABC-family proteins mediated transport
R-CEL-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Protein family/group databases

TCDBi3.A.1.209.3 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Submitted name:
HAlF transporter (PGP related)Imported
Gene namesi
Name:haf-4Imported
ORF Names:CELE_W04C9.1Imported, W04C9.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiW04C9.1a ; CE28355 ; WBGene00001814 ; haf-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 33HelicalSequence analysisAdd BLAST22
Transmembranei53 – 75HelicalSequence analysisAdd BLAST23
Transmembranei87 – 106HelicalSequence analysisAdd BLAST20
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei179 – 202HelicalSequence analysisAdd BLAST24
Transmembranei222 – 243HelicalSequence analysisAdd BLAST22
Transmembranei322 – 344HelicalSequence analysisAdd BLAST23
Transmembranei400 – 425HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ9TZD9
PaxDbiQ9TZD9
PeptideAtlasiQ9TZD9

Expressioni

Gene expression databases

BgeeiWBGene00001814 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.W04C9.1

Structurei

3D structure databases

ProteinModelPortaliQ9TZD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 465ABC transmembrane type-1InterPro annotationAdd BLAST281
Domaini498 – 733ABC transporterInterPro annotationAdd BLAST236

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
InParanoidiQ9TZD9
KOiK05656
OMAiDRICVFL
OrthoDBiEOG091G0HVA
PhylomeDBiQ9TZD9

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00958 3a01208, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9TZD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSTVASRFS WGLILASIDF LACLLFACLH DGTFKFANFT SQFGDFSFFT
60 70 80 90 100
STIDLFLLQF FRFALWMVPA AIHVANKADT LTMWKEPIFC SALLICAASP
110 120 130 140 150
TKLLLLTEKL KPDEFLTFGD TAFLVWNFIS AIILNSSWTR YFSRTPSSYI
160 170 180 190 200
ILEDEDLEVA PKQTFELIFR LLQYCKREWL WHISGFSWLF IYSITRIFVP
210 220 230 240 250
YYTGQVIATV VATKSYPALS NAVYIMTIIS LVSAVAAGFR GGSFEYAYAR
260 270 280 290 300
IQRAIRYDLF HGLVKQDVAF YDAHKTGEVT SRLAADCQTM SDTVALNVNV
310 320 330 340 350
FLRNCVMLLG SMIFMMKLSW RLSLVTFILV PIIFVASKIF GTYYDLLSER
360 370 380 390 400
TQDTIAESND VAEEVLSTMR TVRSFSCENV EADRFYGKLT HTLDVTRTKA
410 420 430 440 450
IAYIGFLWVS ELFQSFIIVS VLWYGGHLVL TQKMKGDLLV SFLLYQMQLG
460 470 480 490 500
DNLRQMGEVW TGLMQSVGAS RKVFEYIDRE PQIQHNGEYM PENVVGKIEF
510 520 530 540 550
RNVHFSYPTR SDQPILKDLS FTVEPGETVA LVGPSGSGKS SCISLLENFY
560 570 580 590 600
VPNAGQVLVD GVPLEEFEHH YIHKKIALVG QEPVLFARSV MENVRYGVEV
610 620 630 640 650
ADTEIIRSCE MANAHGFIMQ TTLKYETNVG EKGTQMSGGQ KQRIAIARAL
660 670 680 690 700
VREPAILLLD EATSALDTES EHLVQEAIYK NLDGKSVILI AHRLSTVEKA
710 720 730 740 750
DKIVVINKGR VEQIGNHETL LKDTNGTYAK LVQRQMMGDQ KPRKRPAVAR
760 770 780
SGPQPAASIN VAGPSQGNAM SLLSTSFSQS ASSVTSH
Length:787
Mass (Da):88,276
Last modified:October 1, 2001 - v2
Checksum:i739536AA8EFAE7A4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V6CLE7V6CLE7_CAEEL
HAlF transporter (PGP related)
haf-4 CELE_W04C9.1, W04C9.1
721Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD73387.1
PIRiT33559
RefSeqiNP_001021666.1, NM_001026495.4
UniGeneiCel.7790

Genome annotation databases

EnsemblMetazoaiW04C9.1a; W04C9.1a; WBGene00001814
GeneIDi171639
KEGGicel:CELE_W04C9.1
UCSCiW04C9.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD73387.1
PIRiT33559
RefSeqiNP_001021666.1, NM_001026495.4
UniGeneiCel.7790

3D structure databases

ProteinModelPortaliQ9TZD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.W04C9.1

Protein family/group databases

TCDBi3.A.1.209.3 the atp-binding cassette (abc) superfamily

Proteomic databases

EPDiQ9TZD9
PaxDbiQ9TZD9
PeptideAtlasiQ9TZD9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW04C9.1a; W04C9.1a; WBGene00001814
GeneIDi171639
KEGGicel:CELE_W04C9.1
UCSCiW04C9.1 c. elegans

Organism-specific databases

CTDi171639
WormBaseiW04C9.1a ; CE28355 ; WBGene00001814 ; haf-4

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
InParanoidiQ9TZD9
KOiK05656
OMAiDRICVFL
OrthoDBiEOG091G0HVA
PhylomeDBiQ9TZD9

Enzyme and pathway databases

ReactomeiR-CEL-382556 ABC-family proteins mediated transport
R-CEL-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Gene expression databases

BgeeiWBGene00001814 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00958 3a01208, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9TZD9_CAEEL
AccessioniPrimary (citable) accession number: Q9TZD9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2001
Last modified: October 10, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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