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Entry version 110 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

Serine-repeat antigen protein 5

Gene

SERA5

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role during the asexual blood stage development by controlling the kinetics of merozoite egress from host erythrocytes (PubMed:25599609, PubMed:28683142). Specifically, prevents premature rupture of the parasitophorous vacuole and host erythrocyte membranes (PubMed:28683142).2 Publications
May prevent merozoite phagocytosis by host monocytes via interaction with host VTN at the merozoite surface (By similarity). Plays a role in parasite growth (By similarity).By similarity
Protease activity is controversial (PubMed:25599609). Has been shown in a number of studies to have protease activity towards a synthetic peptide in vitro (PubMed:13679369, PubMed:24769454, PubMed:29716996). Has also been shown to lack protease activity towards a synthetic peptide in vitro (PubMed:25599609).4 Publications

Caution

In contrast to other serine-repeat antigen proteins (SERA) of the peptidase C1 family, contains a serine residue at the position of the canonical catalytic cysteine and has been shown to lack protease activity. However, other studies show that it has protease activity towards synthetic peptides in vitro (PubMed:13679369, PubMed:24769454, PubMed:29716996).2 Publications3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei596Ancestral active site2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei762PROSITE-ProRule annotation1
Active sitei787PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C01.984

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine-repeat antigen protein 5Curated (EC:3.4.22.-3 Publications)
Alternative name(s):
111 kDa antigen
Serine protease SERA5Curated
p126
Cleaved into the following 6 chains:
p471 Publication
Alternative name(s):
SER36By similarity
p561 Publication
p501 Publication
p181 Publication
p25n1 Publication
p25c1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERA51 Publication
ORF Names:PFB0340c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_0207600

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Conditional knockout at the merozoite stage, does not cause any defect in schizont morphology, merozoite number and maturation initially. During the subsequent invasive cycle in host erythrocytes, merozoite replication is severely impaired due to a premature rupture of the parasitophorous vacuole and erythrocyte membranes resulting in an inefficient dispersal of released merozoites.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi590 – 997Missing : No viable parasite. 1 PublicationAdd BLAST408
Mutagenesisi596S → A: Lacks protease activity. No cellular location and growth defects in host red blood cells. 2 Publications1
Mutagenesisi596S → C: Gains protease activity. 1 Publication1
Mutagenesisi596S → R: No viable parasite. 1 Publication1

Keywords - Diseasei

Malaria

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002647923 – 997Serine-repeat antigen protein 5Add BLAST975
ChainiPRO_000045017723 – 390p471 PublicationAdd BLAST368
ChainiPRO_000045017823 – 200p25n1 PublicationAdd BLAST178
ChainiPRO_0000450179201 – 390p25c1 PublicationAdd BLAST190
ChainiPRO_0000450180391 – 886p561 PublicationAdd BLAST496
ChainiPRO_0000450181391 – 842p501 PublicationAdd BLAST452
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000450182843 – 886Inhibition peptide2 PublicationsAdd BLAST44
ChainiPRO_0000450183887 – 997p181 PublicationAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei183Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi445 ↔ 4971 Publication
Modified residuei549Phosphothreonine; by CPK11 Publication1
Disulfide bondi567 ↔ 572Combined sources2 Publications
Disulfide bondi581 ↔ 610Combined sources1 Publication
Disulfide bondi593 ↔ 636Combined sources1 Publication
Disulfide bondi627 ↔ 672Combined sources1 Publication
Disulfide bondi755 ↔ 809Combined sources1 Publication
Glycosylationi828N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei866Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by CPK1/CDPK1 increases SERA5 protease activity towards a synthetic peptide in vitro.1 Publication
Just prior to merozoite egress from host erythrocytes, proteolytically cleaved into multiple fragments (PubMed:18083098, PubMed:25599609, PubMed:24769454). Cleaved by SUB1 into p47 and p73, p73 is further cleaved by SUB1 into p56 and p18 and p56 is further processed into p50 by an unidentified protease (PubMed:25599609, PubMed:18083098). p47 remains covalently associated with p18 via disulfide bond (PubMed:25599609). p47 can be processed into p25n and p25c by SUB1 (PubMed:25599609, PubMed:18083098). p25c and p25n remain associated with p18 (PubMed:25599609). Proteolytic processing is essential for merozoite egress from host erythrocytes (PubMed:28683142). The cleavage of the propeptide to produce p50 is necessary for protease activity and to promote merozoite egress (PubMed:24769454).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei200 – 201Cleavage; by SUB11 Publication2
Sitei390 – 391Cleavage; by SUB11 Publication2
Sitei842 – 843Cleavage1 Publication2
Sitei886 – 887Cleavage; by SUB11 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9TY95

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9TY95

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during parasite asexual blood stages, specifically in late trophozoite and schizont stages (at protein level).6 Publications
Produced during parasite asexual blood stages, specifically at the merozoite stage just prior to egress (at protein level).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact (via C-terminus) with PTKL (via SAM domain).

1 Publication

Interacts (via C-terminus) with human VTN (via hemopexin repeat 2); may form heterotetramers of two VTN and SERA5 P47 heterodimers; the interaction may protect merozoites from phagocytosis by host monocytes; VTN glycosylation appears to be dispensable for the interaction.

By similarity

Monomer (PubMed:13679369, PubMed:25599609).

Interacts with kinase CPK1/CDPK1 at the schizont stage (PubMed:29716996).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
1207988, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q9TY95, 24 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1997
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q9TY95

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9TY95

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9TY95

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni216 – 253Interaction with PTKL1 PublicationAdd BLAST38
Regioni373 – 390Interaction with host VTNBy similarityAdd BLAST18
Regioni579 – 997Thiol-protease-like1 PublicationAdd BLAST419

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 103Ser-richSequence analysisAdd BLAST58
Compositional biasi205 – 235Poly-SerSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005127_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9TY95

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPHENEF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9TY95

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR025661, Pept_asp_AS
IPR025660, Pept_his_AS
IPR000668, Peptidase_C1A_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00112, Peptidase_C1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00645, Pept_C1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00640, THIOL_PROTEASE_ASN, 1 hit
PS00639, THIOL_PROTEASE_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TY95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSYISLFFI LCVIFNKNVI KCTGESQTGN TGGGQAGNTG GDQAGSTGGS
60 70 80 90 100
PQGSTGASPQ GSTGASPQGS TGASQPGSSE PSNPVSSGHS VSTVSVSQTS
110 120 130 140 150
TSSEKQDTIQ VKSALLKDYM GLKVTGPCNE NFIMFLVPHI YIDVDTEDTN
160 170 180 190 200
IELRTTLKKT NNAISFESNS GSLEKKKYVK LPSNGTTGEQ GSSTGTVRGD
210 220 230 240 250
TEPISDSSSS SSSSSSSSSS SSSSSSSSSS SSSESLPANG PDSPTVKPPR
260 270 280 290 300
NLQNICETGK NFKLVVYIKE NTLILKWKVY GETKDTTENN KVDVRKYLIN
310 320 330 340 350
EKETPFTNIL IHAYKEHNGT NLIESKNYAI GSDIPEKCDT LASNCFLSGN
360 370 380 390 400
FNIEKCFQCA LLVEKENKND VCYKYLSEDI VSKFKEIKAE TEDDDEDDYT
410 420 430 440 450
EYKLTESIDN ILVKMFKTNE NNDKSELIKL EEVDDSLKLE LMNYCSLLKD
460 470 480 490 500
VDTTGTLDNY GMGNEMDIFN NLKRLLIYHS EENINTLKNK FRNAAVCLKN
510 520 530 540 550
VDDWIVNKRG LVLPELNYDL EYFNEHLYND KNSPEDKDNK GKGVVHVDTT
560 570 580 590 600
LEKEDTLSYD NSDNMFCNKE YCNRLKDENN CISNLQVEDQ GNCDTSWIFA
610 620 630 640 650
SKYHLETIRC MKGYEPTKIS ALYVANCYKG EHKDRCDEGS SPMEFLQIIE
660 670 680 690 700
DYGFLPAESN YPYNYVKVGE QCPKVEDHWM NLWDNGKILH NKNEPNSLDG
710 720 730 740 750
KGYTAYESER FHDNMDAFVK IIKTEVMNKG SVIAYIKAEN VMGYEFSGKK
760 770 780 790 800
VQNLCGDDTA DHAVNIVGYG NYVNSEGEKK SYWIVRNSWG PYWGDEGYFK
810 820 830 840 850
VDMYGPTHCH FNFIHSVVIF NVDLPMNNKT TKKESKIYDY YLKASPEFYH
860 870 880 890 900
NLYFKNFNVG KKNLFSEKED NENNKKLGNN YIIFGQDTAG SGQSGKESNT
910 920 930 940 950
ALESAGTSNE VSERVHVYHI LKHIKDGKIR MGMRKYIDTQ DVNKKHSCTR
960 970 980 990
SYAFNPENYE KCVNLCNVNW KTCEEKTSPG LCLSKLDTNN ECYFCYV
Length:997
Mass (Da):111,768
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF26A8A03E512ED5
GO

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 52540.17 Da. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE001362 Genomic DNA Translation: AAC71857.1
LN999943 Genomic DNA Translation: CZT98089.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B71617

NCBI Reference Sequences

More...
RefSeqi
XP_001349586.1, XM_001349550.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT98089; CZT98089; PF3D7_0207600

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0207600.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
812668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0207600

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001362 Genomic DNA Translation: AAC71857.1
LN999943 Genomic DNA Translation: CZT98089.1
PIRiB71617
RefSeqiXP_001349586.1, XM_001349550.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WBFX-ray1.60X564-828[»]
3CH2X-ray1.80X564-828[»]
3CH3X-ray1.79X564-828[»]
BMRBiQ9TY95
SMRiQ9TY95
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi1207988, 24 interactors
IntActiQ9TY95, 24 interactors

Protein family/group databases

MEROPSiC01.984

PTM databases

SwissPalmiQ9TY95

Proteomic databases

PRIDEiQ9TY95

Genome annotation databases

EnsemblProtistsiCZT98089; CZT98089; PF3D7_0207600
GeneDBiPF3D7_0207600.1:pep
GeneIDi812668
KEGGipfa:PF3D7_0207600

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0207600

Phylogenomic databases

HOGENOMiCLU_005127_0_0_1
InParanoidiQ9TY95
OMAiLPHENEF
PhylomeDBiQ9TY95

Miscellaneous databases

EvolutionaryTraceiQ9TY95

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR025661, Pept_asp_AS
IPR025660, Pept_his_AS
IPR000668, Peptidase_C1A_C
PfamiView protein in Pfam
PF00112, Peptidase_C1, 1 hit
SMARTiView protein in SMART
SM00645, Pept_C1, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640, THIOL_PROTEASE_ASN, 1 hit
PS00639, THIOL_PROTEASE_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSERA5_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TY95
Secondary accession number(s): A0A143ZWK2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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